SOVREMENNAYA PEDIATRIYA № 2 – 2013

  • Scientific and practical journal
  • DOI:
  • 10.15574/SP
  • Circulation -
  • 8000
  • Format of the edition -
  • 290x210 mm
  • Frequency -
  • 8 issues a year

Volokha A. P., Chernyshova L. I., Raus I. V.

The challenges of immunization in HIV-infected children (review of literature).

10

Summary. Safety, immunogenicity and efficacy of vaccination of HIV-infected children should be carefully and continuously evaluated because of impairment of immune response to vaccines in children with immunodeficiency. Safety and immunogenicity of vaccines depend on both vaccine type and immune deficiency. Efficacy of immune response to vaccines in children with HIV-infection related to development and maintenance of memory T- and B-cells to antigens. Investigation of B-cells function in HIV-infected children is very important immunologic aspect due to key role of B-lymphocytes in production of protective level of specific antibodies.

Key words: HIV-infection, immunization, children, immunodeficiency, B-cells immunity.

 

 

Yulish E. I., Chernysheva O. E., Krivuschev B. I., Glinskaya E. V, Levchenko A. A.

Impairments of motor-evacuation activity of the digestive tract in children and its correction.

17

Summary. The paper discusses the causes, mechanisms of pathogenesis, clinical manifestations of motor-evacuation disorders of the digestive tract in children and methods for their correction.

Key words: GI-tract dysmotility, children.

 

 

Pavlushun G. A., Furdela V. B., Samson O. J., Andrikevych I. I.

Obesity in childhood: treat or watch?

20

Summary. The causes and trigger factors of overweight and obesity in children of all ages, modern criteria for the diagnosis and principles of prevention is analyzed in article. The aim of this work is to pay attention of district pediatricians and family physicians on this problem and help them to detect and treat children with obesity in time.

Key words: children, obesity, prevention.

 

 

Tokarchuk N. I., Chigir' I. V., Chekotun T. V., Starinets L. S., Savitskaya T. V., Lagoda V. V.

Features of lipid metabolism in infants with protein-energy munutrition.

26

Purpose: To study the features of lipid metabolism in infants with protein-energy malnutrition.

Patients and methods. The 58 of children with protein-energy malnutrition in the age from 1 to 12 months were under observation. The control group consisted from 25 of children the physical development of which were appropriate to the age. The study of clinical and anamnestic data, clinical examination of

children with assessment of their physical development, clinical and laboratory examination are conducted. Determination of lipid metabolism data (cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, very little density lipoproteins cholesterol and atherogenic index) were performed by immunoenzyme method. Determination of serum cortisol levels was performed using immunochemistry system ACCESS. Statistical analysis of the results was carried out by the methods of variation statistics using the program of SPSS 17.0.

Results. Among the risk factors of protein-energy malnutrition in children in the first year of life is an important place takes pathology of perinatal period. In the structure of comorbidity the important place occupied the consequences of hypoxic-ischemic of the CNS. Among the congenital malformations in children with protein-energy malnutrition the prevailed were congenital heart diseases — 19 (33%) of patients and birth defects of the brain — 16 (28%) of patients. There are also detected background diseases: iron deficiency anemia — 32%, rickets — 20%, prenatal infection — 16% of cases. Nutritional factor was not dominant in the development of protein-energy malnutrition. The primary cause of hypotrophy among examined children was the main pathology. A violation of lipid metabolism characterized by significant reduction of the levels of cholesterol, triglycerides, HDL, LDL, VLDL and atherogenic index were established.

Summary. Results of the study are shown a decrease in cholesterol, triglycerides, fractionation lipoprotein and increased levels of cortisol in blood serum of infants with protein-energy malnutrition. The latter may indicates about predominance of lipolysis over lipogenesis in children with protein-energy malnutrition.

Key words: first year of life, protein-energy malnutrition, lipid metabolism, cortisol.

 

 

Kramarev S. A., Vigovsaya O. V.

Treatment of infectious mononucleosis of Epstein—Barr virus etiology in children with the use of recombinant interferon α-2b in the rectal form.

30

Objective: To evaluate the effectiveness of treatment of patients with infectious mononucleosis, Epstein-Barr viral etiology (IM EBV) by a human recombinant interferon -2b (Laferobion) in the form of rectal suppository.

