HEALTH OF WOMAN WH_№6_2011

  • Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

 

Перинатальная служба в Украине: путь к европейским показателям и стандартам.

8

Среди восьми глобальных целей Третьего тысячелетия две непосредственно касаются материнства и детства, а именно: до 2015 года достичь снижения материнской смертности на 75% и младенческой смертности на 67% от уровня 1990 года. Серьезные задачи ставит перед врачами и Национальный проект «Нове життя», предложенный Президентом Украины. Одним из этапов достижения поставленных целей является создание в Украине 27 региональных перинатальных центров. Государственному учреждению «Институт педиатрии, акушерства и гинекологии» НАМН Украины в этом проекте принадлежит роль главного республиканского перинатального центра. О предстоящих изменениях и нынешних задачах современной перинатологии мы беседуем с директором Института педиатрии, акушерства и гинекологии, академиком НАМНУ, доктором медицинских наук, заслуженным деятелем науки и техники Украины Юрием Геннадиевичем Антипкиным.

 

 

Партнерские роды в Украине: осознанная необходимость.

10

Партнерскими родами в столице и большинстве крупных городов Украины уже никого не удивишь. Но еще лет 15 назад отцов или близких родственников, попадавших с роженицей в родильный зал, считали чудаками, а медицинский персонал относился к перспективе присутствия «чужого» человека на родах обузой и фактором риска развития осложнений у роженицы и ребенка, прежде всего – инфекционных. Одноразовый халат и бахилы на будущем папе не казались веским аргументом, а само желание присутствовать на родах скорее воспринималось как прихоть. В то же время, в Европе у женщин, в одиночестве переживающих схватки, могли деликатно поинтересоваться, не мать-одиночка ли она. Теперь в Украине партнерские и семейные роды – такая же реальность, как и в Европейских государствах. О преимуществах присутствия партнера на родах и многих других аспектах работы родильного дома, имеющего статус «Больница, доброжелательная к ребенку», мы расспросили заведующего кафедрой акушерства и гинекологии № 3 Национального медицинского университета им. А.А.Богомольца, профессора, доктора медицинских наук Василия Алексеевича Бенюка.

 

 

Benyuk V., Medvid V., Koval S., Kurochka V.

Complex therapy of gestational varicose illness.

12

Application of complex therapy is effective method of gestational varicous illness treatment and promotes preventive maintenance of trombofilic complications. Application of Dioflan which enters in the complement of complex therapy practically has no contraindications in the postnatal period, unlike the majority of venotonik tablet forms, as it doesn`t render considerable system influence that allows to apply it in a lactation. Easiness in application, the reduction of such displays as a hypostasis, reddening, pain, paresthesias, the itch, dryness of integuments do its application almost irreplaceable at gestational varicous illness treatment of complex therapy the postnatal period.

Key words: gestational varicous illness, compression, Dioflan.

 

 

Gopchuk E. N., Slinchuk N. V.

Nonspecific vulvovaginitis – a tactic with the ineffectiveness of local treatment.

15

Nonspecific vulvovaginitis is one of the most common reasons women seek medical treatment advice. Self-medication, especially local dosage forms, easily recommended in pharmacy stores, is one of the costs of civilization, which reduces the possibility of a rational and timely therapy, due to changes in reaction to drugs, which leads to an imbalance vaginal microbiocenosis. Optimal therapy in ambulatory practice in the treatment of nonspecific infections of urogenital tract are the use of hinolons. Based on the research we have come to the conclusion that the effectiveness of Ciprolet in nonspecific vulvovaginitis after failure of local therapy on nonspecific vulvovaginitis.

Key words: сiprofloksacin, Ciprolet, treatment, vulvovaginitis.

 

 

Татарчук Т. Ф., Ефименко О. А.

Современные подходы к лечению постменопаузального остеопороза.

