HEALTH OF WOMAN WH_№4_2011

  • Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

 

Вітання до Дня медичного працівника.

8

 

 

«Актуальные вопросы развития семейной медицины в Украине»: наши семинары – в помощь врачам.

10

 

 

Помощь детям и женщинам – в благодарность за признание в Укра-ине.

12

 

 

Коломейчук В. М.

Здоров’я сучасної сім’ї в Україні (за підсумками 2000–2009 років).

14

 

 

Гомберг М. А.

Новые европейские рекомендации по ведению больных с хламидийной инфекцией. Основные положення.

21

 

 

Clifton Vicki L (у дозволеному автором перекладі Соловйова Олексія)

Статеві функціональні особливості людського ложиська (placentae).

24

Ключові слова: placenta, ложисько, плацента, стать, вагітність, вага при народженні.

 

 

Linnikov V. I., Bondarenko N. I.

Effect of oral contraceptives on the hemostatic system and lipid metabolism.

30

This work studies the influence of a new oral contraceptive Qlaira containing estradiol valerate and diano-gest, on the hemostasis system and lipid metabolism. Representative of randomized studies, in 30 women taking the Qlaira, and in 28 women taking triphasic OC, containing 30 and 40 mcg ethinylestradiol, of hemostasis thrombophilic markers and lipid profile revealed that Qlaira does not affect thrombophilicly on procoagulant and thrombotic hemostasis, enhances atherogenic coefficient and thus reduces the risk of throm-boembolism, ischemic complications, compared with the OC containing ethinylestradiol.

Key words: oral contraceptives, Qlaira, thrombophilic, lipid metabolism.

 

 

Mueck Alfred O.

Почему диеногест является уникальным прогестагеном для лечения эндометриоза?

33

 

 

Fernбndez-Alba J., Valle-Gay A., Dibildox M., Vargas J. A., Gonzбlez J., Garcia M., Lуpez L. H. и Мексиканская исследовательская группа FENTIMEX.

Фентиконазола нитрат для лечения вульвовагинита: эффективность, безопасность и переносимость однограммовых овулей, применяемых на протяжении короткого двухдневного режима.

40

 

 

Коган Б. Г., Гордеева Г. Д., Белокурова Е. Н.

Современные принципы применения антибиотиков у беременных.

46

 

 

Guseva S. A.

The experience of clinical application of SORBIFER DURULES in patients with iron deficiency anemia.

51

The article represents the experience of clinical application of a new preparation with prolonged action SORBIFER DURULES («Egis», Hungary)in 18 woman with iron deficiency anemia. Obtained results indicate on high efficiency and good tolerability of preparation. SORBIFER DURULES can be recommended to broad application in the treatment of patients with iron deficiency anemia.

Key words: SORBIFER DURULES, iron deficiency anemia, treatment, efficacy.

 

 

Tkachuk T., Tokarchuk Ya.

Cervical cancer and pregnancy: a case study.

54

The article provides a case study of a 30 year old patient with a stage 1b pT1bN0M0G3 non-keratinizing squamous cell carcinoma of the external part of cervical canal, clinical group II, and a 13 to 14 weeks pregnancy. The article describes the diagnostics and successful combined treatment: radical hysterectomy with removal of adnexa and upper third of the vagina combined with Alpharekin medication (Alpharekin® – interferonum ALPHA, recombinant human interferon alpha-2b) possessing three main types of biologic activity: antiviral, immunomodulatory, and antitumor, which allows to expect a long:term positive prognosis.

Key words: cervical cancer, pregnancy, Аlpharekin.

 

 

Уварова Е. В., Лордкипанидзе Б. А., Кротин П. Н., Товстуха Е. А., Малашенкова Т. В., Байдуллина Ф. А.

Эффективность современной негормональной посткоитальной кон-трацепции по результатам многоцентрового исследования.

59

Представлены результаты открытого многоцентрового исследования клинической эффективности и переносимости препарата Гинепристон (мифепристон) в дозе 10 мг однократно как средства постко-итальной контрацепции в 4 федеральных округах России. По данным исследования, применение Гинепристона эффективно для предупреждения нежеланной беременности после незащищенного полового акта (НПА) в 97,8% случаев. Эффективность при применении препарата оставалась высо-кой вне зависимости от дня менструального цикла и времени, прошедшего от НПА. Препарат хорошо переносился и не нарушал существующего ритма менструаций у 67,7% женщин. Гинепристон может быть рекомендован в качестве средства посткоитальной контрацепции как девочкам-подросткам, так и женщинам репродуктивного возраста при НПА. 

