HEALTH OF WOMAN WH_№1_2011

  • Scientific and practical journal
  • ISSN 2307-5074 (Online); ISSN 1992-5921 (Print)

  • DOI:
  • DOI: 10.15574/HW
  • Circulation -
  • 5500
  • Format of the edition -
  • 280x210 mm
  • Frequency -
  • 10 issues a year

Науково-практичний семінар «Актуальні питання збереження репро-дуктивного здоров’я жінок в Україні». Сторінками доповідей.

11

 

 

Актуальные вопросы практической гинекологии.

17

 

 

Малоинвазивная хирургия в гинекологии: женщина имеет право ос-таться женщиной!

21

 

 

Інформаційне повідомлення з робочої наради президії Асоціації акушерів-гінекологів України.

25

 

 

Dho G., Marchese F., Debbia E. A.

Микробиологическая характеристика Lactobacillus plantarum Р17630, содержащейся в пробиотическом препарате Гинолакт для интраваги-нального применения.

27

Проведена оценка концентрации Lactobacillus plantarum (L. plantarum) P17630 – микроорганизма, ис-пользуемого в качестве пробиотика при вспомогательном лечении различных инфекционных заболе-ваний половых путей. Свечи Гинолакт предоставлены компанией «Шарпер». Концентрация бактери-ального загрязнения составляла приблизительно 4×108 колониеобразующих единиц (КОЕ) в 1 мл. Этот штамм был единственной молочнокислой бактерией, выявленной в содержимом влагалища, способной расти в присутствии ванкомицина (12 мг/л) или в среде, содержащей рибозу. Кроме гли-копептида ванкомицина и тейкопланина, микроорганизм оказался резистентным к норфлоксацину, фосфомицину, метронизадолу, клиндамицину, флуконазолу и вориконазолу, а также чувствительным к другим препаратам. L. plantarum P17630 может расти на тампонной основе при рН 4 и 6,5, темпера-туре 30, 37 и 43 °С. Кроме того, штамм способен создавать биопленку. На основе анализа этих фактов сделано заключение, что L. plantarum P17630, входящий в состав свечей Гинолакт, обладает всеми свойствами, необходимыми пробиотику для вагинального применения.

 

 

Повышение медицинской культуры пациенток – залог успешной работы врача.

31

 

 

Образ жизни современной женщины как один из факторов, влияющих на репродуктивное здоровье.

33

 

 

Подольский В. В., Подольский Вл. В.

Гиперактивный мочевой пузырь – проблема женского здоровья (пути коррекции в современных условиях).

35

 

 

Vdovichenko J. P., Shelygin A. S.

Actual aspects of disease of women – medical workers.

39

Results of the spent researches testifies to high frequency of professional disease of medical workers of a various link – doctors and nurses. The received results are necessary for considering by working out of algorithm of diagnostic and treatment-and-prophylactic actions.

Key words: medical workers, disease.

 

 

Загородня О. С., Маркитанюк С. В.

Профілактика вагінального кандидозу після штучного переривання вагітності за допомогою препарату Ітракон®.

41

 

 

Пирогова В. И., Семчишин Р. С.

Эффективность и безопасность нового орального контрацептива на основе эстрадиола (эстрадиола валерат / диеногест) Обзор клиниче-ских исследований.

44

Цель исследования: оценить эффективность и безопасность нового орального контрацептива (ОК), содержащего эстрадиола валерат (Э2В; 1 мг Э2В эквивалентен 0,76 мг 17 бета-эстрадиола) и диено-гест (ДНГ). Дизайн исследования: многоцентровое, открытое, несравнительное исследование из 20 циклов проведено в Германии, Австрии и Испании среди здоровых женщин в возрасте 18–50 лет. Э2В/ДНГ применяли с использованием пошагового снижения дозы эстрогена и пошагового повыше-ния дозы прогестина в течение 26 дней (3 мг Э2В – в 1–2-й дни, 2 мг Э2В / 2 мг ДНГ – в 3–7-й дни, 2 мг Э2В / 3 мг ДНГ – в 8–24-й дни, 1 мг Э2В – в 25–26-й дни, плацебо – в 27–28-й дни). Первичным крите-рием результата применения данного ОК служило количество беременностей на фоне приема препа-рата в подгруппе 18–35-летних женщин. Эффективность контрацепции оценивали путем определения индекса Перла (количество беременностей на 100 женщино-лет приема). При окончательном осмотре определяли уровень удовлетворенности женщин лечением. Результаты: в рамках исследования 1377 женщин применяли препарат Э2В/ДНГ, из них у 13 пациенток на фоне лечения наступила беремен-ность (нескорректированный индекс Перла – 0,73), шесть – вследствие ошибки метода (скорректиро-ванный индекс Перла – 0,34). В подгруппе из 998 женщин в возрасте 18–35 лет зафиксировано 12 беременностей (нескорректированный индекс Перла – 0,94), 5 – вследствие ошибки метода (скоррек-тированный индекс Перла – 0,40). Большинство женщин (79,5%) были либо удовлетворены, либо очень удовлетворены лечением. Побочные явления, связанные с лечением (связь рассматривалась как возможная), наблюдались у 19,8%. В целом на протяжении 20 циклов лишь 10,2% исследуемых преждевременно прервали лечение из-за побочных явлений. Выводы: новый ОК на основе естради-ола обеспечивает высокоэффективную и надежную контрацепцию благодаря комбинации эстрадиола валерата (Э2В) и диеногеста (ДНГ) в режиме динамических дозировок на протяжении 26 дней приема активных таблеток и 2 дней – плацебо. Препарат хорошо переносится и ассоциируется с высокой степенью удовлетворенности потребителей и низким показателем прерывания лечения.