18

 

 

Рыбалко С. Л., Порва Ю. И., Старосила Д. Б., Дядюн С. Т., Руденко А. В., Завилевич М. П., Хаецкий И. К.

Доклад «Моделирование папилломавирусной инфекции in vitro и изучение влияния Протефлазида на репродукцию вируса папилломы».

24

 

 

Markin L. B., Matvienkothe O. O.

Prophylactic-medical measures in pregnant women at the presence of embrional development interruption in the past history.

31

The article presents the results of study of efficacy of intravaginal application of micronized progesterone (Endometrin) in pregnant women at the presence of embrional development interruption in past history. It was established that the usage of Endometrin in the first pregnancy trimester promote the maintenance and development of pregnancy in this women contingent.

Key words: Endometrin, embrional development interruption.

 

 

Ebert Andreas D., Wilson Tina

Диеногест в лечении эндометриоза: обзор клинических даннях.

35

 

 

Доранжон П., Бюва-Эрбо М., Бюва Ж., Тома Ж. Л.

Лечение эндометриоза номегестрола ацетатом (результаты двух предварительных исследований).

39

Эффекты номегестрола ацетата в лечении эндометриоза были оценены в двух предварительных исследованиях. Одно исследование было открытым (n=15), а второе – контролируемым, двойным слепым (n=10). Целью этих двух исследований было сравнение эффективности, переносимости и приверженности лечению при помощи номегестрола ацетатом двух ежедневных доз (5 и 10 мг), принимаемых в течение шести последовательных месяцев пациентками с эндометриозом I–III стадии. В каждом исследовании две дозы номегестрола ацетата улучшили функциональную симптоматику и уме-ньшили по меньшей мере на 40% показатель лапароскопии, установленный в соответствии с крите-риями Американского общества фертильности (American Fertility Society). В контролируемом исследовании клиническое улучшение было значительным при приеме 5 и 10 мг в день, но значительно большим при использовании меньшей дозы. Однако уменьшение показателя лапароскопии не достигло уровня значимости ввиду малого количества обследованных пациентов. В целом генитальные кровотечения были более частыми при приеме дозы 10 мг в день, чем 5 мг в день (56,9% против 32,5% циклов). Результаты этих двух предварительных исследований позволили выбрать дозу 5 мг в день для последующих клинических исследований.

Ключевые слова: эндометриоз, прогестаген, номегестрола ацетат.

 

 

Gopchuk E. N.

Dysmenorrhea and spasms of smooth muscles – aspects of ethiological treatment.

44

Pain sensitivity has a special place, it involves the stimulation of different parts of the nervous and endocrine systems, for it has no single, universal stimulus. Dysmenorrhea, in the modern sense, is a collection of various pain and discomfort experienced by women during menstruation. Despite the large number of studies on this issue, the most controversial questions remain therapy. In the selection of therapeutic drugs should take into account the age of the patient’s pain intensity, the previously applied treatment, anesthetics and their effectiveness, the state of the liver, kidney, pharmacokinetics and pharmacodynamics of the drug. The development of sideeffects of antiinflamatory drugs- the most pathogenetically justified drugs in the treatment of dysmenorrhea is due to the mechanism of action of the latter, associated with inhibition of synthesis of cyclooxygenase. Opportunity to influence one of the etiological factors in the development of dysmenorrhea is provided the use of spazmolytics.

Key words: dysmenorrhea, pain, spasm, No-spa®.

 

 

Goncharenko D. O., Zhaloba G. M., Zhezher A. O., Shatrova K. M.

Peripartal cardiomyopathy.

48

Description and classification of cardiomyopathies is provided in this review. The particular attention is paid to the peripartal cardiomyopathies. The authors consider different theories of etiology and pathogenesis of this pathology. The recommended therapeutic approach to the treatment of obstetric patients is provided.

Key words: cardiomyopathies, peripartal cardiomyopathies.

 

 

Fofanova I. Ju., Ledina A. V.

