• Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

Романенко Т. Г., Чайка О. И.

Современная диагностика эндокринной патологии при беременности (клиническая лекция).




Campbell Stuart

«Мы более не можем не делать ничего для предотвращения преждевременных родов».




Tereshchenko A. V., Hoida N. G., Moiseenko R. A., Dudina A. A.

Operating results perinatal centers in Ukraine.


By the beginning of 2014 in Ukraine created and operates 12 perinatal centers level III (PC III level), it was preceded by considerable work on the preparation and implementation of the regulatory framework, training, introduction of new health technologies and organizational security regionalization of care for pregnant women, women and childbirth. The article summarizes the first results of the monitoring activities of the HRC in the country who have shown the effectiveness of the technologies used. So, in 2013, the HRC Level III was born 57% of pregnant women with congenital heart disease, 34,3% with diabetes, 33,3% with severe pre-eclampsia and eclampsia in Ukraine as a whole. During the year 59% of infants born weighing 500,0-999,0 g and 50.5% – weighing 1000,0-1499 g, 27% of infants with congenital malformations; twice dropped from 6% to 2,9% share of newborns who are transferred to children's hospitals for follow-up care, while the share of reasonably fruit and maternal deaths that occur at HRC III level decreases such I and II levels of care.

Key words: perinatal centers, regionalization of perinatal care, newborn, infant mortality, results of operations.



Roshchina G. F.

Laws of Women's Health.


The possibility and effectiveness of the drug in the treatment of vulvovaginitis Vagisan vaginal dysbiosis and women. Vagisan increases the number of lactic acid bacteria, an acidic environment during recovery and normalization of the vaginal microflora.

Key words: vulvovaginitis, vaginal dysbiosis, Vagisan.



Pines A., Sturdee D. W., MacLennan A. H.

Quality of life and the role of menopausal hormone therapy.


The quality of life of countless menopausal women world-wide has been signifi cantly diminished following the sensationalist reporting of the Women’s Health Initiative (WHI) and the resulting 50% or more decline in the use of hormone replacement therapy (HRT) over the subsequent 10 years. Quality of life is diffi cult to measure as there are so many contributing factors and a large number of different instruments, some of which assess general health and only a few which specifi cally include symptoms related to menopause. HRT improves quality of life of symptomatic menopausal women and some studies of the effects of HRT provide reliable evidence on quality of life other than reduction in vasomotor symptoms. Until there is a better understanding of the minimal risks of HRT for the majority of women, too many will continue to suffer a reduced quality of life unnecessarily.

Key words: quality of life, Women’s health initiative, stopping HRT.



Veropotvelyan N. P., Veropotvelyan P. N., Guzhevskaya I. V.

Alternative approaches to follow-up a missed abortion: controversions of surgical and conservative methods.


Analysis of the results concerning publications dedicated to a missed abortion (MA) is given. Some advantages of the alternative method usage – a medicament abortion in early pregnancy terms in the first trimester – over a traditional surgical treatment are discussed in the article. A mechanical enlargement of cervical duct and scraping of uterine cavity walls are the standards of providing medical aid in case of MA. Additional confirmation of structurally and functionally defective endometrium, risk of potential complications of surgical removal of a non-developing fetal ovum as well as risk associated with anaesthesia create a treat to reproductive health of a woman. Therefore, issues concerning merciful evacuation of uterine cavity in case of MA are extremely topical. Wide popularization of the method requires performance of additional multicentered studies in this direction.

Key words: a missed abortion, mifepristone, misoprostol.



Rybalka A. N., Sulima A. N., Mitrofanova O. A.

Experience with abdominal sacrocolpopexy as a prevention method of posthysterectomy vaginal vault prolapse.


A new method of abdominal sacrocolpopexy was proposed at patients with high risk of posthysterectomy vaginal vault prolapse. High fixing of a vaginal cupule to sacro-uterine ligaments with reconstruction of fascia is a preventive measure of posthysterectomy vaginal vault prolapse.

