HEALTH OF WOMAN WH_№1_2013

  • Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

Nazarenko L. G.

Undifferentiated connective tissue dysplasia: a look obstetrician (Revi-ew).

12

Presented clinical and pathogenetic aspects of connective tissue dysplasia, classification approaches and diagnostic criteria. The data on the frequency and patterns of obstetric pathology associated with undifferen-tiated connective tissue dysplasia. The main directions of the treatment and the possibility of secondary and tertiary prevention of obstetric and perinatal complications associated with dysplasia.

Key words: dysplasia of connective tissue pathology of pregnancy, childbirth, perinatal.

 

 

Аполихина И. А.

Взгляд гинеколога на клинические рекомендации по ведению женщин с ИППП.

22

 

 

Дисгормональная дисплазия молочной железы. Взгляд онколога.

28

 

 

Эндометриоз – загадка века: серия мастер-классов в универсальной клинике «Оберіг» в помощь украинским гинекологам.

32

 

 

Современные аспекты репродуктивного здоровья женщины: данные международных исследований.

36

 

 

Элиминаль гель – победим дисбактериоз ВМЕСТЕ!

44

 

 

Карп Говард

Систематический обзор применения дидрогестерона для лечения уг-розы прерывания беременности.

46

Целью этого систематического обзора было определить, снижает ли пероральный прогестаген (дид-рогестерон) частоту невынашивания беременности у женщин с угрозой прерывания беременности. По базам данных Medline, Embase и Ovid Medline был проведен компьютерный поиск оригинальных работ, в которых упоминался бы препарат Дуфастон или дидрогестерон; поиск ограничивался данными клинических исследований, проведенных с участием человека. Была найдена 21 публикация о терапии дидрогестероном 1380 пациенток в целом. Выявлено 5 рандомизированных исследований, соответствующих критериям мета-анализа, в которых участвовали 660 пациенток. Проведено срав-нение частоты последующих невынашиваний или сохраненных беременностей на одну рандомизи-рованную пациентку в группах приема дидрогестерона и стандартного постельного режима либо при-менения плацебо. Частота невынашиваний у принимавших дидрогестерон составила 13% (44/335) по сравнению с 24% в группе контроля [отношение шансов (ОШ) невынашивания 0,47 (ДИ = 0,31–0,7); отмечено снижение абсолютного риска невынашивания на 11%]. Обобщенные данные о нежелатель-ных явлениях и побочных действиях представлены для 21 исследования и, по-видимому, их частота была минимальна. Хотя контролировать все прогностические и вмешивающиеся факторы невозмож-но, результаты систематического обзора свидетельствуют о значительном (47%) снижении вероятно-сти невынашивания беременности при применении дидрогестерона по сравнению со стандартным уходом, что свидетельствует о реальном эффекте лечения.

Ключевые слова: аборт, Дуфастон, дидрогестерон, невынашивание беременности, прогестерон, угроза прерывания беременности.

 

 

Maged M. Costantine MD, and George R. Saade, MD

Первое кесарево сечение: роль диагноза «дистресс плода».

57

Целью данного обзора является обобщение имеющейся информации о факторах, приводящих к повышению частоты первичного кесарева сечения, особенно это касается роли кардиотокографии (КТГ). В настоящее время доказано, что широкое использование КТГ не снижает частоту неблагопри-ятных перинатальных и неонатальных исходов. А такие проблемы, как низкая чувствительность и на-дежность метода, привели к резкому повышению частоты кесарева сечения. Для любой успешной по-пытки снизить высокую частоту кесарева сечения следует учитывать ограничения, присущие совре-менным методам КТГ.

Ключевые слова: кесарево сечение, кардиотокография, перинатальные и неонатальные неблаго-приятные исходы, измерение рН крови плода, электрокардиограмма плода.

 

 

Hot’ N. R., Slabkyi H. O.

The characteristics of the activity of maternity and childhood service in Regional Clinical Hospital.