Special considerations for urinary tract infection in obstetrcal and gynecological practice.

53

Background: about 10% of women sustain urinary tract infections.

Methods: three hundred pregnant outpatients aged 19–46 years with mean gestation period of 23,2±6,6 weeks and urinary tract infections were enroled into this study. Canephron® N phytotherapeutic formulation containing Herba Centaurii, Radix Levistici, and Folia Rosmarini was used as part of complex therapy.

Results: elimination of bacteriuria was documented in all cases, with no adverse effects or allergic reactions.

Conclusions: Canephron® N proved to be effective and safe as part of complex therapeutic modalities in management of urinary tract infections during pregnancy.

Key words: urinary tract infections, pregnancy, Canephron® N.

 

 

Зароченцева Н. В., Титченко Л. И., Титченко Ю. П., Меньшикова Н. С., Кашина Е. С.

Применение Флебодиа 600 у пациенток с варикозным расширением вен малого таза и синдромом тазовой боли.

58

 

 

Kalenchuk N. I., Polyova S. P.

Clinicolaboratory parallels of M. tuberculosis’ diagnostics in women of fertile age.

62

In the article the data according to diagnostics of tubercular injury of reproductive system in patients suffering pulmonary tuberculosis are presented. It’s shown that in this category of women reproductive function undergoes the qualitative and quantitative functional changes, the early determination of which favors effective prophylactics of diseases caused by tuberculosis.

Key words: tuberculosis, diagnostics, reproductive function.

 

 

Melnikov S. M.

Questionnaire Survey at Sexual Health Assessment Questionnaire of Menopausal Women.

64

At the complex gynaecological, sexological and somatic examination of 350 menopausal women (from 43 till 69) sexual dysfunction cases depending on the age, menopause duration, gynaecological and somatic illbesses (72,6% patients) have been specified.

Key words: menopause, sexual dysfunctions.

 

 

Uvarova YE. V., Ankirskaya A. S., Grigorenko YU. P., Kumykovа Z. KH.

Efficiency of therapies for bacterial vaginosis in nonpregnant women (results of a multicenter study).

67

The authors give the results of a multicenter study of the treatment of bacterial vaginosis (BV) in nonpregnant women of reproductive age. They have evaluated the clinical and microbiological efficiency of t he diagnosis and treatment of BV in 2505 patients from 14 cities and towns of Russia, by using the untified procedure. The combined treatment for BV with oral trichopol in a dose of 250 mg twice daily for 5 days and intravaginal clindamycin cream on days 1 to 3 of trichopol use have been found to be highly effective (clinical and bacteriological effectiveness being 87,3 and 97,4%), by causing adverse reactions in a few cases (4,1%). Candida vaginitis as a treatment complication was detected in 0,8–1/2% of the women. This treat-ment regimen for BV is recommended for clinical practice.

Key words: bacterial vaginosis, metronidazole, clindamycin.

 

 

Bychkova I. O., Tumanova L. I., Islamova O. V., Dzubanchuk T. V.

Clinical and epidemiological study of prevalence of Gestational Diabetes Mellitus and risk factors among pregnant women.

73

The presence of risk factors of gestational diabetes mellitus were analysed in the general population of pregnant women. The obtained data were compared with the results of pregnant women examination on presence of Gestational Diabetes Mellitus. It was determined that there are no reasons for screening based on risk factors because of the same frequency of risk factors among general pregnant population and among patients with Gestational Diabetes Mellitus.

Key words: Gestational Diabetes Mellitus, risk factors, screening.

 

 

Milievskyi O. V., Dubchak A. E.

Urogenital infections and vaginal microbiocenosis in pregnant women with a history of infertility of infectious genesis depending on treatment before pregnancy.

