SOVREMENNAYA PEDIATRIYA № 7 -2012

  • Scientific and practical journal
  • ISSN: 2412-4508 (Online)
    ISSN: 1992-5913 (Print)

  • DOI:
  • 10.15574/SP
  • Circulation -
  • 8000
  • Format of the edition -
  • 290x210 mm
  • Frequency -
  • 8 issues a year

 

Информационное письмо.

9

 

 

Правила подачи материала для публикации с изменениями согласно требованиям ВАК.

10

 

 

События.

12

 

 

Moiseenko R. A., Tereschenko A. V.

Principal positions and further development of the chain of orphanages in the Ministry of Health Care system of Ukraine.

15

Summary. The results of the state policy on health care and social protection of orphans and children deprived of parental care, for the period 1999-2011 years is analyzed. The positions and further development of the chain of orphanages of the Ministry of Health Care of Ukraine are shown.

Key words: orphans, children deprived of parental care, health care, social protection, orphanage.

 

 

Gorban A. E., Volosovets O. P., Berezhnoy V. V., Zakrutko L. I., Vasilenko L. V., Uvarenko S. V.

Monitoring of the main means of scientific communication in the field of Pediatrics in the healthcare of Ukraine for 2008–2011 years.

21

Summary. A retrospective analysis of the basic means of scientific communication in the field of pediatrics in the sphere of health care of Ukraine for 2008–2011 years are presented. The factors affecting the efficiency of a conducted scientific forums are analysed. The effectiveness of innovation in health care practice will facilitate the inclusion of references to the guidelines (GL), which must contain a full description of the innovative technologies, proposed for implementation, or to information letters (IL), which must contain the algorithm for applying this technology, citing a source of evidence. The study of quantitative and qualitative indicators of GL and IL revealed the need to improve the quality of scientific information, such as: study of novelty of the information and its compliance with the principles of evidencebased medicine, providing information about the safety and contraindications to the use of the proposed medical technology, etc.

Key words: information support in the field of pediatrics in Ukraine, means of scientific communication, scientific medical forums, innovations, guidelines, information letters.

 

 

Shevchenko M. V.

Approaches for determining guaranteed basic package of medical services in Ukraine.

28

Summary. In the article the approaches to the definition of a guaranteed level of care (medical services) in Ukraine are presented.

Key words: basic package, guaranteed levels, social norms.

 

 

Gorelik V. V., Gonchar V. V.

Fundamentals training of doctors in microsurgery on the postgraduate stage.

30

Summary. In the article the 5-year experience of teaching of microsurgery grounds at the Department of Pediatric Surgery of the PL Shupyk National Academy of Postgraduate Education is described. The importance of knowledge on the present part of medicine for the practice of doctors of various specialties is shown. The tasks for the further improvement of postgraduate medical education of basic microsurgery are found.

Key words: post-graduate education of doctors, microsurgery.

 

 

Nevirkovets A. A.

The role of the basic aducational departments in the continuous professional improvement for physicians in the system of postgraduate education.

32

Summary. The experience of training for physicians in the system of postgraduate education has been described. The authorr suggest ways to improve practical training for professionals. The schema of practical lessons conduction for courses of internship and specialization was shown.

Key words: continuous professional improvement, system of postgraduate education, practical training.

 

 

Гусева С. П.

Сухой кашель у детей — современные аспекты этиопатогенеза, диагностики и лечения.

34

 

 

Belykh N. A.

Iron deficiency anemia in infants: etiology and prevalence.

37

Summary. The article deals with the results of the regional epidemiological study with questioning of pregnant women, estimation of the hemoglobin concentration in 948 infants, study of their iron status. It was demonstrated the high rate of the iron deficient anemia in infants (349,2/1000). The factors of contributing to the development of iron deficiency in infants included are prematurity, burdened by pregnancy (anemia in pregnant, placental dysfunction), low breast milk iron concentration. The conclusion of the iron supplementation in risk groups (pregnant, infants and lactation women) was made.

