SOVREMENNAYA PEDIATRIYA №4-2012
Киев: опыт пилотного региона.
Розвиток та перспективи «дружніх до молоді» медичних послуг підліткам та молоді в Україні.
10 лет компании Бионорика на рынке Украины.
Proxorov E. V., Lennart T. V., Matsynina M. A.
The rare case of combined Graves' disease and diabetus mellitus type 1.
Summary. A description of an own clinical observation of case of combined Graves' disease and diabetes mellitus 1 type in child is given.
Key words: Graves' disease, diabetes mellitus 1 type, children.
Berezhnoi V. V., Kozachuk V. G.
Domestic adapted milk formulas enriched by oligosaccharides and nucleotides in infant nutrition.
Summary. Breast-feeding promotes the most full physical and brain growth and development, has a unique positive impact on the health of the child. When breast-feeding is impossible the adapted milk formula should be used, which contains in its composition all the functional components of women's breast milk. Domestic milk formulas «Malyutka PREMIUM 1» and «Malyutka PREMIUM 2», enriched by prebiotics and nucleotides, are full-course adapted products for children of 1st year of life as supplementation with mixed feeding, and as a basic food in artificial feeding.
Key words: breast milk, adapted milk formula, prebiotics, nucleotides.
Izumec O. I., Ischuk I. V., Dobiga M. V., Lajko, L. I., Koroljova N. D., Ischuk К. A., Gomon R. A., Ischuk K. N., Negivenko T. P.
Using of the skin method of bilirubinmetria and it`s correction in newborns.
Summary. According to the data of the possible toxicity action of the indirect bilirubin and, as well, as jaundice of the newborn can be a symptom of the other diseases, we should examine infants for the intime estimation of the health conditions that need additional manipulations due to non invasive methods of the study. So, very important place takes study and investigations to the practical use of the non invasive methods of bilirubin concentration analyse.
Key words: newborns, jaundice, bilirubin, skin bilirubinmetria.
Misnik V. P., Klimenko L. A., Zelyonaya N. A., Bryukhanova A. M.
Fruit puree in nutrition of early infancy and infants.
Summary. The study about efficacy of a number of fruit puree by trademark«Gerber» in the nutrition of infants and young children is conducted. The results indicate a satisfactory tolerability and positive impact on the body of all tested puree. At the same time it should taken into account the possibility of food intolerance (including allergic reactions), of some puree, which indicates the necessity of individual approach to the appointment of fruit puree to children, especially from the risk groups of food allergies development.
Key words: infants and young children, food, fruit puree.
Yatskevich I. I., Korzhinskii Yu. S.
The study of specific anti-RSV antibodies levels in the blood serum of infants.
Summary: 41 infants aged 0–10 months were evaluated for the presence of А, М,G immunoglobulins specific for respiratory-syncytial virus (RSV). These in-patients were treated for acute respiratory infections, such as bronchitis, obstructive bronchitis and pneumonia. The levels of specific IgM and IgA were extremely low which can be considered as their absence. There were rather high levels of serum specific IgG detected. In the case of their depletion during the disease course we can evaluate them as maternal antibodies. There was increase of the IgG antibodies observed in some cases nevertheless 4-fold increase as the marker of IgG antibodies production by child's organism was never observed. These findings indicate the imperfection of antibody response of infants of the first months of life to the RSV. This fenomenon can explain the severe course of the RSV infection in infants.
Key words: respiratory-syncytial virus, newborns, infants, specific antibodies.
Marushko Yu. V., Iovitsa T. V., Al' Nazhar M. A.
Clinical value of hydrogen respiratory tests and the possibility of application in the children of infancy.
Summary. Estimation of the diagnostic value of the method of determining the concentration of hydrogen (H2) in exhaled air [s] by the use of gas analyzers in diagnostics of intestinal colics and colics of those caused by lactase insufficiency in the children of infancy. In view of not the invasiveness and the relative cheapness in many instances they are the diagnostic tests of the first line of inspection.
Key words: the children early age, intestinal colics, lactase insufficiency, hydrogen respiratory test.
Ysachova E. V.
Clinical and immunological efficiency of the specific immunotherapy of congenital cytomegaloviral infection.
