- Supplementation of Effective Protective Folic Acid Concentrations for Perinatal Complications Prevention
Supplementation of Effective Protective Folic Acid Concentrations for Perinatal Complications Prevention
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.4(76):17-20; doi 10.15574/PP.2018.76.17
Davydova Iu. V.
SI «Institute of Pediatrics, Obstetrics and Gynecology named after аcademician O. Lukyanova of the National Academy of Medical Sciences of Ukraine»,
Given the increased frequency of comorbidity in pregnant women over the past twenty years, including diseases that hinder folate absorption from food, it is necessary to inform the public and health care providers about the importance of taking 0.8 mg/day of folic acid to ensure an effective protective dose in the blood of women who are planning pregnancy. Taking into account the lack of pregnancy planning in half of cases in our country and the short window for potential positive impact for the prevention of neural tube defects during pregnancy, it is advisable to use medical certified multivitamin complex with folic acid content of 0.8 mg/day (Elevit Pronatal) immediately after intrauterine pregnancy is diagnosed. In case of identified genes polymorphisms, which are encoding folate metabolism and receptor activation, 0.8 mg/day of folic acid should be prescribed to women in the preconception period, at the stage of organogenesis and placentogenesis. It is advisable to disseminate information about the need to take certified vitamin-mineral complex by women of reproductive age when they apply for any kind of medical care to primary care physicians, as well as during routine examinations or calls for gynecological help to obstetrician gynecologists.
Key words: prevention of perinatal complications, folic acid.
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Article received: Aug 12, 2018. Accepted for publication: Dec 03, 2018.