• The clinical-pathogenetic aspects and the optimization of the therapeutic approaches in an acute respiratory-viral infections among children
To content

The clinical-pathogenetic aspects and the optimization of the therapeutic approaches in an acute respiratory-viral infections among children

SOVREMENNAYA PEDIATRIYA.2014.4(60):72-76;doi 10.15574/SP.2014.60.72

The clinical-pathogenetic aspects and the optimization of the therapeutic approaches in an acute respiratory-viral infections among children

Buryak V. N., Такtashov S. I., Маhmutov R. F., Poshehonova Y. V., Shaban N. I., Мoiseevа Т. Y.

Donetsk national medical university named after M.Gorkiy, Ukraine

Purpose: improving the efficiency of an acute respiratory viral infections (ARVI) treatment among children based on studying the nature and the role of the immunopathological processes, identifying the violations and including into the therapy complex a recombinant interferon alfa-2b (Nazoferon).

Patients and methods. There were observed 42children from 3 months up to 3 years old after ARVI. The main group consist of 22 patients who were treated with Nazoferon, the second one consist of 20 sick children with the commonly therapy. The control group consist of the 20 healthy children the same age. There were investigated the complains, life anamnesis and disease, the objective checkup was examined, before and after the treatment it was done the general analysis of peripheral blood and researches исследование IFN-g, TNF, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10 with sIgA content.

Results. The treatment using Nazoferon was more effective than the commonly therapy. The remedy had an influence on the local immune defense mechanisms, recovered the cytokine balance that helped to interrupt the disease symptoms and to recover the haemogram.

Conclusion. Nazoferone is an effective remedy in ARVI therapy among children.

Key words: the acute respiratory viral infections, children, local immunological mucosal barriers of the upper respiratory tract, cytokines, Nazoferon

REFERENCES

1. Богомолов БП. Девяткин АВ. 2003. Клиническое значение нарушений микроциркуляции и гемореологии при ОРВИ и их медикаментозная коррекция. Клин медицина. 81;5: 9-15.

1. Богомолов БП. 2000. Микроциркуляторные и гемостазиологические нарушения у больных гриппом и респираторными инфекциями, отягощёнными сопутствующими заболеваниями. Клин медицина. 78;8: 52—56.

2. Боровиков ВП, Боровиков НП. 1997. STATISTICA — статистический анализ и обработка данных в среде Windows. М, Информационно-издательский дом «Филин»: 608.

3. Крамарев СА, Мощич АП. 2011. Результаты исследования эффективности препарата афлубин при острых респираторных инфекциях у детей. Совр педиатрия. 37;3: 28—31.