Summary. Based on the analysis some parameters of antiviral protection before and after specific immunoglobulin therapy in 18 children of the first three months of life infected transplacentally with the cytomegalovirus its efficiency has been demonstrated.
Key words: children of the first three months of life, congenital cytomegaloviral infection, treatment, anticytomegaloviral immunoglobulin.
Starets Е. А., Nikitina N. А., Kalashnikova Е. А., Sochinskaya Т. V.
Efficiency of using the milk formula Humana HA for infants of first year of life, who are suffering from atopic dermatitis.
Summary. The results of studying the risk factors of atopic dermatitis and efficiency of mixture «Humana HA 1» and «Humana HA 2» «Humana» company (Germany) in the complex of treatment of infants in the first year of life with AD are shown in the article. It is proved, that the feeding of infants with the hypo allergic milk formula shown before are more effective in comparison with other hypoallergic milk formula heal skin АD symptoms, lead to a normal blood level of eosinophils and Ig E; intestine microbiocenosis, have a good taste, do not cause side effects (safe in use).
Key words: Infants of first year of life, atopic dermatitis, hypoallergic milk formula, mixture «Humana HA 1» and «Humana HA 2» «Humana» company (Germany).
Ovcharenko L. S., Kryazhev A. V., Andrienko T. G., Samokhin I. V.
Features of bone metabolism in young children with manifestations of food allergy.
Summary. These features state of the processes of bone formation and functioning of the immune system indicate the presence of the pathological effects of allergic inflammation in the formation of bone tissue in children with food allergies, is directly dependent on the intensity and prevalence of clinical manifestations of food sensitization, which requires timely diagnosis of possible violations, adequate drug and correction of preventive measures.
Key words: children, food allergy, osteogenesis, treatment.
Ovcharenko L. S., Vertegel A. A., Andrienko T. G., Zhihareva N. V., Samohin I. V.
Rational use of antihistamines in the therapy program of food allergy clinical aspects in children.
Summary. The paper presents results of clinical efficacy and safety study of levocetirizine drug «L-cet» use (Kusum Pharm) at food allergy manifestations in children aged 2–6 years. It was proved that «L-cet» drug possesses pronounced and fast therapeutic effect as for food allergy symptoms relief in children. The clinical drug effect is associated with its significant impact on allergy pathogenesis that resulted in positive dynamics of laboratory sensibilization markers. «L-cet» drug showed its good tolerability in patients and high safety profile, particular on the part of cardiovascular system according to control data of QT interval value. Mentioned above gives reasons for its rational use as the first line therapy drug in children aged 2–6 years having food allergy manifestations.
Key words: children, food allergy, treatment, levocetirizine.
Banadyga N. V.
Ways of prevention the allergic diseases for children.
Summаry. Incessant growth of allergic diseases for children requires the search of effective facilities of prophylaxis, especially for children from families with the burdened allergic anamnesis. The effective measure of suppression is the early and protracted pectoral feeding of baby. The discussions on the prophylactic setting of pre- or probiotics for children from the group of risk have been started. Obvious is a necessity of application of prоbiotics for children which do not get human milk, taking into account their ability to modify composition of intestinal flora for the balanced stimulation of the immune system and to diminishing of frequency of allergic pathology.
Key words: children, allergic diseases, prophylaxis.
Marushko Yu. V., Marushko T. V.
Experience of using lexin in complex treatment of reactive arthritis in children.
Summary: In complex treatment of reactive arthritis related to the rhino-pharyngeal infection, it is reasonable to use antibacterial preparation Lexin for children. Using the preparation eliminates the strepto and staphylococcus flora as well as the manifestations of reactive arthritis.
Key words: reactive arthritis, rhino-pharyngeal infection, Lexin.
Kostenko T. O.
Functional state of cardiovascular system in children born from parents exposed to radiation in childhood and adolescence.
Summary. An ultrasonic and ECG examination has been carried out in 198 children and adolescents born from parents exposed to radiation in their childhood and adolescence. Their cardiovascular system parameters have been compared with those of 111 age-mates from Kharkiv population without irradiation in their anamneses. Obtained data indicate a significant rate of cardiovascular deviations such as sinus arrhythmia, bradycardia, derangement of repolarization processes, congenital structural abnormalities of heart with a prevalence of multiple aberrant cords, organic changes in mitral valve cusps and mitral valve prolapse. Requirement of a more intensive regular medical check-up and physical training of this contingent has been substantiated.