Key words: nutrition, iron deficient anaemia, infant, breastfed.

 

 

Ovcharenko L. S., Vertegel A. A.

Antibacterial therapy in children: evolution of effective solutions.

42

Summary. In the article the value of antibiotic therapy in pediatric is shown. The necessity of balanced approach to the prescription of antibiotics in children is pointed out.

Key words: children, antibiotics, safety, efficiency.

 

 

Nagorna N. V., Dubova G. V., Bordyugova Ye. V., Muravskaya I. Yu., Kislytsia V. N., Burka A. A., Muravskaya K. V.

The efficiency of Noofen in correction of psychoemotional status of children with vegetative-vascular dysfunction.

47

Summary. In the work the indicators of psychoemotional status of 115 children (63 girls and 52 boys) from 7 to 16 years with vascular dysfunction (78 pers.) and healthy children (37 pers.) are submitted. In 75,6±4,9% of children with vascular dysfunction the various pathological changes of psychoemotional status are revealed, the elevation of the levels of anxiety, sleep disorders, fatigue, depression, conflict, introversion are the most frequent. The 21-day course of Noofen in the complex of treatment of children with vascular dysfunction increases its efficiency, which was confirmed by a rapid and marked improvement of indicators of psychoemotional status, above all, the degree of anxiety (56,8±8,1% and 13,5±5,6% of patients respectively, p<0,001), the level of stress state (75,7±7,1% and 29,7±7,5% of children respectively, p<0,001) and confliction (56,8±8,1% and 16,2±6,1% of patients respectively, р<0,01). It shows the usefulness of complement the complex of treatment and rehabilitation of children with vascular dysfunction of Noofen.

Key words: children, vegetative-vascular dysfunction, psychoemotional status, Noofen.

 

 

Стуклов Н. И.

Мета-анализ данных переносимости питьевой формы глюконата железа (II), меди и марганца (препарат Тотема) при лечении железодефицитной анемии у детей и взрослых.

52

Эффективность препаратов, содержащих двухвалентное железо, доказана в многочисленных исследованиях и не вызывает сомнения. Препарат Тотема (производство французской компании Laboratoire Innotech International), кроме органической соли двухвалентного железа, также содержит медь и марганец в форме глюконата. Такой уникальный состав позволяет быстро восстанавливать концентрацию гемоглобина и депо железа и при этом обладает хорошей переносимостью. Медь и марганец входят в активные центры белков, обеспечивающих зависимое всасывание железа в кишечнике, быструю утилизацию поступившего в кровь железа тканями, синтезе гемоглобина, регулируют поступление железа в митохондрии, обеспечивают антиоксидантную защиту. В литературе встречаются данные по сравнению переносимости глюконата железа, но, к сожалению, отсутствуют аналогичные исследования мультиэлементного препарата Тотема. Данные же отдельных работ из-за небольшой выборки дают разрозненные результаты. Целью данного исследования было объективно оценить переносимость Тотема, чтобы сравнить полученный результат с существующими мета-анализами по безопасности применения других препаратов железа. Для изучения было отобрано 30 исследований (1077 пациентов), содержащих информацию по переносимости препарата Тотема. Общее число нежелательных реакций на приём препарата составил 10,4%. В основном побочные явления были представлены лёгкими, непродолжительными диспепсическими реакциями (8,5%), не требующими отмены препарата. Только 1,1% пациентов были вынуждены отказаться от дальнейшего приёма Тотема. Сравнение результатов показало, что Тотема обладает лучшей переносимостью, чем сульфат железа II (34,1 и 20%, р<0,005), и сравнимой переносимостью по отношению к препаратам трёхвалентного железа (полимальтозный комплекс гидроксида железа III (14,9%; 0,1<р<0,25), протеин сукцинилат железа III (9,4%; 0,75<р<0,9)).

