HEALTH OF WOMAN WH_№3_2010

  • Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

Подтверждены преимущества повторного последовательного введения системы «Мирена» в отношении контроля цикла и профиля безопасности.

14

 

 

Результаты исследования: Мирена может заменить до 50% гистерэктомий, проводимых с целью лечения обильных менструальных кровотечений.

17

 

 

Jouraa Elmar A., Kjaerb Susanne К.,. Wheelerc Cosette M, Sigurdssond Kristjan, Iversene Ole-Erik, Hernandez-Avilaf Mauricio, Perezg Gonzalo, Brownh Darron R., Koutskyi Laura A., Тауj Eng Hseon, Garcnak Patricia, Aultl Kevin A., Garlandm Suzanne M., Leodoltera Sepp, Olssonn Sven-Eric, Tango GraceW. K., Ferrisp Daron G., Paavonenq Jorma, Lehtinenr Matti, Stebens Marc, Boscht Xavier, Dillneru Joakim, Kurmanv Robert J., Majewskiw Slawomir, Munozx Nubia, Myersy Evan R., Villaz Luisa L., TaddeoA Frank J., RobertsA Christine, TadesseA Amha, BryanA Janine, LupinacciA Lisa C., GiacolettiA Katherine E. D., LuA Shuang, VuocoloA Scott, HesleyA Teresa M., HauptA Richard M., BarrA Eliav

The level of antibodies to HPV and clinical efficacy of preventative application of quadrivalent HPV vaccine.

19

The efficiency of quadrivalent human papilloma virus vaccine (HPV) is due to the development of humoral immunity. We evaluated the relationship between the level of antibodies to HPV in the serum of patients who has received quadrivalent vaccine and the efficiency of vaccination. We examined the results of 17622 women, vaccinated in the 1st Day and then again after 2 and 6 months later. On the first day, and also at regular intervals in the 6-12 months (up to 48 months) all members have the Pap test and the test of genital HPV presence. The examination does not permit to establish the relationship between the parameters of immunity and efficiency of vaccination for the reason of small number of cases of infection. Despite the fact that at 40% of the vaccinated participants the serum antibodies to HPV-18 were not detected for the end of the examination, efficacy against HPV-18 in this group was high (98,4%, 95% CI: 90,5-100,0) in comparison with a high level of incidence in the placebo group. These results may indicate the importance of the role of immune memory at vaccinated persons, or the fact that the antibody titers to HPV-18 below the level determined by standard laboratory methods.

Key words: quadrivalent HPV vaccine, papilloma virus.

 

 

Boris E. N., Gak I. A., Tupis O. Y., Serbenyuk A. V.

New opportunities of prophylactic of cervical cancer by vaccination against human papillomavirus-infection.

28

The article concerns the problem of the incidence of cervical cancer, the peculiarities of development and course of human papillomavirus-infection. The negative dynamic changes of dysplastic cervix epithelium on a background of papillomavirus-infection was shown. The importance of prophylactic of cervical cancer at the present level is substantiated.

Key words: premalignant conditions of cervix, cervical cancer, human papillomavirus-infection, vaccine.

 

 

Schaub A. F., Riener R. and Geissbuhler V.

Акушерский гель Дианатал®: уменьшение продолжительности и сохранение энергии в родах.

32

 

 

Sabatini Rosa, Orsini Giuseppe, Cagiano Raffaele, Loverro Giuseppe

Неконтрацептивные преимущества двух комбинированных пероральных противозачаточных препаратов с антиандрогенными свойствами у подростков.

34

Целью данного исследования была оценка неконтрацептивных преимуществ двух противозачаточных препаратов, содержащих прогестины с известными антиандрогенными свойствами, у девушек-подростков. В данном проспективном исследовании сравнивалось действие двух препаратов, содержащих 30 мкг этинилэстрадиола в комбинации с 2 мг хлормадинона ацетата или 3 мг дроспиренона. Были получены данные за 6 мес у 156 сексуально активных девушек-подростков, принимавших оральные контрацептивы. Исследовано действие этих препаратов на межменструальные кровотечения, дисменорею, акне и патологию волос и кожи. Кроме того, оценено их влияние на сексуальный интерес, частоту половых актов и сексуальное удовлетворение. Оба препарата обеспечивали эффективную контрацепцию, хороший контроль цикла и положительное влияние на нарушения кожи и волос без изменения массы тела. Однако лучшие результаты были получены на фоне препарата, содержащего ацетат хлормадинона (различия были статистически значимыми). Более того, соответствие контрацептивов ожиданиям девушек и хороший комплаенс способствовали тому, что препараты продолжали принимать далее.