79

Urogenital infections and microbiocenosis of vagina in pregnant women with a history of infertility of infectious genesis have been analized as a function of treatment before pregnancy. The results of analysis showed that in 1st trimester of pregnancy 75,6% pregnant women with a history of tube-peritoneal infertility had intensifying of infectious process caused pathogenic microorganisms or sexual transmitted urogenital infections. 51,1% observed pregnant women had significant dissemination of facultative anaerobe bacteria with middle or high microbial seeding. We recommend examination women with a history of tube-peritoneal infertility of infectious genesis for diagnostics sexual transmitted infections including viral infections such as herpes and cytomegalovirus, treatment of women before pregnancy, monitoring of infections in 1st, 2nd and 3rd trimesters of pregnancy and corrections of found disorders.

Key words: infections, microbiocenosis, treatment before pregnancy, infertility of infectious genesis, pregnancy.

 

 

Heryak S. N.

Сlinical effect of application of the Dicloberl 100 in postpartum patients with episiotomy wound and perineal trauma.

82

The investigation was conducted in 60 female patients with rupture of perineum and episotomy wound. In 30 women within 72 hours after birth using rectal candles «Dіkloberl» in a dose of 100 mg. Comparison group were 30 women, comparable in type and severity of disease who received indomethacin candles in a daily dose of 100 mg. 25 healthy untreated women formed the control group. In assessing the state of the patients we found that birth injury induces activation of local and systemic inflammatory reactions and an imbalance in the immune response, which is shown increasing cytokine production (IL-1, IL-6, IL-10), and excessive synthesis of TNF-α. By applying dіkloberl in candles for the first three days after birth reached a credible antiinflammatory and anesthetic effect, including by reducing the production of TNF-α, inhibition of secretion of IL-1, IL-6 and IL-10 stimulation.

Key words: episiotomy, perineal trauma, pain syndrome, inflammation.

 

 

Шляпников М. Е., Кривошеева Г. Н., Бренерова О. В., Кияшко И. С., Панина И. А.

Коррекция вагинального дисбиоза с преимущественно микотическим компонентом накануне срочных самопроизвольных родов.

87

 

 

Gerzanich S. O., Zadorozhna T. D., Dashkevich V. E.

Morphological and immunohistochemical characteristics of placentas from women with varying iodine level during pregnancy.

90

The results of morphological and immunohistochemical study of placentas showed the existence of a number of laws that characterize the interaction of iodine-thyroid homeostasis and structural features of placental tissue in the transplacental exchange in conditions of different iodine supply. Morphological signs of a higher expression of VEGF and the intensity of intra- and paravaskular prevalence in middle and terminal villi and proliferation in placenta syncytium with the formation of «buds» in the placenta, which is part of a compensatory reaction in placental tissue. Established that an important condition of compensatory reserve placental tissue in a limited get the iodine or thyroid diseases is timely provision of euthyreoid condition.

Key words: iodine deficiency, vascular endothelial growth factor, morphological characteristics of placenta.

 

 

Давидова Ю. В., Федорченко Г. В., Булик Л. М., Двуліт М. П.

Особливості перебігу вагітності у жінок, яким було проведено оперативне втручання на щитоподібній залозі під час гестації.

95

 

 

Gopchuk E. N.

Endometritis in outpatient practice – an experience of use of the third generation ftorhinolons.

97

Inflammatory diseases of pelvic organs in women of childbearing age is a major cause of reproductive health conditions. Given the importance and prevalence of this disease requires a correct choice of antimicrobial drugs particularly important timely and proper treatment of inflammatory processes in women of reproductive age. The aim of the work was to study the clinical efficacy of levofloxacin for the treatment of acute or exacerbations of chronic endometritis. The drug Levolet in treatment of this disease is effective and can shorten therapy in advanced performance.

Key words: endometritis, levofloxacin, levolet, treatment.

 

 

Nagornaya V. F., Bailo N. F., Nikolaieva S. V.

Treatment Optimization of Patients with Candidal Vulvovaginitis Before and During Pregnancy.

