• Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

Давыдова Ю. В., Петрова Г. А.

Заболевания щитовидной железы и беременность (клиническая лекция).




Репродуктивное здоровье женщины в XXI веке. Обмен международным опытом в Киеве.




Научно-производственной компании «О.Д. Пролисок» – эксклюзивному разработчику и производителю мультипробиотиков группы Симбитер® в мае этого года исполняется 20 лет.




Davydova Y. V., Liman A. Yu., Ogorodnik S. A.

Iron deficiency anemia is the twenty-first century: ionic and non-ionic iron preparations, practical advice for pregnant women.


The publications covers the actual Iron deficiency anemia issues among pregnant. The main mechanisms and stages of diseases progress are described. Comparative analysis of Iron deficiency anemia and acquired non-Iron deficiency anemia is conducted. Comparative analysis of ionic and non-ionic Iron medications is conducted. The main peculiarities of treatment of Iron deficiency anemia among pregnant are specified.

Key words: pregnancy, iron deficiency anemia, ionic and non-ionic iron preparations, prevention, treatment.



Babenko O. M., Yashin E. G.

Progesterone therapy in obstetrics and gynecology.


The aim of the study was to investigate the efficacy and tolerability of injectable progesterone in ethyloleate for preparation to pregnancy and treatment of threatening abortion in women with luteal phase insufficiency (LFI). Were examined 56 women with LFI and 28 healthy individuals (14 non-pregnant and 14 pregnant wo-men) of the same age and terms of pregnancy. The study showed that women well tolerated therapy by in-jectable progesterone and it was highly effective (78,57% became pregnant and 95,45% of them delivered in term). The authors concluded that the injectable progesterone in ethyloleate is effective and safe in prepara-tion to pregnancy and for the treatment of threatening abortion in women with luteal phase insufficiency.

Key words: luteal phase insufficiency, progesterone, miscarriage.



Vdovichenko Y. P., Vdovichenko S. Y.

Modern aspects of partner childbirth.


The rewie presents information about the roll of partnersip delivery in decreasing of frequency of obstetric and perinatal complications on based on the experience of foreign countries; tendences of the development of pertnership delivery in Ukraine and in the World were analized.

Key words: pregnancy, delivery, partnership delivery, perinatal complications.



Shekera O. G., Shekera O. O., Pidoprigora L. A.

Ensuring the rights of health care workers in the context of medical law in Ukraine.


The paper deals with the regulations for ensuring the rights of medical workers. It also focuses on the issues of the workers’ social and economic defence and the proposals to improve legal regulations of the defence of medical workers’ rights.

Key words: medical law, medical law and regulations, social and economic defence of medical workers, human rights in medical activities.



Padalko A. A., Zhezher A. A., Goncharenko D. A.

Transfusion-related acute lung injury syndrome.


In article is described: etiology, pathogenesis, diagnostics, prevention and treatment of transfusion-related acute lung injury. The clinical case of timely diagnostics and treatment of this complication is provided.

Key words: transfusion-related acute lung injury syndrome, pulmonary edema.



Zhemela N.

Effect of vitamins and micronutrients on pregnancy.


The role of vitamins and minerals during pregnancy is very significant because the mother’s organism is the sole source of all the essential nutrients to the fetus. At the end of pregnancy 50-92% of women were found to be in deficit of more than 2 micronutrients in the serum. Low supply of vitamins and micronutrients forms a high risk of pregnancy and delivery complications.

Key words: pregnancy, vitamins, trace elements, complications, childbirth.



Chuyko М. М.

The modern epidemiology state of problem of intraventricular hemorrhage in premature infants (literature Review and the results of their own research).


Analyzed literature sources and presents the results of their own research on the epidemiological issues the incidence, risk factors and possible outcomes in intraventricular hemorrhage in preterm infants. The role of this species in the structure hemorrhage perinatal morbidity and mortality, which is set the task of finding new and improvement of existing components of prevention and treatment of intraventricular hemorrhage in preterm infants.

Key words: intraventricular hemorrhage, preterm infants.



Safonova I. N., Lukyanova I. S.

Evidence-based medicine, 3rd routine ultrasound scanand fetoplacental pathology, identified in the last trimester of pregnancy (review of litera-ture and Web sources).