Ключевые слова: подростки, оральные контрацептивы, антиандрогенные свойства, неконтрацептивные преимущества, хлормадинона ацетат, дроспиренон.

 

 

Miralles F., Zapata A., Mas M., Borrаs L., Forns M., Artigas R., Puig M. M.

Опиоидсберегающий эффект декскетопрофена трометамола в лечении послеоперационного болевого синдрома после больших операцій на брюшной полости.

40

 

 

Tovstanovs'ka V. A., Vorobey-Vykhivska V. N.

Hyperprolactinemia and medicated methods of its correction.

44

In article the questions of the etiology and hyperprolactinemia pathogenesis is pointed out. There are described the main groups of preparations, which used for treatment of this pathology. The characteristics of high efficiency of dopamine receptor agonist of the III cabergoline generation are presented. The possibilities of use of this preparation in the hyperprolactinemia therapy are discussed.

Key words: hyperprolactinemia, cabergoline, dopamine receptor agonists.

 

 

Бурчинский С. Г.

Возможности магнийсодержащих препаратов в современной медицине.

48

 

 

Nagornaya V. F., Nikolaeva S. V.

New approaches of treatment of chronic vaginal candidiasis.

49

There were conducted some researches of effective application of preparation Zalain for women of childbearing age and for women with symptoms of vaginal candidiasis with the purpose of optimization of charts of different forms of vaginal candidiasis. High clinical and microbiological efficiency, multiplicity of it’s introduction, form of issue, absence of systemic action help Zalain to be advisable for patients of childbearing age and also during pregnancy.

Key words: vaginal candidiasis, Zalain.

 

 

Синякова Л. А., Косова И. В.

Инфекции мочевых путей у беременных. Современные подходы к лечению.

52

В первом русском руководстве по акушерству, составленном Н.М. Максимовичем-Амбодиком, «Искусство повивания, или наука о бабичьем деле» (1784) имелись указания на тесные анатомические связи между половыми и мочевыми органами у женщин. Какова же тактика при нефроуретеролитиазе, нефроптозе, прочих заболеваниях, требующих оперативной коррекции у беременных? Ответ однозначен: желательно устранить урологические заболевания до беременности. Беременность является фактором риска развития как неосложненных (в 4-10% случаев), так и осложненных инфекций мочевых путей.

 

 

Улучшение показателей имплантации и частоты беременностей при использовании вагинального прогестерона при интрацитоплазматической инъекции сперматозоида: ретроспективное исследование.

58

 

 

Лютеиновая поддержка для циклов ЭКО/ICSI интравагинальным прогестероном приводит к более высокой частоте наступления беременностей, чем внутримышечная форма прогестерона.

58

 

 

Применение вагинального прогестерона и перорального дидрогестерона имеют разное влияние на маточно-плацентарное кровообращение на ранних сроках беременности, осложненной угрозой прерывания.

59

 

 

Профилактическое интравагинальное применение прогестерона у женщин с высоким риском преждевременных родов: рандомизированное плацебо-контролируемое двойное слепое исследование.

60

 

 

Риск преждевременных родов при укороченной шейке матки и профилактическое применение прогестерона.

60

 

 

Лечение доброкачественных гиперплазий эндометрия прогестероном, принимаемым в виде вагинальных таблеток, связано с высоким процентом регресса патологических изменений.

62

 

 

Podolskiy V., Kasatkina T.

Results of clinical-epidemiological researches new technologies surgery laparoscopic with proof effectiveness for heighten birth-rate of women fertile age.

63

As a result of carrying out of clinical-epidemiological researches and sociological key modern new technologies (surgery laparoscopic), was become high effectiveness laparoscopic surgery how new technology for save reproductive health and heighten birth-rate in Ukraine.

