HEALTH OF WOMAN WH_№2_2011

  • Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

Клінічний протокол «Комплексна медична допомога під час небажаної вагітності».

9

 

 

Спасем детские жизни вместе!

22

 

 

Нельсон Анита Л.

Левоноргестрел-содержащая внутриматочная система: первая линия терапии при тяжелом менструальном кровотечении.

24

Хроническое тяжелое менструальное кровотечение (ТМК) – это частая гинекологическая патология, вызывающая значительные проблемы со здоровьем и отрицательно влияющая на качество жизни женщины. Хирургическое вмешательство следует ограничить груп пой женщин с патологией органов малого таза, и теми, кому не помогает медикаментозное лечение. Недавно утвержденная Управле-нием по контролю за качеством пищевых продуктов и медикаментов (FDA), США, левоноргестрел-содержащая внутриматочная система является показанным лечением тяжелого менструального кровотечения у женщин, которые желают пользоваться внутриматочными системами для контроля зачатия. Данное утверждение подчеркивает потенциал этого высококлассного метода контрацепции как первоочередного лечения тяжелого менструального кровотечения у женщин любого репродуктив-ного возраста без влияния на фертильность в будущем.

Ключевые слова: тяжелое менструальное кровотечение, левоноргестрел-содержащая внутри-маточная спираль, меноррагия.

 

 

Lello Stefano

Номегестрола ацетат: фармакология, профиль безопасности и терапевтическая эффективность.

32

 

 

Бонетти А., Морелли Л., Кампоминози Е., Ганора Е., Сфорца Ф.

Адгезия Lactobacillus plantarum P 17630 в форме капсул с жидким гелем по сравнению с таковой бацилл дедерлейна в форме таблеток к клеткам вагинального эпителия.

45

Обоснование. Для оценки in vitro способности к адгезии двух бактерий к клеткам вагинального эпи-телия (КВЭ) проведено сравнение продукта А (препарата Гинолакт), содержащего Lactobacillus plan-tarum (L. plantarum) P 17630 в форме капсул с жидким гелем, и продукта В, содержащего бациллу Додерлейна, в настоящее время отнесенную к классу L. gasseri, в форме вагинальных таблеток, которые в течение многих лет представлены на рынках Италии.

Методы. Сравнительный анализ двух представленных на рынке препаратов проведен после откры-того контролируемого исследования. Образцы КВЭ отбирали в лабораторных условиях; тесты на адгезию проводили в Институте микробиологии Католического университета Сакро Куоре в Пьяченце. Исследования проводили на интактных КВЭ, отмытых и отобранных у 20 пациентов, у которых диагностирован бактериальный вагинит и/или вагиноз. Одну капсулу или таблетку, растворенную в изотоническом растворе NaCI, смешивали с суспензией КВЭ. Адгезию молочнокислых бактерий с КВЭ вычисляли с помощью оптического микроскопа и подсчета количества колониеобразующих единиц (КОЕ) после посева на чашках Петри. Кроме того, оценивали тип адгезии.

Результаты. Способность к адгезии продукта А (препарата Гинолакт), содержащего L. plantarum P 17630, оказалась больше, чем продукта В. В культуре продукта А (Гинолакт), посеянного на чашках Петри, обнаружено 106–108 КОЕ в пробе, продукта В – 102–104 КОЕ. В основном L. plantarum

P 17630 прикреплялся к отдельным клеткам, L. gasseri при адгезии образовывал малые цепи.

Выводы. Продукт А (Гинолакт) обладает большей способностью к адгезии к КВЭ, чем продукт В. Отмечено более прочное прикрепление к КВЭ L. Plantarum P 17630. Результаты исследования позволяют предположить, что in vivo продукт А (Гинолакт) с большей вероятностью может обеспечить колонизацию, а значит, лучшую защиту среды влагалища от возбудителей инфекции.

Ключевые слова: молочнокислые бактерии, влагалище, адгезия клеток, эпителиальные клетки.

 

 

Reyes Jose Rodolfo Munoz, Reynoso Carlos Villanueva, Ramos Julio Cesar, Vazquez Jorde Menendez, Uriza Rene Bailon, Vargas Jose Antonio

Эффективность и переносимость 200 мг фентиконазола vs 400 мг миконазола при интравагинальном лечении микотического вульво-вагинита.