Ключевые слова: Тотема, мета-анализ, железа глюконат, железа сульфат, полимальтозный комплекс гидроксида железа, протеинсукцинилат железа, дефицит железа, глюконат меди, глюконат марганца, лечение анемии.

 

 

Klimenko T. M., Markevich V. E., Tarasova I. V., Turova L. O.

The content of cobalt, chromium, manganese in full-term newborn with perinatal hypoxic lession of central nerval system.

61

Summary. In this paper the features of content and trace element balans (cobalt, chromium, manganese) in serum and erythrocytes, and particularly their renal excretion when hypoxic lesions of the central nervous system in full-term infants. Children in the neonatal period characterized by a significant increase in serum and erythrocyte content of Cr and Mn. There is a significant imbalances of serum and erythrocyte Co content. Hypoxichemorrhagic CNS lession accompanied by a significant and long-term changes in the content and balance of micronutrients. One of the factors of imbalance of trace elements in the case of hypoxic lesions of the central nervous system in full-term infants is a significant loss of urine Cо and inhibition of urinary Mn and Cr.

Key words: full-term newborns, perinatal hypoxic CNS, trace element.

 

 

Marushko Yu. V.

Explanation of elimination measures for prevention and treatment of upper respiratory infections in children.

65

Summary. In the work the literature data and own observations according to the role of the nasal cavity elimination therapy in the prevention and treatment of respiratory disease of the upper respiratory tract are generalized.

Key words: respiratory pathology of the upper respiratory tract, nasal mucosa, elimination therapy.

 

 

Kosakovsky A. L., Shatets V. A., Bits V. P.

About application of Septolete plus spray in children during the acute pharyngitis associated with the cold and ARVI and with acute pharyngitis associated with exacerbation of chronic adenoiditis.

71

Summary. The materials from clinical studies of Septolete plus spray produced by «KRKA d.d.» (Slovenia) are presented. Clinical studies were conducted in 30 outpatient pediatric patients with acute pharyngitis associated with colds and acute respiratory viral infections and acute pharyngitis associated with exacerbation of chronic adenoiditis. The results of observations allow making decision that the examined preparation is effective during the treating of present nosology in children.

Key words: Septolete plus spray, acute pharyngitis, children.

 

 

Tatochenko V. K.

How to prevent pneumococcal diseases.

75

Summary. The role of pneumococcal infection in the incidence of the different age groups of population, and the modern methods of prevention (based on materials of conversations with the doctor of medical sciences, professor V.K . Tatochenko) are shown.

Key words: pneumococcal infection, children, vaccination.

 

 

Movchan O. S., Marushko Yu. V.

Clinical aspects of use of Laferobion in pediatrics.

79

Summary. The possibilities of the use of recombinant interferons, including Interferon alpha-2b (Laferobion), in the treatment of various infectious and inflammatory diseases of children from birth are shown.

Key words: recombinant interferons, infectious and inflammatory diseases, children, Laferobion.

 

 

Lezhenko G. O., Pashkova O. Y., Pantyushenko L. I.

Role of Haemophilus influenzae in formation of infectious diseases in children.

84

Summary. In this paper was analyzed and synthesized current views on the role of Haemophilus influezae in the formation of infectious diseases in children. Also was brought our own expertise in determining the frequency distribution of Haemophilus influezae in the pathology of the respiratory tract in children and was determined susceptibility and resistance of the pathogen to antibacterial drugs. Was substantiated expediency of cephalosporins II–III generation in treatment of children with infections, caused by Haemophilus influezae.

Key words: Haemophilus influezae, antibioticresistance, cefpodoxime proxetil, cefuroxime axetil.

 

 

Katilov A. V., Dmitriev D. V., Mazulov A. V.

General principles of diagnosis and therapy of community-acquired pneumonia in children.

93

Summary. In the article were pointed out the main problems of diagnosis and treatment of community-acquired pneumonia in children, as well as the value of timely and rational antibiotic therapy.

