• The modern concept of uterine cancer and its treatment

The modern concept of uterine cancer and its treatment

HEALTH OF WOMAN.2016.7(113):16–22 

The modern concept of uterine cancer and its treatment 

Veropotvelyan P. N., Veropotvelyan N. P., Tsehmistrenko I. S., Bondarenko A. A.

The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog

Perinatal center, Kiev

Uterine fibroids – benign, monoclonal, well-demarcated, encapsulated tumors originating from the smooth muscle of the uterus or cervix cells in the body – one of the most common benign tumors. The emergence and development of uterine fibroids – a multifactorial process, which explains the frequent dissemination and heterogeneity of the tumor itself both morfogistohimicheskim characteristics and clinical manifestations. With the aim of preoperative preparation before removing nodes from patients’ symptomatic uterine myoma appointed agonist of gonadotropin-releasing hormone, progesterone antagonists (mifepristone). In the literature there are publications on the use of synthetic selective progesterone receptor modulator – ulipristal acetate not only for preoperative preparation of patients with uterine myoma, but also to their conservative therapy for 90 days. According to the result of a study conducted by the authors of the publication under the supervision of 11 patients with uterine myoma, reported a significant decrease in the size of fibroids in women surveyed 1/2. Despite the fact that the treatment of selective progesterone receptor modulator reduces the clinical manifestations and the growth of uterine fibroids, the efficacy and safety of its long-term use in patients with «symptomatic» myoma uteri nevertheless calls for further study

Key words: conservative treatment of uterine fibroids, progesterone receptor modulator, ulipristal acetate.


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