HEALTH OF WOMAN WH_№ 5_2011
Carriero C., Lezzi V., Mancini T., Selvaggi L. and the Italian multicentre study group
Применение вагинальных капсул, содержащих Lactobacillus plantarum P 17630, в профилактике рецедивов кандидозного вульвовагинита: многоцентровое проспективное экспериментальное исследование.
Было проведено экспериментальное многоцентровое (на базе 17 женских консультаций Италии) проспективное исследование эффективности препарата на основе Lactobacillus plantarum Р 17630 в качестве вагинального пробиотика в профилактике рецидивов кандидозного вульвовагинита. В исследовании принимали участие женщины возрастной категории от 18 до 45 лет с клиническими проявлениями рецидивирующего неосложненного кандидозного вульвовагинита (КВВ). Общее количество пациенток, включенных в эксперимент, – 476, из них 252 пациентки составили группу наблюдения, которые одноразово получали после менструации 150 мг флуконазола в сочетании с мягкими желатиновыми капсулами препарата на основе Lactobacillus plantarum Р 17630 (Гинолакта); 224 женщины составили группу контроля (лечение только флуконазолом). Клинические результаты сравнивали на этапе включения (Т0), после 4 нед (Т4W) и после 4 мес (Т4М) терапии. Статистический анализ проводили на основе критерия Стьюдента, теста Уилкоксона и критерия хи-квадрата. После 4 мес процент излеченных пациенток в группе, получавшей Lactobacilli, был существенно выше (в 1,7 раза), чем в контрольной группе (82,9% против 71,9%; р=0,003). После 4 мес эксперимента в контрольной группе рецидивы КВВ были отмечены у 59 из 224 пациенток, а в группе наблюдения только у 22 из 252 ( в 2,7 раза меньше); OR=3,74 (2,20–6,34 95% С.І.) и р<0,001. Результаты этого исследования доказывают, что использование в схемах лечения ККВ на фоне антимикотической терапии препарата, содержащего Lactobacillus plantarum Р 17630 (Гинолакт), с микробиологически доказанными свойствами вагинального пробиотика может значительно улучшить результаты проводимой терапии.
Ключевые слова: Lactobacillus plantarum Р 17630, профилактика, рецидив, мягкие желатиновые капсулы, кандидозный вульвовагинит.
Pamfamirov Y. K., Zabolotnov V. A., Pamfamirova G. L., Kucherenko Y. A., Tatevosian A. G., Karapetian O. V.
The modern view on etiology, pathogenesis and treatment of uterine myoma.
The review of modern literature is presented about the existent theories of uterine myoma development. The hypothalamic-pituitary secretion disturbance and ovarian dysfunction are underlaid in existent theories of uterine myoma development. The growth of uterine myoma is predetermined the condition of uterus receptor apparatus. Role of progesteron is confirmed in induction mitogenic effect of growth factors. Molecular genetic reorganization, changes growth factors expression that influence on smoothmuscle cells proliferation and apoptosis are considerable as having a great import. In the light of existing data an angiogenesis is examined as a key factor in development of uterine myoma. The questions of hormonal and surgical methods of treatment are under discussion in patients with a uterine myoma.
Key words: uterine myoma, pathogenesis, hormonal, surgical treatment.
Boris E. N., Sumenko V. V., Gak I. A., Onishchik L. N., Malysheva I. V., Bondaruk O. Y.
Current approach to diagnosing precancer cervical diseases and prevention of cervical cancer.
This article coveres the optimization approaches to the diagnosing of precancer cervical diseases and prevention cervical cancer. Was shown dynamic changes in dysplastic epithelium. The necessity of primary and secondary prevention of cervical cancer by vaccine Gardasil based on own research nowadays.
Key words: precancer cervical diseases, prevention cervical cancer, papyllomovirus of human, kvadrovalente vaccine Gardasil.
Грищенко О. В., Сторчак А. В., Зиневич Е. М.
Возможности коррекции гемодинамических нарушений при гестозе путем восстановления функциональной активности эндотелия.
Gromova O. A., Torshin I. Yu., Hadzhidis A. K.
Adverse effects of iron sulfate in obstetrics, pediatrics and therapeutics.