Key words: children and adolescents, ultrasonic and electrocardiographic examination, cardiovascular system.
Boyko Y. Y., Chernyshov V. P., Omelchenko L. I.
Cytokine's profile of patients with different clinical subtypes of juvenile idiopathic arthritis.
Summary. The publication proves that patients in active phase of Juvenile Idiopathic Arthritis show changes in cytokine profile of their blood serum, which reflect an imbalance in pro- and anti-inflammatory cytokines, and differ depending upon of clinical course of the disease.
Key words: juvenile Idiopathic arthritis, cytokines, pathogenesis.
Omelchenko L. I., Pushkaryova T. N., Datsenko L. A., Dudka I. V., Nikolayenko V. B., Petrenko L. B.
Some psychosomatic aspects of chronic juvenile arthritis in children and adolescents.
Summary. The article highlights the research of the level of situational and personal anxiety in children with juvenile arthritis and features of the structure and type of personality. In 100% of the examined children increased level of personal anxiety in 42.7% — reactive anxiety according to the C.D. Spielberger scale. In 75% of the observed increase in scores on a scale of mental states H. Eysenck and the results orientation of the individual by H. Eysenck.
Key words: chronic juvenile arthritis, ppsychosomatics, personal and situational anxiety, C. D. Spielberger scale, personality structure, personality typology.
Shevchenko N. S.
Reactive arthritis as factor of osteoarthrosis formation in adolescents.
Summary. In order to improve the prevention of osteoarthrosis in adolescents, the clinic manifestations and anomalies in basic pathogenetic links of reactive arthritis have been analysed. The used methods were: clinical, immunological, biochemical, affected articulations radiography, ultrasonography, retrospective analysis of case histories. The prognostic significance of several factors of secondary osteoarthrosis formation in adolescents with reactive arthritis has been examined. It has been established that negative evidences of degenerative changes development in articulations of such patients were: ' inflammatory process duration, the degree of its intensity, ethiological factor, abnormalities in immune homeostasis such as a decrease in general T-lymphocytes level due to T-helpers, an increase in phagocytic activity, a hyperproduction of proinflammatory cytokines (IL-6 and FNO-a), an activation of proteolytic enzymes (collagen, elastase) and a decrease in their inhibitors activities.
Key word: adolescents, reactive arthritis, osteoarthrosis, degenerative changes development in articulations, prevention.
Bogmat L. F., Golovko T. A.
Renyn-anhyotenzyn-aldostaron system status in children with myocardium pathology at different levels of right ventricle functioning.
Summary. The aim of the study is to estimate renin-anhyotenzyn-aldosteron system status in children with myocardium pathology at different levels of right ventricle functioning. There have been examined 92 patients with myocardium pathology (secondary cardiomyopathy, dysplastic cardiomyopathy, rhythm disturbances). Clinical investigations with complaint analysis, antecedent and patient anamnesis data, objective study have been carried. Research of the system RAAS included the study of activity of renin of plasma, maintenance of angiotensin-II and aldosterone in peripheral venous blood through a analysis that was conducted on a meter «Narcotest». Morphofunctional status of right ventricle of heart has been estimated by Doppler ultrasonic cardiometry under M- and B-modes. It is set, for children with myocardium pathology systole disfunction of RV and him desadaptiv alteration formed and make progress on a background activating of the systems of the neyrogumoral adjusting, in particular RAAS.
Key words: renin-anhyotenzyn-aldosteron system, right ventricle of heart, children, myocardium pathology.
Kaladze N. N., Sizova M. A., Semerenko L. A.
The features of physical development of children with extrasystolic arrythmia.
Summary. The results of research of physical development of children with extra-systolic arrhythmia are presented. The resulting data indicate a large proportion (46%) disharmonious development of children with severe deviations of weight and height indexes from normal calculation units (Kettle). In the group of children with extra — systolic arrhythmia increased index of adipose tissue and increased risk of development of metabolic syndrome are detected.
Key words: physical development, index of adipose tissue, extra-systolic arrhythmia, children.
Kaladze N. N., Zagorul'ko A. K., Memetova E. Ya.
Effects of antihomotoxic preparation «Traumeel S» on morphology of thymus tissue of experimental animals with simulated adjuvant arthritis.