Ключевые слова: индекс Перла, эстрадиола валерат, диеногест, оральный контрацептив, Клайра.

 

 

Zhabchenko I. A., Tzypkun A. G., Zhizky A. M., Skripchenko N. Y.

Moderm Approaches to the Placental Insufficiency Problem and Fetus Growth Inhibition (Literature data overview and results of clinical rese-arch of effectiveness and tolerability of Glutargin medication of pregnant women with placental insufficiency with the fetus intrauterine growth inhibition).

52

Present:day literature data about particularities of pathogenesis, diagnostics, placental insufficiency, and its role in fetus growth inhibition and further influence on the pregnancy and delivery is covered in the article. The conclusion has been drawn about Glutargin positive influence on the fetoplacental system, uterine and placental, placental and fetal blood flow. It shows fetus state improvement as a consequence. Glutargin is recommended to be included in the treatment complex of pregnant women with placental insufficiency and fetus intrauterine growth inhibition.

Key words: pregnancy, placental insufficiency, fetus intrauterine growth inhibition, diagnostics, ultrasonic dopplerometrics, Glutargin, treatment, preventive measures.

 

 

Вдовиченко Ю. П., Жук С. И., Мельник О. В.

Беременность двойней – двойное требование к материнскому органи-зму (обзор зарубежной литературы).

64

 

 

Брюно де Линьер

Натуральный прогестерон и его особенности.

68

Обзор посвящен особенностям натурального прогестерона и его отличиям от синтетических прогес-тагенов с точки зрения химической структуры, особенностей связывания с рецепторами, фармакоди-намических свойств и клинических эффектов. Описаны антиальдостероновый эффект натурального прогестерона, а также его метаболиты и их роль в регуляции физиологического уровня андрогенов,механизмы токолитического и анксиолитического действия. Обоснованы преимущества натурального прогестерона перед синтетическими прогестагенами при лечении бесплодия и невынашивания бере-менности. Описаны показания к применению натурального прогестерона в акушерстве и гинекологии. 

 

 

Радзинский В. Е., Ордиянц И. М.

Предменструальный синдром и доброкачественные дисплазии груд-ных желез: реалии и перспективы.

71

 

 

Заключение Рабочей группы Российского общества акушеров-гинекологов по применению микронизированного прогестерона (Утро-жестана).

76

 

 

Венцковская И. Б., Белая В. В., Витовский Я. М., Венцковский К. О.

Онкопатология при беременности: опыт клинических наблюдений.

78

Boris O. M., Sumenko V. V., Kaminskiy A. V., Gak I. O., Malysheva I. V.

Treatment for bacterial vaginosis.

82

The article deals with the use and efficacy of Vahiklin (vaginal capsule which contains 100 mg klindamicine phosphate, 100 mg clotrimazole and produced by Erica Pharma Pvt. Ltd., marketing exercise of the Euro lifecare) as an antimicrobiotic treatment of bacterial vaginosis and mixed infections in women with cervical background processes. After the study was the positive dynamics of subjective and objective condition of the patients indicated good tolerability and safety of this drug.

Key words: Vagiclin, bacterial vaginosis, mixed infections, cervical background processes.

 

 

Nikolin L. B., Yaztsyshyn N. G., Kukurudz S. M., Voloshkevych Y. P.