Patients and methods. The study included 60 children with IM EBV, aged from 1 to 14 years who were divided into two groups by 30 patients on each group. For children from the 1st group except the basic therapy was administered recombinant IFN-α-2b (Laferobion). For children from the 2nd group was administered only basic therapy. During the severe forms of infection in the acute phase of the disease was performed detoxication infusion therapy with glucosesaline solutions. In the presence of tonsillitis children had received in addition to the basic treatment such antibacterial preparations as (penicillin, cephalosporins).

Results. Estimation of the impact of IFN-α-2b (Laferobion) on clinical symptoms of MI EBV has shown that its use resulted to the complete elimination of clinical symptoms in 23.3% and improve the general condition in 60% of patients. The children who had received only standard treatment, the total elimination of clinical symptoms was observed in 16.7% of patients, clinical improvement — in 33.3%, and in 16.7% of children during the rapeat examination was marked decline.

Conclusions. Recombinant IFN α-2b rectal form (Laferobion) is effective and safe in the treatment of IM EBV infarction in children.

Key words: infectious mononucleosis, Epstein-Barr virus etiology, children, human recombinant IFN α-2b.

 

 

Kozachuk V. G.

Palm oil in the baby food.

36

 

 

Banadyha N. V.

The case of mixed-infection: chikenpox and meningococosis infection in a child.

38

Summary. The clinical case of mixed-infection: chickenpox and meningococosis infection is described in the article. At the same time meningococosis infection was having the form of meningococcemia, carditis, polyarthritis.

Key words: meningococosis infection, chikenpox, children.

 

 

Gorovenko N. G., Shunko E. E., Laksha O. T., Rossokha Z. I., Kiryachenko S. P., Pokhilko V. I., Kovalova O. M.

Genetic aspects of need for medical intervention in neonates.

41

Summary. The paper presented the results of a comprehensive assessment of the role of polymorphisms gene ACE AT2R1, TNF-α, MTHFR in the need for medical interventions in neonates. For statistical analysis obtained predictive models with high predictive value. Further studies will facilitate the use of the results of genetic testing to assess of critical state in the newborn and the need for medical intervention.

Key words: gene, polymorphism, newborn.

 

 

Klimenko T. M., Serdtsev E. A., Karapetyan O. Yu., Yatsenyuk O. V.

To the question of management of preterm infants with respiratory distress syndrome.

46

Objective: To evaluate the effectiveness of prevention of pneumonia in preterm infants with respiratory distress syndrome (RDS) during the use of cephalosporins of the II generation in the complex treatment.

Patients and methods. A total of 38 preterm infants with gestational age 28–36 weeks, birth weight 1594,0 ± 181,0 g, Apgar score at 1 '— 4,9 ± 0,3 points, 5' — 6,7 ± 03 points with clinical and radiological signs of respiratory distress syndrome were under observation. Infectious, somatic, obstetric-gynecologic anamnesis of mothers, newborn clinical status and laboratory parameters are studied. For all newborns as a starting antibacterial therapy (ABT) was assigned cefuroxime («Cefumax») at a dose of 50–100 mg / kg / day in 2–3 intravenous administration for 10 days in a complex symptomatic treatment.

Results. The positive result of Cefumax application with the aim of pneumonia prevention obtained in 29 (76.3%) infants with respiratory distress syndrome. In 3 (7.9%) patients Cefumax was ineffective. In 6 (15.8%) infants was impossible to assess the results of treatment by the need to change or enhance of ABT in the first days of treatment.

Conclusions. The study showed a high clinical safety and efficacy of cephalosporin of the II generation (Cefumax) for pneumonia prevention in preterm infants with respiratory distress syndrome.

Key words: preterm infants, respiratory distress syndrome, pneumonia prevention, antibiotic therapy, Cefumax.

 

 

Nagorna N. V., Dubova G. V., Bordyugova Ye. V., Muravskaya1 I. Yu., Kislytsia V. N., Burka A. A., Muravskaya K. V.

Towards improving the quality of life of children with vegetative-vascular dysfunction.