Key words: community-acquired pneumonia, children, diagnosis, antibiotic therapy.

 

 

Vorotniak T. M., Bilous V. V.

Diagnosis of pneumonia in children during acute bronchial asthma indicators by exhaled breath condensate.

98

Summary. We studied the performance of exhaled air condensate in children with bronchial asthma, community acquired pneumonia, community acquired pneumonia against a background of worsening asthma. It is shown that in children with pneumonia against a background of worsening asthma compared to children with asthma without pneumonia in exhaled breath condensate marked decrease in total protein concentration with simultaneous increase of the content of products of oxidative modification of proteins and increased proteolytic activity.

Key words: children, bronchial asthma, exhaled breath condensate.

 

 

Buryak V. N.

Ies of therapeutic approach to the acute bronchitis of children.

102

Summary. Effectiveness and safety of Pectolvan C in the complex treatment of acute bronchitis of children have been studied. It is stated that alongside the secretomotornum and mucolytic effect, the drug restores diminished productivity of sIgA of the upper airways mucous and lysozyme, which, in its turn, normalizes the functional activity of its local immunological barriers. It seems that this fact accounts for a quicker reverse development of clinicallaboratory symptomatology among children treated with Pectolvan C. The above said shows the drug to best advantage compared against other mycolytic agents and expectorants. In this respect Pectolvan C can be regarded as a drug to choose among expectorants during the treatment of acute bronchitis of children.

Key words: therapeutic approach, acute bronchitis, children, Pectolvan C.

 

 

Shef G. G., Marushko Yu. V., Movchan O. S., Zelena N. A.

Experience of use of Cefodox in complex therapy of community-acquired pneumonia in children of different age groups.

107

Summary. Actual problem of the modern pediatrics are respiratory tract infections, particularly pneumonia. In the work the experience of use of Cefadox the preparation of cephalosporin row in the complex treatment of mild community-acquired pneumonia in children of different age groups is summarized.

Key words: respiratory infection, pneumonia, children, Cefadox antibiotic.

 

 

Bezrukov L. O., Koloskova O. K., Ortemenka Ye. P.

Is effective the treatment by inhalation gluco: corticoids of bronchial asthma in children under the neutrophilic type of inflammation of airways ?

112

Summary. There has been done the prospective investigation of cohort of 26 children that suffered from bronchial asthma with signs of neutrophil — mediated inflammation of bronchi. The definite clinical effect of monotherapy by inhalation corticosteroids has been determined (increase of relative risk of achievement of satisfactory level of clinical control — 38,4%, attributive risk — 19,2%, minimally required quantity of patients for the achievement of positive result — 6), and, of the same time, significant improvement of external respiration indices (increase of relative risk of normalization of spirometrical data — 60,0%, attributive risk — 46,1%, minimal quantity of patients — 3). Under the neutrophilic variant of inflammatory changes in airways there has been identified the following risk to achieve bronchial asthma control: odd ratio (OR) of clinical control — 2,3 (95% CI 0,7—7,0), OR of normalization of spirometrical indices — 7,5 (95% CI 1,6—34,8).

Key words: bronchial asthma, neutrophilic type of inflammation, asthma control, inhalation glucocorticosteroids.

 

 

Boiko N. S., Marushko Yu. V

Experience of carbocisteine use in pediatric practice.

115

Summary. The aim of work was to study the efficacy of carbocisteine (Fluditec) for treatment of acute bronchitis in children. Carbocisteine is an effective mucoregulator and its action is different from mucolytics and expectorants in its ability to normalize reologic properties of the mucus and regulates the amount of produced bronchial secretion. This allows to recommend it as a drug of choice during the need of mucoactive therapy of RTI in children.

Key words: Acute respiratory diseases, acute bronchitis, mucoregulators, carbocysteines.

 

 

Glyadelova N. P., Unich N. K., Orlyuk I. B.