Iron deficiency anemia is a frequent condition in children, pregnant women, people of middle and old age. Although mild forms of anemia often exist almost without symptoms, neglect of this condition leads to severe complications, reduces the quality and length of life. For treatment of iron deficiency anemia must use effective and safe iron-containing drugs. This article analyzes the safety of the various generations of iron-containing products and contains the latest findings from clinical studies on adverse effects of outdated pharmaceuticals based on iron sulphate.
Rozhskovskaya N. N., Gladchuk I. Z., Shapoval N. V., Rykhletsky V. N.
Preventive Treatment of Complications after Operative Hysteroscopy.
We performed over 200 operative ons uhysteroskopies using Turusol as dystension solution. Operative hysteroresektoskopies performed due to endometrial polyps (29%), hyperplastic processes of endometrium (27%), submucosal uterine fibroids (20%). Rarer indications include intrauterine synechia (5%), intrauterine septa (5%), retaining parts of the product of conception (3%) and retained fragments of intrauterine device (1%). The average duration of operation was 32,5+12,4 minutes, intraoperative blood loss was 80+25 ml. The frequency of intraoperative complications did not exceed 0.5% (cervical injury, uterine perforation, false entry into the myometrium). We had no incidence of water overload, severe injuries and infectious complications. We believe that the safety of clinical application of hysteroscopy, of course, but technology and operations experience of the surgeon depends on the adequate choice of distension solution. Turusol is the drug of choice as a safe, cost effective and efficient irrigate solution in operative hysteroscopy.
Key words: operative hysteroscopy, complication prevention, Turusol.
Клімактеричний синдром: ігнорувати не можна лікувати.
Kornatskaja A. G., Borisjuk O. J., Lisyanaya T. A., Romanova O. O.
Clinical and microbiological efficiency of application of preparations LIVAROL® and LAVOMAX® for treatment of women with chronic recurring vulvovaginitis caused by candida albicans.
Conducted clinical-laboratory research of efficiency of complex application of local antifungal preparation of LIVAROL®and an inductor of interferon LAVOMAX® (tyrolon 125 mg, tablets) in treatment of 60 women of fertile age with a chronic recurrent vulvovaginal candidiasis. Exposed, that complex application of the specified preparations testifies to high clinical and microbiological efficiency of treatment that allows to recommend their complex application to wide introduction in practice.
Key words: a chronic recurrent vulvovaginal candidiasis, anticandidosis preparation LIVAROL® (ketoconazol), an inductor of interferon LAVOMAX® (tyrolon).
Воронцова А. В., Звычайный М. А.
Состояние биоциноза влагалища при применении микронизированного прогестерона.
Булик Л. М., Ципкун А. Г., Давидова Ю. В., Апресова К. Г.
Преконцепційна профілактика метаболічних порушень у жінок з дифузним нетоксичним зобом.
Bajramova G. R., Kostava M. N.
Evaluation of efficacy and patients’ compliance to complex treatment of nonspecific vaginitis/cervicitis.
Background: the prevalence of nonspecific vaginitis/cervicitis in population is high.
Patients: thirty nonpregnant outpatients with a diagnosis of vaginitis/cervicitis were enrolled into this study.
Intervention: the treatment for every participating patient included: clindamycin phosphate 2% cream 100 mg intravaginally for three nights, Trichopol (metronidazole) 250 mg taken twice daily orally for five days, ofloxacin 200 mg taken twice daily orally for five days, fluconasol 150 mg orally on 2nd and 6th day of the treatment course. Total duration of the treatment course was 6 days.
Main outcome measures: clinical and microbiologic follow-up evaluations were scheduled for days 7–10 and 1 month posttreatment. Patients were interviewed for existing signs and symptoms, adverse events, and compliance.
Results: clinical success and bacteriological elimination were documented in all 30 patients after complex therapy. No serious adverse effects were reported. Mild nausea and dyspepsia in 4 (13,3%) patients resolved spontaneously without discontinuation of therapy. One episode of vulvovaginal candidiasis in 1 month after termination of treatment was attributed to the use of wide spectrum antibiotic for treatment of tonsillitis.
Conclusions: complex therapy appears to be an effective and safe treatment of symptomatic bacterial vaginitis/cervicitis in non-pregnant women.