102

The article deals with the data about possibility of antimycotic setoconazol nitrate and probiotic Fermalak combined use for candidal vulvovaginitis treatment before and during pregnancy. Fermalak use allows to control efficiency and time duration of antimycotic therapy; the complex therapy eliminates the causative agent in 100% of nonpregnant women and in 40% of pregnant women.

Key words: probiotic Fermalak, sertakonazol nitrate, candidal vulvovaginitis.

 

 

Tatarchuk T. F., Kovalenko Ye. P., Filonenko T. G., Kubyshkin A. V.

Expression of steroid hormones receptors and the level of estrogen and progesterone in uterine lavage fluid in women with endometrial hyperplasia.

105

Steroid hormones receptors expression in the stroma and glandular tissue of the endometrium, as well as estrogen and progesterone level in uterus lavage fluid of women with different types of endometrial hyperplasia it was study. In all types of endometrial hyperplasia elevated levels of intrauterine estrogen and pro-gesterone with a relative predominance of estrogens it was showed. Also shows the prevalence of estrogen receptor expression in simple hyperplasia and in the second phase of the menstrual cycle in complex endometrial hyperplasia. In the complex endometrial hyperplasia the difference in the local content of estrogen and progesterone and receptor expression to them is leveling in the tissues of the endometrium . It is assumed that the formation of severe endometrial hyperplasia may involve other mechanisms, different from relative or absolute hyperestrogeny, and investigation of intrauterine hormones together with the receptor expression can be used to hormonal disturbances study and the endometrial hyperplasia development.

Key words: endometrial hyperplasia, steroid hormones, receptors, estrogen, progesterone.

 

 

Veropotvelyan P. N., Veropotvelyan N. P., Pivneva N. V., Volenko N. V.

Disturbances of the menstrual function in very young-young women after a psycho-emotional stress situation.

110

We have made an investigation of 57 patients aged 17–23 who suffer from MFD from 5 months to 2,5 years.The aim of the given investigation was the rehabilitation of the menstrual function and different disturbances of neuro – psychological tension after the experienced stress – «unsuccessful love» – using the method of complex phytohomeopathic therapy. After the made general complex therapy the indices of the hormonal background reliably changed; some positive changes were also revealed in the parametres which characterise endocrine background. Thus, the use of phytotherapy and alternative to the hormonal treatment in order to support the health in very young – young women with the phytohomeopathic preparations Cyclodenone, Remense, Dysmenorm and Tazalok in complex therapy is the main mechanism to normalize the menstrual function, removal of estrogene-progesterone disbalance, reduction of the increased prolactine secretion influencing the hypotalamo-hypophysal-ovarian regulation.

 

 

Pyrohova V., Veresnyuk N., Golyuk N.

Efficiency of the use of preparation of Neotrizol is in holiatry of the mixed base-line defeats of cervices.

116

Application of the combined preparations of local action, which influence on the wide spectrum of possible pathogenic microorganisms and not instrumental in the origin of system allergic reactions and inversion of immune defence of organism, acquires at presence of pathology of cervices, vagina combined with inflammatory processes, special value. It is inspected and treated with Neotrizol 100 patients with the signs of cervicitis. Before treatment for swingeing majority of patients was characteristic polimicrobial surplus conta-mination of vagina and cervices gram-positive coccal and by the stick gram-negative flora, found out 21% patients Candida, in 6% – trichomonas, bacterial vaginosis – in 12%, with simultaneous all of patients have diminishing of amount of Lactobacillus, to complete absence in 23%. Application of Neotrizol allows attaining positive effect after an 8-daily course treatment in 87%, at continuation of treatment for patients with partial efficiency of the first course to 16 days – in 92%. A rapid effect for patients with the mixed base-line defeats of cervices determines the high estimation of efficiency and influence of treatment on a feel and quality of living by patients.

Key words: Neotrizol, base-line diseases of cervices.

 

 

Вовк И. Б., Новик Л. М.