The approaches to routine ultrasound scans of pregnancy adopted in Ukraine and other countries are discussed in the article. The results of Cochrane systematic reviews of researches in obstetric diagnostic ultrasound arestudied. There is provided an analytical overview of the literature and Web sources about diagnosing of fetal anatomical malformations and pathology of fetoplacental system in the third gestational trimester.

Key words: pregnancy, ultrasound diagnostics, third gestational trimester.



Pyrohova V. I., Tsolko O. R.

Evaluation of combined therapy drugs primary dysmenorrhea.


The article discusses the etiology, pathogenesis, diagnosis and treatment of dysmenorrhea with combined drug Spasmil-M. Attention is paid to the individual approach to the selection of symptomatic treatment of primary dysmenorrhea.

Key words: dysmenorrhea, pain syndrome, nonsteroid anti-inflammatory drugs.



Kondratjuk V. K., Emetc N. A., Koblosh N. D., Dziuba G. A., Schurevskaya O. D.

Discharge from the female genital tract (etiology, differential diagnosis and treatment guidelines).


The main types of discharge from the female genital tract in the age aspect, examined the types and causes, as well as the basic principles and methods of treatment for symptoms of abnormal discharge from the geni-tal tract of women. It is shown that use of the drug Tantum Rosa®, through an integrated action (anti-inflam-matory, analgesic, anti-inflammatory, antibacterial) leads to the rapid elimination of clinical symptoms and improve the quality of life of women with mixed infection of genitals.

Key words: abnormal discharge symptom, quality of life of women, mixed infections, Tantum Rosa®.



Benyuk V. A., Szczerba Е. A.

Features of the functional state of the mucous membrane of the vagina and cervix in mixed infections.


The problem of increasing the frequency of inflammatory processes of female genital mutilation and infec-tions are sexually transmitted, is relevant in recent years. According to studies conducted in recent years, urogenital infections are almost always polymicrobial. The results of the functional properties of the squa-mous cells of the vagina and cervix, and implementation of integrated treatment of Candida-chlamydial tservikovaginitov.Pokazano that the pathogenesis sound is the use of topical preparations – Makmiror com-plex and Tantum Rosa®.

Key words: vaginal mucosa, inflammation, mixed infections, Makmiror, Tantum Rosa®.



Makarenko M. V., Govseev D. A., Gorodnichaya L. N., Aksenov V. B.

The problem of surgical treatment of preterm labor with miscarriage.


The article is devoted to the practical methods of treatment of miscarriage pregnancy. The authors reveal the major risk factors and give the classification of miscarriage types, analyze the existing methods of treatment of this problem. They also supply their own effective results, applied in practice in Kiev maternity hospital №5.

Key words: pregnancy, miscarriage, PPI surgical correction, Mersilene thread, cerclage.



Tezikov Y. V.

Comprehensive treatment of placental insufficiency with the inclusion angioprotektory diosmine.


Clinical approbation of application for treatment of placentary insufficiency angioprotection Phlebodia 600 (diosmin) is spent. 122 pregnant women have been included in research with placentary insufficiency, from them 62 pregnant women in addition to basic therapy received Phlebodia 600 on 2 tablets a day (1200 mg diosmin) within a month. The control of productivity of treatment carried out clinical, ultrasonic, immunologi-cal, biochemical, morphological methods of research. At application diosmin authentic improvement of a fruit-placentary blood-groove, normalisation of processes of the programmed cellular destruction, cellular prolife-ration, power supply and indemnifical reactions in a placenta that promotes a birth of children with the best morphofunctional characteristics is noticed.

Key words: placentary insufficiency, treatment, diosmin.



Сабиров Д. М., Артикходжаева Г. Ш., Гафурова Ф. А.

Лечение беременных с заболеваниями мочевыводящих путей.




Zakharenko N. F.

Clinical aspects of endometrial disease.


The article describes the most typical symptoms of endometriod disease, systematization of which promotes better understanding of the pathogenetic mechanisms of the development of different forms of this disease on the basis of research on linkages of clinical manifestations of the immune and hormonal homeostasis. 455 patients of active and reproductive age with endometriosis of various locations were examined. The pre-sence of similar clinical symptoms of varying severity (hyperpolymenorrhea, pain, mastodynia, mastalgia, premenstrual syndrome) confirms similarity of pathogenesis and stages of the process in different forms of endometriosis, which is especially important in the detailed hormonal, immune and morphofunctional investi-gations to diagnose or rule out the disease.