50

 

 

Фонсека Эдуардо Б., Селик Эбру, Парра Мауро, Синг Мандип, Николаидес Кипрос Г.

Прогестерон и риск преждевременных родов у женщин с короткой шейкой матки.

55

 

 

Марченко Л. А., Ильина Л. М.

Недостаточность лютеиновой фазы (критерии диагностики и методы коррекции).

61

 

 

Шляхи зниження материнської смертності в Україні і тактика веден-ня вагітних груп високого ризику.

66

 

 

Podol'sky V. V., Dronova V. L., Teslyuk R. S., Gul'chij M. M.

Particularities of Psychoemotional State of Fertile Women under the Influence of Smoking.

68

The article is devoted to study of psychoemotional state at fertility women which are being under negative influence of tobacco smoking. The causes of stress at women of reproductive age have been analysed.The broughted data shows the considerable higher level of psychoemotional state among fertility women (active and passive tobacco smoker) in comparison with women which gave up tobacco smoking.

Key words: fertility women, psychoemotional state, tobacco smoking, stress.

 

 

Tovstanovskaya V. A., Prilutskaya A. B., Prilutskiy A. I.

A New Approach in Treating Women with the Pelvic Inflammatory Disea-se of Chlamydial Ethiology.

70

The article proves the introduction of Levolet in the complex treatment of urinogenital chlamidiosis to have positive clinical and biological effects in 96.2% of cases. It is connected with the rapid response of causative microorganism to the mentioned medication. It helps to prevent infertility at infectious pathology of urinogeni-tal organs of women and complications during pregnancy.

Key words: chlamidiosis, treatment, fluoroquinolones, Levolet.

 

 

Zhabchenko I. A., Chernenko T. S., Shevel' T. G., Pokhitun M. V., Matyashova O. I.

Particularities of Microflora of Women with Non-cancerous Mastopathy and Candidal Vulvovaginitis Correction.

74

The microbiological study of a sheath in the first and second period of gestation of 137 women with the non:cancerous mastopathy has been carried out. In 43.8% of cases and 46.5% of cases candidal vulvo-vaginitis has been diagnosed. The treatment with Livarol proved its effectiveness. It allows to recommend it for a wide application in obstetrics with the further biocoenosis restoratation with probiotics.

Key words: gestation, candidal vulvovaginitis, non-cancerous mastopathy.

 

 

Duda O. K., Vdovichenko O. P.

Listerellosis: a new perspective of the disease.

79

The problem of listerellosis has been stated in this article in a new perspective. Aetiology, pathogenesis, classification and clinical presentation of listerellosis have been covered in details. Special attention is paid to the disease state of pregnant women and newborns.

Key words: listerellosis, aetiology, pathogenesis, classification, clinic of pregnant women.

 

 

Tuinov V. A., Chebalina Ye. A.

Herpes labialis and henitalis in the family doctor’s practice (clinical lecture).

83

In this work reflected literature’s analysis and results of own experience in the modern, aspect of epidemiology, pathogenesis, main clinical forms, diagnostic, prophylaxis of the herpes labialis and genitalis and it’s consequences.

 

 

Khomych L. S., Andreeva T. I.

Risk factors for adverse outcomes of pregnancy.

90

Adverse outcomes of pregnancies are important public health problems worldwide. There are well recogni-zed risk factors for miscarriages, premature births, low birth weight and small for gestational age fetus (ma-ternal age, history of miscarriages and infertility), and controversial social and behavioral factors (alcohol use, smoking, caffeine consumption, BMI). This review is designed to examine risk factors of such adverse outcomes of pregnancies.

Key words: pregnancy, miscarriage, spontaneous abortion, premature birth, low birth weight, small for gestational age fetus, a risk factor.

 

 

Chayka V. K., Hovorukha I. T., Bilousov O. G., Novikova I. V.

Case report: intraoperative diagnosis of full-term abdominal pregnancy with successful outcome.

95

We report a case of successful outcome of full:term abdominal ectopic pregnancy after IVF. It was diagnosed only during cesarean section. The diagnosis of abdominal pregnancy is really difficult. Sonography is not always efficient in diagnostic of this pathology. Abdominal pregnancy is dangerous for pregnant women and their fetuses.