49

The quality of life of 115 children (63 girls and 52 boys) 7–18 years with vegetative-vascular dysfunction (78 pers.) and healthy children (37 pers.) are presented. At baseline a decrease in quality of life of 67 (84,8±2,9%) individuals with vegetative-vascular dysfunction, significantly higher (p <0,05) in hypertensive type (72,5±5,4% pers.) are submitted. The major reasons were the change of health (56,3±4,0% pers.), decreased concentration (50,7±6,1%), memory impairment (28,4±5,5%), autonomic imbalance (81,5±3,2% pers.), disorders of emotional status (77,5±3,4% pers.). Conducted comprehensive treatment had a positive effect on the quality of life of children with vegetative-vascular dysfunction in both groups with greater severity in patients receiving Noofen. Thus, the inclusion in the complex treatment of Noofen accompanied by improved quality of life in 59 (75,7±7,1%) pers. due to improved well-being of children

(76,2±9,3%), reducing the anxiety (76,2±9,3%) pers., normalization of the autonomic nervous system balance (75,7±7,1%) pers., improving memory (75,0±7,7%) pers., high concentration (64,0±8,8%)pers., reducing stress state (60,7±9,2%) pers. The above justifies the desirability of placing Noofen in complex of medical reabilitational activities for children with vegetative-vascular dysfunction.

Key words: children, vegetative-vascular dysfunction, quality of life, Noofen.

 

 

Nevirkovets A. A.

Dynamics of changes of free histamine in the blood plasma in newborns with perinatal hypoxic damage of the central nervous system.

55

Purpose: To study the content of free histamine (GN) in the blood plasma of newborns with perinatal hypoxic damage of the central nervous system and to study the dynamics of its changes during the treatment.

Patients and methods. A total of 33 infants with perinatal hypoxic damage of the central nervous system (15 boys and 18 girls) who were treated in intensive care and neonatal pathology departments are examined. Children had gestational age from 31–32 to 39–41 weeks, birth weight of which was from1950 g to 4100 g born in full-term 21, preterm —12. The control group consisted of 17 healthy infants (9 boys and 8 girls) of the same age.

Results. In infants with perinatal hypoxic damage of the central nervous system were found material violation of free histamine in the blood plasma, which significantly normalized in the process of treatment.

Conclusions. There is a need for in-depth study of histamine metabolism in infants to understand its pathophysiological role in the formation of a number of clinical symptoms during the hypoxic damages of the central nervous system.

Key words: central nervous system, newborns, histamine, blood plasma.

 

 

Slivinskaya-Kurchak H. B.

Ventilator-associated complications in newborns.

58

Purpose: To determine the frequency and structure of ventilator-associated complications in the neonatal period, the forecast of mortality prognosis according to the history data of children who had received artificial pulmonary ventilation during the neonatal period according to the respiratory disorders.

Patients and methods. A retrospective analysis of 380 history cases of infants who had received artificial pulmonary ventilation (APV) for more than 3 days is conducted.

Results. Occurrence of ventilator-associated complications in infants on artificial pulmonary ventilation depends on: gestational age, birth weight, Apgar scores at 1-minute, consistent application of artificial pulmonary ventilation modes, settings (FiO2, flow, peak inspiratory pressure) and duration of artificial pulmonary ventilation. Occurrence of artificial pulmonary ventilation complications in the neonatal period leads to an increase in the duration of parenteral nutrition and hospitalization of infants.

Conclusions. It is found that a survival rate of infants on artificial pulmonary ventilation depends from the underlying disease, gestational age and birth weight. Increased oxygenation index more than 10% in infants on artificial pulmonary ventilation is one of the predictors of fatal prognosis. The most frequent complications of artificial pulmonary ventilation in the neonatal period are: air leak syndrome, pneumonia, bronchopulmonary dysplasia (BPD), pulmonary hemorrhage.

Key words: artificial pulmonary ventilation, neonatal period, ventilator-associated complications.

 

 

Molochek Yu. A.

Early management of postoperative period after tonzillotomy and tonsillectomy in children.

61

Objective: optimization of management of early postoperative period after tonzillotomy and tonsillectomy in children.

Patients and methods. The study included 60 children: 40 children after conducted tonzillotomy (16 boys and 24 girls) and 20 children after tonsillectomy (7 boys and 13 girls). The patients' ages ranged from 4 to 17 years. There were formed four groups of 15 children in each one. Children from the first group received «Tantum Verde ®» preparation in the postoperative period, the second and the third group — the other antiseptic and local anesthetic preparations. In the fourth control group anti%inflammatory treatment was not performed.

Results. Most revealing was the local anesthetic effect of the «Tantum Verde ®» preparation which is started in 15–20 seconds after application and has been persistent in its regular use in the postoperative period. In the setting of the application of preparation accelerated the disappearance of other signs of reactive inflammation (swelling and redness of the mucous membrane, impaired phonation, and increase of regional lymph nodes).