Key words: abdominal sacrocolpopexy, posthysterectomy vaginal vault prolapse prevention.



Shlapak I. P., Zhezhera A. A., Halushko A. A.

First experience of new domestic combined colloid and hypertonic solutions in intensive therapy of hemorrhagic shock.


The article presents study of domestic combined solution Hekoton conducted at the departments of anesthesiology and intensive care of the Kiev Center of Maternal and Child Health and Kyiv Regional Clinical Hospital. Our experience in the use of this preparation were 21 patients with acute blood loss, traumatic shock. We studied the blood pressure, the heart rate, urine output, the state of the microcirculation. The results of our study revealed efficacy of Hekotonu. The advantage of this preparation also include balanced pharmaco-economic component. This allows us to recommend it to widespread use as a «starter» drug in treatment of hypovolemia and shock of varying degrees, which allows in short time achieve the desired therapeutic effect and reduce the risk of complications.

Key words: volemic effect, hypovolemic shock, blood pressure, hekoton, combined solution.



Herman A. Y. Golyanovsky O. V., Rubinstein A. M.

Vaginal birth in women with a uterine scarclinical experience.


During the study we have identified the selection criteria, the main indications and contraindications for vaginal birth in women with a uterine scar. According to the obtained results, it follows that with proper identification and compliance of safety criteria about 20% of pregnant women with a uterine scar can successfully deliver.

Key words: vaginal birth after cesarean, cesarean section, uterine rupture.



Mamedova S. Sh., Aliyeva E. M., Mamedova A. Q., Bayramova Q. М., Bayramova E. V.

The echoqraphic features of existing tubal pregnancy.


The goal of investigation is determination of echographic indicators of uterus endometrium of pregnant with developing tubal pregnancy. There was examinet 34 woman with wxisting tubal pregnancy. The clinical examination included ultrasound investigation of leng, width, antero-posterior diametr of the uterus, thеakness of endometrium, sires of ovum with vaginal transduser. It was revealed that there is no difference between the echographic indicators of uterine endometrium at developing tubal pregnancy and normal uterus without pregnancy. The probability of ovum visualization increases at delayed menstruation more than 14 days. The visualization of embryo with yolk sac inside in the tubal area is positive at the late periods of missed menstruation.

Key words: developing tubal pregnancy, ovum, embryo, yolk sac, echography.



Zabolotnov V. A., Ribalka A. N., Miklin O. P., Kosolapova N. V., Suprunenko D. V.

Atypical uterine leiomyoma.


The paper presents data on atypical uterine leiomyoma, classification, difficulties of surgical treatment. The factors that cause massive bleeding when achieving hemostasis and surgical treatment itself may pose a significant challenge are determined. A clinical case of atypical uterine leiomyoma is analyzed.

Key words: аtypical uterine leiomyoma.



Petrova G. A., Davydova Iu. V.

Cytokine balance peculiarities in pregnant women operated for the thyroid gland during pregnancy.


The peculiarities of cytokine metabolism in women operated on the thyroid gland during pregnancy before and after surgery are represented in this publication. It was stated that the cytokine dysbalance is more meaningful in pregnant with diffuse toxic goiter. The surgery with the consequent hormone replacement therapy had the positive influence on the thyroid hormones metabolism. The hormone replacement therapy by micronized progesterone in women with signs of threatened abortion led to the improvement of pregnancy cytokine paradigm.

Key words: thyroid gland, cytokine, pregnancy, thyroid surgery.



Benevskij A. V.

Preventive maintenance incompetence and irondefecyte anemias at pregnant women with thyreotoxicoses.


Results of the spent clinical and additional methods of researches confirm efficiency of the algorithm improved by us medical – preventive actions that consists in frequency decrease obstetrical and perinatal complications at pregnant women with thyreotoxicoses. It grants to us is right to recommend it for wide use in practical public health services.