Key words: endometrioid disease, clinical manifestations, morphofunctional characteristics, hormonal and immune homeostasis.



Shpak I. V.

Prediction of obstetric, perinatal complications in women infected with influenza virus.


327 is inspected pregnant. Chances of development of obstetric and perinatal complications at presence of polymorphism of genes of COL1A1 (Т/Т), РАІ-1 (4G/4G), endotelial cyntase oxide of nitrogen (eNOS3), at pregnant, infected the virus of flu, was made by 1,7 and are within the limits of confidence interval (CI 0,53–2,19; P=0,95). Conducting of pre-conception preparation and application of the offered measures does not influence on frequency of polymorphism of the probed genes, but instrumental in the prophylaxis of origin of

obstetric-perinatal complications.

Key words: virus of flu, polymorphism of genes of COL1A1, РАІ-1, endotelial cyntase oxide of nitrogen, obstetric and perinata complications.



Радзинский В. Е.

Преждевременные роды и перспективы применения прогестерона для их профилактики.




Danilko V. A., Islamova E. V., Koval S. D., Medved V. I., Yanyuta S. M.

Aplastic anemia and pregnancy.


The article presents a description of the cases of severe aplastic anemia during pregnancy.

Key words: aplastic anemia, pregnancy.



Yudina T. V., Terekhova N. V., Sergiyenko S. N.

Influence of phytotherapy on properties of urine, as direction of pathogenetic treatment of pyelonephritises at pregnant women.


The problem of pyelonephritis at pregnant women retains its clinical and social relevance. The purpose of research was to study the changes of physico-chemical and microbiological properties of the urine of preg-nant women with pyelonephritis under influence of the phytotherapeutic drug trinephron-zdorovye and their pathogenetic significance to improve clinical efficiency of treatment of this pathology. Due to influence on physico-chemical and microbiological properties of urine, the phytotherapeutic drug trinephron-zdorovye significantly improved a course of pyelonephritis at pregnant women, reducing the duration of its symptoms and laboratory signs, with shortening of periods of hospitalization. The application of trinephron-zdorovye allows to reduce frequency of relapses of this pathology and development of asymptomatic bacteriuria.

Key words: pyelonephritis at pregnant women, infection of urinary tracts, complication of pregnancy, intra-uterine infection, bacterial film, trinephron-zdorovye.



Veropotvelyan N. P., Smorodskaya E. P.

Modern trends of fetal surgery and characteristics of the anesthetic supplement.


The article presents the current trends of fetal surgery: open, closed minimally invasive fetal surgery and the EXIT procedure with the followed surgical treatment of the newborn. These methods require a lot of manipu-lations, monitoring of the mother and the fetus (fetuses) and are associated with certain risks for them. An evolution of the embryo formation of intrauterine fetal pain sensitivity (nociception) is described . The approa-ches and the principles of anesthetic management with different methods of fetal surgery are preresented. The features of the effects of different methods of anesthesia (general, regional, local, combined) for anato-mic and functional status of the fetus and its application to different methods of fetal surgery are discussed. Special attention is paid to the peculiarities of anesthetic management during minimally invasive surgery per-formed under the fetockopy and ultrasound supervision which began to develop in Ukraine. The details of the advantages, limitations and disadvantages of the different routes of administration of anesthetics and analgesics of the fetus, especially dosage and possible side effects are shown. A review of available and proprietary protocol fetal anesthesia, depending on the type and duration of fetal operations and require-ments to immobilize the fetus are proposed. The issues of fetal anesthesia at eliminating abnormal fetuses are dicussed.

Key words: fetal surgery, fetal pain, fetal anesthesia.



Tovstanovskaya V. A., Prilutskaya A. B., Prilutsky A. I., Mikheev L. M., Slavuta G. B.

The modern approach in the treatment of bacterial vaginosis in pregnancy.


Based on this study, we determined the high therapeutic efficacy of topical drug Milagin in bacterial vaginosis in pregnant women, its good tolerability, which provides for prevention of infectious complications in both the mother and the newborn, and the drug can be recommended for widespread use in obstetric hospitals for prenatal as a vaginal pregnant.

