• Scientific and practical journal
  • DOI:
  • 10.15574/SP
  • Circulation -
  • 8000
  • Format of the edition -
  • 290x210 mm
  • Frequency -
  • 8 issues a year

Chernyshova L. I., Bondarenko A. V., Kostyuchenko L. V., Volokha A. P., Yakimovich S. A., Savvo O., Rabosh O. V., Nikonets L. D.

Prospects and problems of establishment of the national registry of patients with primary immunodeficiency.


Summary. National Registry of Patients with Primary Immunodeficiency (PID) contains information about 650 patients (30 nosological entities) from 24 regions of Ukraine, who was diagnosed during 1995–2011 years. PID structure by the link of defeat of immune system in Ukraine is similar to the European Registry. In Ukraine, almost at all nosology PID is observed in 5–10 less then registration of these diseases in the world. Genetic confirmation of the diagnosis performed at 101 (15.5%) patients. Number of diagnosed primary immunodeficiency diseases is growing every year, hence the need of systematic data about the detected mutations, characteristics of the course of disease, analysis of the effectiveness of different treatments.

Key words: primary immunodeficiencies, registery of patients, the frequency of registration.



Orlyuk I.B., Kozachuk V. G.

Antihomotoxic treatment of lymphadenopathy in children (view on the problem).


Summary. In the article the advantages of antihomotoxic therapy in the treatment of ENT diseases and childhood infections are shown. The characteristics of antihomotoxic preparations and patterns of its use in a variety of infections in children are presented. High efficiency and safety of antihomotoxic is the basis for their inclusion in the mono- or combination therapy with allopathic preparations in medical practice pediatricians, infectious disease specialists, otolaryngologists and general practitioners.

Key words: lymphadenopathy, ENT diseases, childhood infections, antihomotoxic therapy.



Krivopustov S. P., Dziuba O. L., Grechina L. M., Iordanova S. V., Lukovnikova E. A.

Headadache in children: features of pathogenic treatment.


Summary. The experience of the use of complex homeopathic preparation which is containing ginkgo biloba, hawthorn and white mistletoe, in the treatment of headache in children with autonomic dysfunctions is shown. High efficacy and good tolerability allow recommending its use in children.

Key words: headache, autonomic dysfunctions, blood pressure, homeopathic preparations.



Баранов A. А., Богомильский М. Р., Волков И. К., Геппе Н. А., Козлов Р. С., Козлова Л. В., Коровина Н. А., Манеров Ф. К., Мизерницкий Ю. Л., Намазова Л. С., Насонова В. А., Самсыгина Г. А.. Сергеева Т. В., Спичак Т. В., Страчунский Л. С., Таточенко B. К., Якушин С. Б.

Применение антибиотиков у детей в амбулаторной практике. Практические рекомендации.




Kozakevych V. K., Kozakevych O. B.

Prebiotics and nucleotides in the diet of the children of the firs year of life.


Summary. The clinical effectiveness of domestic mixtures with oligosaccharides and nucleotides «Malyutka-1 premium» and «Malyutka-2 premium» in the feeding of infants is studied. The results of conducted study showed that the mixture is well tolerates, provide requirements of the children of the first year of life in important nutrients.

Key words: children, artificial feeding, breast-milk substitutes, adaptation, prebiotics, nucleotides.



Vertegel A. A., Ovcharenko L. S.

Additional medical support with antibacterial therapy in children: the necessity or polypharmacy? Part 1. Probiotics.


Summary. The data from numerous studies about the safety and efficacy of probiotics for the prevention of antibiotic-associated diarrhea in children is analyzed.

Key words: children, antibiotics, safety, probiotics, allergy.



Reznichenko Yu. G., Yartseva M. O.

Preventive mesures of the most common diseases in young children — residents of the big industrial city.