Key words: clinical-epidemiological researches, sociological key, reproductive health, new technologies.

 

 

Крылова О. В., Васнецова О. А.

Определение потенциальных потребителей контрацептивных средств.

66

 

 

Бенюк В. А., Макаренко Г. И., Поворознюк В. В., Дзерович Н. И.

Современные аспекты женского остеопороза.

69

 

 

Vdovichenko Y., Gopchuk O.

Treatment of cervical intraepithelial neoplasia – the review of modern possibilities.

76

In the article information is resulted on issue of treatment of cervical intraepithelial neoplasia which is aqute in the aspect of oncological prophylaxis. Modern ethiological and pathogenetical aspects and medical directions are represented. Among effective littleinvasion therapeutic measures application of the portable cryosurgical system of Gistofrizer is illustrated.

Key words: cervical intraepithelial neoplasia, portable cryosurgical system of Gistofrizer, cryolysis, treatment.

 

 

Lutsenko N. S., Geraskina L. R., Evtereva I. A., Demyanko Yu. A.

Nonhormonal dysmenorrhea therapy and prevention of proliferative processes in the mammary gland.

80

The effect of Assalix phytomedication («Bionorica», Germany) in the complex treatment of dysmenorrhea at women with diffusive dishormonal diseases of the mammary glands (DDDMG) was studied. Examination included 50 women and to the 25 of them in the complex therapy was included Assalix phytopreparation. At women with pain syndrome secondary to the DDDMG were observed increase of the number of leukocytes in peripheral blood, erythrocyte sedimentation rate, body temperature and cardiac rate. Use of Assalix achieve the desired clinical effect and thus reduce the additional pharmacological stress on the female organism. Thus, besides the direct effect due to the possible influence of the drug on a massive induction of apoptosis of tumor cells, blocking of COX-2 in this case is able to reduce the uncontrolled proliferation of cells.

Key words: women, mammary gland, dishormonal disease, dysmenorrhea, pain, nonsteroidal anti-inflammatory drugs.

 

 

Levitskaya A. V.

The state of hormonal factors and immunity system in women after in vitro fertilization.

84

The problem of courses and outcome of pregnancy and delivery in women after in vitro fertilization is considered in this research. The information about the courses and outcome of these pregnancies are given. Hormonal factors and immunity system during these pregnancies is investigated.

Key word: pregnancy and delivery after IVF, the state of immunity system.

 

 

Dubossarskaya Z. М., Dubossarskaya Yu. А., Andrishina О. V.

Ecosystem of vagina and modern approaches to treatment of bacterial vaginosis (clinical lecture).

88

The modern view on forming of vaginal ecosystem just after the birth of a girl, interrelation of the immune and endocrine systems in forming of microecological health of new-born and human population in total are elucidated. We gave some attention to bacterial vaginosis as disbiosis of vagina and pathogenetic treatment of this widespread pathology is offered.

Key words: vaginal microbyocenosis, bacterial vaginosis, immune defense, Tergynan.

 

 

Chorny V., Chernyshov V., Sudoma I.

The use of TNF inhibitors for correction of immunological parameters in multiple IVF failure. Case report and the review of the literature.

93

The case of the use of tumor necrosis factor (TNF) inhibitor (etanercept) in woman with infertility and multiple ART failures. In general this woman has 6 unsuccessful IVF ICSI cycles. After investigation of immunological parameters of the blood the increase of intracellular TNFα production and CD4+TNFα+:CD4+IL10+ cells was found. Pregnancy was achieved in two ART cycles before which the TNF inhibitor etanercept was prescribed. In the first cycle it was extrauterine pregnancy, in the second – intrauterine pregnancy which ended with live born infant. Only several investigations (2 articles and 2 abstracts) devoted to the use of TNF inhibitors in treatment of infertility and pregnancy losses were found in the literature. The questions of safety, effectiveness and usefulness of TNF inhibitors in the сorreсtion of reproductive problems are discussed.

Key words: in vitro fertilization, tumor necrosis factor (TNF), Th1:Th2 ratio, TNF inhibitors, etanercept.