Conclusions. Non-steroidal anti-inflammatory preparation for local application «Tantum Verde ®» is quite effective, safe and convenient for use in children who are undergoing surgery on the oropharynx.

Key words: tonzillotomy, tonsillectomy, postoperative period, local anesthetic preparations, Tantum Verde ®.

 

 

Ovcharenko L. S., Tkachenko V. Yu., Vertegel A. A., Andrienko T. G., Zhikhareva N. V., Samokhin I. V.

A new method of effective therapy of impaired nasal breathing in acute rhinosinusitis in children.

65

Objective: To optimize treatment and prevention programs of acute rhinosinusitis in children.

Patients and methods. A total of 50 children with acute infectious rhinosinusitis in the setting of ARVI in the age from 2 to 6 years, randomly distributed into two groups of 25 children in each one were under observation. The children of the first group received «Meralis.» Children of the second group received a 0.05% solution of xylometazoline. The «Meralis» preparation was used in the form of a nasal spray based on the water of the Adriatic Sea with the content of 0.05% solution of xylometazoline, in bottles of 10 ml. Mode of use: for one injection in every bow at the request, but not more than 2 times a day.

Results. In the setting of the application of «Meralis» was marked more rapid improvement of the clinical symptoms of the underlying disease. It is registered cytoarchitectonic restoration of the nasal mucosa with the strengthening of its functioning and protective barrier characteristics (increased concentration of secretory sIgA) during the use of «Meralis». During the 5-day application in children «Meralis» preparation had shown good tolerability and safety.

Conclusions. The use of «Meralis» preparation in the program of therapy for acute rhinosinusitis with ARVI in children aged 2–6 years has significant advantages over application of conventional xylometazoline.

Key words: children, rinosinusitis, decongestants, xylometazoline, sea water.

 

 

Терапия кашля у детей с применением препаратов на растительной основе: отечественный опыт.

70

Belykh N. A., Plugatarenko N. A., Gubina I. V., Golovin V. V.

Comperison of the effectiveness of external preparations in the treatment of acute pharyngitis in children.

74

Purpose: To study the effectiveness of the use of Theraflu Lar and Dekatilen preparations in the complex therapy of over!fives children with acute pharyngitis.

Patients and methods. The efficacy and safety of preparations by clinical and pharyngoscopic picture, estimation of parents and the patients themselves are studied in 64 children in the age of 6–15 years (34 boys and 30 girls) with acute pharyngitis who were treated at the viral box department of Lugansk City Children's Hospital № 4. By the method of random selection children were divided into 2 groups: to the 1st group were included 33 children who had received Theraflu Lar in tablet form, to the 2nd group — 31 children who had received external preparation Dekatilen.

Results. In the treatment of acute pharyngitis in children Theraflu Lar is characterized by a pronounced analgesic effect. Reduction of pathological symptoms in patients receiving Theraflu Lar after 7 days of the treatment was minus 18.22 points and in children who had received Dekatilen – minus 15.88 points.

Conclusions. The high efficiency of the modern combined preparation Theraflu Lar is defined by its active antiseptic and local anesthetic effects, well tolerance and convenient for the patient presentation. It is reasonable to use this preparation in the clinical pediatric practice.

Key words: children, upper respiratory infections, acute pharyngitis.

 

 

Bulat L. M., Tokarchuk N. I., Oleinik V. S., Chekotun T. V., Starinets L. S., Savitskaya T. V., Lagoda V. V.

Features of inflammatory response during the community-acquired pneumonia in prematurely born infants.

79

Objective: To evaluate the immunological status and indicators of IL-1β and IL-10 during the community-acquired pneumonia in infants born with low and very low birth weight.

Patients and methods. A clinical, laboratory and instrumental examination of 137 children aged 1 month to 1 year of age is conducted. To the main group included 52 children who were born prematurely and were under hospital treatment for the reason of community-acquired pneumonia. To the comparison group were included 55 children who were born prematurely, were under hospital treatment at the moment of observation had no acute pathology. To the control group were included 30 healthy infants.

Results. As a result of immunological examination of infants, in patients with community-acquired pneumonia born with LBW and VLBW is revealed violations in the cellular and humoral components of the immune system and also reducing the functional capacity of phagocytes. It is found a specific immune response, depending on the severity of community-acquired pneumonia in children born with VLBW.