 

 

Nimenky M. V., Denysenko S. V.

Optimization of the assisted reproduction clinic efficiency. Example of a successful pregnancy outcome using minimally invasive surgery.

65

The effectiveness of minimally invasive surgery as part of an IVF program in a patient with congenital ano-malies of the reproductive system.

Key words: optimization, infertility, ART, minimally invasive surgery, malformations of the uterus, unicor-nuate uterus, ectopic pregnancy, heterotopic pregnancy.

 

 

Кисина В. И.

Вагинальные инфекции: клиническое значение и лечение.

67

 

 

Asadov D., Asatova M., Yadgarova K.

Trend of achievement of MDG 5 – improvement of maternal health.

71

Review of literature was carried out to analyze trends of achievement of MDG 5 – improvement of maternal health. There are two targets for assessing progress in improving maternal health(MDG5): reducing the maternal mortality ratio by three quarters between 1990 and 2015, and achieving universal access to repro-ductive health by 2015. In 1995, 2000, 2005 and 2008 WHO, UNICEF, UNFPA and World Bank developed country, regional and global estimates of maternal mortality and made attempt to assess trends in MMR at the regional and global level. An estimated 358 000 maternal deaths occurred worldwide in 2008, a 34 percent decline from levels of 1990. Despite this decline, developing countries continued to account for 99 (355 000) of the deaths. The MMR in 2008 was 40 in CIS countries. During the period 1990-2008 90 coun-tries including 9 countries of CIS showed a decline of 40% in MMR. Review discusses potential reasons

contributed to decline of MMR.

 

 

Bondarenko N. P., Shirobokov V. P., Lakatosh V. P., Lazarenko L. N., Kostenko O. Y.

B19 parvovirus infection and its influence in pregnancy.

76

A modern condition of problem of parvovirus: infection and its significance during pregnancy are analyzed. There are represented the data concerning the diffusion of parvovirus- infection in pregnant women, particularities of epidemiology, clinical course, methods of diagnostics and therapy of this infection during pregnancy.

Key words: parvovirus-infection, pregnancy, intranatal condition of fetus.

 

 

Shadrin O. G., Marushko R. V., Marushko T. L.

Multiprobiotics as a method of correction of mucin barrier in the course of inflammatory intestinal diseases in infants.

82

Done comparative studies in order to research the level of mucin glycoproteins and their derivatives in fesses samples of children with chronic post-infectious colitis. Proved that the use of functional foods such as multi-probiotics in the complex therapy of chronic colitis in children of early life, leads to the improvement of status of preepithelial mucus barrier and micribiota in large bowel and therapeutic results of the disease.

Key words: multiprobiotics therapy, chronic colitis.

 

 

Жабченко І. А., Черненко Т. С., Невишна Ю. В., Похитун М. В.

Особливості вагінального мікробіоценозу у вагітних та його корекція в разі дисбіотичних зсувів.

87

 

 

Ромащенко О. В.

Обоснование использования различных форм Фарматекса: от юности до зрелости.

90

 

 

Veropotvelyan P. N., Veropotvelyan N. P., Bondarenko А. А.

Usage of the new method of darsonvalreflexotherapy in the complex treatment of chronical salpingooophorotis.

94

We have made an analysis of investigation in 107 women with chronical salpingo-oophorotis (CSP). The first group was formed of 53 women who received a complex therapy. The second group included 54 patients who apart from a complex therapy as well as the women of the first group got an additional influence of dar-sonval radiation with a coronary discharge on the biologically active spots. The state of the immune system was investigated using quantitative and functional tests which characterize cell and hymoral chains of the immunity: the quantitative detention of T- and β-lymphocytes. The work shows that the analysis of the dyna-mics in the immune values testify the primary influence of DRT on the reconstruction of the most important immunoregulatory subpopulation with a simultaneous increase in the immunoregulatory value indices. In the patients who received only ethiopathogenetic therapy considerable changes of the studied values were not detected. A considerable restoration of the reproductive function should be mentioned in the women of the second group in comparison with the first one. Thus, usage of darsonvalrexlesotherapy (DST) with an ethio-pathogenetic treatment is more effective in the clinical recovery of the patients.