 

 

Lazoryshynec V. V., Shpak I. V., Kaminskyy V. V., Boris E. N., Onyschyk L. N., Serbenuyk A. V.

Acute respiratory viral infection in pregnant women: epidemiology, aetiopathogenesis, characteristics of clinical courses, modern methods of diagnosting and treatment.

97

This article analyses authoritative international and national recommendations connecting the problem of acute respiratory viral infection in pregnant women. Considered aspects of epidemiology, clinical courses, modern methods of diagnosting and treatment of acute respiratory infections in pregnant women, including pandemic influenza.

Key words: acute respiratory viral infection, influenza A virus subtype H1N1, pregnancy, premature labor, antenatal fetal death, maternal mortality.

 

 

Golyanovskyy O. V.

Prognosis of the massive obstetric hemorrhage.

102

Clinical risk factors on obstetric hemorrhage during pregnancy, delivery and postpartum were analyzed. Determined 8 main valuable prognostic risk factors on massive obstetric hemorrhage. Estimated coefficient of clinical risk on massive obstetric hemorrhage. Two methods of the surgical hemostasis in cases of the massive postpartum hemorrhage were compared. Effectiveness the two methods of surgical hemostasis were confirmed. Practical mathematic prognostic model on massive obstetric hemorrhage was developed.

Key words: massive obstetric hemorrhage, risk factors, prognostication, mathematical modeling.

 

 

Reznichenko G. I., Reznichenko Yu. G., Bessarabov Yu. M., Makienko T. S., Reznichenko N. Yu., Plotnykova V. M., Potebnya V. Yu.

The Use of Essentiale® forte N, Essentiale® N in Treatment of Pregnant Women with Placental Insufficiency and Preeclampsia.

105

The phospholipids metabolism in pregnant women with placental insufficiency and preeclampsia has been studied. It has been fixed, that pregnant women with placental insufficiency and preeclampsia had the violated phospholipids metabolism. The use of preparation Essentiale® forte N, Essentiale® N permits to normalize the phospholipids metabolism, to decrease the frequency of complications during deliveries and the newbornsmorbidity.

Key words: placental insufficiency, preeclampsia, treatment, Essentiale® forte N, Essentiale® N.

 

 

Серов В. Н., Тютюнник В. Л., Михайлова О. И.

Современные представления о лечении плацентарной недостаточности.

109

 

 

Kravets O. M.

Placenta and placental structures in obstetric practice.

113

The placenta is an important fetal circulation organ which provides functional systems of substances between mother and fetus. Adequate functioning of placenta provides adequate fetal development. Cases mentioned in our practice and characterized by difference in the structure and kind of placenta have ended in trouble-free birth of healthy fetuses, and these cases should not be qualified as a placental inefficiency.

Key words: placenta, placental structure anomalies.

 

 

Grishchenko O. V., Lakhno I. V., Stupak I. I.

Correction possibilities of hypohalactia inpreeclamptic ladies after cesarean delievery.

116

It was performed the investigation of 92 postpartum women, 62 from them had cesarean delievery in connection with severe preeclampsia. The infringements of metabolic homeostasis and reduction of the bioelemental maintenance in case of traditional postoperative period establishment were determined. The application of Tivortin before operation and a nutritious medication Berlamin modular usage for the early enteral feeding had promoted to normalisation of metabolic processes and function of a lactation in patients after cesarean section.

Key words: preeclampsia, abdominal delievery, metabolic homeostasis, bioelements, hypohalactia, Tivortin, enteral feeding.

 

 

Kolomiyceva A. G., Bobyk Y. Y.

The functional state of thyroid gland during pregnancy under the condition of natural iodine deficiency.

119

We investigated the functional state of the thyroid gland during pregnancy in three biochemical regions of Transcarpathian region, the endemic for iodine deficiency in the environment. We have found that with increasing of the gestational age the concentration of total-triiodthyronine and free thyroxin reliably decreases and is accompanied by increasing of thyrotrophic hormone. The concentration of T3 and thyrotrophic hormone among pregnant women from the highland and foot-hill parts of the region during the corresponding trimesters of the pregnancy was higher than among the healthy pregnant women, though the concentration of the T4 was lower that can affirm the intensification of deiodinising processes of T4 in the peripherial tissues and the increased syntheses of T3 by the thyroid gland

Key words: pregnancy, hormones of thyroid gland, iodine deficiency.