Efficiency and Safety of Original Cabergoline Use in Patients with the High Risk of the Ovarian Hyperstimulation Syndrome in the Assisted Reproductive Treatment Cycles.

91

On the basis of the given research with the aim of explaining the dependence at the OHS superovulation stimulation in the assisted reproductive treatment (ART) cycles and its severity degree due to the original cabergolin application in the dose of 0.5 mg per day, starting with the next day of the follicule puncture for the period of 5 – 8 days in order to prevent a recurrence of this condition, the frequency of OHS occurance of moderate and severe degree has been proven. At its onset the alleviation of the symptoms and the reduction of the time of duration without influence on the gestation rate and its further development has been exami-ned. The dynamics analysis of OHS has been carried out according to the clinical and laboratory data. The-refore, according to the OHS duration, the dynamics of rising and the reduction of symptoms, it can be noted that the patients, receiving the original cabergolin, had seldom severe forms of OHS, the duration of OHS was shorter. It is shown by better dynamics of laboratory findings normalization.

Key words: Ovarian Hyperstimulation Syndrome, assited reproductive treatment (ART), cabergolin, dopamine agonistic.

 

 

Lisitsyna N. V.

Efficiency of the combination of phytomedicines in treatment of dyshormonal noncancerosus hyperplasia of mammary glands and accompanying depressions.

95

The problem of treatment of noncancerous diseases of hormonal dependent organs of a female organism is lighted up in the article. Information about influence of dyshormonal infringements in morphofunctional reor-ganization of mammary glands is resulted. High clinical efficiency of joint action of preparations Mastodynon® and Helarium Hypericum® in treatment of dyshormonal diseases of mammary glands and correction of accompanying depressions is convincingly proved.

Key words: mammary glands, dyshormonal infringements, mastopathy, Mastodynon, Helarium Hyperi-cum.

 

 

Vdovychenko Yu. P., Gopchuk E. N.

Ciprolet – preparation of choice in treatment of women with an aquite cystitis.

98

The most frequent display of the uncomplicated infections of urinary tract are aсute cystitis. Treatment of cystitis became the content with difficult in connection with increasing bacterial stability to the anti-infectives, especially to the beta-lactame antibiotics and trimeteprim-sulfametocsazole. Ciprofloxacin (Ciprolet) renders the rapid bactericidal operating on microorganisms, being both in the stage of rest and reproductions. On the basis of the conducted research we came to the conclusion about efficiency of the use of Ciprolet in therapy of the acute uncomplicated bacterial cystitis of women. Correlation of price and quality of preparation, and similarly possibility of step therapy and efficiency of setting a short course makes him one of the preparations to choose in treatment of women with an acute cystitis or intensifying of recrudescent cystitis.

Key words: сystitis, Ciprofloxacin, Ciprolet, treatment.

 

 

Boyko V. I., Babar T. V.

Tactics of conducting a lactation at intraamnial infection.

102

Results of the spent researches testify, that a lactation at women with a virus infection in the anamnesis, demonstration during pregnancy and at delivery is very important scientific task, which decision should have the differentiated character taking into account received by us results. It will allow to seize results delivery patients with a virus infection in the anamnesis, especially in aspect of normalisation lactation function and preventive maintenance hypogalactia.

Key words: intraamnial infection, a lactation.

 

 

Boris E. N., Shalko M. N., Malusheva I. V., Sorokina I. V.

Correction of postoperative intestinal paresis development.

104

The work contains problems of prevalend, reasons end mechanisms of development of the pathology and olso metods of correction of postoperative paresis of intestine in women undervent operative treatment using laparoscopic and abdominal access on organs of smoll pelvis. The data indicating the importence of Espumi-zan treathment to prevent and remove disorder of motor fanction of intestine in patients are represented in the article all this positively influences the guality of recover of operated patiets and allows decreasing dura-tion of bad-deys in the hospital that is economically beneficial and nessecary for the clinic and the state as well.

Key words: early postoperative period, Espumizan®, postoperative paresis of intestine, constipation, mete-orism, difficulty in passage of flanes.

 

 

Venckovskij B. M., Kaminskyy A. V.

ARVI in pregnant womеn: particularity of diagnostic and flow.

110

This article reflectes etiological factors which cause disease of anacute respiratory virus infection (ARVI), and also particularity of diagnostic criteria of respiratory diseases of conducting airway in pregnant womеn.

Key words: acute respiratory virus infection, pregnancy, respiratory organs, immune system, the anamnesis.

 

 

Ковригина Е. С., Казанец Е. Г., Карамян Н. А., Айвазова Д. Х., Лукьянова Е. Г., Панфилова Е. Л.

