• Seasonal features of formation of chromosomal aberrations in Central and Sauth-Eastern regions of Ukraine: а retrospective analysis of 20 years. 

Seasonal features of formation of chromosomal aberrations in Central and Sauth-Eastern regions of Ukraine: а retrospective analysis of 20 years. 

HEALTH OF WOMAN. 2016.4(110):91–97; doi 10.15574/HW.2016.110.91 
 

Seasonal features of formation of chromosomal aberrations in Central and  Sauth-Eastern regions of Ukraine: а retrospective analysis of 20 years. 

Veropotvelyan M. P., Kodunov L. O., Pogulyay Y. S.

The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog 
 

Objective: to define good and bad months for fertilization embryos with normal chromosome set in a temperate continental climate and average values of insolation, the Central and South-Eastern regions of Ukraine (Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv region).


Materials and methods. For the study were selected in 1711 food concept missed abortion (SG) in the I trimester (925 (54.06%) with chromosomal abnormalities and 786 (45.94%) with normal karyotype derived from women living in Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv regions, for the period from 1997 to 2015. The average term of pollutants was 8±3 weeks.

Because the levels of solar insolation for Dnepropetrovsk, Zaporozhye, Kirovograd, Nikolaev, Kherson, Cherkasy were not statistically different, the average level of this indicator were removed for the region.

Analysis of the reliability of the samples was carried out by the differences of the angular transformation of Fisher.


Results. According to the survey the proportion of embryos with chromosomal abnormality among missed abortion was 54%. Of these, 49.08% are trisomy (without double trisomies – 2.7%); 12.86% – monosomy X; 18.16% – triploidy (69, XXX; 69, XXY, 69, XYY) 9.94% – tetraploid; structural adjustment – 5.95%; 1.31% – mosaic form of CP.

Analysis of the seasonality of conception of healthy full-term infants and embryos from HP in association with the level of insolation in the region showed that the months with the highest level of insolation (April-August) coincide with an increase in the level of registered impregnations healthy full-term babies and the smallest number of fertilized with HP, while in autumn-winter period (October-March) observed peak fertilization HP.


Conclusion. The highest level of the formation of the entire KP amongst non-viable pregnancies prenatally diagnosed fetuses and children born there between November and March. A feature of normal fertilization trend is that a large number of them were registered in the period from July to October.


Key words: chromosomal abnormality, the seasonal distribution of fertilization, meiotic division, metatonin, lyuteinizuyuchy hormone, follicle stimulating hormone.


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