Барьерные методы контрацепции: преимущества и недостатки.

120

 

 

Lieshcheva T. V.

Treatment Particularities of Uterine Annexes Inflammatory Processes against Intrauterine Contraception and Their Sonographic Aspects.

123

Process of adnexa in intrauterine contraception – There were examined 60 patients, 50% use in intrauterine contraception of moment inflammatory process of adnexa. As have shown results of researches inflammatory process of adnexa in intrauterine contraception were detected purulent adnexa 20%, formation of purulent tubo-ovarian tumour at 30% woman.

Key words: echography, inflammatory process of adnexa, intrauterine contraception.

 

 

Lomaga Y. Y.

The comparative aspects of fetoplacential complex and thyreoid system at pregnant woman at multipara woman.

125

This work is devoted to studing the extragenital diseases at pregnant woman at multipnara woman with folloving positive effect on clinical current of pregnancy and sorts and also perinatal outcomes delivery. These woman make group of high risk in obstetrical and perinatal pathology, so this problem is actual nowadays and needs careful studing and research.

Key words: multipara woman, hormones, fetoplacential complex, thyreoid system.

 

 

Semenina G. B.

Hyperprodution of Anti-Mullerian Hormone in pathogenesis chronic anovulation at the polycystic ovary syndrome.

128

Defined prodution level of Anti-Mullerian factor (AMF) in the follicular device of 26 women with polycystic ovary syndrome (PCOS) and 22 women with kept folliculogenesis and ovulation. Immunogistohimichesky definition of level AMF in follicular cages ovaries has shown, that at patients with PCOS higher level AMF in granulosis cages at all stages folliculogenesis is observed, and also there is no decrease in level AMF in process of growth follicles antrales, observed in norm. Hyperproduction AMF, possessing expressed influence inhibiting on the follicular device is supposed, that, can be result of infringement differentiation of gonades a fruit because of genetic or other reasons and be cause of infringements folliculogenesis and ovulation.

Key words: Anti-Mullerian Factor, polycystic ovary syndrome.

 

 

Zadorozhna T. D., Vovk I. B., Kalyuta A. A., Pustovalova O. I.

Prognostic significance of protein expression р16INK4a in cervical intraepithelial neoplasia in a background of inflammatory diseases of the cervix.

131

In article presents results on the overexpression of the protein p16 (INK4a/CDKN2a), which is one of the markers of tissue differentiation of pathological processes in the cervix. It is established, that at immunocytohistochemical research cervical smears and biopsies, the positive expression of p16 (INK4a/CDKN2a) was observed in dysplastic changes in epithelial cells of the cervix and the presence of human papillomavirus DNA of high oncogenic risk. However, the positive expression of p16 marker (INK4a/CDKN2a) in women with a negative HPV test indicates that such patients can not be excluded from a group at high risk of developing cervical cancer and points to the possibility of neoplastic transformation of epithelial cells of the cervix uterus.

Key words: human papilloma virus, inflammatory genital deseases, overexpression of р16 (INK4a/ CDKN2a), cervical intraepithelial neoplasia (CIN), immunocytohistochemical research.

 

 

Uvarova E. V., Lobodina I. M., Veselova N. M.

Clinical importance of Tranexam use for uterine bleeding arrest in puberty.

136

The paper presents the results of clinical and laboratory study of the girls aged 11–18 with pubescent uterine bleeding (PUB) treated by non-hormonal symptomatic hemostasis by means of Tranexam and nimesulide. The obtained data testify to high effectiveness of the drug Tranexam used for uterine bleeding arrest and for bleeding prevention in girls with heavy but regular menstruations. Tranexam helped to stop bleeding quickly and effectively, side effects and negative impact on adolescents’ organisms being practically absent.

Key words: pubescent uterine bleeding (PUB), hemostasis, tranexamic acid.

 

 

Vdovichenko J. P., Rud V. A.

Hysterectomy at women of reproductive age: the nearest and remote consequences.