61

The article deals with the results of the survey of the maternity and childhood service in Lviv Regional Clini-cal Hospital during 2009-2011. There have been presented the general indexes of the structural units’ acti-vity, where women are provided with medical aid. The analysis of obstetrics and neonatology departments’ work in Regional Hospital has been shown.

Key words: Regional Clinical Hospital, maternity and childhood service, the indexes of work.

 

 

Veropotvelyan M. P., Poguliay Y. S.

Noninvasive prenatal diagnosis: origins, realities, immediate prospects.

65

One of the goals of modern perinatology and medical genetics is the creation a safe and reliable prenatal diagnosis. Trying to solve this problem was proposed alternative approach – a non-invasive sampling of fetal material (fetal cells and fetal cell-free DNA (cffDNA) later from maternal blood in early pregnancy). To date, this method is used to determine Rh-status, sex of the fetus, revealing some monogenic diseases, diagnosis of chromosomal aneuploidies (21,18,13, X, Y). We consider various approaches of applying such techniques for mass screening of pregnant women. The development of this direction of prenatal diagnosis performed in two trajectories: the expansion of spectrum of detectable pathology and increase diagnostic accuracy studi-es.

Key words: prenatal diagnosis, monogenic diseases, screening of pregnant women, non-invasive methods.

 

 

Kaminskyy V. V., Shypko I. N.

Of obstetric and perinatal complications in pregnant women on a back-ground of genital herpes and cytomegalovirus infection after assisted reproductive technologies.

72

Analyzed the anamnestic data, the results of serological examination, especially during pregnancy, childbirth, postpartum, fetal and newborn in women with herpes virus and cytomegalovirus infection after use of assis-ted reproductive technologies. Application of treatment (Immunomax, immunoglobulin anticytomegalovirus and against herpes simplex virus type 2 human, viferon, Flebodia, Essenciale forte, vitamin E, elevit, utra-zhestan and heksykon) allowed to reduce the incidence of obstetric and perinatal complications in this con-tingent of women.

Key words: cytomegalovirus infection, genital herpes, pregnancy, miscarriage, childbirth, baby, newborn, assisted reproductive technology.

 

 

Pirogov V. I., Tomic N. V., Pertsovich V. N., Shurpyak S. A.

Modern aspects of overcoming pain in gynecological practice.

76

Despite the large range of modern medications and pain treatment methods problem of postoperative pain is one of the leading places in gynecological practice. For overcoming postoperative pain traditionally use narcotic analgesics, but side effects of these drugs require searching of alternative techniques for pain treatment in postoperative period. So today in a comprehensive approach to overcoming postoperative pain preferred non-narcotic drugs, in combination with peripheral action analgesics – non-steroidal anti-inflammatory drugs (NSAIDs) The purpose of our study was to evaluate the efficacy and safety of use deksketoprofen trometa-mol in postoperative pain treatment in patients after transvaginal hysterectomy. Study showed introduction deksketoprofenu trometamol after transvaginal hysterectomy provides a stable, effective and long lasting pa-in relief, reduces the need for narcotic analgesics and does not cause side effects that are inherent narcotic analgesics.

Key words: pain, dexketoprofen trometamol (Deksalgin), transvaginal hysterectomy, effective pain relief.

 

 

Ledina A. V., Prilepskaya V. N.

Premenstrual syndrome: possibilities of non-hormonal treatment.

79

Objective. To study the efficacy and tolerance of an extract from the plant Vitex agnus castus in the treat-ment of moderate and severe premenstrual syndrome (PMS) in reproductive-aged women. Subjects and methods. One hundred and twenty-one women with PMS were followed up for 6 months, during which the patients filled out their health assessment diaries every day and also the tested psychological questionnaire thrice. They took agnucaston (cyclodynon) that contained 40 mg of the Vitex agnus castus extract as one tablet daily immediately after awakening during 3 menstrual cycles. Results. A significant improvement occurred in 67.8% of the patients (according to the diary entries) and in 59.3% of the women (according to the questionnaire data). A subjective improvement was reported by 86.4 and 96.2% of the women according to the data of their diaries and questionnaires, respectively. The side ef-fects associated with the use of the drug were noted in 13 (10.7%) women. Serious adverse reactions occu-rred in none patient. Conclusion. Agnucaston is an effective and acceptable drug to treat PMS.