Summary. Morphological research of thymus is conducted on 15 white laboratory of pure breeds rats of line of «Wistar» with the designed adjuvant arthritis, 5 from them got antihomotoxic therapy by preparation of Тraumel C. To the necessity of antygomotoksych correction testify diminishing of dystrophy changes of fabric of thymus in the conditions of this experiment.
Key words: adjuvant arthritis, experiment, thymus, rats, treatment, antihomotoxic therapy.
Bredun O. Yu.
Adenoids in children and its complications.
Summary. Adenoiditis prevalence in children age is amount up to 29% of all diseases of the upper respiratory tract. The number of complications such as acute otitis media and sinusitis has no tendency to decrease. Modern preparations «Izofra», «Polideksa with phenylephrine» and «Otofa» are effective and safe against these diseases.
Key words: adenoids, acute otitis media, sinusitis, Izofra, Polideksa with phenylephrine, Otofa.
Karpova E. P., Sokolova M. V.
The choice of rational methods in the treatment of acute infectious rhinitis in children with allergic anamnesis.
Summary. The experience of inclusion of VIBROTSIL preparation into complex therapy of acute rhinitis with ARI in children with allergic rhinitis in history is shown. VIBROTSIL is an effective and safe preparation, its use allow reduce the duration of systemic antihistamines of the second generation, to prevent aggravation of allergic rhinitis and consequently reduce the pharmacological burden on the patient. This confirms the usefulness of VIBROTSIL during this pathology.
Key words: acute rhinitis, allergic rhinitis, acute respiratory infection, VIBROTSIL.
Lezhenko G. A., Pashkova E. E., Pantushenko L. I.
Management of antibacterial treatment of the recurrent bronchitis in children.
Summary: The study performs the analysis of efficiency of oral administration of antibiotic Cefutil (cefuroximum axetil) in treatment of the recurrent bronchitis in children. It shows that Cefutil is an effective and safe medicine and can be recommended for treatment of the recurrent bronchitis in children with the signs of bacterial infection.
Key words: children, recurrent bronchitis, nitric oxide, Cefutil.
Yulish E. I., Balychevtseva I. V., Vakulenko S. I., Gadetska S. G.
Differentiated approaches to the treatment of recurrence of forms acute obstructive bronchitis in children.
Summary. 117 four years children, suffering from obstructive bronchitis, were under supervision. Frequency of infecting with intracellular pathogens was determined for these children. Manifestation of the disease, level of IgE, IL-1, IL-2, IL-4, IL-10 are compared in the research. Genesis of interferon according to infecting is studied. We developed a method of causal treatment of differentiated depending on the causative factors of infectious diseases.
Key words: obstructive bronchitis, intracellular infections, children.
Chernyshova L. I., Yakimovich S. A., Donskoi B. V., Galazyuk L. V.
Protective role of local immunity in the prevention of the upper respiratori tractdiseases in children.
Summary. As a result of conducted investigations was revealed, that local immunity of mucous membrane of children with often episodes of disease characterized the decline of such important protective factors as Mip1α and IgG and imbalance of connections between the indexes of innate and adaptive immunity. Has been established, that IRS19® raises those protective factors of local immunity, which differ children with often episodes of disease from the children of control group, which means Mip1α and IgG . Besides the renewal of direct connections between separate factors may be one of explanations of positive prophylactic action of IRS19® in diminishing of frequency of respiratory diseases in children.
Key words: bacterial lysates, children with often episodes of disease, mucosal immunity, Mip1α, immunoglobulin, saliva.
Slepov О. К., Ryzhenko О. V., Ponomarenko O. P.
Diagnostics and medical tactic at thymic hyperplasia, complicated by the compression of respiratory tracts, at chindren.
Summary. In the article the conducted analysis of inspection and treatment 98 children with the compression of respiratory tracts, conditioned by thymic hyperplasia. Trained clinical displays and anatomic features of compression of respiratory tracts at these children. Developed algorithm of inspection and medical tactic at children with the compression of respiratory tracts, conditioned thymic hyperplasia. Explored direct and remote results of conservative treatment and surgical correction of children with the compression of respiratory tracts at thymic hyperplasia.
Key words: thymic hyperplasia, compression of respiratory tracts, children.