Summary. The examination of 117 children of the first year of life, living in the big industrial center, and of 245 children from the city with minor anthropogenic load is conducted. There are found disturbances of development, immunity and microbiota stutus in children who are resides in the conditions of industrial city. The positive effect of prophylactic use of probiotics on the health condition of the present group of children is shown.

Key words: children, immunity, microbiocenosis, probiotic.



Matvienko N. V., Lukyanenko O. V.

Hearing disorders in newborns and infants.


Summary. In the article the results of screening research of hearing in 1076 newborns are shown. Found that an important risk factor of hearing disorders in newborns is prematurity. The necessity of echo-screening application in newborns is proved.

Key words: hearing disorders, screening research, newborns.



Smolar N. I., Solonko G. M., Dubetsky-Grabous I. S., Bezvushko E. V., Moschich A. P.

Increase of efficiency of primary teeth caries prevention by the way of cooperation of pediatrics and child dentistry.


Summary. Taking into account the high rates of caries of primary teeth and modern risk factors for its development a set of preventive measures aimed at the formation of caries-resistant enamel structure was created. The role of the pediatrician in the prevention of primary teeth caries was defined, aimed at formation of a positive motivation of parents to dental prophylaxis.

Key words: baby teeth, tooth decay, prevention.



Bezkaravayny B. A., Solovyova G. A., Repin G. I., Maksimenko J. V.

Features of cardiorespiratory adaptation in preterm infants during kangaroo mother care.


Summary. This article presents the results of daily monitoring ECG with parallel recording reopneuvmogrammy of 30 premature babies who are nursed by the mother care kangaroo, and 22 infants are nursed with standard care. Established the existence of periodic breathing with respiratory pauses of all newborns and significantly more severe electrical instability of myocardium in children whose mothers did not use the method of kangaroo mother care.

Key words: premature infant, kangaroo mother care method, rheopneumography, 24-hour monitoring of ECG.



Berezhnoi V. V., Kozachuk V. G., Glyadelova N. P., Korneva V. V., Koroleva V. A., Lischinskaya M. R.

Modern aspects of threatment of acute stenosing laryngotracheitis in children.


Summary. The evaluation of clinical efficacy and safety of rectal administration of prednisone (Rektodelt 100) in treatment of acute stenosing laryngotracheitis (ASLT) is conducted. Advantages of the drug allow recommending it for widespread clinical use during the ASLT in children at all stages of urgent medical care.

Key words: acute stenosing laryngotracheitis, urgent medical care, corticosteroids, Rektodelt.



Ovcharenko L. S., Vertegel A. A., Andrienko T. G., Red'ko I. I., Zhikhareva N. V., Samokhin I. V.

Efficiency of nasal irrigations by «Aqua Maris» spray in children with frequent recurrence of nasopharyngeal diseases.


Summary. The investigation of efficacy and safety of «Aqua Maris» nasal spray for treatment and prevention of recurrent adenoiditis and / or adenotonsillitis in children at the age 2-7 years was conducted. The positive effect of the preparation is due to several effects: the restoration of the normal functioning of the barrier-cleaning function of nasal epithelium; regeneration of cytoarchitectonic of mucosal nasopharyngeal; eradication of pathogenic and conditionally pathogenic microflora; increasing concentrations of secretory sIgA in saliva; safety of use.

Key words: children, rhinosinusitis, adenoiditis, nasal irrigations, Aqua Maris.



Boyarskaya L. N., Podlianova E. I., Forul M. I., Merezhko A. S.

Role of ECG-screening during the indentified risk of heart disease in school children.


Summary. The aim of examination was to demonstrate thet the early detection of undiagnosed cardiac risk may be facilitated by adding ECG-screening to history and physical examination in the school-age population.

Key words: ECG-screening, the school-age children, cardiac risk.



Yemets I. M.

Innovative organizational strategy for critical congenital heart disease.