Key words: incompetence, irondefecyte anaemia, thyreotoxicoses.



Padalko А. A., Zhezher A. A., Mehedko V. V., Romaniuk O. U.

Features of the cardio-pulmonary resuscitation in pregnant.


In article is described: the causes of cardiac arrest in pregnancy; physiological changes during pregnancy, which affect the effectiveness of resuscitation; features resuscitation in pregnancy.

Key words: cardiopulmonary resuscitation, pregnancy.



Prilutsky A. I., Prilutskaya A. B., Kush V. N.

Features of treatment of varicose disease and its complications in pregnancy.


The study showed high clinical efficacy of Lioton® 1000 in pregnant women with varicose disease, its good tolerability and absense of topical and systemic adverse action. Results which were founded confirm the priority of Lioton® 1000 using in the treatment of varicose disease in pregnant women.

Key words: varicose veins , pregnancy, drug Lioton® 1000.



Khudiyeva G. Z., Aliyeva E. M., Mamedova A. G., Bayramova G. M., Qarasova M. A.

The features of fetoplasentar blood circulation of pregnant with inflamatory desease of kidneys and urinary tract.


The goal of our investigation is estimating of condition of utero-placental and fetoplacental blood suply of pregnant with inflamatory deseases of kidneys and urinary tract. Using dopplerography were examined the blood circulation in right and left uterine arteries, umblical artery, middle cerebral artery of the fetus, vessels resistancy index, pulsatily index and average speed of blood circulation in arteries. It was achieved that the early signs of fetoplacental insufficiency increasing of resistancy index and decreasing of average speed of blood circulation in uterine and umblical arterias.

Key words: dopplerography, vessels resistancy index, pulsatily index, fetoplacental insufficiency.



Poluyanova O.

Effect of pregravid preparation on the course vaginal birth among women with uterine scar.


This article describes the perspective of reducing the frequency of repeated cesarean section on account of vaginal birth among women with one scar on a uterus with the help of pregravid preparation. To make a complex of pregravid preparation that includes immunostimulating, absorbable and vitamin therapy in combine with hormonal correction, antioxidants prescription as a preventive actions, psycho prophylaxis, diagnostic hysteroscopy, the course of physiotherapeutic procedures – amplipulse therapy, stimulates the reducing of the pregnancy complications, increases the probability of the successful vaginal birth attempt.

Key words: scar on the uterus, cesarean section, pregravid training, VBAC.



Makarenko M. V., Govseev D. A., Protas R. V., Krushinskaya E. J.

Effectiveness of the implementation of standards of pregnancy and childbirth in women diabetes.


The article has the results of pregnancy and childbirth which women with diabetes melitus who were treated at the extragenital department of kiev city maternity hospital number 5. It is possible to obtain significant improvements in perinatal indicators and thus significantly reduce the number of complications of diabetes after the introduction to the work of separation standards of examination and treatment of pregnant women with diabetes mellitus.

Key words: diabetes mellitus, diabetic fetopathy, caesarean section, heavy preeclampsia.



Skripchenko N. Y., Tihaja V. G.

Treatment of miscarriage in pregnant women, using natural micronized progesterone.


The results of treatment of threatened abortion in 30 patients with uterine leiomyoma natural micronized progesterone Luteinum. The efficiency of this method of treatment evidenced by the rapid elimination of clinical symptoms of threatened abortion, acceleration regression ultrasound markers of threatened abortion, reducing the number of complications of pregnancy in these women and reducing the time of their stay in hospital.

Key words: threatened miscarriage, uterine leiomyoma, natural micronized progesterone.



Lutsenko N. S., Al Suliman H. M., Potebnya V. Yu., Mazur O. D., Ostrovskiy K. V., Sokolovskaya I. S.

Comparative analysis of the uterine involution of primiparous and multiparous women within 48 hours after labor.