Key words: darsonvalrexlesotherapy, restoration of the reproductive function.

 

 

Гомберг М. А.

Бактериальный вагиноз и новые инфекции, с ним ассоциированные.

98

 

 

Kornatskaya A. G., Danilenko E. G., Brazhuk M. V.

Psychoemotional State and the Possibility of its Correction in Women with the Reproductive Losses.

103

Emotional stress as a manifestation of the Adaptation Syndrome, accompanies the reproductive losses which include ectopic pregnancy. Psychoemotional state and psychosomatic disorders in patients with ecto-pic pregnancy depends on expression of anatomic changes, adhesion process, duration and treatment in-fertility. Combined treatment that included emotional stress positively affects patients and improves perfo-rmance psyhoemotional but psyxosomatic changes require further study and treatment.

Key words: psyhoemotional state, correction, ectopic pragnency.

 

 

Серов В. Н., Тютюнник В. Л., Твердикова М. А.

Применение препаратов магния в акушерской практике.

106

 

 

Belykh N. A., Valiyev O. A., Kovalenko N. N., Minyaylo N. P., Sapelnikov A. Y.

Improper feeding of the pregnant us provision for condition of the for-mation deficiency.

110

The article deals with same of the results of the regional study of the antenatal micronutrients formation of children (iron and iodine). The impact of the insufficient nutrition on the rate of the iodine deficiency disorders and iron deficiency anemia in pregnant was demonstrated. The high level of iodine and iron deficiency disor-ders necessitates an integrate approach to their treatment and preventative measures.

Key words: рregnancy, fetus, iodine deficiency, iron deficiency, nutrition.

 

 

Glushko O. I., Golyanovskyy O. V.

The efficiency of uterotonic drugs for the hypotonic haemorrhage cessation.

116

The article is focused on the results of learning the efficiency and safety of uterotonic drugs of the prolonged action of carbetocin use for the hypotonic haemorrhage cessation in the early postpartum period. It is proved, that the new therapeutic approach makes it possible to reach quick bleeding cessation, to reduce hemorrha-ge, to decrease the frequency of usage of surgical hemostasis and the necessity of blood preparations infu-sion.

Key words: obstetrical bleedings, uterine tonus, carbetocin, oxytocin.

 

 

Avramenko T., Gerevich G., Savchenko S.

The placental disfuncton in pregnants with rheumatic heart diseases.

118

The data of monitoring of mother:placental and fetus hemodynamics in pregnants with rheumatic heart diseases have shown in article. In result of analysis of data it was determine that rheumatic heart diseases being and grow result in disorders of system of mother-placentafetus, which in for one’s turn part influence on increase of frequency of complication of pregnancy and delivery.

Key words: pregnancy, rheumatic heart diseases, placental disfunction, complications, utero-placental-fetus hemodynamic.

 

 

Bogomazova V. I., Padenko N. V., Chernyaeva Y. V., Lepіkhov P. О., Turpakova G. N., Bruk B. B.

Diabetes and pregnancy. Pathologic changings risk of the fetuses and newborns.

122

Possible typical feature pathology of the fetuses and newborns in diabetic pregnancy was analyzed in this article. Ultrasonic signs congenital abnormality of the fetuses and newborns was illustrated.

Key words: prenatal diagnosis, diabetes, embryopathy, fetopathy.

 

 

Vdovichenko J. P., Shlemkevich A. M.

Preventive maintenance obstetrical and perinatal pathologies at women with various forms of barreness in the anamnesis.

127

Results of the spent researches have shown, that use of the offered algorithm of treatment-and-prophylactic actions at women with barreness various genesise in the anamnesis with application differentiated the approach allows it is essential to lower not only frequency of reproductive losses, but also the cores obstetrical and perinatal complications that is the decision of the important problem modern obstetrics.

Key words: obstetrical and perinatal a pathology, various forms of barreness.

 

 

Marichereda V. G.

Analisis of association of perinatal infection and preeclampsia develop-ment.