Key words: full-term abdominal ectopic pregnancy, diagnosis.

 

 

Sukhin V., Mihanovskiy A., Krugovaja I., Slobodjanjuk O., Skripnik L., Fedorenko N., Radchenko A.

A giant fibromioma in nulliparous woman. Case report.

97

The article presents data on the frequency of occurrence of giant uterine fibroids, case report, the data of clinical and instrumental examination of the patient.

Key words: giant uterine fibroids, nulliparous women.

 

 

Татарчук Т. Ф., Косей Н. В., Самосійна О. О., Васильченко Л. А., Джупін В. О.

Комплексне застосування інноваційних технологій у лікуванні тяжкої форми клімактеричного синдрому в жінок з лейоміомою матки.

101

 

 

Bubnov R. V., Mukhomor O. I.

Trigger Point Dry Needling under Ultrasound. A New and Unreported Technique Case report and literature review.

106

The aim of the study was to examine the use of trigger point dry needling under ultrasound guidance and myofascial release for the treatment of myofascial pain, to increase the provability of the puncture treatment by visual verification. A review of modern and traditional approaches to the myofascial pain treatment was presented. For the first time the trigger point was visualized by ultrasound (US) in this study and needling therapy of pelvic muscles by ultrasound examination was performed as well. The primary experience is embedded in clinical practice. The ultrasound imaging technique significantly improve the detection accuracy and specificity of verification the trigger points, as the causes of myofascial pain, as well as it is usefull for the dynamic control of the effectiveness of their treatment. Inactivation of MTrPs by dry needling appears to be the result of the mechanical action of needle, since it can be successfully accomplished without the use of local anesthetics or other materials. The use of ultrasound can significantly improve the effectiveness and safety of the deep dry needling as an optimal method of inactivation of trigger points. We believe that use of deep dry needling is inadequate without ultrasound guidance, as the precise puncture of certain muscles can not be performed accurately without ultrasound visual navigation.

Key words: pelvic pain, ultrasound diagnosis, pain therapy, acupuncture, the puncture under ultrasound guidance.

 

 

Коноводова Е. Н.

Железодефицитные состояния: когда и кому назначать Тотему?

112

 

 

Nesterov I. M., Ailamazyan E. K., Totolyan Areg A.

Optimization of local therapy for vaginal infections and dysbioses.

117

The authors investigated the clinical and immunological efficacy of the interferon inducer 5% cycloferon lini-ment (Scientific Technological Pharmaceutical Firm «Polysan», Saint Petersburg) during intravaginal mono-therapy for nonspecific vaginitis (NV), Candida vaginitis (CV), and bacterial vaginosis (BV), as well as its immunomodulatory effect. During a prospective study, the total clinical and microbiological efficiencies of a course of therapy were 74%; in the clinical groups, it was 68.2% for NV, 93,7% for BV, and 75% for CV. A placebo-controlled study showed that the clinical efficacy of the agent was 88.8%; there was a 2,6-fold reduction in the total incidence of the pathological types of vaginal biocenosis as compared to placebo. The drug is well tolerated by patients; it causes no allergic reactions or other adverse events. The basic mecha-nism of the drug’s immunomodulatory effect is to affect local vaginal immunity and it is manifested by the following immunological changes in vaginal secretions: an increase in vaginal tissue-blood barrier perme-ability; compensation for baseline diminished local IgG and IgA synthesis not only due to the higher diffusion of immunoglobulins from the bloodstream, but also due to the normalization and increase of their local synthesis. The use of the agent as a basic drug is promising and warranted during a course of immune-oriented therapy for infectious and inflammatory diseases and dysbioses of the lower female genital tract. The main use regimen for 5% cycloferon liniment to correct vaginal microbiocenosis is as follows: daily intravaginal instillations of 5 ml for 10 days.

Key words: cycloferon, vaginal infections and dysbioses, local immunity, immunomodulation.

 

 

Pirogova V. I., Kozlovsky I. V., Shurpyak S. O.

Preventive Treatment of Inflammatory Diseases of Pelvic Organs of Women with Intrauterine Surgery because of Missed Miscarriage.

122

The article deals with the findings of the effectiveness and safety of preparation Distreptasa (rectal suppo-sitory) for preventive treatment of inflammatory diseases of pelvic organs of women with missed miscarriage.