Современные методы диагностики железодефицитной анемии у беременных и критерии оценки эффективности ферротерапии.

114

 

 

Подольський В. В., Дербак А. В.

Стан репродуктивного здоров’я вагітних, яким проведено хірургічне лікування цервікальної інтраепітеліальної неоплазії до вагітності.

118

 

 

Kuzemenska M. L.

Influence of various localisation leiomyoma of uterus on obstetrical and perinatal outcomes of delivery.

123

Results of the spent clinical-functional researches, women with presence leiomyoma of uterus make group of high risk on development perinatal pathologies against burdened pregravidare background, the complicated current of pregnancy, infringements uterine-placentary, and in further and born-placentary haemodynamics, a condition of unstable balance hormonalsyntecical and metabolic function of a placenta with excessive pressure and a gradual exhaustion adaptable possibilities of system mother-placenta-born. All it, and also insufficient efficiency of the standard treatment-and-prophylactic actions, is the essential basis for working out and introduction of the differentiated complex of treatment-and-prophylactic actions at pregnant women with leiomyoma of uterus of various localisation.

Key words: leiomyoma of uterus, pregnancy, childbirth.

 

 

Boyko V. I., Kalashnik N. V.

Cesarean Section of Women with a Metabolic Syndrome.

126

The obtained results show, that the double layer Roverdenovsky stitch is an optimum technical variant of a uterus cut sealing of women with the uterus scar and with the metabolic syndrome. It is also effective at first abdominal delivery. The given technique, proved by the research, can be recommended for a wide use in practical public health services.

Key words: a cesarean section, a metabolic syndrome.

 

 

Gopchuk E. N.

Efficiency of medical and preventive application of preparation Lioton 1000 gel at chronic venous insufficiency during pregnancy.

128

From data of different authors for the 50–96% women of chronic venous insufficiency (CVI) first appears du-ring pregnancy by reason of origin of additional factors. Pharmacological therapy of CVI is based on applica-tion of medications, the action of which is sent to stabilizing of structural components of venous wall, increa-se of her tone and improvement of microcirculation. We conducted research the purpose of which was an estimation of efficiency of application of preparation of Lioton 1000 gel for pregnant with CVI. The conducted clinical research enables to draw conclusion, that local application of preparation Lioton 1000 gel for the pregnant was an effective method of treatment of CVI and prophylaxis of venous complications.

Key words: сhronic venous insufficiency, treatment, prophylaxis, Lioton 1000 gel.

 

 

Грищенко О. В., Сторчак А. В., Шевченко О. И.

Преимущества антибактериальной терапии орнидазолом при опера-тивном родоразрешении пациенток с преждевременным излитием околоплодных вод.

132

 

 

Игнатко И. В., Октябрьская Е. А.

Опыт использования Актовегина при фетоплацентарной недостаточности у беременных группы высокого риска внутриутробного инфицирования плода.

137

 

 

Mogilevkyna I. O., Kachur А. Yu., Illyna I. O., Shemyakyna N. M., Babenko О. М.

«Gold standard»: is it really gold for estimating of postpartum blood loss in case of vaginal delivery.

142

The authors conducted the study to compare the quantity of postpartum blood loss in case of vaginal delivery estimated by weighing and by photometry. It demonstrates greater accuracy and the usefulness of blood loss assessment using the «HemoСue Plasma/Low Hb» photometer. The formula for calculating of true blood loss was proposed based on the data obtained by weighing.

Key words: postpartum blood loss, weighing, free hemoglobin.

 

 

Prishchepa A. P.

Placentary dysfunction at pregnant women with a syphilitic infection.

145

Results of the spent researches testify, that additional use антигомотоксической for correction of placentary dysfunction at patients with a syphilitic infection allows to seize therapies obstetrical and perinatal outcomes of delivery at the expense of improvement a functional condition fetoplacental complex and correction of system immunity. The received results allow recomend given a technique for wide use in practical public health services.

Key words: a syphilitic infection, placentary dysfunction.

 

 

Boris E. N., Sumenko V. V., Onishchik L. N., Bondaruk O. Y., Malysheva I. V.

The New View on Treatment of the uncomplicated infections of urogeni-tal system of pregnant women.

147

The article represents the results of studing an efects of AflazinTM as antibacterial preparation for pregnant women with uncomplicated infections of urogenital system. We get positive dynamics of women subjective and objective status, good reactions and safety of this preparation.