Key words: bacterial vaginosis, treatment, pregnancy, Milagin.



Vdovichenko Y. P., Goncharuk N. P., Poluyanova O. M.

Pregnancy and childbirth in women with a scar on the uterus after cesarean section – a real danger or unfounded fear.


The article reflects the perspective of reducing the frequency of repeated cesarean sections through vaginal delivery in women with a scar on the uterus. Analyzing the cases of successful VBAC the predisposing fac-tors for their conduct are identified: pregnancy age, vaginal parity, and weight of the fetus, the interval bet-ween births more than 2 years, pregnancy term, regular prenatal observation and psychological readiness of women. A high readiness of the women with a scar on the uterus before the next pregnancy is needed. The main factor of an adequate training is still a psycho prophylactic training.

Key words: scar on the uterus, cesarean section, pregravid training, VBAC.



Dyndar E. A.

Obstetrical and perinatal complications of women with superfluous weight of a body and a metabolic syndrome.


Results of the spent clinical researches have shown that presence of superfluous weight of a body and a me-tabolic syndrome at women of reproductive age is the essential factor of development obstetrical and perina-tal complications. Thus their frequency increases in process of increase in size of an index of weight of a bo-dy and degree of expressiveness of a metabolic syndrome. For deeper understanding of occurring process-es carrying out of additional laboratory and functional researches is necessary.

Key words: obstetrics, perinatology, superfluous weight of body, metabolic syndrome.



Nazarenko L., Tarusina O. V.

Low hight of women as significant and independent factor obstetric and perinatal risk.


Determined the proportion of women with hight 157 cm or less in 2002, 2007, 2012 years. Found the growth rate from 7.7% to 12.1%. Based on the study of features of pregnancy and childbirth in women with low hight (less than 155 cm). found that the incidence of hypoxic-ischemic lesions of the fetus, birth trauma, obstetricinjuries, operational procedures levels in such women are 2-10 times higher than the population. The conclu-sion about the appropriateness of individual-typological approach in modern obstetric clinic.

Key words: low growth, pregnancy, childbirth.



Protsepko A. A., Kostjuk A. L.

Influence not differentiated dysplasia of connecting fabric at an incontience of urine at women during pregnancy on quality of life of patients.


Results of the spent researches testify to an essential role not differentiated dysplasia of connecting fabric in development of an incontience of urine during pregnancy and after the delivery. It proves to be true the cli-nical aspects of the given pathology studied by us, and also negative influence on quality of life. The receiv-ed results are necessary for considering by working out of algorithm of diagnostic and treatment-and-prophy-lactic actions at an incontience of urine at women during pregnancy and after delivery.

Key words: quality of life, the urine incontience, not differentiated dysplasia of connecting fabric.



Chemer N. M.

Chronic сerebral venous discirculation in women in first trimester of pregnancy.


The current work presents the results of clinical examination pregnant women with complicated of the first trimester of pregnancy who had chronic сerebral venous discirculation. There were examined 103 gravida in first trimester of pregnancy with cerebral venous discirculation syndrome. Clinical presentation is in detail described on the different stages of disease – subclinical, functional violations and venous encephalopathy. There was detected that some women had compromised history that could be premorbid condition before pregnancy.

Key words: cerebral venous discirculation, venous encephalopathy, pregnancy, clinical presentation.



Savicheva A. M., Rybina E. V.

In vitro evaluation of the effect ofpolygynax on the microorganisms iso-lated from the female vagina.


The effect of polygynax on 24-hour cultures of 163 strains of the microorganisms isolated from the vagina of reproductiveaged women was evaluated in an in vitro experiment. The concentrated solution of polygynax and its dilutions in isotonic sodium chloride solution were tested. Gram-negative bacteria were found to be highly susceptible to the antibacterial agents contained in polygynax. Yeast-like fungi of the genus Candida were susceptible to nystatin that is a component of polygynax. The lactobacilli isolated from the vagina of reproductive-aged women were resistant to polygynax even at the lowest concentration.

Key words: vulvovaginitis; cultures of microorganisms isolated from the female vagina, polygynax.



Sinetar E. A., Loskutova M. N.

The influence of the drug Aflazin® on the adhesive properties of micro-organisms – pathogens of catheter-associated infections.