Key words: miscarriage, missed miscarriage, inflammatory diseases of pelvic organs, Distreptasa.

 

 

Bichkova Y. О., Medved V. І., Hominska Z. B., Bliznuk Z. V.

Hormonal mechanisms in the development of gestational diabetes melli-tus and the role of antiinsulin antibodies in the origin ofthis pathology.

128

The amount of imunoreactive insulin, C:peptide, unconjugated estriol, human placental lactogen, cortisol and autoantibodies to glutamatdecarboxylase were determined at pregnant women with gestational diabetes mellitus with the aim of detection of pathogenetic mechanisms of this pathology. It was identified, that for the women with gestational diabetes mellitus there are an increase in amount of immunoreactive insulin and C-peptide that indicates the hyperinsulinemic state of such patients and probably resistance to insulin. Patients with gestational diabetes have increased content of cortisol and human placental lactogen – contrinsulinemic hormones which cause resistance to insulin. The increased content of estriol in the serum of regnant women with gestational diabetes mellitus testifies the tension in functioning of fetal adrenal gland and violation of fetal development. In women with gestational diabetes mellitus there are some cases with the presence of autoantibodies to glutamic acid decarboxylase which indicates the autoimmune process to the antigens of pancreatic β-cells.

Key words: gestational diabetes mellitus, insulin, C-peptide, unconjugated estriol, human placental lacto-gen, cortisol, autoantibodies to glutamic acid decarboxylase, resistance to insulin.

 

 

Martsynyak-Dorosh О. М.

Influence of sense of sense of life is on food habits.

134

This article examines influence of level of feeling of sense of life on forming of food habits. The results of the research indicate that women with excessive weight and obesity show diminished level of feeling of sense of life and wrong food habits which show up in the consumption of greater amount of meal in stress situations.

Key words: feeling of sense of life, food habits, noetic activity, temporality, noetic qualities, noetic position.

 

 

Bondarenko O. M.

The peculiarities of the psychoemotional state of the women with uteri-ne leyomioma during the first year after the burn.

138

The psychoemotional state and some stress hormones of 25 women with uterine leyomioma were studied after the birth period of 3 and 6 months, also these aspects were investigated with 10 healthy women within the same period of time after the birth. It is revealed that the improvement of the psychoemotional state of the women with uterine leyomioma within after-birth period occurs slower than of the healthy ones at the same time it is not found substantial difference between two examined groups of women according to the indexes of stress hormones in their blood.

Key words: pregnancy, stress hormones, leyomioma, psychoemotional state.

 

 

Chayka V. K., Babich T. Yu.

Family delivery practice and preparing to it in Donetsk Regional Centre for Maternity and Child Care.

141

The family delivery practice and preparing to it was analyzed on the base data in Donetsk Regional Centre for Maternity and Child Care during 15 years (since 1996 till 2010 years), the 386 pregnant conditions were estimated during pregnancy and delivery on the base of anonymous questionnaires. It was proved the wor-king out system in women with prenatal preparation with husbands was more effective, than ordinary one. Complicates in delivery were decreased that led to health newborns childbearing, to early breastfeeding and to welfare in family.

Key words: family delivery, prenatal preparing, stress, newborn, obstetric complications.

 

 

Danylko V.

The Delivery Peculiarities and Stationary Treatment Quality for Pregnant Women with Diabetes Mellitus in Ukraine.

146

The article deals with peculiarities and quality of special stationary treatment of pregnant women with diabe-tes mellitus and delivery peculiarities in Ukraine according to the health institution level. We propose many new measures for improvement of obstetric- endocrinological treatment for patients with diabetes mellitus in Ukraine.

Key words: delivery, diabetes mellitus.

 

 

Achmedova T. N.

Features of current of pregnancy at women with a diabetes.

148

The researches lead by us have shown, that current of a diabetes during pregnancy proceeds wavy, with propensity to ketoasidosis, hyper and hypoglykemiyae to conditions. In the first weeks of pregnancy current of a diabetes at the majority of pregnant women remains without changes, or observe improvement of tole-rance to carbohydrates, that stimulates allocation of insulin by a pancreas. In second half of pregnancy, due to the raised activity hormones (glucagon, placentary lactogen, prolactin) worsens tolerance to carbohydra-tes, diabetic complaints amplify. The third stage is connected to sorts and the postnatal period. During sorts there is a danger metabolic asidosis which can quickly proceed in diabetic. During a lactation the need for glucose is lower, than up to pregnancy, in it doubtless change of balance of hormones which is caused by development of pregnancy affects.