Plant immunomodulator Bioaron C: experience of use for preventative measures and treatment of infectious diseases of upper respiratory tract in children.

121

Summary. The article deals with the treatment and preventative measures of acute respiratory viral infections (ARI) in children. The given review of literature data about clinical results of "Bioaron C" application in children with ARVI, including sickly and long lasting ill children, proves the feasibility and safety of its inclusion in the treatment regimens.

Key words: acute respiratory infection, children, Bioaron C, therapy, preventative measures.

 

 

Еrshova I. B., Оsychniuk L. М., Reschikov V. А., Chernova Е. V., Gavrish L. I.

Features of etiology of non-hospital pneumonia in children at this stage.

126

Summary. We examined 129 children of age 2–16, which were treated in children's hospital №3 of Lugansk in period from september to december 2011 with non-hospital pneumonia and ARD with sinusitis. We have marked frequency of different localization of the inflammatory focus in all children and depending on age. We analyzed results of bacteriological research smear from pharynx and nose: most frequently isolated pathogens and their antibiotic sensitivity.

Key words: non-hospital pneumonia, etiology, antibiotic sensitivity.

 

 

Shevchenko N. S., Lebets I. S., Nelina I. N., Kashkalda D. A.

Three-year results of observations of adolescents with osteoarthritis in the treatment.

128

Summary. The results of clinical and laboratory observations of adolescents with osteoarthritis who received differential treatment. The therapeutic complexes include chondroprotectors, anti-inflammatory drugs, non-drug tools that are aimed at correcting metabolic disorders of connective tissue structures of the cartilage, the elimination of the inflammatory process, improve the microcirculation. During the period of three years of observation revealed a positive trend in the clinical and paraclinical indicators and its dependence on the duration of treatment. Revealed that the first year of therapy primarily reduced the clinical and ultrasonic manifestations of the disease. Three-year duration of the treatment contributes to a substantial improvement in the metabolism of proteoglycans and collagen, reducing the activity of enzymes of catabolism of collagen and elastin, with increased activity of their inhibitors, normalization of relations in T cell-mediated immunity, content ІL-1β, IL-6. Preservation of high activity of the enzyme catabolism of collagen, disorders of balance in the functioning of elastase – an inhibitor of elastase, high performance TNF-α, according to the presence of X-ray and ultrasound studies progression of the pathological process, which are observed in adolescents with two or three years of treatment, requires further treatment of and its correction.

Key words: adolescents, osteoarthritis, treatment, metabolism of connective tissue, immunological parameters.

 

 

Kaladze N. N., Zagorul'ko A. K., Memetova E. Ya.

The functional state of the thymus in patients with JRA (clinical and experimental part).

132

Summary. In the article morphological changes the fabric of thymus are represented at the design of adjuvant arthritis on 12 white rats of line of «Wistar». Іn the conditions of this experiment has found dystrophy changes of cellular elements of thymus. During SCТ of thymus at 16 patients with JRA, dependence of atrophic changes of the duration of disease and form. The level of hormone of thymus, α1-thymosin, is studied at 34 children with JRA in age from 7 to 16 years, the rate of which was reduced in comparison with the control group.

Key words: adjuvant arthritis, experiment, thymus, rats, children, juvenile rheumatoid arthritis, diagnostic.

 

 

Marushko Ie.

Nailfold capillaroscopy in pediatric rheumatology.

137

Summary. Nailfold capillaroscopy is reliable method for evaluating microcirculation in children with systemic inflammatory connective tissue diseases and juvenile rheumatoid arthritis. Our research revealed impairment of microcirculation in children with juvenile rheumatoid arthritis and systemic lupus erythematosus, the lesser group has authentically more pronounced changes.

Key words: nailfold capillaroscopy, children, rheumatic diseases.

 

 

Kovalchuk T. A.