Uterine involution is the most appropriate predictor of current postpartum period. The article presents results of the comparative analysis of uterine contractile activity during the first two days after physiological labor of primiparous and multiparous women. It’s determined that physiological course of postpartum period is characterized by simultaneous decrease of almost all studied sizes of the uterus during the first 48 hours after labor. The only exception is the length of the cervix of the uterus, that increases gradually. The biggest changes occur within first 12 hours after labor, that defines exactly this term for screening of subinvolution and pathology of involutive function of the uterus, both for primiparous and multiparous.

Key words: postpartum period, uterine involution, ultrasound.



Dzhelomanova S. A., Dankina I. A., Dzhelomanova E. S.

Role of antiphospholipid antibodies in preeclampsia.


The article presents data on the role of antiphospholipid antibodies in the pathogenesis of preeclampsia. questions of determining the diagnostic value of different types of antiphospholipid antibodies.

Key words: preeclampsia, antiphospholipid antibodies, and pregnancy.



Ventskivskyy B., Vitrenko D.

Peculiarities postoperative period in women depending on the method abdominal delivery.


This paper presents data on the characteristics of the course of the postoperative period, depending on the method of abdominal rodorozrishennya, urhentnosti category, presence of comorbidity. 1. For hemorrhage: the least blood loss during elective surgery in Derfleru method and by the method of Stark. 2. For the duration of the operation: the method of Stark regardless of category urhentnosti lowest duration of surgery (41–44 min). 3. For the duration of maternity hospital in the postoperative period: lowest length of stay during routine operations, regardless of the method of cesarean section (4,1±0,03 days). 4. For the percentage of complications in the mother had no complications during the operation of Derfleru, but the result is little information as held 26 (8,7%) operations given by the total number of transactions. 5. In the state of the newborn: during the operation routinely regardless of the method of cesarean section one of the children is not transferred to the neonatal intensive care unit. In conducting clinical and laboratory examination in women three months after operative delivery anemia often manifested in women who reoperated (35,8%) in urgent procedure (26,3%), the method Derflera (46,1%). Pathological cytological picture usually accompanied by clinical signs of inflammation of the vagina. The second degree of purity of vaginal contents were diagnosed in 94 women (31,4%), and the third – in 34 women (11,3%). These are mainly patients who are operated on again in urgent order, regardless of the method of cesarean section.

Key words: rodorozrishennyе, caesarean section, category urhentnosti, laparotomy, the postoperative period.



Zhukovskaya I. G., Semenova M. V.

Evaluation of the efficiency of rehabilitation measures using pharmatex (benzalkonium chloride) in women with diseases of the cervix uteri after destructive treatments.


Sixty-five radiowave-treated patients aged 20 to 32 years with diseases of the cervix uteri were examined. In the postoperative period, 34 patients from the study group used Pharmatex vaginal cream once daily for 20 days; 31 women (a comparison group) received a combined (dexpanthenol 0.1 g and chlorhexidine bigluconate 0.016 g) agent intravaginally for 10 days. Clinical, laboratory, instrumental, and morphological studies were conducted in all the women. There was evidence for the well tolerability of benzalkonium chloride (Pharmatex cream), accelerated epithelization processes in the cervix uteri, and a significant reduction of complications (lymphorrhea, hemorrhage) in the postoperative period, which may recommend Pharmatex as a cream for wide clinical application.

Key words: abnormalities of the cervix uteri, regeneration, destructive treatment, Pharmatex.



Trohimovych O. V.

The features of cytokine status of women with early pregnancy loss.


The cytokine status is studied in women with threatened abortion and miscarriage in terms of 4–11 weeks of pregnancy. Increase of production of proinflammatory cytokines IL-1β, IL-6 and decrease of concentrations of anti;inflammatory cytokine IL-4, IL-10 indicating inappropriate fetoprotektiv trigger mechanisms. Studies of cytokine status is important for the evaluation of the immune response, forecasting the development of gestational complications and pregnancy outcomes for mother and fetus: changes in the balance of pro- and anti-inflammatory mediators at the local and systemic level are the criteria of threatened abortion.