Summary. We described innovative organizational strategy for neonates who have prenatal diagnose of critical congenital heart disease (cCHD) with focus on earliest surgical repair, using autologous umbilical cord blood. Since September of 2009 to August of 2012, 390 neonates with cCHD were operated at our institution. For this period 50 neonates underwent the new strategy. Neonates were admitted to the cardiac department during an hour after birth. No patients required ICU admission, interventional procedures, mechanical ventilation or medications before surgery that result in significant positive economic effect compared with conventional approach. Mean age at operation was 3.9±1.1 hours (2–6). Mean volume of harvested cord blood was 85±24 mL (50–140). Forty (80%)neonates underwent open cardiac surgery without homologous blood transfusion.

Key words: prenatal diagnoses, neonatal cardiac surgery, autologous umbilical cord blood.



Belih N. A.

Experience with the carbocysteine application in children with acute respiratory diseases.


Summary. The article deals with the results of the study the clinical efficiency of the drug Fluditec in children with acute respiratory diseases. The estimation of efficiency was by the clinical evaluation positive dynamic of cough and assessment of patients and their parents. The pronounced Fluditec therapeutic effect and safety in treating cough in children was made.

Key words: children, acute respiratory diseases, cough, carbocysteine.



Торшхоева Л. Б., Глухарева Н. С., Заплатников А. Л.

Принципы рациональной терапии острых респираторных вирусных инфекций у детей.


Modern approaches to phytotherapy of acute and chronic upper respiratory tract diseases: world scientific experience.


Summary. The International Summit «Phytoniring Research and Experience Summit» was held in June of this year, in the frame of which the world scientific experience in applying of modern phytotherapeutic preparations in the treatment of catarrhal diseases has been consolidated. Also were presented the results of studies on the effectiveness of the drug Imupret.

Key words: catarrhal diseases, phytotherapeutic preparations, phytoneering, Imupret, Bronchipret.



Nedelskaya S. N., Kuznetsova O. D., Klyatskaia L. I., Tolmacheva Yu. S.

Control over seasonal allergies in children on the base of aerobiologic researches of pollen grains of fungal spores, zaporizhya city.


Summary. The problem of seasonal allergy the etiologic factor of which is pollen and spores of micromycetes is described. Connection is exposed between seasonal symptoms and by the level of pollen and spores micromycetes in mid air.

Key words: children, hypersensitivity, aeroallergens, monitoring of the dust and micromycetes.



Aryaev N. L., Shevchenko I. M., Gornostaeva N. Y., Kuzmenko I. V., Titkova E. V.

Clinical value of ursodeoxycholic acid in treatment of atopic dermatitis of children.


Summary. Efficiency of application of ursodeoxycholic acid was investigated in complex therapy of atopic dermatitis of children. The most effective method is the complex therapy of atopic dermatitis with including of preparation »Ukrliv».

Key words: children, atopic dermatitis, »Ukrliv».



Ovcharenko L. S., Vertegel A. A., Andrienko T. G., Red'ko I. I., Zhikhareva N. V., Samokhin I. V.

Efficiency of enterosorption by «Atoxil» preparation in the program of therapy of the clinical manifestations of food allergy in children.


Summary. The evaluation of clinical efficacy and safety of use of silicon dioxide in the form of powder for suspension («Atoxil») in the complex treatment of food allergies in children by the age from1 to 5 years is conducted. High efficiency and lack of side effects allow recommending the inclusion of Atoxil to the standard therapy of clinical manifestations of food allergy in children from the beginning of the second year of life.

Key words: children, food allergy, enterosorption, silicon dioxide.



Shadrin O. G., Klimenko V. A., Karpushenko Yu. V., Adaryukova L. M., Ivakhnenko E. S.

Modern approaches to patient management with food allergies.


Summary. The algorithm of diagnosis and treatment of patients with food allergy was represented in the article. The algorithm is based on the recommendation of the National Institute of Allergy and Infectious Diseases (NIAID, 2010) and Guidelines World Allergy Organization — «Diagnosis and Rationale for Action against Cow's Milk Allergy» (DRAGMA, 2010). The authors' experience wastaken into account.