Key words: premenstrual syndrome, agnucaston.

 

 

Vdovichenko S. J.

Actual aspects of partner labours in the conditions of typical city mater-nity hospital.

83

Obtained given (indicators of a parent traumatism, frequency and character of operative intervention and health of newborns) testify that partner childbirth is a serious reserve in frequency decrease obstetrical and perinatal pathologies. At the same time, arises more number discussional questions it is necessary for which decision to devote yet one scientific research. It dictates necessity of carrying out of scientific researches for the given direction.

Key words: partner childbirth, obstetrical and perinatal outcomes.

 

 

Dubossarskaya Z. M.

Peculiarity of infusion therapy in obstetrics bleedings (literature overe-view).

85

Possibility of awareness of pathogenetic approach is analysed to the prevention of maternity death rate at the obstetrics bleeding, which occupy a leading place in the structure of maternal losses. The comparative estimation of some infusion facilities, allowing not only to treat the obstetrics bleedings but also warn critical complications after them.

Key words: obstetric bleedings, crystalloids, colloids, maternity death, solutions of hydroxiethyl starch.

 

 

Shekera O. G., Tsarenko A. V.

The socio-medical aspects of health (the literature review).

90

In this paper, based on the Laws of Ukraine and fundamental international documents the social significance the category of «health» and its main components and factors that shape it are defined. The importance of the Social Medicine and Public Health Management as a science in the modern world is discussed.

Key words: the health, the Social Medicine and Public Health Management, the health care system, the legislative base of the health care system.

 

 

Voloshina N. M., Pashchenko C. M., Shchurov M. F., Makarova J. M., Pauk O. P.

Non-hormonal therapy of proliferative processes of breasts and endome-try.

94

Medical research of using the preparation Indol-F® for the treatment of breasts and endometry withing 35 patiets has been made. The effectiveness of the treatment of proliferative processes has been proved by the clinical and laboratory experiments.

Key words: non-malignant hyperplasia of breasts, endometrial hyperplasia, Indol-F®, therapy, prophylaxis.

 

 

Zaporozhan V. N., Tarabrin O. O., Saleh O. M., Loshenko I. O.

Diagnosis, prevention and correction of complex activation of fibrinolytic components of the hemostatic system in premature detachment of nor-mally situated placenta.

99

The aim was to reduce perioperative blood loss in women with PONRP. Patients were divided into 2 groups depending on the choice of hemostatic therapy. State of hemostasis, before, after, and the day after the ope-ration was controlled – low frequency pezoelektricheskoy thromboelastography (NPTEG). The study provid-ed data that the use of tranexamic acid to reduce perioperative blood loss by 38.65% in this group of preg-nant women.

Key words: pregnancy, blood loss, premature detachment of normally situated placenta, fibrinolysis.

 

 

Vdovichenko Y. P., Gopchuk E. N.

STI treatment in accordance with international standards.

105

This paper presents an overview of current international protocols treatment of chlamydial infection. Azithro-mycin is indicated as the drug of choice for the treatment of chlamydial cervicitis, including in pregnant wo-men.

Key words: C. trachomatis, treatment, diagnosis, azithromycin.

 

 

Golyanovskiy O., Himenko M., Bachynska M.

The use of electrosurgical techniques in obstetric and gynecological pra-ctice.

109

This paper reviews the application of different methods of electrosurgery during obstetric and gynecological surgery as laparotomy or laparoscopy. Present our own experience with radiofrequency scalpel and argon plasma coagulation of tissue during caesarean section and gynecological abdominal operations. The advan-tages and indications for use of various methods of electrosurgery in obstetric and gynecological practice.

Key words: electrosurgery, radiowave scalpel, argon plasma coagulation, laser photocoagulation, air-plas-ma coagulation.