130

Study of the perinatal infection value, as a risk factor for preeclampsia, is conducted for pregnant patients with preeclampsia. It was settled, that trichomoniasis, candidiasis, CMV, chlamydial and nongonococcal urethritis were associated with development of preeclampsia with high degree of probability. Infecting of CMV is associated with the risk of development of preeclampsia in a greater degree, what other infections. These results, probably, represent one of mechanisms of strengthening of the inflammatory response, that is registered at preeclampsia. An active exposure and treatment of genital and urinary tract infection can be recommended, as a component of the program in preconceptional preparation for women from the group of risk of preeclampsia, and also its secondary prophylaxis in the early terms of pregnancy.

Key words: preeclampsia, perinatal infection, CMV, risk factor, prophylaxis.

 

 

Tkachenko Z. S.

Effectiveness of prenatal diagnosis in the families with a segregating Robertsonian translocation.

135

Structural chromosomal rearrangements are detected in couples with infertility, recurrent miscarriages, birth of a child or children with an unbalanced karyotype. In the article we present a case of identifying transloca-ti\on Down syndrome in a fetus with familial segregation of a Robertsonian translocation.

Key words: prenatal diagnosis of Down syndrome, reproductive loss, spontaneous pregnancy.

 

 

Manasova G. S.

Dynamics of the maintenance of the some calciumregulated hormones and of the bone tissue remodeling marker’s in the not complicated preg-nancy and the early postnatal period.

138

The article presents the data of the dynamic survey of the structural state of the bone tissue, some calcium-regulated hormones and the marker’s remodeling of the bone in 38 healthy pregnant women. The survey was conducted in the II-nd, III-eat trimesters of the pregnancy and on the fourth day after birth. By the che-miluminescence immunoassay was determined in blood concentrations of vitamin D, parathyroid hormone (PTH), osteocalcin and β-CrossLaps. The mineral density of the bone tissue was determined by ultrasound densitometry. Investigation of the total, ionized calcium, phosphorus, the levels of the urinary calcium excre-tion was performed complexometric method. The dynamics in the blood of the healthy pregnant women has been a gradual reduction of the calcium, phosphorus and vitamin D levels. The parathyroid hormone’s acti-vity increases in the III-eat trimester of pregnancy and declines after birth. The concentration of the osteocalcin with increasing gestational age significantly decreased, whereas the levels of the fragments of the collagen’s I type increases. The data of the densitometry’s reflect the gradual bone loss. This changes evi-dence of the instability mechanisms of the regulating of the calcium levels in the blood during physiological pregnancy. The remodeling of the tissue in the healthy pregnant women is characterized by the predomina-nce of the bone’s resorbtion over its synthesis, which leads to the development of the osteopenia.

Key words: pregnancy, bone tissue, remodeling.

 

 

Vdovichenko J. P., Ledin D. S.

Influence of the prolonged hormonal contraception on character menstrual functions.

143

Results of the spent researches testify to high clinical efficiency of the prolonged hormonal contraception, and also about low level of various by-effects. Except us the positive effect of the prolonged reception of hormonal contraceptives on менструальную function of patients is noted. The received results dictate necessity of carrying out of the further researches for the given scientific direction which will allow to reveal the positive and negative moments of the prolonged hormonal contraception.

Key words: the prolonged hormonal contraception, menstrual function.

 

 

Маланчук Л. М., Кучма З. М., Маланчук С. Л.

Дисменорея – прояви та сучасні підходи до лікування.

146

 

 

Vdovichenko J. P., Kishakevich I. T.

Mediko-social features at women with natural menopause.

149

Results of the spent researches testify, that mediko-social features are of great importance in a clinical cur-rent natural menopause. The received results are necessary for considering by working out of a complex of diagnostic and treatment-and-prophylactic actions.

Key words: natural menopause, mediko-social features.

 

 

Квашенко В. П., Малова Ю. А., Бабенко О. М.

Комплексная терапия простой неатипической гиперплазии эндометрия у женщин репродуктивного возраста.

151

 

 

Elchin Guliev Rafael

The effect of various training factors on the menstrual function of female athletes.