 

 

Petrenko I. G., Bogomazova V. I., Kuchto A. P., Agababov R. M., Gulkov Y. K.

Mesenchymoma and pregnancy.

122

Description of rare tumour (mesenchymoma) of retroperitoneum is given in the article. Pathology is educed during an inspection in the first trimester of pregnancy. Enabled by us acquaintance of doctors of perinatal diagnostics, surgeons, pathologist with the ultrasonic, anatomic, histological features of this tumour, tactic of conduct of pregnancy, births and by a prognosis.

Key words: pregnancy, mesenchymoma, prenatal diagnostic.

 

 

Dankina I. A.

The features of the pregnancy course at patients with rheumatic heart defects secondary to the iron deficiency anemia.

125

The purpose of investigation is to study of specific features of a gestation course in women with rheumatic heart defects in combination with iron-deficient anemia. 160 pregnant women were examined in the III-rd trimester of pregnancy, 75 females had rheumatic heart defects combined with iron-deficient anemia, they made up the main group, 50 pregnant women had IDA and 35 had RHD, they constituted the groups of comparison. The RHD pregnant women in combination with IDA demonstrated a more severe course of gestation, disorder of homeostasis, more expressed decomposition of blood circulation. A high incidence of perinatal complications in women emphasizes the necessity in developing an adequate obstetric tactics.

Key words: rheumatic heart defects, iron-deficient anemia, pregnancy.

 

 

Dashkevych V. Ye., Payenok O. S.

Influence of autoimmune thyroiditis during pregnancy in the conditions of natural iodine deficiency.

127

Under a supervision there were 159 expectant mothers which constantly live in the conditions of natural iodine deficiency: 111 with autoimmune thyroiditis (АТ) and 48 without thyroid pathology. It is set that in 31,5±44% of patients with АТ the initial stage of thyroid hypofunction is diagnosed in the first trimester of pregnancy. Pregnancy and births in women with АТ is more frequent complicated by the threat of breaking, placenta insufficiency, premature outpouring of waters and hypoxia of fruit, what for women without thyroid pathology. On a background the reception of thyroxine the patients with АТ during pregnancy do not have the violations of the thyroid functional state.

Кey words: thyroid, autoimmune thyroiditis, pregnancy.

 

 

Podolsky V. V., Tsipkun A. G., Maruhno V. V., Nikishina V. V.

Effect of some anesthetics on tone and contractile function of uterus.

131

The article presents an experimental data about effect of anesthetics on tone and contractile function of uterus in white Wistar rats. The contractile ability of uterus of pregnant rat female has been demonstrated in experiment upon influence of narcotic analgesics and local anesthetics. Data obtained can be useful for decision about necessary to use anesthetics during delivery.

Key words: anesthetics, analgesics, uterus, experimental data.

 

 

Tovstanovskaya V. A., Vorobey-Vykhovskaya V. N.

Ethiology, pathogenesis and the treatment of vulvovaginal candidiasis.

135

In the article the aspects of ethiology, pathogenesis and the treatment of vulvovaginal candidiasis is represented. The main ways of the treatment of this disease are pointed out. It is proved the importance of the etiotropic treatment.

Key words: vulvovaginal candidiasis, etiotropic treatment, backset.

 

 

Borys E. N., Gak I. A., Shalko M. N., Tkachuk R. R.

Modern approaches to treatment of inflammatory urogenital diseases caused by intracellular agents.

140

Some recent literature data and results of our own observations and research for effective methods of intracellular urogenital infection treatment are presented. The importance of specific interferon-containing preparations, in particular Genferon®, in treatment of infection caused by intracellular agents, in prevention of complications and relapses is underlined.

Key words: genital herpes, interferon, Genferon®, prevention of relapses.

 

 

Gopchuk Ye. N.

Premenstrual syndrome – main ethiopathogenetic aspects and modern therapy by TazalokТМphytopreparation.

145

In the article the review of modern concept of etiologic theories of PMS development and the main ethiopathogenetic ways of its treatment, including the use of modern phytotherary preparation TazalokТМ is represented.