 

 

Zhabchenko I. A.

Features of functioning and factors of virulence of uropathogenic stam-ms of Esherichia coli and their value in clinical practice.

114

To the article modern data are driven about the factors of virulence of uropathogenic stamms of collibacillus, able to initiate development of infections of urinoexcretory ways. An accent is done about clinical meaning-fulness of this problem in obstetric and perinatal practice.

Key words: infections of urinoexcretory ways, collibacillus, uropathogenic stamms, virulence, pregnancy, complications.

 

 

Artyomenko V. V.

Clinical factors in patogenesise of born arrests of development.

117

Results of the spent researches testify, that the placentary dysfunction defining weight hypoxia and degree of an arrest of development of a born, develops as a result of influence of a complex of various factors. Their combination, duration of influence define expressiveness not only morphological changes in a placenta, but also its functional insufficiency. The received results are necessary for considering by working out of algo-rithm of diagnostic and treatment-and-prophylactic actions at women of groups of various risk.

Key words: a born arrest of development, patogenesise, clinical factors.

 

 

Ruban J. A.

Features of formation and functional condition fetoplacental complex af-ter auxiliary reproductive technologies.

120

Results of the spent researches testifies to high frequency of development of placentary dysfunction at wo-men, which gestation with use of auxiliary reproductive technologies. The received results testify to necessity of working out of algorithm of diagnostic and treatment-and-prophylactic actions on purpose to improvement perinatal outcomes of delivery.

Key words: auxiliary reproductive technologies, fetoplacental complex.

 

 

Goncharuk N. P., Gurzhenko O. Iu.

The research of the dynamics of Caesarean sections frequency at ano-malies of labor activity, uncomplying a medicinal correction for the peri-od 2001-2011 years.

122

In the work there were studied data on Caesarean sections frequency, on the level of urgent operations, on the Caesarean sections structure in the interests of mother, dynamics of Caesarean sections frequency at anomalies of labor activity, uncomplying a medicinal treatment during the period 2001-2011 years at the Kyiv municipal maternity hospital №1. The increase of Caesarean sections frequency is marked. Also the positive tendency of decrease of urgent operative interventions frequency pays attention on itself. For the studied period it is noted the considerable reduction of Cesarean sections frequency at anomalies of labor activity, uncomplying a medicinal treatment.

Key words: caesarian section, anomalies of labor activity, uncomplying a medicinal correction.

 

 

Veropotvelyan P. N., Veropotvelyan N. P., Guzhevskaya I. V.

Cytokines in the mother-placenta-fetus system in physiological and pa-thological advancement of Pregnancy.

126

An overview of the literature concerning the main functions of cytokines in physiological and pathological ad-vancement of pregnancy is performed. According to a great number of publications it is assumed that the prognosis of pregnancy complications is determined by peculiarities of the organism's immune reactions. It is revealed that the pregnancy advancement may be influenced by both an extremely strong immune respond and deficiency of pro inflammatory function. A change of the immune hemostats is a leading factor in the structure of the gestational complications, determination of fetoplacental dysfunction which condition the for-mation of perinatal pathology.

Key words: cytokines, pregnancy complications, immune response, interleukins.

 

 

Zanko S. N., Pishchenko Y. A.

Рharmacoepidemiological and pharmacoeconomic analysis of drug the-rapy of edema, proteinuria and hypertensive disorders in pregnancy in hospital.

130

The results of the рharmacoepidemiological and pharmacoeconomic analysis of therapy of edema, protei-nuria and hypertensive disorders in pregnancy in obstetric hospitals are presented in article. Drug therapy in actual practice is characterized by a surplus list of medicines in comparison with the standards of treatment, polypragmacy, a wide use of injections for treatment of mild severity of gestosis, irrational distribution of costs. Introduction in practice two-level control system for the use of drugs, the evaluation criteria of rationa-lity of drug treatment, a list of essential medicines for this pathology and education measures has allowed to reduce the drug load, use of parenteral dosage forms, eliminate the irrational distribution of financial costs, without any reduction in the clinical efficacy of pharmacotherapy of this complication of pregnancy.

