• Reproductive disorders associated with genetically determined tendency to hypercoagulability 
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Reproductive disorders associated with genetically determined tendency to hypercoagulability 

HEALTH OF WOMAN.2015.7(103):130–133; doi 10.15574/HW.2015.103.130 

Reproductive disorders associated with genetically determined tendency to hypercoagulability 

Veropotvelyan N. P., Pogulyay Y. S., Klimenko S. V., Arbuzova S. B.

«Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog

Institute of experimental radiology of the State establishment «National scientific center»

Donetsk specialized center of medical genetics and prenatal diagnosis, Mariupol 

A study to determine the SNP’s in genes associated with susceptibility to blood clots and abnormal folate metabolism (FGB G455A, FII G20210A, FV 1691A, PAI-1 5G/4G, MTHFR C677T, MTR A2756G) in groups of women with early pregnancy losses episodes (n=781) and women who had a history of one or more episodes of placental /chorion abruption, stillbirth or antenatal fetal death (n=59) were conducted..

Analysis of the survey results showed that the genotype frequency FII G/A group of early miscarriage is 4 times higher than population prevalence of mutations G20210A FII (5.8% vs. 1.4%; p <0.05); frequency of genotype G/A FV group of miscarriage is 2.2 times lower than this mutation prevalence; combination heterozygous genotype C/T 677 MTHFR + A/G 2756 MTR significantly to 2.98 times more common in the group of women with multiple episodes of early abortion (20.56% vs. 6.9%; р<0.01); genotype FGB A/A 455 at 4.66 times significantly more common in placental /chorion abruption (77.78% versus 21.7%; р<0.01); associative links with the pregnancy losses and the polymorphic variant gene PAI-1 could not be found. 

Key words: hereditary thromobophilia, miscarriage, placental abruption. 


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