Key words: cytokines, threatened abortion, miscarriag, early pregnancy.



Kira Е. F., Artymuk N. V., Gajtukieva R. A., Muslimova S. Z.

Biocenosis and functional activity of an epithelium of a vagina at local treatment of an aerobic vaginitis polygynax and tergynan. Multicenter randomised controllable comparative research.


The given research is devoted comparative studying of efficiency and safety of preparations polygynax and tergynan in treatment of an aerobic vaginitis (АV). Estimated clinical (degree of reduction of objective and subjective symptoms) and microbiological efficiency of therapy by the specified medical products at the patients suffering АV. Besides, studied rate of disappearance of an inflammation of a vagina, functional activity of an epithelium of a vagina, influence of preparations on a condition of a normal microflora of a vagina upon termination of therapy and spent an estimation of quality of a life before therapy АV. For the decision of tasks in view investigation and treatment of 60 women of genesial age (18–45 years) with diagnosis АV is carried. Research is executed according to the international specifications and rules GCP. As a result of the carried out research it has been established that polygynax and tergynan are comparably effective and safe at treatment АV. Polygynax and tergynan are equally effective the relation of is conditional-pathogenic microorganisms – originators AV. Polygynax is a preparation of a choice for treatment АV. Tergynan it can be applied as a complex preparation to treatment bacterial vaginosis and АV. Polygynax does not render immunosuppressive action on a vagina epithelium thanks to what restoration of functional activity of an epithelium after treatment polygynax occurs faster, than after treatment tergynan. After treatment quality of a life of patients as a whole has improved in each of studied groups.

Key words: aerobic vaginitis; polygynax; tergynan; treatment; multicenter randomised controllable research.



Dolenko O. V.

Clinical-ultrasound evaluation and treatment of ovarian dysfunction in women of reproductive age.


The data the clinical efficacy of phytotherapy phytoneering drug in some forms of ovarian dysfunction in women of reproductive age on the basis of clinical, hormonal and ultrasound investigations.

Key words: ovarian dysfunction, ultrasound investigations, phytotherapy, Cyclodynon®, clinical efficacy, women of reproductive age.



Veropotvelyan N. P., Veropotvelyan P. N., Guzhevskaya I. V., Tsekhmistrenko I. S.

A clinical view on pathogenesis of adenomyosis and pathogenetic therapy.


In this article we can find the data on the modern ways of treating patients with adenomyosis . A series of publications and our own studies show that a rational pathogenetic treatment in patients with inner endometriosis enable to increase clinical effectiveness of the treatment mentioned above. This treatment is, first of all, directed to the realization of organ saving tactics and reconstruction of reproductive function in women patients. However, hormonal methods of therapy are not the only way of treating patients. Working on new schemes and methods of therapy can increase the positive chances of patients’ treatment with inactive adenomyosis, and can stop it’s turning into active form.

Key words: hysteroscopy, laparoscopy, adenomyosis, Vizan, lavomax.



Gladchuk I. Z., Semenyuta O. M., Onyshchenko Y. V.

Analysis effectiveness of the methods of infertility treatment amongst females with PCOS and hyperprolactinemia: retrospective study.


The study was aimed to assess the clinical effect of the various methods of infertility treatment amongst females with PCOS and hyperprolactinemia. There was demonstrated that the multifactorial infertility i.e. combination of hyperprolactinemia and PCOS occurs amongst every third female with fertility disorders. The differentiated use of the conservative medication treatment allows restore fertile function in 33.8%. There was stated that the surgical induction of ovulation by the laparoscopic partial ovarian destruction allows increasing the effectiveness of the complex treatment of infertility up to 40%. There is discussed the expedience of the development of the algorithm of the differentiated use of the methods of infertility treatment amongst females with PCOS and hyperprolactinemia.