Key words: edema, proteinuria and hypertensive disorders in pregnancy, pharmacoepidemiology, pharma-coeconomics, rational use of medicines.

 

 

Romanenko T. G., Ignatyuk T. N.

Features of the immune homeostasis in pregnant women with high risk of infection.

135

The results shows that pregnant high infectious risk changes in indicators of local and systemic immunity, cytokine status are significant prognostic markers. Levels of proinflammatory cytokines ІL-1 ІL-2, PNP-α and anti-inflammatory cytokines: ІL-4-10 is the ІL ІFN-γ in serum and in vaginal secretions can be used as a pre-dictor of complications even before the clinical manifestations, clinical features pregnancy in pregnant wo-men in this group. The study of these parameters extend rational choice, pathogenetically substantiated therapy and thus reduce the incidence of placental insufficiency and intrauterine infection in these patients.

Key words: placental insufficiency of infectious origin, intrauterine infection, immune homeostasis, cyto-kine status.

 

 

 

Квашенко В. П., Яшина Е. Г.

Клинико-патогенетическое обоснование альтернативных методов ле-чения пациенток с менопаузальными расстройствами и оценка дина-мики качества жизни женщин в менопаузе.

139

В статье изложены результаты исследований эффективности препарата Лайфемин® (на основе стан-дартизированных растительных экстрактов Naturex, Франция) и оценена динамика качества жизни у пациенток с менопаузальными расстройствами. Установлено, что комплексные растительные препа-раты, содержащие фитогормоны и фитоэстрогены, проявляют многоплановое воздействие на орга-низм женщины в период менопаузы и обеспечивают более выраженный клинический эффект по сра-внению монокомпонентыми растительными средствами.

Ключевые слова: климактерический период, менопаузальные расстройства, Лайфемин®, лечение, качество жизни.

 

 

Zakharenko N. F., Kosei N. V., Kovbasiy V. P.

Peculiarities of local hormonal homeostasis of fertile aged women with hyperproliferative uterine diseases.

145

The results of the research show hormonal dyscrasia, namely, gonadotropin increase, relative hyperstroge-nemia at the expense of local production, hyperprolactinemia, hypercortisolemia and their relations with so-me autocrine mechanisms of pathogenesis both of isolated type of uterine leiomyoma and its combination with adenomyosis. Uterine leiomyoma combined with adenomyosis is developed under the state of relative hyperstrogenemia and hyperprolactinemia in general, and especially in local blood circulation, while under isolated type such changes are detected only at the local level. In women with leiomyoma combined with adenomyosis estradiol in uterine vein is detected in higher concentration than in uterine artery and, on the contrary, testosterone and dehydroepiandrosterone – sulfate is in lower concentration. It affords grounds for speaking of leading role of increasing estrogens local synthesis in uterine for the account of active aromati-zation of androgens of ovarian and epinephral origin in pathogenesis of this disease. Under isolated uterine leiomyoma reducing concentration of dehydroepiandrosterone – sulfate and progesterone in uterine vein concerning uterine artery can be observed. It can indicate in favor of their participation in the processes of leiomyoma growth. Thus, mainly local disgormonemia in women with hyperproliferative uterine pathology is detected, especially under conditions of their combination, which can be an evidence of essential role of autonomous mechanisms that regulate tumor growth in pathogenesis of given pathology.

Key words: uterine leiomyoma, adenomyosis, estrogens, progesterone, prolactin, aromatization, pathoge-nesis.

 

 

Vdovichenko Y. P., Gopchuk E. N.

Bacterial vaginosis and nonspecific vaginitis – a rational therapy.

149

Mucosal genital tract normocenozis in women of reproductive age is one of the factors that provide reproduc-tive health. Due to the high incidence of bacterial vaginosis and nonspecific vaginitis and their undeniable ro-le in the development of pathological processes urogenital tract an urgent problem is to optimize the existing regimens of treatment. The results of studies of the effectiveness and safety of topical clindamycin in the tre-atment of bacterial vaginosis and nonspecific vaginitis in women of reproductive age, including during preg-nancy is presenter in the article.

