• Regulatory and adaptative processes in the mother–placenta–fetus system in pregnants with neurovegetative disorders 
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Regulatory and adaptative processes in the mother–placenta–fetus system in pregnants with neurovegetative disorders 

HEALTH OF WOMAN. 2016.4(110):84–90; doi 10.15574/HW.2016.110.84 

Regulatory and adaptative processes in the mother–placenta–fetus system in pregnants with neurovegetative disorders 

Vorobey L., Tkachuk R.

National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev

Kiev city center of reproductive and perinatal medicine 

The objective: the impact of disadaptation changes of the mother–placenta–fetus system in pregnants with neurovegetative disorders on obstetric and perinatal complications frequency.

Patients and methods. 58 pregnant women with perinatal losses and neurovegetative disorders were examined during the trial. The clinical course of pregnancy and deliveries, newborns status, the hemodynamic and endocrine links changes of mother–placenta–fetus functional system were studied.

Results. The increased resistance and reduced hormone levels compared with control (p<0.05) were observed in pregnant women with neurovegetative disorders. Pregnancy and deliveries in women with neurovegetative disregulations are characterized by increased frequency of complications such as: placental dysfunction (1.3 times), fetal growth retardation (2.5 times), preterm deliveries (2.4 times), fetal distress (3 times), operative deliveries (2 times), postnatal newborns disadaptation.

Conclusion. A broked placentation, accompanied by functional failure of the mother–placenta–fetus system from early gestation with hemodynamic and endocrine disorders was established in pregnant women with neurovegetative disorders, which has an adverse effects on pregnancy, deliveries and fetus.

Key words: neurovegetative disorders, adaptive mechanisms, system mother-placenta-fetus, Doppler.


1. Ozhiganova IN. 1994. The Features of Patomorphological Relations in the mother-placenta-fetus system during complicated pregnancy.

2. Karasev Yu. 2003. System psycho-neuro-immunological mechanisms of women organism adaptation capabilities.

3. Fedorov MV, Sapelkyna IM. 1974. The metabolism features of mother-placenta-fetus system. Studies of the 2nd Moscow Institute 29(5):271-273.

4. Uhnal LV. 2007. The role of hemodynamic disorders correction in the mother-placenta-fetus system in complex treatment of placental insufficiency in pregnant women with preeclampsia.

5. Avdeeva MV, Schehlova LV. 2007. Neuro-humoral regulation features of circulatory system during physiological pregnancy. Obstetrics and Gynecology 4:3-5.

6. Trifonova EF. 1997. Clinical and metabolic criteria of placental insufficiency diagnosis and prevention in women with recurrent miscarriage.

7. Ivanova OYu. 2011. The formation mechanisms of hemodynamic system of mother-placenta-fetus during physiological and complicated pregnancy.

8. Kryukov S. 2010. Adaptive features of the system "mother-placenta-fetus" with regard to its stereofunctional organization using normobaric oxygen therapy in pregnant women with placental insufficiency.

9. Kyoko Kasahara, Kenji Takakura, Koichi Takebayashi. 2001. The role of human Chorionic Gonadotropin on decidualization of Endometrial Stromal Cells in Vitro. Clinical endocrinology and metabolism 86;3:1281-1286. http://dx.doi.org/10.1210/jc.86.3.1281http://dx.doi.org/10.1210/jcem.86.3.7281; PMid:11238521

10. Knofler M, Saleh L, Bauer S. 2004. Transcriptional regulation of the human chorionic gonadotropin beta gene during villous trophoblast differentiation. Endocrinology 145:1685-1694. http://dx.doi.org/10.1210/en.2003-0954; PMid:14715707

11. Engin Oral MD, Mehmet R, Genc MD. 2004. Hormonal monitoring of the first trimester of pregnancy. Obstet. And Gynecol. Clinics of North America 4;31:767-778. http://dx.doi.org/10.1016/j.ogc.2004.08.004; PMid:15550334