Key words: diabetes during, pregnancy.

 

 

Posokhova S. P., Nitochko K. O.

The course of pregnancy, labour and perinatal outcomes in women with premature rupture of membraines at preterm birth.

150

196 pregnant women were examined. Among them the main group consist 96 women with premature ruptu-re of membraines which gave birth in a term 22-35 weeks of pregnancy. The preconditions for PPROM in this group of women were the high percentage of extragenital diseases, particularly infectious, the compli-cations during the course of pregnancy and the presence of pathological microorganisms in the cervical and vaginal canals. The most cases of PPROM were at the 22–31 weeks of gestation (65.6%), which are the risk factors for perinatal infection for the premature newborns. Unreasonable prolongation of pregnancy in wo-men with PPROM had the adverse perinatal outcomes for the newborns with the weight up to 1000 g (the rate of mortality was 83.33%), poor impact for the newborns with the weight up to 1500 g (the rate of mortality was 25%). These data requires further study regarding the timing of delivery for newborns of such weight categories.

Key words: preterm premature rupture of membraines, the course of pregnancy, perinatal outcomes.

 

 

Yupatоv E. Y.

Chronic venous insufficiency and pregnancy.

156

Current survey contains the review of the main etiological and pathogenetic factors, which leads to chronic venous insufficiency in obstetrics&gynecology. Modern diagnostical approaches and principles of conser-vative treatment in pregnant women are given.

Key words: pregnancy, chronic venous insufficiency, reasons, diagnostics, treatment.

 

 

Golyanovskyy O. V., Kaminskyy V. V., Zelyavska N. M., Chernov A. V., Kulchickyy D. V.

Carbetocin prophylaxis of obstetrical bleedings in the risks group puerperant.

161

In the given work results of research, concerning efficiency new uterotonic drugs of the prolonged action – carbetocin – after vaginal delivery at the active management of third stage of labor in women with high risk of atonic bleedings to compare with oxytocin are presented. We proved, that 100 мg IV injection carbetocin reduced the volume of blood loss, the need for additional uterotonic drugs with prolonged administration, massage the uterus and also causes more rapid uterine involution in the postpartum period than the use of 10 IU oxytocin.

Key words: obstetrical bleedings, uterine insufficiency, hysterectomy, active management the third stage of labor, carbetocin, oxytocin.

 

 

Simrok V. V., Koryavaya T. F.

The evolution of nonradical methods of treatment of gestosis.

164

In the review the views on the problem of nonradical methods of treatment of gestosis are represented. The attention is accentuated on the different points of view of the application of groups of medicines which are used for the treatment of a given pathology and also some data concerning their effectiveness. Some special attention is paid to modern methods in the complex therapy of a given pathology in pregnant women.

Key words: pregnancy, gestosis, nonradical methods of treatment, effectiveness.

 

 

Tkachik S. J.

Forecasting dyscoordinational patrimonial activity.

169

Results of the spent researches testify, that at the moment of the beginning of sorts the basic, even the «exclusive» role in the development forecast dyscoordinational patrimonial activity is played by the factor «maturity» of a cervix of a uterus. The actions directed on preparation of a neck of a uterus (introduction intracervical or intravaginal gels, use laminarii, antagonists of calcium, etc.), and also antianemia therapy at pregnant women are considered as means of decrease in risk of occurrence dyscoordinational patrimonial activity.

Key words: dyscoordinational patrimonial activity, forecasting.

 

 

Lakatosh V. P., Belaya V. V., Leush S., Zagorodnaya A. S., Mandrikova A. S.

A case of twin reversed arterial perfusion with favourable fetus outcome.

171

A case report of twin reversed arterial perfusion syndrome completed in 32 gestation weeks by birth of pre-mature newborn and acardial fetus is considered in the article. Literature dates about genesis and frequency of syndrome are discussed, the necessity of preterm operative delivery is given.

Key words: twin reversed arterial perfusion syndrome, monochorial twins, acardial fetus.

 

 

Венцковская И. Б., Белая В. А., Загородняя О. С.