Key words: vaginitis, cervicitis, clindamycin, metronidazole, fluconasol, ofloxacin.
Vdovichenko Y. P., Gopchuk E. N.
Anti-inflammatory therapy of acute salpingitis in women with polycystic ovaries.
Inflammatory diseases of the genital organs of women of childbearing age is one of the main causes of violations of reproductive health. Feature of the inflammatory lesions is a rare presence monoinfection. Given the importance and prevalence of inflammatory pelvic requires the correct choice of antimicrobial resistance, especially important the timely and quality treatment of acute inflammatory processes in women with chronic genital and neuroendocrine diseases, such as polycystic ovaries, as this group was originally in a state of impaired reproductive potential and requires a careful approach when choosing a therapy. The aim was to study the clinical efficacy of ciprofloxacin for the treatment of acute salpingitis in women with polycystic ovaries. Ciprolet drug use in treatment of this disease is effective and can reduce the time of therapy while maintaining therapeutic efficacy.
Key words: salpingitis, polycystic ovaries, ciprofloxacin, Ciprolet, treatment.
Gopchuk E. N.
Correction of neurological disorders in women with climacteric syndrome.
Women’s health in the perimenopausal period is not only medical but also social significance in connection with the change in the demographic structure of society. Among a variety of complaints voiced by women, there are symptoms psychological and organic. Many women experience depression, mood swings, sleep disturbance, anxiety, memory loss, headaches, due to a reaction to estrogen deficiency in the central nervous system. In the treatment of both acute and chronic pain in traditional medical practice is the use of nonsteroidal antiinflammatory drugs. Ibuprofen is traditionally considered the «gold standard» of security, which is particularly important in the treatment of chronic pain syndromes.
Key words: menopausal syndrome, headaches, migraine, Іbuprofen.
Bogomazova V. I., Roslaкov B. I., Strongovskay N. S., Bruk B. B.
Angiomyofibroblastoma. Case from gynaecology.
The interesting and rare case from the gynaecological practition – angiomyofibroblastoma of the vagina is considered in the article. The tumor was located in anterior part of perineal, in vaginal vestibule between external urethral meatus and minor lips with extention on anterior vaginal vault. The patient was diagnosed and operated by gynaecologist and urologist. The terminal diagnosis was defined after tumors immunohistology.
Key words: gynaecology, angiomyofibroblastoma, immunohistology.
Gopchuk E. N.
Chronic venous insufficiency: diagnosis, therapy and prevention of complications of pregnancy (literature review).
Pharmacological therapy CVI based on the use of drugs, for stabilizing the structural components of the venous wall, increasing its tone and improve microcirculation. The literary review shows the effectiveness of the drug Lioton-1000 gel in pregnant women for treatment and prophylaxis of venous CVI complications.
Key words: сhronic venous insufficiency, treatment, prophylaxis, Lioton 1000 gel.
Bondarenko N. P., Lakatosh V. P., Shirobokov V. P., Bobyr V. V., Gujevska I. V.
Lab-diagnostics and impact of parvovirus B19 infection on course of pregnancy.
The purpouse of investigation is to study the influence of parvavirus infection (PVI) on gestation. The investigation of 130 pregnant women with different gestational complications (43 patients in I trimester, 46 – in II and 41 in III) and 40 women with uncomplicated gestation in I,II and III trimester is carried out. It was made an immuneenzyme analisis for PVI B12 immunoglobulins G and M. All other TORCH agents are excluded at all patients. It is found out, that PVI infection by pregnancy is associated with such complications, as bortion, pretem labour, nonimmune hydrops fetalis, congenital malformation, placental disfunction , distress, asphyxia, anemia. The probability of fetal death decreases by pregnancy progressing. The investigation results confirm the expedience of PVI Ig diagnostic by pregnancy for perinatal loss decreasing.
Key words: parvovirus B19, parvovirus infection in pregnancy, nonimmune hydrops fetalis.
Duda O. K., Vdovychenko Yu. Р., Boyko V. O., Mamonenko-Morozova I. Yu.
Chronic viral hepatitis C in pregnant woman: clinical-epidemiologic features.