Key words: reproductive health, infertility, polycystic ovarian syndrome, hyperprolactinemia.



Reznichenko G. I., Potebnya V. Yu., Plotnikova V. M.

The use of combination of ciprofloxacin and tinidazole for prevention of purulent-inflammatory complications after minor gynecologic surgery.


Despite permanent improvement of technical and pharmacological aspects of ensuring the efficiency and safety of minor surgical interventions in case of gynecological pathology, the frequency of purulent-inflammatory complications can substantially increase. There is a wide range of antimicrobial drugs for prevention and treatment of purulent – inflammatory diseases in women in the postoperative period after minor gynecologic operations. Antimicrobial agent should have antianaerobe efficiency, cause rapid bactericidal action, have high antimicrobial activity, be stable to β-lactamase, easy to use and dosage, have minimal toxicity and maximum safety. Such requirements for minor gynecologic surgeries correspond to combine of ciprofloxacin and tinidazole. The range of action of preparation covers gram-negative bacteria: Escherichia coli, Klebsiella, Salmonella, Рroteus, Shigella, Enterobacter cloacae, Morganella morganii, Providencia, Citrobacter, Serratia marcescens, Campylobacter jejuni, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Haemophilus influenzae, Haemophilus parainfluenzae, Bacillus anthracis., Moraxella catarrhalis. Сombination of ciprofloxacin and tinidazole is effective against gram-positive bacteria: Staphylococcus, Streptococcus, including Streptococcus рneumoniae, Listeria monocytogenes, Corynebacterium spp. Tinidazole causes antiprotozoal action against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia; bactericidal activity against anaerobic bacteria – Bacteroides spp., including Bacteroides fragilis, Bacteroides melaninogenicus, Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp. The advantages of combination of ciprofloxacin and tinidazole use after minor gynecologic surgical interventions for prevention of purulent-inflammatory complications are its high effectiveness against all major pathogens, maximum safety and tolerability, the high stable concentration in the possible areas of infection and economic feasibility.

Key words: minor gynecologic surgery, prevention of complications, combination of ciprofloxacin and tinidazole.



Dovgan A. A.

Features of the clinical characteristic of women with reproductive losses in anamnesis.


Results of the spent researches testify that patients with reproductive losses in anamnesis differed from women of group of comparison under following characteristics: to number of sorts, frequency of smoking, an index of somatic health, age of a sexual debut and a condition of reproductive health. It dictates necessity of the further studying of the given scientific problem for working out of advanced algorithm of diagnostic and treatment;and;prophylactic actions.

Key words: reproductive losses, the clinical characteristic.



Orazov M. R.

Problematic aspects of cervical pathology in women with pelvic pain syndrome of adenomyosis.


The article is devoted to one of the most topical problems of gynecology – the problem of pelvic pain caused by adenomyosis and cervical pathology. The specific frequency of adenomyosis in the structure of genital endometriosis reaches 70–90%. The interest to the problem lies in the fact that the simultaneous synchronous involvement in the pathologic process muscle and an endometrial tissue and connective tissue components extracellulyar matrix, can’t touch the epithelial tissue of the cervix. The study involved 24 women of reproductive age with pain syndrome of adenomyosis as a core group and a comparison group consisted of 10 women of similar age without painful disease. The results of the study showed that in patients with pain syndrome of adenomyosis in the reproductive age are quite common related pathological conditions in the cervical epithelium with the prevalence of the virus associated intraepithelial lesions.

Key words: adenomyosis, pelvic pain, cervical pathology, intraepithelial lesions.



Podolskyi V.l., Lisyana Т. О., Ponomar’ova І. G.

Condition microecology genital tract in women with reproductive health changes in violation of vegetative homeostasis.


