• The role of endothelial dysfunction in the cardiovascular pathology ormation in children with connective tissue dysplasia

The role of endothelial dysfunction in the cardiovascular pathology ormation in children with connective tissue dysplasia

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):98-103; doi 10.15574/PP.2018.75.98

Oshlyanska O. A., Hyndych Yu. Yu., Сwet L. O., Studenikina O. M., Sribna W. D.
SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Kyiv
SI "National Research Center for Radiation Medicine NAMS of Ukraine", Kyiv

Objective: to study the features of endothelial function in children with connective tissue dysplasia on the basis of blood chemistry values (L-arginine, the total value of nitrites and nitrates in the blood serum) and compare them with the level of key parameters of lipid metabolism and 25(OH)D3 in blood serum.

Materials and methods. A general clinical examination of 57 children with signs of connective tissue dysplasia and without such signs was conducted on the basis of the inpatient clinic of the SI "National Research Center for Radiation Medicine NAMS of Ukraine". The patients' complaints, objective status, general clinical instrumental examination data, biochemical values (L-arginine, total values of nitrites and nitrates in blood, lipid metabolism indicators and 25 (OH)D3 in serum) were studied.

Results. Analysing the results obtained, it was found significantly increased nitrogen oxide by-products in the blood serum of children with signs of connective tissue dysplasia as compared to the children without such signs. It was revealed that in children with signs of connective tissue dysplasia the associated metabolic disorders of lipid and nitrogen oxide metabolism develop, which caused the development of endothelial dysfunction.

Conclusions. In children with signs of connective tissue dysplasia, there is a tendency to decreased atherogenic β-lipoprotein levels in blood serum; substantially increased values of L-arginine and nitric oxide in blood serum. The vitamin D3 level is significantly reduced in both study groups that requires further research to determine the feasibility of administration of the pharmacological drugs of this vitamin in order to correct endothelial dysfunction in children with connective tissue dysplasia.

Key words: children, vascular disorders, connective tissue dysplasia, nitric oxide, L-arginine, vitamin D3.

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Article received: Jun 07, 2018. Accepted for publication: Sep 16, 2018.