Key words: premenstrual syndrome, treatment, TazalokТМ.

 

 

Borysyuk O. Ju., Kornatska A. A.

Clinical and microbiological efficiency of complex application of preparations of Hemomicyn® and Livarol® for treatment of women with chronic inflammatory diseases of genitals caused by mixed chlamydia trachomatis and ureaplasma urealyticum infections and recurrent vaginitis caused by candida albicans.

151

Conducted clinical-laboratory research of efficiency of complex application of makrolyd antibiotic of Hemomicyn® and local antifungal preparation of Livarol® in treatment 50 women of fertile with chronic inflammatory diseases of genitals caused by mixed chlamydia trachomatis and ureaplasma urealyticum infections and recurrent vaginitis caused by candida albicans and statistical analysis of results more than 25 thousands individual registrations cards of women which took part in the research with the indicated design. Exposed, that complex application of the indicated preparations testifies to high efficiency this kind of treatment, that allows to recommend their complex application to the widest introduction in practice.

Key words: with chronic inflammatory diseases of genitals, chlamydia trachomatis, ureaplasma urealyticum, recurrent vaginitis caused by candida albicans, makrolyd antibiotic of Hemomicyn®, vaginal supositorium Livarol®.

 

 

Tovstanovska V. О, Avramenko S. О, Kushch V. M., Vorobey-Vyhivska V. M.

Experience with vaginal suppositories Erotex while taking combined oral contraceptives.

158

The title deals with the problems of family planning. The authors accent attention on the important role of the reproductive health in female fertility, distinguish the place of contraception in conserving of the sexual system’s health. The results of effectiveness of Erotex in prevention of pregnancy, when the course of oral contraception is disorder, are presented. The effectiveness of Erotex in protecting in front of sexual transmitted disease is discussed. The convenient of using of Erotex is explored.

Key words: Erotex, СОС, reproductive system.

 

 

Vdovychenko Yu. P., Gopchuk E. N.

Effectiveness and safety of Livial in the context of evincible medicine.

162

International experts acknowledged the necessity of clever application of preparations, which substantially improve quality of life of women in menopause. Enormous amount of large-scale researches, sent to the study of problems of menopause and searches of effective methods of maintenance of health and improvement of quality of life of women during the menopause were conducted at last decades in the countries of near and distant foreignness. Results of researches, sacred to efficiency and safety of Livial, commented in the article specify on that, timely and protracted his rational application presents serious potential for upgrading of life of considerable part of woman population of Ukraine.

Key words: Livial, treatment, menopause, climacteric syndrome.

 

 

Подольський В. В., Касаткіна Т. О., Лісяна Т. О.

Мікробіоценоз урогенітальних органів та корекція його порушень у жінок фертильного віку з наркотичною залежністю.

166

Проведені клініко-епідеміологічні дослідження дали змогу зробити аналіз стану репродуктивного здоров’я та мікробіоцінозу урогенітальних органів у популяції жінок фертильного віку з наркотичною залежністю, що дозволило розробити систему заходів для корекції порушень репродуктивного здоров’я в цього контингенту.

Ключові слова: клініко-епідеміологічні дослідження, репродуктивне здоров’я, порушення мікробіоценозу, наркотична залежність.

 

 

Тучкина И. А., Зобина Л. Ю., Лесовая М. А., Тучкина М. Ю.

Патология пубертата и реализация репродуктивного потенциала женского организма: клинико-терапевтические параллели.

175

 

 

Podolskyi V. V., Shulzhenko T. M.

Some clinical and morphological aspects of human papilloma virus infection.

180

On the background of increased genital malignant lesions in young women studying aetiology, pathologrnesis and pathology of cervix are very actuality. Serining cytology test of cervix and detection of human papillomavirus tyre are one of methods of prophylactic neoplasia cervix. Information is resulted about possibility of the use of Isoprinosin in complex treatment of diseases of neck of uterus, caused human papillomavirus infection.

Key word: cervicalis neoplasia, factors risk, human papillomavirus infection, cytological test, Isoprinosin, treatment.