140

Results of the spent researches testify, that rehabilitation of patients of reproductive age after hysterectomy should have the individualised character with early use of the directed hormonal therapy taking into account a wide spectrum of arising changes of a homeostasis and a functional condition of ovariums. Selection of preparations for the directed hormonal therapy and its duration should have the individualised character and dynamically to change taking into account the basic clinicallaboratory, ehografical and psychological indicators. The offered algorithm is simple and popular for practical public health services.

Key words: hysterectomy, reproductive age, consequences.

 

 

Грищенко О. В., Сторчак А. В., Струк Т. А.

Комплексная реабилитационная терапия у пациенток с воспалительными заболеваниями органов малого таза – залог сохранения репродуктивной функции.

143

 

 

Chayka V. K., Chayka A. V., Bogoslav Yu. P., Nosenko O. M., Koktishev I. V., Zorkova O. V., Chernous V. A.

Prognostication and prevention of reproductive health disorders in obese women.

152

Based on the conducted complex clinical-anamnestic and laboratory observation of obese female patients, a system of prognostication of reproductive health disorders in obese women has been developed; its effectiveness has been tested on the group of patients of examination group. Diagnostic effectiveness of the developed methods is 79,6%, prognostication value of the positive prognosis is 85,6%, while that of the negative prognosis is 74,3%. The developed system of prognostication and prevention of reproductive health disorders in obese women resulted in decreasing frequency of reproductive system diseases and preventing the development of amenorrhea, abnormal uterine bleedings, hyperplasia of endometrium and infertility.

Key words: reproductive health, obesity, reproductive health disorders in women, prognostication.

 

 

Tatarchuk T. F., Kasyanchuk N. Y., Kasey N. V., Ganzhyj I. Y., Kapshuk I. M.

Pathogenetic Aspects of Reproductive Health at Metabolic Syndrome in Women.

155

The article justifies the necessity of developing a gender-adjusted system of metabolic syndrome prevention and care. Recommendations are required for slowing down progressing of morphological and endocrine/ metabolic changes in order to maintain or recover fertility, as well as to prevent metabolic syndrome development in future in adolescents and young women with diencephalic manifestations and various clinical forms of polycystic ovaries. In patients of perimenopausal age, not only lipid profile correction and antihypertensive therapy are important, but also appropriate management of gynecological disorders, which is related to higher risk of hormone-dependent neoplasms development.

Key words: metabolic syndrome, reproductive hormones, cytokines.

 

 

Voroby V. D.

Reproductive health of women with genital an endometriosis.

161

Results of the spent researches testify to negative influence genital endometriosis on a condition of reproductive health of women. The decision of this scientific problem demands the complex and stage-by-stage approach, since effective diagnostics of female barreness and finishing adequate preventive maintenance obstetrical and perinatal complications. The offered algorithm of diagnostic, treatment-and-prophylactic and rehabilitation actions allows to lower frequency of infringements of reproductive health at women with genital endometriosis and can be widely used in practical public health services.

Key words: genital endometriosis, reproductive health.

 

 

Matyukha L. F., Goida N. G.

Reproductive Medicine is One of the Priorities of General Practitioners Training.

163

The article covers a component of family physiologist competition, which is assistance to preservation of women reproductive health. The family physiologists’ knowledge level of reproductive health issues have been analyzed and medical aids which should be committed when the physiological pregnancy after specific knowledge and practical skills acquisition have been suggested.

Key words: family physiologist, reproductive health, physiological pregnancy, competitions, subject improvement.

 

 

Podol'sky V. V., Derbak A. V., Chernyshov V. P.

Immunological Changes in Women Infected with Human Papilloma Virus.

166

The performed investigation testify thet complex step-by-step etiotropic treatment with compulsory inclusion of immune and antivirus preparations is highly-effective therapy in pathology of uterine neck, infected with human papilloma virus. Іn some cases with complex step-by-step therapy it is , according to individual indices, – diathermoconisation of uterine neck.