Key words: uncomplicated infections, urogenital system, AflazinTM, reproductive health, antibacterial the-rapy.

 

 

Jaremko M. I.

Pregnancy and childbirth at women with an endometriosis in the anam-nesis.

153

Results of the spent researches testify, that the functional condition fetoplacental complex at women with an endometriosis in the anamnesis is characterised by high level of infringements from a functional condition of a born, a placenta and volume amniotical waters against expressed haemodynamic and endocrinological infringements, in the core, the subcompensated character, but in some cases and decompensated changes that leads to high frequency operative delivery in this group. Use of an offered technique allows to spend essentially correction of placentary dysfunction and to warn development serious obstetrical and perinatal complications.

Key words: pregnancy, childbirth, an endometriosis.

 

 

 

Shlapak I. M.

Perinatal outcomes repeated cesarean sections.

155

The carried out analysis has shown, that after repeated cesarean sections the condition of newborns authen-tically is worse than section, that it is possible to explain a significant amount of premature birth (22,0%) and high frequency of placentary insufficiency (20,0%). Healthy at a birth there were 47,0% of newborns of the basic group and 44,0% of newborns of group of comparison. Other children had a various pathology, basica-lly complex. The neurologic infringements, which frequency authentically between newborns of both groups prevailed did not differ (17,0% and 18,0%, р>0,05), but was above among children of the basic group (30,0%). At the newborns taken at a repeated cesarean section, in 30,0% of cases signs morhpofunctional immaturity, that much more often, than in comparison group (16,0%), despite lacking an authentic difference (p>0,05) were noticed.

Key words: a repeated cesarean section, perinatal outcomes.

 

 

Sadovoj A. P.

Optimisation of forecasting of an arrest of development of a born at vari-ous forms of placentary dysfunction.

157

Results of the spent researches testify, that forecasting of an arrest of development of a fruit at women with various forms of placentary dysfunction is a basis of rational tactics of conducting pregnancy and a method choice delivery. The offered technique is enough simple and popular, that gives the chance its wide use in practical public health services.

Key words: a born arrest of development, placentary dysfunction, forecasting.

 

 

Zaporozhan V. M., Mikhailenko O. V.

The state of redox homeostasis of patients with endometriosis.

159

In plasma and cytosol of red blood of patients with endometriosis observed significant increase in the content sulfhydryl groups decrease disulfid compounds soluble proteins and low molecular compounds and thus increase the correlation between SH / SS-groups. In the plasma of patients with endometriosis is significantly increased content of oxidized and reduced nikotinamid coenzymes and decrease the ratio of NAD / NAD•N. In plasma and red blood endometriosis patients had increased POL place against the backdrop of moderate growth of glutathionereductase and reciprocal reduction of superoxide. Described changes characteristic of metabolic acidosis and evidence of adaptive capacities of the strain.

Key words: endometriosis, acid-based balance, oxidative stress.

 

 

Potapov V. A.

Clinical Judgement of Effectiveness of Nonsteroidal Antiinflammatory Drug Revmoksikam in Pain Syndrome Relief at Primary Dysmenorrhea.

163

The degree of effectiveness and safety of home Cox-2 selective inhibitor, Revmatoksikam (rectal supposito-ries, 15 mg) in primary dysmenorrheal (PD) treatment of 20 patients have been estimated. The pain syndro-me intensity before and after treatment was assessed according to the VAS 10-point score. All patients with PD, especially with the mild dysmenorrhea, had an apparent analgetic and a good clinical performance of rectal suppositories Revmatoksin use (meloxicam) one time per week. A steady effect has been achieved after a single treatment on the first menstruation day. The conclusion about drug Revmoksikam use advi-sability has been drawn while treating abnormal PD. Due to good tolerability and absence of adverse events after its application in the form of rectal suppositories, 15 mg the chosen therapy regiment can be considered safe and optimal.

Key words: primary dysmenorrheal, pain syndrome, Revmoksikam.

 

 

Podol'sky V. V., Gul'chiy M. M.

Effects of Tobacco Smoking on Reproductive Health of Fertile Age Wo-men.

167

In this systematic review we address the central remaining question of how tobacco smoking affects fertility and discuss possibilities for intervention policy. Smoking prevalence in Ukraine among women of reproduc-tive age is 11,2%. Published data suggest that smoking is associated with impared folliculogenesis, stero-idogenesis, implantation and early placentation, endometrial receptivness and tubal function which can lead to infertility and increase the risk of complications during pregnancy. This evidence strongly supports the promotion of smoking cessation in fertile age women that could be achieved through effective policies and programs.