The effect of the drug Aflazin® (UTIroseтм) and separate its combination with levofloxacin on adhesive pro-perties of opportunistic microorganisms. Found that adding the active ingredient of the drug Aflazin® (UTIroseтм) leads to a significant (p≤0,05) decrease of adhesion of microorganisms in the 1,4>5,0 times in comparison with control. Adding a combination of the active ingredient of the drug Aflazin® (UTIroseтм) and levofloxacin led to further decline adhesion the studied strains.

Key words: Aflazin®, adhesion, catheter-associated urinary tract infections, conditionally pathogenic mic-roorganisms.



Gopchuk E. N.

Algodysmenorrhea – correction of syndrome with modern.


Information about the modern aspects of algodysmenorrhea therapy is presented in the article. Present clini-cally experience reflects the using nonsteroid untiinflamatory drugs with a view to therapy pain syndrome in women with algodysmenorrhea.

Key words: algodysmenorrhea, treatment, prophylaxis, nimesulid.



Neymark A. I., Shelkovnikova N. V.

The effectiveness of the drug in the treatment of Saguenay women with urogenital disorders during the peri- and postmenopausal women.


The article presents the results of research based on observation of 50 women aged 50-65 years with uroge-nital disorders (OAG). Group 1 (n = 20) received only causal treatment (3 mg once monural and furamag 50 mg 3 times daily for 7 days, intravesical instillation with sintomitsinovoy emulsion number 10 candles with sea buckthorn oil vaginally 2 times a day number 20). Group 2 (30 patients) received an additional Sagenit 1 tablet per day for 3 months. The observation of the patients was carried out for 6 months. The patients in group 2 who received the Sagenit, by the end of therapy was a significant improvement mirotsirkulyatsii mu-cous membranes of the urinary bladder and the vagina. Found that estrogen drug Sagenit allows to stop the symptoms of PEM, renew or improve sex life and ultimately significantly improve the quality of life of these women.

Key words: urogenital disorders, menopause, Sagenit, treatment.



Vdovichenko U., Gopchuk E.

Rational antibioticprophylactice after intrauterine surgery.


The article presents an information about rational antibioticprophylaxis in gynecological practice with the use of widely available and highly effective substances, combined in one drug.

Key words: tinidazole, ciprofloxacin, treatment, prevention, intrauterine surgery.



Zhuk S. I., Koshmerynska A. M., Taran O. A.

Modern DNA diagnosis of human papillomavirus infection.


The paper highlights new approaches to the DNA diagnosis of human papillomavirus (HPV) infections in wo-men of reproductive age in inflammatory and non-inflammatory disease of cervix. Different types of HPV viru-ses that affect genital tract, simultaneous contamination with several types of viruses in cervical pathology and dependence of clinical picture on quantitative load of papillomavirus. The researched proved that with the help of quantum 21 in real time it is possible to carry out not only high-quality DNA diagnostics but also quantitative determination of 21 type of papilloma viruses that affect genital tract, as well as to verify the reli-ability of material intake. It has been proved that the new suggested approach to DNA diagnostics of papillomavirus infection in real time can be used in inflammatory and non-inflammatory disease of cervix; therefore taking into consideration the obtained results it becomes possible to develop a profound treatment strategy and clinical observation of patients.

Key words: inflammatory and non-inflammatory disease of cervix, papilloma virus infection, quantum 21, polymerase chain reaction.



Veropotvelyan P. N., Lakаtosh V. P., Guzhevskaya I. V., Tsekhmistrenko I. S., Yaruchik S. P., Polonec I. A.

Pregnancy and pappilomavirus infection.


VPH is an agent of some widespread diseases of female genitals. In particular, its oncogenial types cause cytological changes of uterus neck’ epithelium,its dysplasia and cancer. In the article points of VPH infection pathogenesis are given, data about a developed vaccine for VPH are represented, as well as methods to cure the infection. The data of the literature view show a high VPH rate in the pregnant, a role of VPH in the processes of cancerogenesis. Subclinical forms of the infection as well as CIN must be cured prior the preg-nancy. Thus, to optimise pregravidary preparation we have performed a complex (including immunocorrecti-ve, ethiotropic) therapy of the patients who suffer from VPH on the stage of a pregnancy planning. As a re-sult of the performed investigations the following conclusion can be made: a complex ethiotropic treatment (including «Isoprinosin» and «Alferekin») is highly effective in the patients with uterus neck’ pathology cau-sed by VPH which is proved by the data of the clinical, laboratory and instrumental methods of investigation.