Key words: bacterial vaginosis, nonspecific vaginitis, clindamycin, Milagin.

 

 

Mitsoda R. M.

Denervation vulva solution of ethyl alcohol in women with persistent itching.

154

The paper presents the results of a solution of ethanol to denervation for persistent itching vulva. Shown that denervation of the vulva 95% solution of ethyl alcohol is not technically challenging, affordable, not costly and highly effective intervention that helps women break the vicious circle for persistent itching vulva, and thus improve their quality of life.

Key words: persistent itching, vulva, denervation, ethyl alcohol.

 

 

Kravchenko E. V.

Correction features of disbiotic violations of vagina at the hormonal uns-table states in women.

156

At the hormonal unstable states in women (during pregnancy, in the period of menopause and puberties’) the drug of choice for the treatment of bacterial vaginosis could be antibacterial drugs that do not influence on the lactobacilli level in vaginal content, just the same drug is Hexicon. The local uses of the drug Hexicon results in the rapid purchase of acute symptoms of bacterial vaginosis and effectively perform prophylaxis of relapses in women during pregnancy, in the period of menopause and puberties’.

Key words: disbiosis of vagina, dishormonal states, correction.

 

 

Zuck S. I., Taran O. A., Kashmerinskaya A. M.

The prospects of a test-system «Femoflor 16» with vaginal dysbiosis.

159

The aim of our study was to test clinical testing «Femoflor 16» («NPO DNA Technology», Moscow), develop-ed for the study of genital tract microbiota among women that use polymerase chain reaction in real-time. In article had analyzed the characteristics of the vaginal microbiota in 97 patients with bacterial vaginosis. The use of polymerase chain reaction in real-time had assessed the ecological community of the urogenital tract revealed that 54,6% of patients had moderate or severe violations of vagina biocenosis. Test «Femoflor 16» allowed us to determine which groups of microorganisms suspended mainly caused disbiosis.

Key words: test-system «Femoflor 16» microbiocinosis, bacterial vaginosis, real-time PCR.

 

 

Pamfamirov Y. K., Zabolotnov V. A., Karapetian O. V., Volchenko I. G., Puchkina G. A.

The organ-preserving treatment of uterine myoma.

162

Presents the results of examination and treatment of 40 patients reproductive age with uterine myoma. They were undergone myomectomy by laparotomia: 33 women nonpregnant, 7 – during pregnancy. While choos-ing the volume of surgical intervention for women of childbearing age who are interested in saving or regene-ration reproductive function, it is necessary to follow the principles of reconstructive-plastic conservative sur-gery.

Key words: uterine myoma, myomectomy, preconception.

 

 

Simrok V.

Local drug use of thiotriazolin in combined therapy of uterus benign pro-cesses.

165

Many studies suggest that the development of uterine fibroids and endometriosis are often accompanied by impaired regional hemodynamic changes in water and electrolyte balance, protein balance, immune home-ostasis. Inclusion in the scheme of complex treatment of vaginal suppositories Dalmaksin accelerates reg-ression of inflammation, positive effect on the endometrium, increases the efficiency of the basic therapy, prevents the development of complications and reduces the treatment time.

Key words: endometriosis uterine, uterine myoma, endometrial, thiotriazolin, Dalmaksin.

 

 

Storozhuk M. S., Protsepko O. O., Rud V. O.

Topographic and hemodynamic characteristic of myoma nodes in women of reproductive age.

168

In this article the topography and hemodynamic of myomas nodes in 78 women of reproductive age are pre-sented due to US examination enhanced by Doppler. The control group was presented by 61 non-pregnant women without gynecological pathology. The data of control group were accepted as normal. The features of myomas nodes location in 3 planes in depend of intramuscularsubmucosal/submucosal or intramuscularsu-bserosal/subserosal disposition were found. The hemodynamic was estimated in uterine arteries and arteries of the nodes. The regularities of nodes blood supplying in depend of their location were determined. It must be taking into account by operative gynecologists choosing surgical route, type and place of uterotomy dur-ing myomectomy in women of reproductive age.