The application in the treatment of res piratory karbotsisteina pathology in children.
Summary. Cough is a frequent cause for parents visit pediatrician. In most cases, it is a symptom of diseases of the respiratory system and upper respiratory tract in children. Careful history, including clarification of the specific characteristics of cough, an objective examination, and laboratory and instrumental examinations are helpful for correct diagnosis. Fljuditek is effective and safe in treatment of diseases of the respiratory system and upper respiratory tract in children and can be recommended for use in pediatric practice.
Key words: сough, children, karbotsistein, Fljuditek.
Nedelskaya S. N., Akulova E. Y.
The analysis of school uneasiness at children sick of a bronchial asthma by results of medico-psychological testings.
Summary. The analysis of school anxiety is conducted by an individual questionnaire 36 children of middle and senior school age that were on stationary treatment concerning bronchial asthma in the allergist separation of Zaporizhzhya child's hospital. Results of the complex use of medico-psychological tests (by Phillips, Burdone) in to statistical datas it is testified comparing to considerable specific gravity and specific of factors of school anxiety for every school age. Realization to the patients by bronchial asthma to the children of differentiated, according to school age-dependent periods, will allow a medico-psychological correction substantially to improve efficiency of therapy due to diminishing of displays of school anxiety and change of relation of children to treatment.
Key words: bronchial asthma, children, school anxiety, medico-psychological tests, middle school age, senior school age.
Tsodikova O. A.
Effect of phytopreparation «Imupret» on the index data of peripheral blood in children with recurrent respiratory tract infections.
Summary. The comparative analysis of index data of peripheral blood in children with recurrent respiratory infections is carried out. The dependence of peripheral blood indices on the type of general nonspecific adaptive reactions of the child is detected. Dynamics of blood indexes allowed evaluating the effectiveness of the use of herbal immunomodulator Imupret in the complex of rehabilitation measures that have been clinically confirmed by the elimination of inflammatory and allergic processes, reduction of endogenous intoxication and vegetative disorders.
Key words: phytopreparation, adaptive reactions, leukocyte index.
Senatorova G. S., Chernenko L. M.
Clinical and laboratory characteristics bronchopulmonary dysplasia in children.
Summary. Bronchopulmonary dysplasia — one of the pressing problems of Pediatrics, whose significance goes beyond the neonatal and is considered a chronic obstructive disease of young children. The paper presented the results of the study clinical course and evaluation of laboratory studies of children with bronchopulmonary dysplasia.
Key words: Bronchopulmonary dysplasia, clinical and laboratory research, children.
Marushko Yu. V., Todika Y. I.
Clinical experience of use of proton pump inhibitor omeprazole (Оmez®, dr. Reddy's) in treatment of gastroesophageal reflux disease in children.
Summаry. In the work there was analyzed data of world literature and our observations on the use of proton pump inhibitor omeprazole in children. The high clinical efficacy of omeprazole in the treatment of gastroesophageal reflux disease in children.
Key words: gastroesophageal reflux disease, esophagitis, children, omeprazole.
Helicobacter pylori-assosiated diseases from the standpoint of maastricht-4 concensus.
Summary. Recomendations of Maastricht-4 Concensus concerning principles of diagnostics and treatment of Helicobacter pylori are discussed. It's accentueted, that reliable aetiological diagnostics and differentiated therapy of helicobacter-associated diseases taking into consideration clinical form and age of sick child is necessary in childhood.
Key words: child, H.pylori, diagnostics, treatment.
Nezgoda I. I., Bodnaryuk E. V.
Clinical and immunological features of rotavirus infections in children: currrent approaches to treatment.
Summary. The effectiveness and safety of "Enterol 250" in the complex treatment of rotavirus infection in infants is shown thus can be recommended in the treatment of present disease.
Key words: rotavirus infection, infunts, Enterol 250.
Shadrin A. G., Chernega N. F.
Application of sorption methods during hepatic disorders associated with intestinal dysbiosis in infunts.
Summary. In the article the results of efficacy of the use of «Atoxil» in the complex treatment of infants with hepatic disorders associated with intestinal dysbiosis are shown.
Key words: infants, hepatic disorders, Atoxil.
Shadrin O. G., Ignatko L. V., Gerasimiuk S. I.
Application of espumizan in the complex therapy of gastroesophageal reflux disease in children.