Key words: pregnancy, human papillomavirus infection, combination therapy, treatment, izoprinozin, Alfa-rekin.



Melnikov S. N.

Genital herpes antiviral chemotherapy.


In this article the questions of the etiotropic treatment effectiveness of genital herpes are considered. Due to valacyclovir treatment predicted regression of clinical symptoms of disease occurs, as well as the normalization of the immune system, as evidenced by the restoration of cellular and humoral chains. Comparators showed temple safety profile as all patients tolerated treatment well, and there were no any side effects. Va-lacyclovir therapy enables to enhance the quality of life of patients, to restore their social adaptation and harmony of sexual relations.

Key words: genital herpes, Gerpeval, valacyclovir, treatment.



Prilutskaya A. B., Avramenko S. A., Tsapenko T. V., Prilutsky A. I., Slavuta G. B.

The immune status of patients infected with chlamydia, and its correction drug Laferobion.


The results of the study indicate the presence of secondary immunodeficiency in patients infected with chla-mydia. Laferobion drug use in these patients leads to the restoration of both cellular and humoral immunity, contributing to the elimination of chlamydia from the body and the onset of full recovery of patients in 96.2% of cases.

Key words: urogenital chlamydia, treatment, immune status, Laferobion.




Adamovskaya T. N.

Peculiarities of management of patients with endometriosis-associated infertility.


The concentration of anti-mullerian hormone, follicle stimulating hormone, estradiol, IGF-1 in serum were tested in 91 patients. Women over 35 years in addition to determine the level of luteinizing hormone the day of ovulation. The data of this study suggest to extend the time of pregnancy, and its frequency in women used hormone therapy with reduced ovarian reserve. The greatest incidence of pregnancy was (60.0%) found in women with a deviation from the nominal of reproductive age downward (ie with a better prognosis). Thus, the analysis of the results of the study shows the usefulness of a differentiated approach to the management of women with endometriosis-associated infertility considering the indicators of ovarian reserve.

Key words: endometriosis-associated infertility, pregnancy, ovarian reserve parameters, protocol management of patients.



Dankovich M. D., Vorobei-Vykchovsky V. N.

The course and forms of infertility. The opportunity of diagnostic and treatment today.


The title deals with the ethiologic agents and pathogenetical mechanisms of the infertility’s appearing. The main methods, using in diagnostic of infertility are described. The pluses and minuses each of them are observed. Conservative and surgical methods of the treatment are discussed. The need of the choice of one or another method in different clinical situations is grounded. Also, the new conceptions in this field and perspective ways out of this problem are presented. The importance of medical tactic in diagnostic and treatment of infertility is explained.

Key words: infertility, assistant reproductive technologies, infertility factor.



Tkachuk T.

Reproductive health of women with malignant tumors of external genitalia.


We have researched the reproductive health of 294 women aged 51 to 85 with vulvar cancer during the diag-nostics and treatment of carcinomas of female external genitalia. 195 (66.3%) of the patients started mens-truating at the age of 12–14, 99 (33.7%) at the age of 15–16. The majority of the patients, 258 (87.8%), had no age deviations in the cessation of menstrual function. 276 (93.9%) of the patients have given birth, 153 of them (52.0%) have given birth three or more times. The incidence of gynecological diseases was not found to be higher than that in the respective age groups of female population, with the exception of background and pre-cancerous pathology of female external genitalia, the incidence of which in the sample was 71.8%. Thus no significant disorders of the menstrual or reproductive function were found in women with vulvar can-cer. The disorders of reproductive health cannot be considered as a component of the development of malig-nant tumors of external female genitalia.

Key words: reproductive health, malignant tumor, vulva, menstrual function.



Zarichanska H. V.

Epidemiology and risk factors human papillomavirus (HPV) ofthecervixuteri.


Determined the frequency of human papillomavirus (HPV), a high degree of tumorigenicity among the female population.The main factors of risk of infection and progression papilomovirus infection genital localization. Studied the immune status of women with HPV high degree of tumorigenicity.

