• The sonographic features of neonatal jaundice
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The sonographic features of neonatal jaundice

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.4(76):87-92; doi 10.15574/PP.2018.76.87

Lukianova I. S., Medvedenko G. F., Tarasiuk B. A., Golovchenko O. V., Solodushchenko V. V.
SI «Institute of Pediatrics, Obstetrics and Gynecology named of academician O.M. Lukyanova NAMS of Ukraine», Kyiv

Purpose — to determine the main ultrasound features of neonatal jaundice based on the etiological factors, frequency and peculiarities of manifestations.

Patients and methods. The sonograms of 328 neonates were analyzed over the period of 2013–2018. All patients had an in-depth clinical and laboratory examination. Sonography was carried out according to generally accepted protocols by state of the art equipment. All the cases were divided into four clinical groups, which demonstrated abnormal hepatic sonograms. 138 neonates were with the signs of conjugating jaundice due to immaturity of enzymatic systems (group I). Another 54 cases of isoimmune conflicts due to Rh or group incompatibility (group II). 108 newborns demonstrated signs of parenchymal jaundice of infectious genesis (group III). After all, 28 cases indicated obstructive jaundice (group IV).

Results and conclusions. Conducted studies have shown that the most frequent were jaundices conditioned by diffuse liver damage (caused by intrauterine infection) and as a result of the development of isoimmune conflicts. Obstructive jaundices were the most seldom. They were revealed in deeply preterm infants with cholestasis and biliary atresia. Follow-ups would be paramount in cases of the hepatic sonograms with combined lesions. While there appeared clear signs of either group I or group II. Additional examinations (such as MRCP) were required if it was not possible to distinguish one condition from another sonographically.

Key words: jaundice, newborn, ultrasound, neonatal period.


1. Tarasyuk B., Lukianova I., Medvedenko G., Gridina T., Zhadan E. (2013). Echographic peculiarities of jaundice syndrome in children. Radiation Diagnostics, Radiation Therapy. 2–3: 17–23.

2. Baumann U, Ure B. (2012). Biliary atresia. Clin Res Hepatol Gastroentero. 36: 257—259. https://doi.org/10.1016/j.clinre.2012.03.017; PMid:22609296

3. Davis AR, Rosenthal P, Escobar GJ et al. (2011). Interpreting conjugated bilirubin levels in newborns. J Pediatr. 158: 562—565. https://doi.org/10.1016/j.jpeds.2010.09.061; PMid:21074172 PMCid:PMC3058149

4. Debra H. Pan, Yolanda Rivas (2017). Jaundice: Newbornto Age 2 Months. Pediatrics in Review. 38: 499. PMid:29093118

5. Fawaz R et al. (2016). Guideline for the evaluation of cholestatic jaundice in infants. J. Pediatr. Gastroenterol. Nutr. 64: 1—7.

6. Hodgson JM, van Someren VH, Smith C et al. (2017). Direct bilirubin levels observed in prolonged neonatal jaundice: a retrospective cohort study. BMJ Paediatrics Open 2018. 2: e000202. doi 10.1136/bmjpo-000202.

7. Moyer V, Freese DK, Whitington PF et al. (2004). Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 39: 115—128. https://doi.org/10.1097/00005176-200408000-00001; PMid:15269615

8. NCC-WCH Guideline Development Group. Neonatal Jaundice — NICE Guideline. R. Coll. Obstet. Gynaecol. 2010: 457—475.

Article received: Sep 09, 2018. Accepted for publication: Dec 14, 2018.