Results of assessment of the functional status of joints in ill by juvenile rheumatoid arthritis children with help of CHAQ questionnaire.

142

Summary. The study involved 120 patients — 60 patients with juvenile rheumatoid arthritis, 30 patients with reactive arthritis and 30 healthy children. With help of CHAQ questionnaire was showed that rheumatoid arthritis in children is characterized by functional abnormalities in such daily activities as dressing and grooming, arising, eating, walking, hygiene, reach, grip, errands, chores and play. The relationships between the disability index and main clinical and laboratory signs of juvenile rheumatoid arthritis substantiate the feasibility of using CHAQ questionnaire to assess the functional status of joints in this group of patients.

Key words: functional status of joints, questionnaire CHAQ, juvenile rheumatoid arthritis, children.

 

 

Lebec I. S., Panko N. O.

Characteristic symptoms of the articular form of juvenile rheumatoid arthritis at an early stage of the disease.

146

Summary. 77 children with inflammatory lesions of the joints have been examined in the study. The most informative clinical features and laboratory findings diagnosing Juvenil Rheumatoid Arthritis and reactiv arthritis in the first months of disease onset have been established during the study period. The results presented demonstrate a high diagnostic significance of antibodies to the cyclic citrullinated peptide (anti-CCP). The necessity of performing ultrasonic investigation of the clinically intacted joints for revealing

subclinical synovitis is highlighted in the article.

Key words: Juvenil Rheumatoid Arthritis, diagnostics, clinic, antibodies to citrullinated peptides.

 

 

Kvashina L. V.

The treatment of calcium and vitamin D metabolic disorders at malabsorption child syndrome.

150

Summary. There are mechanisms of calcium metabolism's impairment at malabsorption child syndrome and approaches how to manage this problem with calcium and Vitamin D medicines described in this article.

Key words: children, calcium homeostasis, malabsorption child syndrome.

 

 

Marchenko T. Z., Кvit D. I., Тomkiv Ya. V., Sakalosh L. P., Nykytyuk S. I., Тomkiv Z. V., Тyzyo О. M., Vitkovska N. V.

Possibilities of therapy's efficiency and compliance increasing in children with functional gastrointestinal diseases.

157

Summary. Integrated 14-day therapy of functional gastroduodenal diseases using Domrid suspension in 10 children of early age helped elimination of clinical signs and positive dynamics of body mass, and in 21 child 4–18 years — the elimination of clinical, endoscopic and sonographic changes with good tolerance and absence of allergic and adverse reactions, which helped to increase compliance of treatment.

Key words: children, gastroesophageal reflux, gastroesophageal reflux disease, functional dyspepsia, domperidone.

 

 

Abaturov A. E.

Metabolic syndrome and digestive tract pathology in children.

161

Summary. The reasons of origin, diagnostic criteria, the impact and direction of the treatment of metabolic syndrome in children are shown. The role of gastroenterologists and nutritionists in the organization of prevention and treatment of this condition is underlined.

Key words: metabolic syndrome, diagnostic criteria.

 

 

Kozakevich V. K.

Modern functional foods in prophylaxis and treatment of functional gastrointestinal dysfunctions in infants of the first year of life.

167

Summary. The role of functional foods in the development and normalization of the gastrointestinal tract in infants is shown. The study of the effectiveness of an adapted milk formula «Malutka premium 1» with prebiotics and nucleotides in infants of the first year of life is conducted. The results of clinical approbation of milk formula have shown that its application is the best in the organization of preventive care for healthy children of the first months of life, who are on the bottle-feeding, and also children requiring prophylaxis or treatment of minimal gastrointestinal dysfunctions.

Key words: infants, infant nutrition, artificial feeding, infant milk formula, prebiotics, nucleotids.

 

 

Gischak T. V., Marushko Yu. V., Zlobinets A. S.

The use of magnesium and potassium combined preparation in the complex therapy of children with diskinesia and cardiometabolic disorders.