In the article were analyzed epidemiologic anamnesis of 52 pregnant woman with chronic viral hepatitis C. It has been established, what sexual and intrahospital ways are the main important mechanism of transmission (in 49,1% cases). Were revealed clinical-laboratory features of chronic viral hepatitis C in pregnant woman and its negative influence on pregnancy and development of complications. Examination of the markers of viral hepatitis C are necessary and important for an effective measures for decreasing of complications of pregnancy and prophylaxis of parental infection.
Key words: chronic viral hepatitis C, pregnant, epidemiologic anamnesis, clinical-laboratory features.
Nimen'kiy M. V.
Optimization of Care Delivery Algorithm of Patients with Ectopic Pregnancy.
In the present article we’ve analyzed an optimized algorithm of the complex fertility treatment in cases of ectopic pregnancy. We’ve confirmed the need to integrate methods of minimally invasive surgery into assisted reproduction programs.
Key words: algorithm, ectopic pregnancy.
Писарева С. П.
Применение Сумамеда (азитромицина) в акушерстве и гинекологии.
Приведены обобщенные данные о применении Сумамеда (компания Тева) в акушерстве и гинекологии, опубликованные в последние годы в отечественной и зарубежной литературе. Показана высокая эффективность препарата при применении в различных формах и по разным схемам для лечения генитальных инфекций в акушерстве и гинекологии.
Ключевый слова: гинекология, генитальная инфекция, лечение, Сумамед.
Подольський В. В., Задорожна Т. Д., Подольський Вл. В.
Клініко-морфологічні аспекти плацентарної недостатності.
Markin L. B., Shatylovytch K. L.
Characteristic peculiarities of the fetal aortic circulation in complicated course of gestational process.
Рeculiarities of the fetal aortic circulation in complicated pregnancy course were studied. It was established that complex research of the aortic isthmus and descending aorta blood flow gives an opportunity to obtain a view of compensatory reactions of the fetal cardiovascular system, carry out perinatal prognosis .
Key words: aortic isthmus, descending aorta, fetus, circulation.
Zhuk S. I., Oshovskyy V. I., Parpaley E. I., Oshovska I. O.
Congenital diafragmatic hernia: pathophysiology and treatment in era of microinvasive fetal surgery.
Basic modern views towards the reasons, pathogenesis, course and management of congenital diaphragmatic hernia were covered in the article. Current data is a trial of unification of diagnostic, prognostic and prophylactic approaches regarding the raised problem.
Key words: congenital diaphragmatic hernia, balloon tracheal occlusion, fetal surgery.
Pysarieva S. P., Kyrylova L. G., Tolkach S. M.
Magnetic Resonance Tomography in Complex Health Assessment of fetus at Herpes Virus Infection in Pregnant Women.
Examination of 90 pregnant women of the risk groups of intrauterine herpesviral infection was organized. Amongst examined by means of MRT in 11 (37,9%) events were revealled different structure abnomalities of the development of the fetal nervous system. MRT is reasonable to use for revision and detailed elaboration of the diagnosis of embriofetal brain injury attached to intrauterine herpesviral infection.
Key words: herpes virus infection, ultrasound investigation, MRT.
Лихачева А. С., Редько И. И.
Респираторные вирусные инфекции в структуре внутриутробных инфекций у новорожденных: диагностика, клинические варианты течения.
Sandulyak T. V., Berdikov A. Ya.
The Health Condition of Newborns from the mothers with pyelonephritits.
The health condition of the fetus and newborn with acute and latent pyelonephritis of the pregnant was studied under the condition of the modern prenatal and perinatal medical service. Risk factors of adverse influence of the mother’s pathology on the development of the fetes and newborn were pointed out and the adaptive newborn tendency was estimated. On the basis of above mentioned risk factors influence the fetus patho-genic calendars were made and the preferences of the first and secondary prophylaxis of congenital imperfections, abnormalities of development and kidney dysplasia were considered.
Key words: pyelonephritis of pregnant, the influence of the latent duration of the urinary tract of fetus and newborn, kidney dysplasia formation.
Leshcheva T. V.
Reproductsve health of women at various methods of contraception.