Роль скрытых тромбофилических состояний в патогенезе угрозы преждевременных родов.

173

В статье приведен обзор литературы о происхождении, клинических появлениях и распространенности антифосфолипидного синдрома (АФС). Показаны значительная распространенность лабораторных критериев АФС среди беременных с угрозой предварительных родов и его корреляция с клини-ческими проявленими тромбофилического состояния.

Ключевые слова: антифосфолипидный синдром, антифосфолипидные антитела, угроза преждевременных родов.

 

 

Kuritsina S. A.

Risk factors and migration variants it is abnormal the located placenta.

177

Results of the spent researches testify, that risk factors of a pathological current gestation at abnormal pla-centation are: the age is more senior 30 years; high parity; infections urogenital path; structural infringements of a uterus (a hem / an anomaly myoma/). The basic criteria of migration of a placenta are: localisation con-cerning uterus walls, speed and a process variant. Three types of speed of moving of a placenta are defined: slow – less 0,3sm/w; moderated – from 0,3 to 0,5sm/w; fast – more 0,5sm/w. Are allocated also finished (full migration) and not complete variant (incomplete migration) moving process. The received results are nece-ssary for using by working out of tactics of conducting pregnancy at patients of this group.

Key words: an abnormal arrangement of a placenta, risk factors, migration.

 

 

Маменко М. Е., Белых Н. А.

Эффективность антенатальной йодной профилактики в регионе легкого йодного дефицита.

179

В статье приведены результаты регионального исследования, включавшего анкетирование, опреде-ление медианы йодурии, проведения УЗИ щитовидной железы у беременных, изучение показателей функционирования гипофизарно:тиреоидной системы женщин и рожденных ими детей. Проведен сравнительный анализ эффективности разных видов йодной профилактики. Продемонстрировано, что недостаточное поступление йода в организм беременной приводит к напряженному функциониро-ванию гипофизарно-тиреоидной системы матери и плода, осложненному течению перинатального периода, высокой частоте неонатальной гипертиреотропинемии. Сделан вывод о необходимости проведения антенатальной йодной профилактики с применением препаратов калия йодида в дозе 200 мкг в сутки.

Ключевые слова: йодный дефицит, гипофизарно-тиреоидная система, неонатальная гипертирео-тропинемия, новорожденный, профилактика.

 

 

Grabar V. V., Feskov A. M., Zhilkova E. S.

Noninvasive prenatal diagnosis of aneupoidy using transcervical trophoblastic cells in assisted reproduction.

185

The possibility of noninvasive prenatal diagnosis of aneuploidy using transcervical trophoblastic cells in preg-nant women in assisted reproduction was investigated. It is shown that trophoblastic cells could be identified among the maternal cells using monoclonal antibodies recognizing trophoblastic marker HLA-G, and the subsequent applying of FISH on these cells reveals aneuplody of embryo. By using this technique in 6 weeks’ gestation we found aneuploidy 47XYY and 45X0, confirmed by cytogenetic study of chorionic villi and amniocites. This noninvasive procedure could provide a useful platform for prenatal diagnosis of early preg-nancy after further investigation to establish its efficacy.

Key words: noninvasive prenatal diagnosis, aneuploidy, transcervical trophoblast cells, assisted reproduction.

 

 

Zhuk S. I., Schurevska O. D., Kobasa O. D., Zhuk V. P.

Perinatal Psychology – Course of specialization.

189

The article showed experience of course thematic improvement on perinatal psychology, the main areas of theoretical and practical training. The main problems encountered in the process of teaching and ways of their possible solutions.

Key words: perinatal psychology, specialization.

 

 

Manasova G. S.

Dynamics of the maintenance of the some calciumregulated hormones and of the bone tissue remodeling marker’s in the not complicated preg-nancy and the early postnatal period.

