• The immune phenotype of pregnant women infected with parvovirus B19, a non-immune fetal hydrops: clinical cases
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The immune phenotype of pregnant women infected with parvovirus B19, a non-immune fetal hydrops: clinical cases

HEALTH OF WOMAN. 2016.6(112):59–61 

The immune phenotype of pregnant women infected with parvovirus B19, a non-immune fetal hydrops: clinical cases 

Bondarenko N. P., Lakatosh V. P., Aksonova A. V.

A.A. Bogomolets National Medical University, Kiev

Perinatal center, Kiev


The article analyzes the performance of immunograms of pregnant women in three clinical cases of non-immune fetal hydrops caused by parvovirus B19 infection that resulted in death in 2 cases. Demonstrated that two patients with the normal parameters of humoral immunity, a decrease of quantitative indicators of T-lymphocytes and the main effectors of antiviral cellular immunity – cytotoxic CD8+ lymphocytes and NK-cells as compared with the data of the third patient for which was characterized by the activation of the cellular component of antiviral immunity that is contributed to the effective elimination of the infection and prevent severe fetal losses, which stayed alive. We consider it necessary to focus the attention of physicians on this medical aspect that the functional activity of the immune system of pregnant women is an important factor in case of parvovirus B19 infection which determines the efficiency and speed to overcome the infection and predict its consequences for the child.


Key words: parvovirus B19, non-immune fetal hydrops, immune phenotype.


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