157

In this article, the author analyzed the influence of skill level, exercise and kind of sport on the reproductive function of sportswomen. The study was conducted on the big stuff. 104 athletes with menstrual disorders and 34 female athletes who do not have menstrual irregularities were under the supervision. On the basis of these studies found that the level of sport skill, training mode, age of sport activity and the kind of sport have some extent affects on the menstrual function of the athletes. The greatest percentage (38,4%) of menstrual dysfunction observed among female gymnasts.

Key words: menstrual function of female athletes, training factors.

 

 

Lysenko B. M.

Diagnostics optimisation adenomyose at urgent uterine bleedings.

159

Results of the spent researches testify to a considerable role adenomyose in development urgent uterine bleedings, and also about high effective offered algorithm of diagnostic actions with use of modern diag-nostic technologies.

Key words: adenomyose, uterine bleedings, diagnostics.

 

 

Никитин О. Д., Жабицкая Л. А.

Спаечная болезнь: влияние на репродуктивную функцию. Пути преодоления.

161

Статья посвящена основным вопросам этиологии, патогенеза и профилактики послеоперационных спаек как одной из ведущих причин нарушения репродуктивной функции. Отмечено, что частота возникновения спаек зависит от оперативного доступа, объема оперативного вмешательства, техничес-ких средств, которые были использованы, и методов профилактики спайкообразования. Определены основные пути профилактики спайкообразования во время оперативного вмешательства и в послеоперационный период. Подчеркнута необходимость разработки новых эффективных лекарственных средств для предупреждения образования послеоперационных спаек.

Ключевые слова: бесплодие, послеоперационные спайки, лапароскопия.

 

 

Timonina T. V., Zaritskaya V. I., Irkin I. V., Silchenko V. P.

Morphological features of endometrial polyps, emerge consequently inflammatory processes in the uterine cavity in women of reproductive age.

165

the study of polyps endometriya resulting from inflammatory processes in the uterus viyavleno that the endometrium is the tissue that responds well to hormonal changes, and endometrial polyps also arise due to the endocrine, nervous, hormonal disruptions in the body. Just polyps may emerge in infectious diseases of genital organs, the erosion of the uterus, inflammation, post-abortion, curettage of the uterus. Long:term morphological and functional changes in the mucosa of the corpus uteri in chronic endometritis rise to the possibility of abnormal afferent structures in the central nervous system, regulating the activity of the hypothalamic-pituitary-ovarian system. Violations of this system lead to the development of secondary hypofunction ovarian anovulation formation by type of absolute or relative hyperestrogenia and, therefore, hyperplastic processes in the endometrium.

Key words: morphology, endometrium, polyp, scraping.

 

 

Andriiets O. A., Shkrobanets І. D., Tsysar Y. V.

Role pathology of the endocrine system in gynecological diseases in girls.

167

The level of the disease incidence and prevalence of gynecologic and certain endocrine pathology in Bucovyna girls of pubertal age have bun characterized.

Key words: girl, Bucovina, endocrine system, uterine bleeding.

 

 

Nesterenko A. V., Morgunov A. A.

The chemotherapy of the ovarian cancer with the combination of hepato-protector enerliv.

169

The article is covered information regarding using of hepar protective drug Enerliv in chemotherapy of the ovarian cancer. It is showen results re look out for 31 patients what have regarding chemotherapy with Enerliv. Reserved results confirms about effect of using a Enerliv during a chemical therapy of the ovarian cancer.

Key words: ovarian cancer, chemotherapy, The hepar protective drugs, Enerliv.

 

 

Podol'sky V. V., Zadorozhnaya T. D., Yeschenko O. I., Pokryshko S. M., Derbak A. V.

Immunological Particularities of Placenta and Endocervix Immunocy-tochemistry in Parous Women and Women Infected with the Human Papilloma Virus.

173

The analysis of the obtained research data from the placentae of women infected with Human Papilloma Virus who didn't get treatment at squamous stratified epithelium dysplasia of the II-III degree showed the widespread changes in the deciduas, extravillous trophoblast with the apparent apoptic changes of decidual cells and cytotrophoblastic cells which also had a high expression of proliferous-cellular-nuclear antigen in the nuclei and СЕА and p16 in the cytoplasm on the background of placental insufficiency and middle degree of manifestation of compensatory reactions. The women infected with the HPV and who were not treated also had more evident changes of glandular epithelium, and at the cervical intraepithelial uterine cervix neoplasia of the II-III degree that declared itself with the strength of expression Ki 67 and p16 pointing at the oncological destruction in the ectocervix of the given group of women.