191

The article presents the data of the dynamic survey of the structural state of the bone tissue, some calcium-regulated hormones and the marker’s remodeling of the bone in 38 healthy pregnant women. The survey was conducted in the II-nd, III-eat trimesters of the pregnancy and on the fourth day after birth. By the chemi-luminescence immunoassay was determined in blood concentrations of vitamin D, parathyroid hormone (PTH), osteocalcin and β-CrossLaps. The mineral density of the bone tissue was determined by ultrasound densitometry. Investigation of the total, ionized calcium, phosphorus, the levels of the urinary calcium excre-tion was performed complexometric method. The dynamics in the blood of the healthy pregnant women has been a gradual reduction of the calcium, phosphorus and vitamin D levels. The parathyroid hormone’s acti-vity increases in the III-eat trimester of pregnancy and declines after birth. The concentration of the osteoca-lcin with increasing gestational age significantly decreased, whereas the levels of the fragments of the colla-gen’s I type increases. The data of the densitometry’s reflect the gradual bone loss. This changes evidence of the instability mechanisms of the regulating of the calcium levels in the blood during physiological preg-nancy. The remodeling of the tissue in the healthy pregnant women is characterized by the predominance of the bone’s resorbtion over its synthesis, which leads to the development of the osteopenia.

Key words: pregnancy, bone tissue, remodeling.

 

 

Shun'ko E. E., Tischenko V. K., Omelchenko L. V., Strizhak S. K.

Oxidative Modification of Plasma Protein in Newborns in Critical Condition.

195

The research on changes at the molecular level of newborns in critical state was held. The levels of oxidative modification of blood plasma proteins were determined of babies who were treated in department of intensi-ve care of regional children hospital. 68 babies were examined. The state of health babies mothers, their gy-necological, obstetrical anamnesis, complications, which had place during pregnancy and labor process ha-ve been analysed. The risk factors of the birth in the critical state have been detected; the observation for the state of health child in first and second year’s life has been realized. The findings can be used in forecasting the recovery time for babies.

Key words: newborns, level of oxidative modification of blood plasma proteins, critical state, forecasting.

 

 

Серов В. Н., Тютюнник В. Л., Твердикова М. А.

Предменструальный синдром: тактика ведения пациенток в амбулаторно-поликлинической практике.

202

 

 

Gorban N. E.

Features of the genital tract microbiocaenosis in women of reproductive age with ovarian retention cyst with chronic inflammatory diseases of the genitals.

206

Produced a comprehensive study of indicators of reproductive tract microbiocaenosis of 119 women with ovarian retention cyst with chronic inflammatory diseases of the genitalia, of 30 patients with chronic inflam-matory diseases of the pelvic organs, 20 women of reproductive age who had no gynecological pathology. The data obtained suggest that in women of reproductive age the development of ovarian retention cysts characterized by deeper microbiocaenosis disorders of genital tract than in inflammatory processes genitalia- an essential colonization of conditionally pathogenic flora, accompanied by a significant decrease in the number or absence of lactobacilli and the development of bacterial vaginosis.

Key words: retention cysts of ovaries, chronic inflammatory diseases of the genitals, genital tract microbi-ocaenosis, conditionally pathogenic flora.

 

 

Tatarchuk T. F., Kasyanchuk N. Y., Kapshuk I. M.

Selecting hormonal contraception for women with metabolic syndrome.

210

The article reviews the issue of selecting an appropriate hormonal contraceptive for women with metabolic syndrome (MS). Among the wide variety of contraceptive pills, the combinations drospirenone/30 ethyni-lestradiol (EE) and drospirenone/20 ethynilestradiol (EE) are the most valid choices by its influence on vari-ous mechanisms of MS pathogenesis. They can be used not only for the sake of contraception, but as me-ans of metabolic control as well, since it has antiandrogenic, hypolipidemic and antihypertensive effects without lowering tissue sensitivity to insulin. Creating a contraceptive comprising drospirenone/20EE combi-ned with 0,451 mg metafolin (natural metabolite of folic acid) was an important achievement for women with MS. In women of reproductive age suffering MS, the use of folates is indicated not only for reducing the risk of fetal malformations during pregnancy due to discontinuation of treatment, but also for preveting cardiova-scular disorders caused by the atherogenic effect of folate deficiency:related hyperhomocysteinemia.

Key words: metabolic syndrome, hormonal contraception, drospirenone, folates.

 

 

Baskakov P. N., Osmanov E. M., Petrova O. P., Zalinyan M. V.

Diagnosis and treatment of cervical cicatricial deformities.

217

The article describes the main clinical characteristics of diagnosis of cicatricial deformities of the cervix. The cytological, colposcopic, morphological characteristics of this pathology are studied. The colposcopic and morphological parallels are observed. The management tactics at cicatricial deformities of the cervix is dis-played.