171

Summary. Combined pathology of the digestive tract and the cardiovascular system is an actual problem of Pediatrics. Inclusion of «Ritmokor» the combined preparation of magnesium and potassium to the complex treatment of children with biliary dyskinesia and cardiometabolic disorders positively effect on the biliary tract, provides improved myocardial metabolism, lids to normalization of potassium and magnesium in the blood serum. This allows recommending preparation for widespread use in the combined treatment for children with biliary pathology and secondary cardiomyopathies.

Key words: Combined pathology of the digestive tract and the cardiovascular system, biliary dyskinesia, potassium and magnesium, «Ritmokor».

 

 

Nadraga O. B., Litvin G. O., Potseluyko N. M.

Efficacy of use of «Atoxil» sorbent in the complex threatment of rotavirus gastroenteritis in infants.

177

Summary. The clinical study of the use of Atoxil sorbent in the treatment of acute gastroenteritis of rotavirus etiology in infants is conducted. In the setting of use of preparation just from the first days of the treatment the best dynamic of the body temperature normalization, reduce of the frequency of bowel movements, cessation of vomiting, the overall state improvement and normalization of appetite were found. High efficacy and good organoleptic properties allow recommending it for use in pediatric patients.

Key words: rotavirus infection, gastroenteritis, infants, enterosorbents, Atoxil.

 

 

Denisova M. F., Musyca N. M.

Prognostic significance of indirect serological markers of liver fibrosis in the early diagnosis of transformation of chronic hepatitis B in liver cirrhosis.

182

Summary. The problem of diagnosing liver fibrosis and its monitoring during treatment — the actual problem of modern hepatology. Particular attention is paid to a non-invasive methods of diagnosis. The article presents the clinical and paraclinical characteristics of children with chronic viral hepatitis B; proved informative indirect serological markers of fibrosis, defined risk criteria of transformation of chronic viral hepatitis B in liver cirrhosis.

Key words: chronic hepatitis B, children, fibrogenesis, indirect serological markers.

 

 

Zadorozhna T. D., Mostovenko R. V., Beresenko V. S.

Morphology features of iron metabolism in children with chronic hepatitis C.

186

Summary. There represented the results of histologic and histochemical studies of biopsies of liver in 20 children with chronic hepatitis C (HCV). It was stated that in 75% studied bioptats the storage of iron in different structures of liver lobes took place. It was revealed that ratio of iron storage in hepatocytes, macrophages and other structures of liver is almost equal. It was stated, that level of iron in liver tissues influences on the degree of inflammation and activity of fibrotic process in this organ.

Key words: children, chronic hepatitis C, biopsies of liver, iron.

 

 

Platonova O. M.

The effectiveness of the treatment and diagnostic measures in functional bowel diseases using the approach of evidence based medicine.

189

Summary. The review of the publications dedicated to the problem of treatment and diagnosis of FBD among children allows to determine that the best evidence of high effectiveness was obtained for probiotics and trimebutin. There is discussed the expediency of the further investigations of the diagnostic value of the clinical-instrumental and clinical-laboratory methods for the development of the objective diagnostic criteria of IBS and other FBD.

Key words: functional bowel diseases, irritable bowel syndrome, treatment, diagnosis, evidence based medicine.

 

 

Bodnar G. B.

Pathophysiological aspects of formation of functional bowel disorders in children.

192

Summary. In article presented the modern data concerning the physiology and pathophysiology of the colon. Consistently describes the main function of the colon their definition, classification and pathophysiological aspects of the formation of its functional disorders in children.

Key words: colon, pathophysiological aspects, children.

 

 

Tsymbalista O. L., Bobrykovych O. S., Kravchenko V. I.

Characteristic of thyroid gland diseases among children and teenagers of the Precarpathia.

