• The role of vitamin D in maintaining women’s health and the modern principles of correction of the D-status

The role of vitamin D in maintaining women’s health and the modern principles of correction of the D-status

HEALTH OF WOMAN. 2018.9(135):44–49; doi 10.15574/HW.2018.135.44

Pуrohova V. I. , Shurpyak S. O. , Oshurkevich O. O. , Zhemela N. I. , Okhabska I. I.
Lviv national medical University named Danylo Galitsky

The article presents an assessment of the effectiveness of various doses of cholecalciferol for the correction of vitamin D-deficient states.

The objective: to study the prevalence of vitamin D deficiency in women of reproductive age with reproductive health disorders and the effectiveness of its correction with the use of Olidetrim.

Materials and methods. Surveyed 350 residents of Lviv and Lviv region, aged 20 to 35 years, who planned the implementation of reproductive plans. Vitamin D deficiency was diagnosed in 275 (78.6%) of the women surveyed, of whom 160 were included in further research with informed consent. Depending on the proposed scheme for the correction of vitamin D deficiency, the patients were divided into groups with distribution into subgroups depending on the level of 25(OH)D in the blood.

Results. It has been established that vitamin D-deficient states in women of reproductive age at the preparatory stage for pregnancy occur in 78.6% of cases, while vitamin D deficiency is most often manifested in women with a BMI of 30–35 kg/m2. The intake of vitamin-mineral complexes containing 400 IU of cholecalciferol, as well as the daily intake of 2000 IU of cholecalciferol, does not prevent the development of deficiency of vitamin D and does not provide for their correction. The use of cholecalciferol in a daily dose of 4000 IU (Olydetrim 4000, Polpharma, Poland) during 3 months of pregravid preparation allows correction of the balance of vitamin D, but it is also insufficient to eliminate severe vitamin D deficiency, which determines the need to take higher doses cholecalciferol in this category of women.

Conclusion. The results indicate a significant prevalence of vitamin D deficiency in women of reproductive age. Correction of deficiency and deficiency of vitamin D from the pregravid preparation stage and during the first trimester of gestation reduces the incidence of early and late gestational complications.

Key words: vitamin D deficiency, cholecalciferol, Olidetrim, pregnancy complications.

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