The results of study of microbial spectrum of urogenital organs among women with changes in reproductive health which accompanied by violations of autonomic homeostasis are showed in the article. Obtained data shows changes in microecology of the genital tract and their connection with autonomic homeostasis disorders among fertile aged women with violations of reproductive health, and need in further control and observation.

Key words: violations of reproductive health, autonomic homeostasis disorders, ANS dysfunction, ANS dysfunction syndrome, microbial spectrum of urogenital organs.



Reshetnyak O. V.

Compex approach to the diagnostic women with chronic fungous genitourinacy candidiasis.


The results of clinical and microbiological research of women suffering by recidiving chronicle urogenital pathology of mycotic origin are presented. Possibility of origin of relapse is rotined due to reinfection women with the untreated oral cavity.

Key words: candidosis, oral cavity, chronical urogenital pathology.



Boris E. N., Onischik L. N., Sotnichenko A. V.

Optimization of the treatment of chronic hyperandrogenic anovulation in patients with endocrine infertility on the background of PCOS.


The article presents the results of a clinical study of therapeutic efficacy and safety of the drug containing flutamide, which was attended by 86 patients with polycystic ovary syndrome (PCOS) with menstrual irregularities and hirsutism. Investigations were carried out in two stages: clinical and laboratory examination (during the menstrual cycle) and treatment (3–6–9 months). Patients who met the inclusion criteria, received anti;androgenic drug flutamide containing a daily dose of 125 mg three times a day for 6 months. The study confirmed that the use of flutamide for the treatment polycystic ovary syndrome that cycle is accompanied by disturbances and hirsutism, contributes to more efficient recovery of reproductive potential in women.

Key words: hirsutism, polycystic ovary syndrome, menstrual disorders, chronic hyperandrogenic anovulation, the antiandrogen, flutamide.



Prilutskaya A. B., Prilutsky A. I., Dziatko Y. V.

New approaches to treatment of chronic inflammatory diseases of the pelvic organs nonspecific etiology.


Based on studies conducted have determined that treatment with natural origin Tribestan. patients with chronic pelvic inflammatory disease contributes to limit the manifestation of exudative inflammation, inactivation of inflammatory mediators, and the restoration of local iimuniteta obtaining 95.3% of the positive therapeutic effect, which makes extensive use of this drug in the treatment of chronic forms of PID.

Key words: chronic inflammatory diseases of the pelvic organs, the treatment, the drug of natural origin Tribestan.



Hourani I. F.

Impact assessment of electric welding biological tissues at a rate of postoperative complications in patients with benign tumors of the brest.


Postoperative complications were studied in 156 patients with benign tumors of the breast. 76 patients was performed traditional sectoral resection, 80 patients conducted surgery using electric welding machine EK- 300M1. A comparative analysis of postoperative complications set significant advantages of using electric welding of biological tissues over the traditional method of operation. Using electric welding biological tissue during the operation such complications as suppuration of wound, marginal necrosis, surgical erysipelas inflammation significantly decreased by 7,7–10,6%. Bleeding during surgery and postoperative hematoma not met even once. Operative time decreased by an average of 6,2±2,3 minutes.

Key words: breast, sectoral resection, complications, welding of biological tissues.



Zakharenko O. S., Dikusarow V. V.

Hormonal homeostasis in women with sterility in case of external genital edometriosis.


The paper presents the findings pertaining to hormonal homeostasis in women with sterility in case of external genital edometriosis.

Key words: genital endometriosis, sterility, reproductive function.



Vdovichenko J. P., Kuritsina S. A., Ursaki N. O.

Diagnostics and preventive maintenance of perinatal pathologies at abnormal placentation.