Summary. The experience of the use of Espumizan®L in the treatment of GRD in children is shown. Efficacy and safety allow us to recommend its use in the treatment of GRD in children.
Key words: gastroesophageal reflux disease, children, complex therapy, simethicone preparations.
Denisova M. F., Chernega N. V., Beba Yu. V.
New possibilities in the treatment of chronic nonspecific intestinal diseases in children.
Summary. The effectiveness of biologically active supplement «Zakofalk NMX» in the complex treatment of children with ulcerative colitis and irritable bowel syndrome is studied. It is proved that «Zakofalk NMX» has anti-inflammatory, trophic, prebiotic effect, promotes more rapid recovery of trophic mucosa of the colon, reduces the frequency and severity of pain anddyspeptic syndromesand improves quality of life. The results of study certifies about good clinical efficacy and tolerability of the drug, which can be recommended for the treatment ofchronic non-specific bowel disease in children.
Key words: chronic nonspecific intestinal diseases, biologically active supplement, ZakofalkNMX.
Abaturov A. E., Gerasimenko O. N.
The role of probiotic Lactobacilli in the treatment of Helicobacter pylori infection in children.
Summary. The article presents data on the effect of a probiotic containing Lactobacillus, in the treatment of H. pylori infection in children. It is shown that the appointment of probiotic helps improve the effectiveness of eradication of H. pylori in children with chronic gastroduodenal pathology associated with H. pylori.
Key words: Helicobacter pylori, chronic gastroduodenitis, microbiota, children, probiotics.
Chuiko M. M.
Modern prevention components of non-troumatic intraventricular bleeding in premature infants.
Summary. In the articles considered basic directions of ante- and postnatal prophylaxis of intraventricular hemorrhages for premature infants.
Key words: untraumatic intraventricular hemorrhages, premature infants.
Izyumets O. I., Vinnichuk L. L., Marchuk O. I., Laiko L. I., Koroleva N. D., Shamray I. E., Zimoglyad M. I., Shevchuk A. V.
Syndrome of vegetative distonia in children, comparative effect of neurotropic therapy.
Summary. Vegetative disorders is one of the most burning problems of the modern medicine, that caused by their widespread in different age categories of the patients. Syndrome of the vegetative dystonia (SVD) — is the most frequent pathology that observed in 50% of the children and teens. During the additional objective study signs of the vegetative dystonia can be found in 64% of the teens. It's established that frequency of the SVD increased during the study at the primary school; just 14–20% of children have full balance of the different parts of the autonomous nervous system. In the population of the teen-girls vegetative dystonia meet 2,5 times more regularly than in boys.
Key words: syndrome of the vegetative dystonia, neurotrophic therapy, treatment of SVD.
Dudnyk V. M., Zvenigorodskaya G. Yu.
Experience of the use of phytopreparation «Kanefron®N» during the acute uncomplicated pyelonephritis in children.
Summary. The results of the use of preparation «Kanefron®N» in the complex treatment of acute uncomplicated pyelonephritis in children is shown. It is established that appointment of Kanefron®N contributes to stabilization of the clinical condition of patients, reducing symptoms of intoxication (improved appetite, reduced general malaise and temperature normalization), improvement or elimination of urinary syndrome and changes in blood tests. In connection with this appointment of Kanefron®N can be regarded as one of the perspective methods in the complex pharmacotherapy of acute pyelonephritis in children.
Key words: acute pyelonephritis, children, Kanefron®N.
Poberskaya V., Yanchenko T., Evseeva S.
Psychological status of children, who recovered from cancer, after sanatorium resort rehabilitation.
Summary. In the case of observations of 191 children in different periods of remission and hematological diseases the most common solid tumors have been carried a dynamic assessment of psychological status in a children's sanatorium. There are founded increased rates of the aggression's index, irritability, anxiety, phobias against a background of high level of neuroticism. Positive effect of sanatorium complexes is in reducing of the levels of physical, verbal and indirect forms of aggression, in reducing symptoms of anxiety, anger, suspicion and guilt. The immediate and long-term results of sanatorium treatment was a positive trend in quality-of-life index for physical, psychological and social components.
Key words: children, cancer, sanatorium rehabilitation, psychological status, quality-of-life index.
Загадочные болезни: детство под угрозой.