Key words: fertility, tobacco smoking, folliculogenesis, endometrium, implantation.

 

 

Gopchuk E. N.

Treatment and prophylaxis of ovulation syndrome for women on a background therapy of syndrome of policyst ovaries.

171

An information about the modern aspects of syndrome of policyst ovaries presented in the article. Clinical experience over of the use of nonsteroid antiinflammatory preparations is brought with the purpose of pro-phylaxis and therapy of ovulation syndrome for women on a background stimulation of ovulation.

Key words: syndrome of policyst ovaries, treatment, prophylaxis, nimesulid.

 

 

Hasanova N. N., Aliyeva E. M., Asadova Sh. Sh.

Particulary of postmenopausal osteoporosis from women with surgery menopauza.

174

Perpuse of investigation: To investigate clinical, functional, hormonal results and data using photon absorpti-ometry from women with surgery menopauza. Methods & material of investigation: To investigate 75 patients with ovario-and histeroektomiya. Were define leves of FSH, LH, E2, high density lipoprotein-xolesterol, low density lipoprotein-xolesterol and used bone densitometry. Resuls of investigation: Incidence of postmenopausal of osteoporosis from women with surgery meno-pauza consist 10%.Was define high incidence of osteopeniya from this patients.

Key words: osteoporosis, osteopeniya, surgery menopauza, ovario-and histeroektomiya.

 

Сенчук А. Я., Доскоч І. О.

Ефективність місцевого використання комбінованих препаратів для лікування вульвовагінітів у гінекологічній практиці.

177

 

 

Ledin D. S.

Influence peroral and vaginal hormonal contraception on changes micro-biocenose sexual ways.

182

Results of the spent researches testify to absence of negative influence of various methods of hormonal contraception on a condition microbiocenose sexual ways. It is necessary for considering at working out of algorithm of preventive maintenance of not planned pregnancy, especially at women with initial infringements microbiocenose sexual ways.

Key words: hormonal contraception, microbiocenose sexual ways.

 

 

Dankina I. A., Dzhelomanova S. A.

Use of monophase oral contraceptives for cupping of premenstrual syndrome.

186

We study the role of the preparation Regulon at treatment of premenstrual syndrome at the women of a different age. It is exposed, that this estrogen-gestagen preparation is effective for сupping of most symp-toms of difficult pathological complex arising up in premenstrual days. This research allows to recommend the preparation Regulon for treatment of patients with a premenstrual syndrome.

Key words: premenstrual syndrome, menstrual cycle, contraceptive preparation Regulon.

 

 

Потапов В. А.

Опыт использования гигиенического средства «Гинофит» в коррек-ции кислотности влагалища у женщин репродуктивного возраста с отрицательным посткоитальным тестом.

189

 

 

Логутова Л. С., Гаспарян Н. Д., Горенкова О. С., Кручинина Е. В., Алимова Н. Г.

Противорецидивный эффект различных антимикотических препаратов местного действия.

192

 

 

Nastradina N.

Treatment optimisation recedive background diseases of a cervix of a uterus.

196

Results of the spent researches testify, that the complex approach to the decision of a difficult scientific prob-lem with additional use of immunocorrectiontherapies allows to raise efficiency of treatment and to lower frequency recediving. It allows recomend the given technique for wide use in practical public health services.

Key words: recedive background diseases of a cervix of a uterus, treatment.

 

 

 

Strahovezky V. S.

Modern aspects of pyoinflammatory diseases of appendages of a uterus.

198

Results of the spent researches testify, that for formation of the full clinical characteristic of the patients, ap-pendages of a uterus suffering by pyoinflammatory diseases probably on the basis of the analysis of age of patients, the social status, features of formation menstrual function and kinds of its infringements, age of the beginning of a sexual life, studying of genital function and frequency of abortions, duration of use intrauterine contraceptive, the reasons of development of pyoinflammatory diseases of appendages of a uterus frequen-cy intrauterine the interventions, the transferred gynecologic diseases and operative interventions. Carefully spent clinical characteristic of patients will allow to develop the most effective algorithm of diagnostic and treatment-and-prophylactic actions.

Key words: pyoinflammatory diseases of appendages of a uterus, aspects.

 

 

Boyko V. I., Terehova N. I.

Preventive maintenance postoperative complications at gynecologic sick senior age groups.

201

Results of the spent researches testify, that the advanced technique preventive maintenance postoperative complications at sick senior age groups with genital pathology allows to lower essentially frequency posto-perative complications. It occurs against adequate correction of infringements micribiocenoce of sexual ways and the immune status. The technique is idle time, popular and wide application in practical public health services can find.