Results of the spent researches testify that the type of placentation and especially presence abnormal placentation influences a functional condition fetoplacental complex, and also development of perinatal pathologies. For timely diagnostics placentary dysfunction and frequency decrease perinatal it is necessary for a pathology early ehografical inspection of localisation of a placenta with the subsequent dynamic inspection of patients for an estimation of processes of migration of a placenta. The way and terms delivery women with abnormal placentation depend on localisation of a placenta, completeness of its migration and a functional condition of fetoplacental complex.

Key words: perinatal pathology, abnormal placentation, diagnostics, preventive maintenance.



Ruban J. A.

Features of current neonatal period and early adaptation of newborns from women in childbirth after auxiliary reproductive technologies.


The analysis of a condition and early adaptation of newborns from women in childbirth after auxiliary reproductive technologies has shown that perinatal outcomes in the basic group and comparison group have some distinctions which depend on expressiveness of initial pathological changes, from a variant of treatment of barreness, from indemnification extragenital pathologies, and also from tactics of conducting pregnancy, in particular from a well;founded choice of schemes of hormonal support.

Key words: auxiliary reproductive technologies, neonatal period, adaptation of newborns.



Melnyk Y. M.

Combined screening in the first and second trimester of pregnancy.


Screening of pregnant women is a complex system that includes not only conducting certain tests and examinations, but also provide a pregnant family with adequate information about the disease, which is aimed at finding the present screening test, and in case of fetus disease detection – about modern possibilities of treatment or abortion. The introduction into clinical practice of modern automated approach of calculating risk in non-invasive prenatal prevention allows to optimize and dramatically increase the effectiveness of screening. The article highlights contemporary approaches to prenatal diagnosis of chromosomal abnormalities and systemized the main key points that determine the conduct of high-quality prenatal diagnosis.

Key words: combined screening, pathology, fetus, risk of abnormalities calculation program, pregnant.



Dankyna I. A., Dgelomanova S. A., Dankyna V. V.

Estimation of efficiency of preparation of azithromycin at treatment of mixed infections for patients of reproductive age.


We are study efficiency of preparation of azithromycin at treatment of mixed infections for the patients of reproductive age. It is educed, that comfortable single application, absence of side effects and high therapeutic efficiency of preparation of azithromycin, allow recommending this antibiotic for treatment of patients with the mixed urogenital infection.

Key words: preparation of azithromycin, patients of reproductive age, mixed urogenital infections.



Taran O., Bulavenko O.

The modern aspects of combination therapy of cervical neoplasia associated with HPV infection.


Human papillomavirus (HPV) have been identified in the most cases of cervical precancerous disease and cervical carcinomas. Several factors may be associated with higher rates of surgical treatment failure, including highgrade CIN, large lesion size, satellite HPV-related lesions, involved margin, persistent of HPV infection. The purpose of our study was to evaluate the effect and toxicity of the antivirus therapy of cycloferon in the complex treatment of HPV-positive women affected CIN I and CIN II after radio-wave excision. According to analysis of our investigation we can conclude that cycloferon is safe and necessary component of the treatment of precancerous cervical pathology. Surgery with the antivirus therapy of cycloferon promotes elongation interrecurrent period, cessation of viral shedding, accelerates reparative processes in the areas of damage, saves of the architecture of the cervix and vaginal biocenosis normalizes.

Key words: HPV infection, cervical neoplasia, radio-wave excision, cycloferon.



Tovstanovska V. A., Sakharova I. O., Kruk O. Y., Kush V. N.

Evolutional features of symbiosis of neoplasty processes of induced papillomavirus infection and immune system and possibility of their suppression.


The evolutional features of symbiosis of tumours and immune system are expounded in the article. The mechanisms of immune defence are examined that take place in the organism of man at infikuvannii by the onkogennimi cultures of papillomavirus infection. The presented information is about specificity of mechanisms of slipping out of tumours from the immune system. Scientific basis of immunosupresivnikh properties of onkobilkov of papillomavirus infection is exposed.

Key words: virus papillomavirus infection of man, immune system, T-cell, onkobilki, peredrak and cancer of neck of uterus.



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