• Serum levels of VEGF in blood serum in type 1 diabetes patients with microangyopathy and arterial hypertention
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Serum levels of VEGF in blood serum in type 1 diabetes patients with microangyopathy and arterial hypertention

HEALTH OF WOMAN. 2017.10(126):54–57; doi 10.15574/HW.2017.126.54

Mogylnytska L. A.
Khmelnitsky Regional Hospital

The objective: to determine the serum level of VEGF as a marker of endothelial dysfunction in type 1 diabetic patients with microangiopathy, to study of the association of arterial hypertension and the level of this factor, its relationship with the other risk factors for cardiovascular disease.
Materials and methods. We examined 23 type 1 diabetic patient with microangiopathy and arterial hypertension, 10 type 1 diabetic patient with microangiopathy without hypertension and 28 healthy control subjects. Serum levels of VEGF were determined by immunoenzyme assay. The data were presented as means±SD. Statistical analysis was performed using the Mann — Whitney U-test, Person rank correlation coefficient, multiple regression analysis.
Results. We found an increased serum level of VEGF in type 1 diabetic patients with microangiopathy and arterial hypertension compared to control group (50.13±7.31 and 22.67±4.02 ng/ml respectively; р<0.05), and in type 1 diabetic patients with microangiopathy without hypertension compared to control (42.67±7.46 and 22.67±4.02 ng/ml respectively; р<0.05). Serum level of was elevated in type 1 diabetic patients and arterial hypertension compared to group of diabetic patients without hypertension (50.13±7.31 and 42.67±7.46 ng/ml respectively; р<0.05). Also, the level of fibronectin correlated with key markers of carbohydrate and lipid metabolism (p<0.05).
Conclusion. The revealed changes of VEGF serum levels could reflect an endothelial dysfunction in patients with type 1 diabetes with microangiopathy and arterial hypertension. Arterial hypertension, hyperglycemia, dyslipidemia appear to be significant contributing factor to the elevation of VEGF.
Key words: VEGF, endothelial dysfunction, type 1 diabetes, arterial hypertension.

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