Key words: cervix, scar deformity, ectropion, endocervicitis, zone junction epithel atypical transformation zone, CIN.

 

 

Kravets O. M., Vasylyeva L. A., Kucher N. N.

Medical treatment of the distrophical diseases of vulva at themenopausal women.

222

It is revealed that increase in time of menopause lead to increase in frequency of the distrophical of vulva. In the distrophical diseases of vulva used the “Ovarium compositum” medicine of the antihomotoxical therapy, intravaginal phonophoresis with “Traumeel S” ointment and applications of the “Traumeel S” ointment. It was is noted the reliable efficiency (p<0,001) of proposing complex in releases of the main symptoms, pH norma-lization of the vagina secretion and attainment of the constant remission of the distrophical diseases of vulva.

Key words: menopausal women, distrophical diseases of vulva, antihomotoxical therapy.

 

 

Бобрицкая В. В.

Тканеселективная фитотерапия метаболических расстройств при хирургической менопаузе.

225

 

 

Прилуцкий А. И., Прилуцкая А. Б.

Оптимизация лечения хронических воспалительных заболеваний органов малого таза неспецифической этиологии.

229

На основании данных проведенного исследования определили, что лечение диклофенаком (препа-ратом Диклоберл, Берлин Хеми) больных с хронической формой ВЗОМТ способствует ограничению экссудативного проявления воспалительного процесса, инактивации медиаторов воспаления, восста-новлению местного иммунитета и получению в 95,3% положительного терапевтического эффекта, что позволяет широко использовать данный препарат в лечении хронической формы ВЗОМТ.

Ключевые слова: хронические воспалительные заболевания органов малого таза, лечение, нестероидные противовоспалительные препараты, диклофенак.

 

 

Voloshin A. A.

Features of a hemostasis after laparoscopical conservative miomectomy.

232

Results of the spent researches testify to high risk trombohemorragical complications at patients after lapa-roscopical miomectomy. It dictates necessity of improvement of algorithm of diagnostic and treatment-and-prophylactic actions.

Key words: laparoscopical miomectomy, a hemostasis.

 

 

Давыдова Ю. В., Двулит М. П., Кнопик С. А.

Лечение хронических воспалительных заболеваний хламидийной этиологии.

234

 

 

Azimova E. I., Sultanov S. N., Nishanova F. P.

Specially scientific practical medical center of obstetrics and gynecolo-gist of Republik of Uzbekistan, Tashkent.

238

We are studied some aspects of the use of the Proteflazid in the complex treatment for the threat of inter-ruption of pregnancy in females with herpes genitalis ( HSV infection).

Key words: herpes genitalis, Proteflazid.

 

 

Шинелева Е. Н., Маринкин И. О.

Комплексное лечение патологии шейки матки и влагалища, вызва-нной вирусом простого герпеса.

241

 

 

Dzhelomanova S. O., Dan'kina I. A.

The Problem of Urinogenital Trichomoniasis.

244

The results of examination of 45 patients, 25 of which used preparation Meratin to treat urinogenital tricho-moniasis are discussed in this research. The findings prove the therapy to be very effective. Due to the findings Meratin can be considered medication number one for treating trichomoniasis.

Key words: ourogenitalniy trihomaniaz, medical treatment, Meratin.

 

 

Долгушина В. Ф., Ахматова А. Н., Беренда М. А.

Эффективность Изопринозина в лечении хронического цервицита, ассоциированного с папилломавирусной инфекцией.

246

 

 

Vdovychenko Yu. P., Chermak I. I.

Premature interruptions of pregnancy at women of late reproductive age with barreness in the anamnesis.

250

Results of the lead researches testify, that patients late reproductive age with barreness in the anamnesis make group of high risk on development premature interruptions of pregnancy, and various genesise: infec-tious, endocrinological and mixed. Use of the offered differentiated approach of the approach to carrying out of treatment:and:prophylactic actions normalization of a functional condition fetoplacental a complex and microbiozinose sexual ways promote, that finally allows to improve results delyveries women of group of high risk. The technique is simple and popular, that allows to recommend it for use in practical public health ser-vices.

Key words: premature interruption of pregnancy, late reproductive age, barreness, preventive maintenance.