Key words: Children, Food Allergy, Diagnostics, Treatment.



Us'ka V. R.

Effectiveness of application of the method of physical rehabilitation of children who suffer from asthma in the therapeutic complex.


Summary. The method of physical rehabilitation of children who suffer from asthma is conceded, the combination of four initial positions of bronchus drainage and manual interference which consists and its effectiveness is prove.

Key words: bronchial asthma, the physical rehabilitations, children.



Shumnaia T. E.

Clinical and anamnestic features of allergic diseases in children of zaporizhya region.


Summary. A comparative study of clinical features of current medical history of allergic disease (AD) in children of Zaporozhya region and the cities of Zaporozhya region (Primorsk, Berdyansk) is conducted. It is found that the implementation of the «atopic march» with bronchial asthma development is more peculiar for urban children whose mothers often had abnormal pregnancy and childbirth. For children with AD is more typical high polymorphism of complaints and at least two co-morbidities. Comprehensive assessment of clinical and anamnestic features of AD in children allow identifying the risk factors of allergic diseases development for formulation of personalized preventive and therapeutic measures, differentiated approach to forecasting of the social adaptation of the child and its overall health.

Kay words: allergy diseases, children, clinical and anemnistic featuers, big industrial city.



Marushko Yu. V., Todyka Yu. I.

Experience using ursodeoxycholic acid in children with disorders of the colloidal composition of bile.


Summary. In this paper, an analysis of the world literature with the study of trends in therapeutic approaches to management of pediatric patients with biliary sludge. The efficacy of the drug ursodeoxycholic acid against ceftriaxone associated sludge.

Key words: children, gall-stone disease, Ursodeoxycholic acid, biliary sludge, ceftriaxone.



Abaturov A. E., Gerasimenko O. N.

Mechanisms role nonspecific protection in the development of inflammation of gastric mucosa in children with Helicobacter pylori infection .


Summary. The article presents data on the role of innate immunity factors in the development of chronic inflammation of gastric mucosa in children with Helicobacter pylori infection. Shown peculiarities in the expression of TLR4 in biopsies of gastric mucosa content and sCD14 in serum of children with chronic gastroduodenitis associated with Helicobacter pylori, in the acute stage.

Key words: Helicobacter pylori, chronic gastroduodenitis, children, TLR4, sCD14.



Belousova O. Yu.

Intestial dysbiosis during the functional constipation in children and its correction by Laktiale.


Summary. The possibility of use of symbiotic Laktiale with the aim of correction of intestinal biocenosis during the functional constipation in children of preschool age is studied. Effectiveness of the drug allows its recommending for widespread clinical use in pediatric patients.

Key words: preschool children, functional constipation, intestinal dysbiosis, Laktiale.



Mazur V. I., Shumnaia T. E.

State of hepatobiliary system and pancreas in children with allergic diseases and dermo-respiratory syndrome.


Summary. In the article the results of examination and treatment of 175 children (93 boys and 82 girls) at the age from 3 to 18 years with allergic disorders are presented. In 66% of children with allergic diseases in the pathological process was involved the gastrointestinal tract. The detected changes of the pancreas and the liver in patients with allergic conditions are reversible and can be treated as reactive changes. In the complex therapy of the main children's group (56 boys and 44 girls) thiotriazolin were included. The results of study show the feasibility of application of the present preparation into the complex therapy of allergic diseases in children.

Key words: allergies, dermo-respiratorny syndrome, pancreas, liver.



Abaturov A. E., Zavgorodnyaya N. J.

Proliferative activity and antimicrobial resistance of gastric mucosa in conditions of chronic HP-associated gastritis in children.


Summary. In this article data of changes in proliferative potential of gastric epithelial cells and production of local non-specific protective factors betadefensins in chronic HР-associated gastritis in children are presented.

