• The features ratio of chromosomal abnormalities and terms of persistence of gestational sacs among undeveloping pregnancies in cases without embryo (anembrioniya) and with the existing embryo: analysis of 1328 cases
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The features ratio of chromosomal abnormalities and terms of persistence of gestational sacs among undeveloping pregnancies in cases without embryo (anembrioniya) and with the existing embryo: analysis of 1328 cases

HEALTH OF WOMAN.2015.5(101):74–80; doi 10.15574/HW.2015.101.74

The features ratio of chromosomal abnormalities and terms of persistence of gestational sacs among undeveloping pregnancies in cases without embryo (anembrioniya) and with the existing embryo: analysis of 1328 cases

Veropotvelyan N. P., Kodunov L. O.
«Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog

The paper presents the analysis of the frequency, spectrum of chromosomal aberrations (CA) and the timing of death in the group of undeveloping pregnancy without embryo (anembrioniya) and with the existing embryo (without heart beats). The timing of persistent gestational sac at miscarrying pregnancies with different CA and without in the association of the presence or absence of fetal structures were also investigated.
1328 missed abortions were karyotyped by direct method (material was obtained from different cities and districts of Dnipropetrovsk, Kirovohrad, Zaporizhia, Mykolaiv, Kherson, Vinnitsa, Cherkassy, Poltava regions of Ukraine and Crimea). The assessment of presence, condition and developemt of the gestational sac and its structural elements was carried out using high resolution transvaginal sonography.
According to the US, the cases of anembrioniya among the first trimester missed abortion were 30.6%. The frequency of chromosomal aberrations in the missed abortions cytotrophoblast villi among anembriony, and in the presence of the embryo was 59%. Trisomy 14, 15 confirmed three times, and monosomy X – six times more likely to die in the embryonic period than preembrionic one. It was revealed that tetraploid gestational sac duration of persistency significantly shorter.

Key words: karyotype, missed abortion, chromosomal abnormalities, anembrioniya, gestational sac.

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