 

 

Benyuk V. O., Nikoniuk T. R., Usevich I. A., Sherba O. A.

Conditions of gumoral and cellular Immunity in the treatment chronical relapsed candida – herpetic vulvovaginitis.

185

Having an aim to study a state of cellular immunity we have examined 238 women of neproductive age, among them 138 are associated with candida – herpetic infection of genitals. According to the result of our investigations on women’s immunity with candida – herpes mixt – infection we discovered the decrease of endogenic interferon producing, the decrease of lumphocits number (CD3+ and CD4+ cells), which lead to the violation of immunity – regulatory index and cytocsical potential of blood lumphocits. Present pecular; ties of lisocum degree and degree of immunoglobylinum in blood of cervical mucus gives a basis to speak about serious changes of humoral immunity when having candida – herpetic mixt – infection which is a foundation for searching of new pathogenetic methods of curing with taking into account of facts of patho – physiological pecularities. On the basis finding high efficiency of the Itracon and tiloron use in medical treatment of candida – herpetic vulvovaginits.

Key words: сandida – herpetic vulvovaginits, humoral immunity, cellular imunity.

 

 

Pisareva S. P., Rudakova N. V., Tolkach Т. S.

Immune homeostasis among pregnant women with prematurity of pregnancy with cytomegaloviral and herpetic infection.

191

The influence of specific serotherapy («Імуноглобулін антицитомегаловірусний людини рідкий» та «Імуноглобулін проти вірусу герпесу звичайного 2-го типу») have been studied among 45 pregnant women with miscarriage at the presence of cytomegalovirus and herpes simplex virus of 2 type. Contents of lymphocytic subpopulations, IgG, IgA, IgM in blood, as well as concentration of C3 component of complement and lysozime in cervical mucus were studied. As a result of provided treatment with specific immunoglobulins, condition of lymphocytic subpopulations in blood and concentration sIgA and lysozime in cervical mucus was normalized among pregnant women with combined herpetic infection.

Kay words: pregnancy, immunity, prematurity, CMV, HSV-2, serotherapy.

 

 

Тапильская Н. И.

Применение Вильпрафена у пациенток с бесплодием и привычным невынашиванием беременности на этапе прегравидарной подготовки.

194

 

 

Bulyk L., Davydova Iu., Sidorova I., Voloshina T.

Efficacy of pregravide preparation in women with diffuse nontoxic goiter.

198

The publication covers the crucial issues of prophylactics of thyroid disorders and their negative influence on reproductive female function, pregnancy period and perinatal outcome in women with diffuse nontoxic goiter. The suggested original complex of pregravide preparation proved to be effective in observed group of women on the stage of pre-conception and during pregnancy.

Key words: diffuse nontoxic goiter, preconceptional counseling, iodine deficiency, pregnancy.

 

 

Benyuk V. A., Shevchenko S. B., Likholay P. A.

Functional monitoring in prognostication of the perinatal complication at gemelli.

202

The outcome is the frequency of obstetric and perinatal complications depends on the type of placenta. As a result we came out with some prognostic criterias on ultrasonografic basis for delivery plans in multifetus pregnancy.

Key words: gemelli, monosygotal, perinatal complications.

 

 

Usevich I. A., Benyuk V. A., Sadek Anaam Khadi

Morfokardiogemodinamika of the fetal at pregnant with premature.

205

Research of morfokardiogemodinamik fetal is conducted at pregnant with the threat of premature in different gestations periods. The got results of research allow to develop the methods of prognostication, prophylaxis and influence on the adaptation-homeostasis mechanisms of intrauterine fetal and new-born.

Key words: premature, fet placental insufficiency of, morfokardiogemodinamika.

 

 

Bogomazova V. I., Chernyaeva Y. V., Stepanova I. A., Lepikhov P. A., Turpakova G. N., Abdullin R. F.

Тeratomas (prenatal diagnosis experience).

207

Cases description of prenatal diagnostics of teratomas of fetus is given: sacrococcygeal and cervical localization. The ultrasonic features of tumours, information of histological researches, inspection in an early neonatal period, stages of surgical treatment and prognosis, are shown.

Key words: prenatal diagnosis, sacrococcygeal teratoma, cervical teratoma.