Key words: human papillomavirus (HPV), human papillomavirus infection, cervix uteri, epidemiology, risk factors.



Egorov A. A.

Modern possibilities in the diagnosis of status of the fetoplacental complex in women after organopreservation treatment of borderline cancer of the uterine cervix and initial stages of cancer of the uterine cervix.


Magnetic – resonance imaging is perspective researche in obstetrics and oncogynecology. Usage of mag-netic – resonance imaging allowed to diagnose status of a placenta and fetal central nervous system with a high precision of anatomic interpretation in women after organopreservation treatment of borderline cancer of the uterine cervix and initial stages of cancer of the uterine cervix.

Key words: pregnancy, magnetic – resonance imaging, cancer of the uterine cervix, cervical intraepithelial neoplasia.



Marchenko N. E.

Risk factors of threatened preterm labor in the II trimester of pregnancy.


The examination of 50 pregnant women with the threat of preterm labor in the II trimester determined follows risk factors of preterm labor: 1. Adverse social, professional and personal factors; 2. Burdened gynecological history; 3. Burdened obstetric history; 4. Extragenital pathology; 5. Complications of this pregnancy. Prophy-lactic of miscarriage in the II trimester should be in preventing negative impacts of these risks factors starting already from the I trimester of pregnancy.

Key words: threatened preterm labor, II trimester of pregnancy.



Melenchuk L. M.

Determination of the level of erythropoietin as a marker of adequate assignment of treatment in pregnant women with infectious diseases of kidneys and anemia on moderate and severe stages.


We determined the level of erythropoietin in pregnant women in the groups with acute pyelonephritis, chronic pyelonephritis, combined with anemia in terms of 28 to 40 weeks of pregnancy.The groups of pregnant wo-men with inflammatory diseases of kidneys are divided by the level of hemoglobin in blood. In the course of study we found that in a group of pregnant women with acute pyelonephritis correlation was negative (R2=0,22; Hb–E=0,47) between the level of hemoglobin and erythropoietin in blood, so the lower level of hemoglobin means the higher levels of erythropoietin. In a group of pregnant women with chronic pyelone-phritis correlations are negative too, but less pronounced (R2=0,03; Hb–E=-0,16), and direct correlations are observed only in pregnant women with chronic pyelonephritis and severe anemia, and in pregnant women with chronic renal insufficiency of 1 degree. It is shown that the level of erythropoietin in pregnant women with acute pyelonephritis and anemia of light and medium ranges normally, more speciffic in the upper units of norm. In women with chronic pyelonephritis erythropoietin level in blood depends on the state of renionhi-tension system of kidneys. It means that at high levels of erythropoietin in blood of pregnant women with chronic pyelonephritis anemia there is an iron deficitiency, and at low – erythropoetin deficitiency which, the-refore, requires specific treatment by erythropoietin. Therefore, determination of erythropoietin in blood of pregnant women with infectious diseases of kidneys in combination with anemia of heavy and medium se-verity may be considered as a marker of adequate treatment assignment.

Key words: erythropoetin, pregnancy, urinary tract, anemia.



Аntonjuk М. I., Dola О. L., Yemets N. O.

Analysis of medical-social state of women who have had preterm birth.


In the article medical-social state of women who have had preterm birth are investigated. The reasons which caused the threat of premature delivery were identified. This results is a necessary in the development of complex actions for the prevention of obstetrical and perinatal pathologies.

Key words: medical-social state, preterm birth, prevention.



Yaremchuk T. P.

Vaginal microbiocenosis recovery – is one of improvement directions of perinatal consequence of syphilis.


Hard form of vaginal disbiosis has been designated on the ground of bacterioscopic and bacteriological rese-arch accordingly in 60 and 45 pregnants with syphilis. The necessity of vaginal microbiocenosis bacteriologi-cal control in treatment dynamics and before labor has been proven.

Key words: pregnancy, syphilis, vaginal microbiocenosis.



Nazarenko L. G., Babajanyan E. N., Yakovenko E. A., Romadina O. V., Lihachova N. V.

The case of prenatal diagnosis of epulis.


Possibility of ultrasonic prenatal diagnostics of congenital malformations is described at a fruit – epulis

Key words: ultrasonic research, congenital malformations, epulis.