Key words: myoma, topography, hemodynamic, reproductive age.

 

 

Znamenska T. K., Kirilova L. G., Shveykina V. B.

Diagnostic of Hypixemic-Ischaemic Brain Damage of Preliminary-Born in Acuity.

172

As a result of complex clinical instrumental as a result of complex clinical, instrumental, ELISA studies the changes in the level of brainderived neurotrophic factor (BDNF) in preterm infants are examined, depending on the functional and structural changes in ischemic and hemorrhagic nature (swelling of the brain, periven-tricular leukomalacia, intraventricular haemorrhage) and without them, with hypoxic-ischemic brain damage. The correlation between the anthropometric data and performance level of BDNF are marked.

Key words: brain neurotrophic factor (BDNF), hypoxico-ischemic CNS involvement, periventricular leuko-molacia, intraventricular hemorrhags, ely born children.

 

 

Laponog S.

аЕЕG changes after hypoxic injury in the newborns with hypoxic-ischae-mic encephalopathy treated by therapeutic hypothermia.

178

These preliminary results show decrease in mortality without significant increasing major neurodevelopmen-tal disability. Farther follow-up is needed. Еvolution of amplitude-electroencephalographic (аEEG) changes after hypoxic injury was observed mature newborns with hypoxic-ischaemic encephalopathy treated by the-rapeutic hypothermia. Appearance of DNV pattern within 148,8 hours after birth was associated with normal neurodevelopmental outcomes at 12-18 months. The time of SWC onset has a predictive value for neuro-developmental outcome at 12-18 months.

Key words: hypoxic-ischaemic encephalopathy, therapeutic hypothermia, newborns with sever asphyxia.

 

 

Farkhat A. G.

Treatment of anovulatory infertility in women with polycystic ovary syn-drome.

182

Proposes a new solution of the urgent problems of modern gynecology – restore reproductive health of women with polycystic ovary syndrome. A comprehensive treatment plan of the hypothalamic-pituitary-ovarian dysfunction in PCOS with the inclusion of nicergoline, which is a correction of cerebral metabolism and peripheral blood flow. It is shown that the inclusion in the scheme of nicergoline complex conservative treatment of patients with PCOS Bol than half percent of cases ensures a positive clinical outcome.

Key words: anovulatory cycle, infertility, PCOS.

 

 

Vdovichenko J. P., Beraja D. J.

Features of barreness and condition of ovarial reserve at women with autoimmune thyroid gland pathology.

185

Results of the spent researches testify, that at patients with barreness prevalence thyreoidal pathologies in 3,8 times above in comparison with fertility women (48% and 12,5%). In structure of a pathology of a thyroid gland prevails carrier of antibodies to thyreoperoxidase in a combination to ultrasonic signs autoimmune thy-reoidite (24% and 8,7%); subclinical hypothyreos (8,6% and 2,5%) and euthyreoidal craw (7,8% and 2,5%). The obtained data testify to decrease in key parametres of ovarial reserve at patients with autoimmune thy-reoidite in comparison with group of women without a thyroid gland pathology that is possibly connected with autoimmune genesise of this pathology. The leading place in structure of the reasons of barreness at women with autoimmune thyreoidite occupies external genital endometriosis (34,4%); At patients with hypothyreos – endocrinological barreness (29,8%), at women with euthyreoidal craw and without a thyroid gland pathology – tube-peritoneal barreness factor (33,3% and 39,8%). The received results are necessary for considering by working out of algorithm of diagnostic and treatment-and-prophylactic actions.

Key words: barreness, thyreoidal pathology, ovarial reserve.

 

 

Яков Порфирьевич Сольский (к 90-летию со дня рождения).

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Домашние роды: прошлое, настоящее, будущее

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