196

Summary. Reduction of the thyroid gland (TG) diseases is observed among children and teenagers of the Precarpathia during the last five years in all climate-geographical regions especially in the mountainous ones. Rate of TG pathology is higher in teenagers than in children. Among TG diseases diffuse nontoxic goiter of the 1st stage predominates (95,5–96,5%). Respectively the level of ioduria median in this region corresponds to the slight iodine deficiency. In the metabolic syndrome in teenagers TG diseases are diagnosed more often (p<0,001) than among all population.

Key words: children, teenagers, thyroid gland pathology, iodine deficiency.

 

 

Muratova E. G.

Doppler sonography of the main vessels of the neck in children with І diabetes melitus.

200

Summary. A comparison of Doppler indices of blood flow in the main vessels of the neck in children with different duration of diabetes melitus. Doppler sonography proposed criteria for the diagnosis of diabetic angiopathy.

Key words: children, diabetes, major vessels of the neck Doppler sonography.

 

 

Fomina S. P.

Pathomorphosis of glomerulonephritis with nephrotic syndrome in children.

203

Summary. After year 2000 qualitative changes in glomerulonephritis with nephrotic syndrome course in Ukrainian children were identified. The aggravation of disease presentation was found: number of patients with typical nephrotic syndrome was significantly reduced; proportion with concomitant hematuria, hypertension, and impaired renal function in the disease onset was increased; age and histological focuses were changed; sensitivity spectrum to conventional steroid treatment has deteriorated. However, the use of national protocols of immunotropic treatment maintained the sustainability of remission in steroid sensitive nephrotic children, and steroid resistance accompanied by significantly reducing the risk of chronic renal failure in follow up 60 months. These facts indicate a disease pathomorphosis, and confirm the effectiveness of the Ukrainian therapeutic strategy in respect of nephrotic children.

Key words: steroid sensitive nephrotic syndrome, steroid resistance nephrotic syndrome pathomorphosis, treatment, survival function, children.

 

 

Проблемные вопросы бронхиальной астмы у детей: итоги научной встречи специалистов и интерактивной телеконференции.

207

 

 

Shооmnaya Т. E.

The role of chemical matters in development of allergic diseases as ecological pathology for children.

209

Summary. The article is devoted the modern nosotropic aspects of determination of role of chemical matters in development of allergic diseases as ecological pathology for children in the conditions of unfavorable factors of environment for the further improvement of prophylactic measures.

Key words: allergic diseases, chemical matters, ecological pathology, children.

 

 

Ivanova L. A.

Clinical value of bronchial inflammation factors and respiratory ways hyperresponsiveness under the severe bronchial asthma in schoolchildren.

212

Summary. 57 children with severe bronchial asthma and their 65 age mates with the moderately severe cases were observed at the department of pulmonary disease and allergology of the Chernivtsi regional children hospital. The study showed that the content of nitric oxide metabolites and aldehyde and ketoderivatives of 2.4 dinitrophenylhydrazones of neutral character in the expired air condensate was presumably higher in patients with the severe bronchial asthma. Non-specific bronchial hyperresponsiveness was presumably higher in children suffering severe bronchial asthma due to bronchial hyperresponsiveness as well as hyperreactivity of the respiratory ways. The factors of oxidative albumins modification occurred significantly associated with catalase activity and factor of bronchial spasm in the patients with severe BA. In children with moderately severe course of the disease there was the inverse correlation between catalase activity, the content of nitric oxide metabolites in the expired air condensate and the factor of bronchial spasm.

Кey words: children, bronchial asthma, bronchial inflammation factors.

 

 

Parkhomenko L. K., Ieshchenko A. V.

Medical and social aspects of tobacco smoking in adolescents.

215

Summary. Data on the harmful effect of smoking on adolescent body, the relevance of the prevention of tobacco dependence in children and adolescents, the role of health professionals in the prevention of a healthy lifestyle are presented in the article.

Key words: adolescents, tobacco smoking, tobacco dependence.

 

 

Дети «в себе»: история исследования аутизма .

219