- Role of genetic factors in the development of premenstrul syndrome
Role of genetic factors in the development of premenstrul syndrome
HEALTH OF WOMAN. 2018.5(132):84–86; doi 10.15574/HW.2018.132.84
Pakharenko L. V.
SHEE «Ivano-Frankivsk National Medical University»
To identify risks of development of any disease is a priority of modern medicine. The article deals with ESR1 gene polymorphisms and its role in the development of premenstrual.
The objective: of this study was to investigate the frequency of polymorphic variants of A-351G gene estrogen receptor ESR1 in patients with various forms of premenstrual syndrome.
Materials and methods. Molecular genetic analysis of ESR1 gene polymorphism was determines in 50 women with premenstrual syndrome (25 women of them had edematous form of disease, 25 – neuropsychical one; 25 suffered from mild form, 25 – severe one). 25 women without diagnosis of premenstrual syndrome were examined as controls.
Results. The study of A-351G polymorphism estrogen gene ESR1 demonstrated no statistically significant differences in the frequency of distribution of genotypes and alleles between women with premenstrual syndrome and without this pathology. However, the frequency of GG genotype in women with severe PMS was significantly higher in 8.0 times compared with healthy women (χ2=4.87; p=0.03) and in women with edematous form of PMS – in 7.0 times (χ2=3.72; p=0.05).
Conclusion. Thus, a polymorphic variant of A-351G estrogen receptor gene ESR1 can be regarded as a marker for the development of premenstrual syndrome. Pathological variant GG genotype is significantly associated with the presence of edematous and severe forms of the disease.
Key words: premenstrual syndrome, genetic factors, development.
1. Aganezova NV. 2011. The role of hereditary and hormonal factors in the development of premenstrual syndrome. Journal of Obstetrics and Women's Diseases. LX (1): 12-20.
2. Livshits GB, Kucherenko AM, Podlyosna SS, Kravchenko SA, Livshits LA. 2012. Analase of the allelic polimorphism of the ESR1 gene in the middle of the population of Ukraine. Cytology and Genetics. 4:31-39.
3. Aganezova NV, Morozova EB, Chukhlovin AB, Korchagina ZV. 2011. Associations of manifestations of premenstrual syndrome in the psychoemotional sphere with gene polymorphism of ER-1 receptor gene. Journal of Obstetrics and Women's Diseases. LX (2): 14-20.
4. Zaporozhan VM, Boris OM. 2011. Linkage of the low response rate to stimulation of ovulation in patients with polycystic ovary syndrome with functional genetic polymorphism. Medico-social problems of family. 3:35-39.
5. Order № 676 of Ministry of Health of Ukraine. 31.12.2004. Approval of clinical protocols for obstetric and gynecological care. Electronic resource. Way of access: URL: http://www.moz.gov.ua/ua/portal/ dn_20041231_676.html . Title from the screen.
6. Smetnik VP, Tymilovich LG, editors. 1995. Neoperative Gynecology: Guidance for doctors. Book 1. SPb., SOTIS: 129-38.
7. Wang W, Li Y, Maitituoheti M, Yang R, Wu Z, Wang T et al. 2013. Association of an oestrogen receptor gene polymorphism in Chinese Han women with endometriosis and endometriosis-related infertility. Reprod Biomed Online. 26(1):93-8. https://doi.org/10.1016/j.rbmo.2012.09.007; PMid:23177411
8. Miller A, Vo H, Huo L, Roca C, Schmidt PJ, Rubinow DR. 2010. Estrogen receptor alpha (ESR-1) associations with psychological traits in women with PMDD and controls. J Psychiatr Res. 44(12):788-94. https://doi.org/10.1016/j.jpsychires.2010.01.013; PMid:20172536 PMCid:PMC2948969
9. Joshi G, Pradhan S, Mittal B. 2010. Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C>G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population. Cephalalgia 30(3):311-20. https://doi.org/10.1111/j.1468-2982.2009.01967.x; PMid:19673915
10. Schürks M, Rist PM, Kurth T. 2010. Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis. Cephalalgia 30(11):1306-28. https://doi.org/10.1177/0333102410364155; https://doi.org/10.1177/0333102410362929
11. Sundermann EE, Maki PM, Bishop JR. 2010. A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition. Menopause 17(4):874-86. https://doi.org/10.1097/gme.0b013e3181df4a19; PMid:20616674 PMCid:PMC2901885
12. Woo HY, Kim KH, Lim SW. 2010. Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents. Korean J Lab Med. 30(1):76-83. https://doi.org/10.3343/kjlm.2010.30.1.76; PMid:20197727