Key words: gynecologic patients, postoperative complications, preventive maintenance.

 

 

Boris E. N., Sumenko V. V., Malysheva I. V., Bondaruk O. Y., Shalko M. N.

Optimizing treatment strategy of chronic vaginal candidiasis in womеn of reproductive age.

203

The article analyzed the efficacy of the drug product Funit (capsules of 100 mg, daily dose of 200 mg) ma-nufactured by “NOBEL PHARMA” as antimicrobiotic and antifungal therapy in womеn of reproductive age with chronic vaginal candidiasis. The positive dynamics of subjective and objective states surveyed, good tolerability and safety of this drug, improving the quality of life for womеn.

Key words: chronic vaginal candidosis, Funit, Candida nonalbicans.

 

 

Nosenko O. M., Rutynska G. V.

Dismenorm in the treatment of premenstrual syndrome (dysphoric disor-der of late luteal phase).

209

The authors studied the effectiveness of Dismenorm in premenstrual syndrome. It is proved that the inclusion of Dismenorm in a comlex treatment of premenstrual syndrome for 3 months significantly reduces the avera-ge duration of the manifestation of its symptoms in a loop in 3.45-fold, reducing the average frequency of persistence of 16 of 29 symptoms in 2,08 times, lower level of prolactin in 1,31-fold and increased level of progesterone in the 1,90-fold. Natural products of Dismenorm avoid side effects and allergies. The authors believe that the drug may be recommended for widespread use in clinical practice for the prevention and treatment of premenstrual syndrome as firstline drugs before prescribing hormones and the selective sero-tonin reuptake inhibitors, as well as in patients with intolerance to hormonal preparations.

Key words: premenstrual syndrome, dysphoric disorder late luteal phase, the quality of life, Dismenorm.

 

 

Vikhlyaeva E. M., Savel’eva I. S., Gorodnicheva Zh. A.

Possibilities of a clinical use of antiprogestins in obstetrics and gyneco-logy.

216

The possibility of using antiprogestins in obstetric and gynecological practice for therapeutic purposes is determined by a key role of progesterone in a complex regulation of normal functioning of the reproductive system and by specificity of realization of its inherent physiological effects due to the presence of progeste-rone receptors with tissue selective properties in the target organs. Determination of a selective contribution of Pr-A and Pr-B in the physiological action of progesterone was the basis for a targeted use of antiproges-tins in obstetric and gynecological clinical practice. Mifepristone – a synthetic steroid with antiprogestagen properties – is capable of strong bonding with progesterone and glucocorticoid receptors, and also has anti-glucocorticoid and weak antiandrogen activity and double progestin-agonist/antagonist activity. The pre-sented evidence indicates a wide range of problems arising in connection with a possible clinical use of antiprogestins in clinical practice. It is also evident that this branch of reproductive medicine has a potential for further development in both fundamental research and clinical application.

Key words: pharmaceutical abortion, uterine leiomyoma, mifepristone, misoprostol.

 

 

Vdovichenko J. P., Lysenko B. M.

Features of genital endometriosis at patients with thyroid dysfunction.

226

Results of the lead researches testify, that at patients with an endometriosis and a pathology of a thyroid gland are revealed following clinical displays: an anemia, adiposity, later menarhe, short menstrual cycle. At these patients the combination to a myoma of a uterus on a background of infringement hypotalamo-hypo-fizare regulation expressing in decrease of function ovaries and functional activity of a thyroid gland is fre-quently marked. Reduction free threeiodtyronine is most expressed at an endometriosis and a pathology of a thyroid gland. Decrease in functional activity of a thyroid gland is combined with dysfunction hypotalamo-hypofizare system accompanying with decrease of function ovaries. The received results are necessary for taking into account in practical public health services at carrying out of diagnostic and treatment-and-prophy-lactic actions.

Key words: diseases of a thyroid gland, an endometriosis.

 

 

Zaporozhan V. M., Dubinina V. G., Boris O. M.

The role of functional genetic polymorphism in developing the ovarian hyperstimulation syndrome in the ART use amongst patients with polycystic ovarian syndrome.