The results of the conducted researches testify that pregnancy and births for women, which utilize VMK flow with the high level of complications by comparison to patients, which accepted GK. Among different gestational complications it is possible to select such, as placenta insufficiency (43,3% and 20,0%), intensifying of urogenital infection (20,0% and 6,7%), violations of microbiocenosis of sexual ways (30,0% and 16,7%), premature births (10,0% and 3,3%), premature break of fetus shells (23,3% and 16,0%), anomalies of childbirth (20,0% and 10,0%), and distress fetus (26,7% and 16,7%), which results in high – frequency of caesarian sections (26,7% and 13,3%). Women, which utilize VMK make the group of high risk in relation to development of perinatal pathology as compared to women, which accepted GK. Among different perinatal complications more frequent than other there are various forms of asphyxia newborn (33,3% and 13,3%), delay of prenatal fetation (30,0% and 20,0%), postgipoksical encephalopatia (26,7% and 13,3%) and prenatal infecting (20,0% and 6,7%). For prognostication of complications of reproductive health of women (in that chimle obstetric and perinatal) was created neuronetwork computer system. The amount of correct prognoses made, on the average, 84%, that it is allowed to recommend it for the use in a practical health protection.
Key words: reproductive health, intrauterine contraception, hormonal contraception, preventive maintenance, forecasting.
Кузьмин В. Н.
Новые подходы диагностики и лечения вульвовагинита у женщин.
Кандидозный вульвовагинит является наиболее распространенным инфекционным поражением слизистой вульвы и влагалища. За последние годы распространенность данного заболевания неуклонно растет, а его удельный вес в структуре инфекционных поражений вульвы и влагалища составляет 30–45%.
Ключевые слова: инфекция, вульвовагинит, кандидоз, антимикотики, иммуномодуляторы.
Давыдова Ю. В., Двулит М. П., Тудай В. М.
Бактериальный вагиноз: современные аспекты патогенеза, преконцепционной профилактики при экстрагенитальной патологи.
Boiko A. I.
Patients with a solitary kidney in gynecologist’s practice: monitoring tactics and complications’ prevention.
The aim of our research is to underline the importance of constant monitoring for patients who underwent nephroctomy due to different reasons, to draw gynecologists’ attention to the possibility of stone formation in the solitary kidney with or without nephrolithiasis in the patient’s anamnesis.
Key words: solitary kidney, nephroctomy, urolithiasis, nephrolithiasis, functional ability, urgent help, obstructive anuria.
Яшина Е. Г.
Современные подходы к терапии кандидозного вульвовагинита с позиции гинеколога-эндокринолога.
Vdovichenko J. P., Baranovsky G. A.
Modern features of clinical semiology of nonspecific infectious diseases of a vagina.
Results of the spent researches testify, that characteristic clinical signs («curdled» allocation, a smell of the «rotten» fish, expressed diffussion hyperemia mucous) are registered only at disease monoforms (a candidiasis, bacterial vaginose, nonspecific vulvovaginite), and formation of various bacterial and bacterialfungoid associations of microorganisms in vaginal biotope leads to change of a clinical picture and formation nonsymptoms disease forms.
Key words: nonspecific infectious diseases of a vagina, clinic.
Azaks in treatment of genital micoplasmosis.
Present research demonstrates an efficiency of antibacterial preparation Azaks in therapy of genital micoplasmosis.
Key words: micoplasmosis, treatment, prophylaxis, Azaks.
Veropotvelyan P. N., Veropotvelyan N. P., Saprikina N. A., Sviridov M. N.
Apoplexy of ovary: A new view on the old problem.
The aim of the given investigation is to reillustrate in the article some points of etiology and pathogenesis of ovary apoplexy as the introduction of new technologies has recently changed the approach to the iagnostics and treatment of the pathology. The results of our investigation indicate the necessity of various rehabilitation measures directed at the regulation of the ovary function and relapse’ preventive measures to preserve the reproductive function after the performed operation of ovary apoplexy.
Key words: apoplexy of ovary, diagnostics, relapse, preventive.
Structure of Cervical Lesions in Women with Metabolic Syndrome.
Prevalence and colposcopic features of exocervical lesions in women with metabolic syndrome do not have significant differences as compared to respective characteristics in healthy women of reproductive age. This can testify for that the infectious agent’s influence prevails in the development of cervical lesions rather than the peculiarities of hormonal homeostasis. However, it should be noted that women with metabolic syndrome should undergo colposcopic screening of cervical epithelium according to the commonly used protocol in order to prevent cancer.