Key words: Human Papilloma Virus, infection, vesical cervix, treatment.

 

 

Авраменко С. А., Прилуцкая А. Б., Прилуцкий А. И.

Практические аспекты лечения хронических воспалительных заболеваний органов малого таза хламидийной этиологии.

173

Проведенное исследование позволяет рекомендовать при хронических воспалительных заболеваниях органов малого таза хламидийной этиологии применение препарата Сумамед, который обеспечивает в 96,2% положительный клинический и бактериологический эффекты, тем самым обусловливая возможность профилактики бесплодия при инфекционной патологии мочеполовых органов женщин, а также развития осложнений при беременности.

Ключевые слова: хламидиоз, хронические воспалительные заболевания органов малого таза, лечение, Сумамед.

 

 

Панкратов В. В.

Роль комбинации системного и местного лечения при трихомониазе.

178

 

 

Pitko V. A., Guz I. A., Loginova O. A., Lukyanchikova L. A., Demidenko A. D.

Human Papilloma Virus: Treatment and Preventive Measures.

180

The are discusses of the current issues of treatment and prevention of disease papillomavirus infection genital. Pathogenetic substantiation of appointment for the prevention of immunodeficiency, the antiviral action Lаvоmax.

Key words: human papillomavirus infection, Lаvоmax, cervical dysplasia.

 

 

Kozak O. M.

Pathogenetic aspects of treatment of chronic inflammatory diseases of genitalia in women of reproductive age.

184

In article results of efficacy of local ozone therapy in multimodal treatment of chronic inflammatory diseases of genitalia (CIDG) are presented. Results of research showed that use of ozone significantly increase efficacy of CIDG therapy by increase of protective collagenolytic activity of peritoneal excudate.

Key words: chronic inflammatory diseases of genitalia, laparoscopy, ozone therapy, diagnostics, treatment.

 

 

Kondratyuk V. K., Yemets N. О., Kobloch N. D., Pustovalova O. I., Gorban N. E.

Efficiency of complex application of Azitrox and Vagical in the treatment of inflammatory diseases of uterus cervix and chlamydia infection.

187

In the article we may see the results of clinical and laboratory research of efficiency of complex application of makrolyd antibiotic Azitrox and vaginal suppositories Vagical in the treatment of 60 women of fertile age with inflammatory diseases of uterus cervix and chlamydia infection. The rapid clinical convalescence and decline of frequency of relapses of inflammatory processes of uterus cervix are marked. The wide application of Azitrox and Vagical in the treatment of inflammatory diseases of uterus cervix associated with chlamydia infection was recommended.

Key words: inflammatory diseases of uterus cervix, chlamydia infection, treatment, Azitrox, Vagical.

 

 

Rybalka A. N., Egorova Y. A., Zabolotnov V. A., Homulenko I. A.

The clinic, morphology and features of the hormonal background of the complicated and uncomplicated tumoreminent processes of the ovaries.

191

Given the specific features of clinical, morphological and hormonal background at various complicated and uncomplicated tumor similar processes of the ovaries in 110 women: with follicular bones-31, bones of the yellow body-63, endometrium bones-16. Held clinical, immunohistochemical study, evaluated the level of expression of Er and Pr. given recommendations on prevention and treatment of this pathology.

Key words: neoplastic processes in ovaries, clinical picture, morphology, endocrine profile, complications.

 

 

Toryanik E., Gnatuk V.

Feto-state and embryogenesis in pregnant female rats with arterial hypertension.

194

We studied the state of embryos and fetogeneza pregnant female rats. It was determined that hypertension in pregnant female rats increases the pre-and postimplatatsiynyh losses, reductions in fetal weight, placental weight and diameter, glycogen depletion of the intermediate and labyrinthine zones.

Key words: pregnancy, hypertension, fetogenez, embryogenesis.