228

The study was aimed to assess the role of polymorphism of FSHR and ESR1 genes in the determination of OHS during the use of the modern reproductive technologies amongst females with PCOS. There was stated that the frequency of SS genotype by FSHR is 39%, SN – 48%, NN – 23%, GG genotype by ESR1 – 39%, GA – 50%, AA – 11% among females with PCOS. The incidence of OHS was 31.0% amongst the patients whereas the combination of heterozygote genotypes SN by FSHR and GA by ESR1 increases the risk of OHS in three folds (OR=3,1 ДІ 95% (2,5; 3,6). The combination of homozygote variants i.e. NN by FSHR and AA by ESR1 makes the outcome be unlikely. For prognosis and prevention of the unfavorable clinical outcomes viz. OHS when ART is used among females with PCOS there is expediently to implement into the clinical practice genotyping with the detection of allele variants of FSHR and ESR1.

Key words: polycystic ovarian syndrome, ovarian hyperstimulation syndrome, genetic polimorphism, assisted reproductive technologies.

 

 

Rozhkovska N. M., Strelnik A. I., Shevchuk A. V.

Vaccine effectiveness against genital papillomavirus infection: the role of immune status and prospecives of improvement method.

233

The study was to evaluate the effectiveness of vaccine genital papillomavirus infection depending on immu-ne status. Shown that women with HPVI in 70% cases of cervical dysplasia occurs under CINI-CINII, in 12,5% – inflammatory pelvic disease in 77,5% – co:infection with herpes simplex virus types 1 and 2. In 25% patients infected with HPV were determined vysokoonkohenni virus strains, while in 12,5% of patients took place in several strains of HPV infection. For patients HPVI is characterized by high activity of secretory IgA immunoglobulin in a moderate increase in IgM antibody activity and normal activity levels of IgG, α-interferon and γ-interferon. However, in 52,5% of patients have one or more indicators of humoral immunity at the bot-tom border of norm. Vaccines in HPVI without immunotherapy can significantly reduce the risk of relapse (safety explosives = 0,18 (CI 95% – 0,08, 0.42). Against Immune interferon inductors increases vaccine effi-cacy (safety explosives safety explosives = 0.91 (0,04, 4.07).

Key words: genital papillomavirus infection, vaccine, immunity, immune correction, interferon inductors.

 

 

Grishchenko O. V., Lakhno I. V., Ostanina V. I., Ovcharenko A. T.

Lavomax application for the treatment of genital human papillomavirus infection in women.

236

We have examined 84 patients with HPV infection which were prescribed 10 pills of Lavomax according to the protocol. The patients with HPV have shown the signs of extragenital chronic inflammatory diseases in combination with various gynecological diseases. The HPV infection was accompanied with vaginal dysbio-sis characterized by a predominance of anaerobic, coccal flora and the presence of Candida and ureaplas-ma. It was associated with immunodeficiency. The Lavomax application has improved the processes of pha-gocytosis and vaginal flora restoration. It has provided the elimination of HPV in 98.8% of cases, the comple-te irreversible effect of warts destruction and cervical conization, further normal colposcopy in all cases.

Key words: human papilloma virus, treatment, Lovamax.

 

 

Тихомиров А. Л., Сарсания С. И.

Комплексное лечение смешанных генитальных инфекций.

240

 

 

Dubchak A. E., Milevsky A. V.

Cytomegalovirus Disease in Women with the Uterine Tube Peritoneal Infertility.

246

Women with the infertility of inflammatory etiology on the background of the inveterate cytomegalovirus disease (CMVD) have been examined. Microbiocenosis of the reproductive tract, the frequency of occurren-ce of CMD kinesis markers, the condition of immune system cellular component in women with the uterine tube peritoneal infertility, anti-inflammatory and antiviral treatment effectiveness have been scrutinized.

Key words: cytomegalovirus disease (CMVD), infertility, Valavir®.

 

 

Ribalka A. N., Zabolotnov V. A., Rumyantseva Z. S., Egorova Ya. A., Belyalova E. I., Kaznacheev E. A., Homulenko I. A.

Features of clinical picture at different tumular educations and tumours of ovaries at girlies and teenagers.

250

In the article the materials of inspection are represented 555 girlies and teenagers with tumular educations and tumours of ovaries in age from 3:18 years. The features of clinical picture at formations of ovaries in child’s and juvenile age are selected.

Key words: tumular educations and tumours of ovaries, girlies and teenagers, clinical picture.

 

 

Захарцева Л. М., Манжура Е. П., Вакуленко Г. В., Пекур Е. А., Пак Л. В.

Гиперэкспрессия белка p16INK4a в эпителиальных клетках шейки матки и его значение в оценке риска формирования рака.

253

 

 

Нікітін О. Д., Жабицька Л. А.

Етіопатогенетичні аспекти безплідного шлюбу.

259