Гайструк А. Н., Булавенко О. В., Гайструк Н. А., Шевчук М. В., Притула Л. В.

Современный взгляд на многоплодную беременность с элементами доказательной медицины.


Для определения причин развития осложнений многоплодной беременности и их предупреждения был проведен клинико-статистический анализ 27 индивидуальных карт беременных и историй родов у женщин с многоплодием, которые находились под. диспансерным наблюдением в женской консультации и рожали в течение 2010–2011 годов на базе ВМКПБ № 2 г. Винницы, и проведен мета-анализ исследований, связанных с многоплодием.

Ключевые слова: многоплодная беременность, осложнения, диспансерный надзор.



Nechay O.

Prenatal diagnostic of haemolytic disease of the newborn by molecular genetic methods.


We studied 109 pregnant women with Rh sensitization during 2010-2012 in the department of extragenital pathology and pathology of pregnancy of Lviv Regional Clinical Hospital. We performed amniocentesis in 21 cases of Rh sensitization which were diagnosed by multiple anti-Rh antibody titer rated from 1:2 to 1:512, but had no ultrasound features of Rh-conflict. In 4 (19,0%) of these cases we got Rh negative fetus blood type result by using polymerase chain reaction test of amniocytes, despite the high anti-Rh antibody titer rated from 1:64 to 1:512. It was resulted in evoiding of stimulation of preterm delivery and reduction of duration of stay in hospital.

Key words: pregnancy, haemolytic disease, Rh sensitization, amniocentesis, rhezus factor.



Babajanyan E. N., Romadina O. V., Yakovenko E. A., Zhadan I. A.

On the question of the need to third ultrasound prenatal screening.


The paper shows the efficiency of the third ultrasound prenatal screening for the diagnosis of congenital mal-formations and abnormalities of the fetoplacental complex late manifestation in order to improve perinatal mortality.

Key words: ultrasound screening, fetoplacental complex, congenital malformations.



Arbuzova S. B., Astahov V. M., Nikolenko M. I.

Strategy of prenatal screening for congenital and hereditary pathology within the framework of perinatal care.


Developments of prenatal diagnosis permit to detect a wide spectrum of congenital and hereditary pathology in early gestational age. It requires to set an optimal screening strategy, to provide standartization of every examinations’ stage, appropriate doctor’s training, system of quality control and audit. On the bases of 12-years own experience in prenatal diagnosis the main conditions for effective prevention of congenital birth defects were determined

Key words: prenatal diagnosis, prenatal genetic screening, congenital malformations, chromosomal pathology.



Posokhova S. P., Nitochko K. O., Fіsun V. G.

The frequency of congenital infection at preterm premature rupture of membranes at 22–34 weeks of gestation.


In the article results of retrospective research of frequency of congenital fetal infection depend of the latency time to birth in 150 pregnant women with preterm premature rupture of membranes of a gestation age of 22–34 weeks of pregnancy. Frequency of a congenital infection was the gestation of 22–27,5 weeks highest in terms, irrespective of duration of latency time to birth, in 28–31,5 weeks increased in proportion to duration of latency time to birth, in terms of a gestation of 32–34 weeks the latency time to birth >168 hours authentically increased percent of newborns with congenital pneumonia. Frequency of the intrauterine infection of a and mortality at newborns closely correlated with infection of pregnant women by pathological infective agents (r=0,95±0,02), development chorionamnionitis (r=0,99±0,01) and morphologically confirmed inflammatory process in the placenta at PPROM (r=0,76±0,1).

Key words: preterm delivery, preterm premature rupture of membranes, long latency time to birth, conge-nital infection.



Udovika N., Romanenko I.

The pregravid preparation as the leading factor of child health formation.


The questions of the formation of the initial health of the child in the Lugansk region are discussed. It was shown that the planning of a pregnancy and responsible pregravid preparation for bearing should be the le-ading links. The stages of pregravid preparation for smoking parents on the example of the effects of smok-ing on the fetus and the future health of the child were considered. The hazards of routine medical diagnostic procedures during pregnancy were determined. The healthy way of life and its wide promotion in society sho-uld be the factors in the formation of the future health of a society members.

Key words: pregravid preparation for bearing, smoking, healthy lifestyle.



Самая женская «болезнь».