Key words: gestation, placenta, Human Papilloma Virus infection, CEA, p16.

 

 

Аковбян В. А.

Азитромицин (Cумамед) как препарат первого выбора при лечении урогенитального хламидиоза.

177

 

 

Дубчак А. Є., Мілєвський О. В.

Цитомегаловірусна інфекція у вагітних жінок з трубно-перитонеальною безплідністю в анамнезі.

184

Вивчено перебіг вагітності, стан цитокінового профілю, мікробіоценоз статевих шляхів у вагітних з безплідністю запального генезу в анамнезі на фоні цитомегаловірусної інфекції. Виявлено, що у вагітних, що отримували етіотропну протизапальну терапію в якості прегравідарної підготовки, до складу якої входив противірусний препарат Валавір®, ускладнення вагітності зустрічались у 30% обстежених, тоді як у жінок, які не отримували лікування – у 100% обстежених.

Ключові слова: вагітність, цитомегаловірус, цитокіни, безплідність, Валавір®.

 

 

Martsynyak-Dorosh Oksana

Connection between appearance itself and by the level of sense of life.

188

This article examines connection between self perception and the level of feeling of sense of life in over-weight and obese women and in patients suffering from saccharine diabetes. This research shows that these women have a negative perception of self which, in turn, influences negatively their level of feeling of sense of life. The research results may prove useful in developing a plan for overweight and obesity treat-ment.

Key words: perception of Self, feeling of sense of life, obesity, saccharine diabetes, Real Self, Ideal Self.

 

 

Toryanik E. L.

Gestosis and reproductive loss in pregnant female rats.

191

It is proved that the conduct of an aqueous solution of N-nitro-L-arginine causes symptoms that are characteristic of preeclampsia. In pregnant female rats with experimental preeclampsia there was a significant reduction in body weight, craniacaudal size of the fruit, the death and resorption of fetuses in the litter.

Key words: pregnancy, preeclampsia, reproductive losses.

 

 

Hourani I.

Effect of quercetin and thiotriazoline on cyclophosphamide-induced pne-umofibrosis in rats of different genetic lines.

193

On the model of cyclophosphamide:induced lung injury the role of enzymes of pro- and antioxidant system in rats of different genetic lines was investigated in the development of oxidative stress, induction of inflamma-tion and fibrogenesis in the lungs. The greatest lung injuries occurred in spontaneously hypertensive rats, in which high level of prooxydant enzyme NADPH-oxidase and nitric oxide synthase, and low level of antioxi-dant enzyme superoxide dismutase were genetically caused. Introduction of сyclophosphamide in these rats led to growth of malondialdehyde and protein carbonyl groups in lungs in 1,8 times, C-reactive protein in 1,5 times, transforming growth factor β1 in 1,8 times, the molecules of average weight in 2,1 times, lisophosphati-dylcholine by 29% and reduction of phosphatilcholine by 25%. Quercetin and Thiotriazoline showed powerful antioxidant, anti-inflammatory and antifibrogenic properties, restoring the biochemical parameters in rats of Wistar and Fisher genetic lines. At the same time in spontaneously hypertensive rats the complete norma-lization of parameters did not occur.

Key words: сyclophosphamide, pneumofibrosis, Quercetin, Thiotriazolin.

 

 

Мухомор О. І., Бужава І. І., Дегтярюк М. В., Бубнов Р. В.

Роль соноеластографії у визначенні прогнозу пункційного лікування утворень яєчників.

197

 

 

Бубнов Р. В., Мухомор А. И.

Лечение тазовой боли с помощью собственного метода «сухого» иглоукалывания триггерных точек под ультразвуковым контролем. Технологическая инновация.

200

 

 

Бубнов Р. В., Мухомор О. І.

Сучасні тривимірні технології візуальної діагностики в гінекологічній практиці.

201

 

 

Козаренко Т. М., Воробьова Л. І.

Можливості сонографії в діагностиці та оцінці ефективності лікува-ння гестаційної трофобластичної хвороби.

202