Key words: metabolic syndrome, colposcopy, cervical lesions.
Use of Mirena LNG-IUS in patients with menorrhagia after treatment of cervical intraepithelial neoplasia of different grades (CIN I, CIN II, and CIN III).
The article provides information on treatment of menorrhagia in 67 patients after radical treatment of cervical intraepithelial neoplasia (CIN I, CIN II, and CIN III) by insertion of Mirena LNG-IUS. The data provided in the article evidence that such treatment is possible and highly effective in this patient group.
Key words: Mirena, menorrhagia, cervical intraepithelial neoplasia.
Abdukhalilovna Djalilova Surayyo
Analysis of the information on diseases of cervical cancer and medical activity among women in Tashkent City.
For cervical cancer prevention should be strengthened awareness among the population not only through the activities of health workers, but also enhance the mass media: television, radio, newspapers and magazines. Lack of awareness of the female population entails a low cancer alertness, which in turn is one of the reasons for late detection of cervical cancer in advanced stages.
Posoкhova S. P., Maistruk G. P., Humenuk L. Y., Nikolayeva S. V., Bannikov V. I.
Safe abortion as the alternative way of saving the reproduction potential of adolescents.
The article contains the results of performing the medical abortion of 90 adolescent primigravidas. The patients were given 200 mg of mifepristone and 400 mg («Mir-Pharm», Russia) of misoprostol (Mirolut, «Mir-Pharm», Russia) sublingually to terminate the pregnancy at the term of up to 63 days starting from the first day of the last menstruation. The successful completion of the medical abortion was observed in 96,7% cases. Thus, our data prove the high efficiency and safety of the medical abortion of adolescent girls.
Key words: medical abortion, mifepristone, misoprostol, adolescents.
Adamov M. M.
Pregnancy and childbirth after the auxiliary reproductive technologies executed at absence and presence uterine tubes.
Results of the spent researches testify, that delivery women, pregnancy at which has come after auxiliary reproductive technologies, mother-placenta-born, and complex genesise is accompanied by high frequency perinatal pathologies owing to considerable level of infringements in system. Removal uterine tubes as a source of a chronic infection, before performance of auxiliary reproductive technologies allows to improve essentially obstetrical and perinatal results of delivery. It grants to us is right recomend such approach for selective use in practical public health services.
Key words: auxiliary reproductive technologies, uterine tubes, pregnancy, childbirth.
Nikitin O., Gontar J., Ilyin I., Zhabitskaya L.
The role of cytogenetic examination of patients with impaired reproductive function.
A pathological state of the reproductive system often caused by chromosomal abnormalities. Chromosomal pathology in the population average of 1% among patients with disorders of the reproductive function of frequency of chromosomal abnormalities according to various researchers reaches 20%. Research based on data from 462 patients who had been karyotyping: in 52 patients was a violation of the karyotype, which is 11.3%.Note the fact that the highest frequency of violations of the karyotype was found in patients with habitual (15.3%). While in patients with a history of children with multiple birth defects, disorders marked by the lowest percentage (4.3%).
Key words: violation of the reproductive system, cytogenetic examination, chromosomal pathology.
Chernega T. V.
Anti-commissural gel application for women with tubular infertility.
The efficiency of anti-commissural therapy following laparoscopy has been analyzed. The authors have described in detail and substantiated the stages of treatment and preventive measures with subsequent analysis of reproductive function restoration in women with tubular infertility.
Key words: infertility, laparoscopy, anti-commissural gel, pregnancy.
Astakhov V. M., Batsylieva O. V.
Medical-Psychological and Social Aspects of Reproductive Behaviour Formation under Modern Conditions.
The article presents factors which have influence on the reproductive behavior. The carried out analysis of literature data and result of own researches shown particularity of reproductive behavior and nesses of the complex program for its optimization.
Key words: reproductive behavior, reproductive health, personality, family, demography.
Муротова Н. Х.
Менеджмент общественного здравоохранения с учетом социально-экономических, культурных и медицинских особенностей семейно-брачных отношений в Узбекистане.
Федорченко Г. В., Баранова В. В., Давидова Ю. В.
Особливості психоемоційного стану жінок, оперованих на щитоподібній залозі під час вагітності.