Key words: chronic gastritis, HP-infection, proliferation marker, beta-defensins, children.



Khomenko V. E.

Functional gustrointestinal disorders in older children.


Summary. The article deals with contemporary ideas about ethiopathogenesis, clinical manifestations, diagnostic and treatment of childhood functional gastrointestinal disorders (according to Rome III criteria).

Key words: functional gastrointestinal disorders, children, Rome III criteria.



Karnauh Н., Shutova H.

Characteristics remineralizing potential of oral fluid in children with gastroduodenic disease.


Summаry. 40 patients with gastroduodenic pathology were observed and 20 patients without gastroduodenic pathology. We defined changes in content of oral fluid, which can be risk factors of developing of dental tissues pathology, in basic group.

Key words: gastroduodenic pathology, oral fluid, tooth.



Комбинированный фитопрепарат против инфекций мочевыводящих путей.




Ysachova E. V., Silina E. A., Konakova O. V., Denisenko I. G., Kurochkina T. I.

Specifics of severe form of congenital cytomegaloviral infection (clinical case).


Summаry. The article describes clinical course of severe form of congenital cytomegaloviral infection. This clinical case points for some problematic questions in diagnostics and treatment of this disease in newborn.

Key words: congenital cytomegaloviral infection, newborn, severe form, diagnostics, clinical picture, treatment.



Nagornaya N. V., Bordyugova H. V., Muravskaya K. V., Mokryk I. U., Kartashova O. S.

Di George's syndrome: from classic triad to variety of clinical displays.


Summary. Di George syndrome is a primary immunodeficiency disease characterized by defecate of T-cell immunity, hypoparathyroidism and abnormalities of the heart and the greate vessels. The syndrome is caused by the defects of development of the third and fourth pharyngeal pouches , which leads to aplasia of thimys, hypo- or aplasia of parathyroid glands and malformations of the heart and greate vessels. A variety of clinical manifestations caused diagnostic difficulties. The article contains three our observations of Di George syndrome in children.

Key words: Di George syndrome, congenital immunodeficiency, thymus.



Glyadelova N. P.

Experience of the use of antiviral herbal preparations in the treatment and prevention of influenza and other acute respiratory viral infections in children (literature review).


Summary. The problem of effective, safely treatment and prevention of influenza and other acute respiratory viral infections is one of the urgent problems of clinical pediatrics. In the article the data on the use of antiviral preparations for the treatment and prevention of viral respiratory infections in children is summarized. The literature review devoted to the pharmacological properties of native antiviral herbal Immunoflazid, Proteflazid is conducted. Clinical result of their use in children with acute respiratory infection proves the feasibility of including these preparations to the therapeutic and prophylactic scheme.

Key words: children, influenza, acute respiratory viral infection, antiviral drugs, treatment, prevention, Immunoflazid, Proteflazid.



Kotlova J., Pecherskaya K., Kurochkina T.

Nutrition and evaluationof physical development of the premature VLBV end ELBV infants on the first year of live (the review of literature).


Summary. In the literature review presents current data the characteristics of physical development and nutrition in the first year of life of children born with VLBV and ELBV about. Discussed issues of enteral nutrition. Practical recommendations are given. Shows the evaluation of preterm infant's physical development and the amount of laboratory control.

Key words: premature infant, young child, feeding, complementary feeding, physical development.



Mochalova A. A.

The health status of intellectually gifted children.


Summary. They studied the health of 157 intellectually gifted younger students. Prescribe a higher frequency of autonomic dysfunction, and astenoidnogo digestivnogo somatotype, decreased physical development. Identified: predominantly type sympathicotonic autonomic reactivity and gipersimpatikotonicheskaya. Installed more formed alpha-and beta-rhythms, elevated levels of adrenaline and reduced content of serotonin.

Key words: children, intelligence, and health status.



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