• Role of proangiogenic factors in the formation of placental barrier structures in pregnant women with congenital heart defects and anaemia

Role of proangiogenic factors in the formation of placental barrier structures in pregnant women with congenital heart defects and anaemia

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):27-30; doi 10.15574/PP.2018.75.27

Butenko L. P., Kyhlevych S. M., Davydova Iu. V.
SI «Istitute of Pediatrics, Obstetrics and Gynecology by academician O.M. Lukyanova of NAMS of Ukraine», Kyiv

Objective: to study the expression of placental growth factor (PGF) in the placenta of women with congenital heart defects, heart failure and anaemia; retrospectively evaluate the process of angiogenesis in the placental barrier structures in this group of women.

Materials and methods. The morphological and functional features of 120 placentas of women with congenital heart defects and anaemia were analysed using the «Placenta passport» method (Placenta study protocol. Form No. 013–1/0, approved by the order of the Ministry of Health of Ukraine No. 417 dated August 19, 2004), and immune histochemical tests were conducted to study PG1F expression in placental barrier structures in these placentas. An indirect streptavidin-peroxidase method was used to detect the expression PlGF level. The control group composed of 30 results of similar tests in women with a physiological pregnancy, the absence of congenital heart defects and anaemia.

Results and conclusions. According to immune histochemical test of the PlGF expression in the placental barrier structures of women with operated and non-operated congenital heart defects and anaemia, inference should be drawn that the hypoxia has a substantial impact on the placental barrier formation in the early stages of gestation; is secondary, in our opinion, to the hypoxygenation of tissues due to heart failure and a decrease in the oxygen saturation of erythrocytes. In this group of women, preconceptional counselling should be conducted, based on the results of which can be carried out the pregravid preparation, including prevention of latent iron deficiency and heart failure progression.

Key words: placental growth factor, pregnant women, congenital heart defects, anaemia.


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Article received: Jun 03, 2018. Accepted for publication: Sep 17, 2018.