Conclusions. Low indices of IL-1β and IL-10 in prematurely born infants indicates about lack of activity of pro-inflammatory and anti-inflammatory cytokines, the immaturity of the immune system of premature child and a weak response to bacterial colonization.

Key words: immunological indices, interleukins, community acquired pneumonia, children.

 

 

Berezhnoi V. V., Korneva V. V.

Hypertensive crisis in children. Emergency management.

84

Summary. The analysis of the hypertensive crisis course in children is conducted. The basic manifestations of hypertensive crisis complications are shown. The main therapeutic approaches of the emergency management during the uncomplicated and complicated hypertensive crises in children are resulted. Medical tactics during these conditions in the pre!hospital setting separately pointed out. The features of pharmacotherapy depending on age, underlying disease, the background state, clinical variants of the hypertensive crisis course in children are analyzed.

Key words: hypertensive crisis, children, emergency management, pharmacotherapy.

 

 

Kovalchuk T. A.

Quality of life in children with juvenile rheumatoid arthritis by the results of survey by questionnaire CHQ.

89

Purpose: To study the quality of life in children with juvenile rheumatoid arthritis, by the way of survey of parents by questionnaire CHQ.

Patients and methods. A total of 55 patients with juvenile rheumatoid arthritis and 28 practically healthy children were under observation. The quality of life of children was assessed using an adapted Ukrainian language version of questionnaire CHQ in the modification of the PF50 (parent form) with a pre!proven psychometric properties. Parents of children aged from 5 to 18 years independently answered on 50 questions.

Results. It is found that growth of the number of affected joints, arthralgias intensity, degree of functional disorders of the musculoskeletal system, the activity of rheumatoid process had influence on the physical health of children. More frequent behavior disorders are marked in boys, in girls it is mental health disorders. Mental health disorders are inherent in children with progressive course of juvenile rheumatoid arthritis.

Conclusions. The course of juvenile rheumatoid arthritis in children accompanied by a decline of not only physical, but also psychosocial health, increase of overall tension in the families of these patients. Deterioration in physical health prevails over psychosocial disorders. Gender differences of psychosocial health of patients with juvenile rheumatoid arthritis are found.

Key words: juvenile rheumatoid arthritis, quality of life, questionnaire CHQ, children.

 

 

Kaladze N. N., Filonenko T. G., Sizova O. A.

The features of ultrastructural changes of small intestine mucosa in experimental modeling of adjuvant arthritis.

95

Summary. The estimation of the ultrastructural changes of the small intestine mucosa is conducted. The characteristic changes of the ultrastructural components of the small intestine mucosa during the modulating adjuvant arthritis which is manifested mainly by degenerative and destructive processes in enterocytes are determined.

Key words: ultrastructure, electron microscopy, small intestine, juvenile rheumatoid arthritis.

 

 

Buznytska E. V.

Functional diseases and violation of biochemical markers of liver fibrosis in adolescents with obesity.

98

Summary. The article presents the results of basic investigators that demonstrate the functional diseases of liver in adolescents with obesity. Authors studied diagnostic role of serum markers of liver fibrosis of non-alcoholic fatty liver disease. Authors showed that determination of collagen type IV, fibronectin, N-terminal propeptides and C-terminal telopeptides of collagen type I for diagnosis of liver fibrosis had high sensitivity.

Key words: children, adolescents, non-alcoholic fatty liver disease, liver fibrosis, obesity, diagnostics methods.

 

 

Хасанова Е. Е.

Комплексное лечение детей с лямблиозом и сопутствующим дисбактериозом кишечника.

103

Ключевые слова: лямблиоз, паразит, дисбактериоз кишечника, дети, полиморфизм клинических признаков, энтеросорбция, кишечный синдром, микрофлора, запор, диарея, псиллиум, санирующий эффект.

 

 

Kryuchko T. S., Nesina I. M., Zin'kovskaya S. M.

To the question of treatment optimization of children with irritable bowel syndrome.

108

Purpose: pathogenetic substantiation and evaluation of therapeutic efficacy of the drug «Trimetabol» in treatment of children with irritable bowel syndrome (IBS).

Patients and methods. Under observation were 61 child with irritable bowel syndrome, who was hospitalized and 25 practically healthy children. To verify the diagnosis of irritable bowel syndrome patients conducted conventional laboratory and instrumental examination and determination of the level of serotonin in the blood serum by fluorometric method. Children of the main group (n = 35) in the setting of basic therapy of irritable bowel syndrome received Trimetabol. The children of the second group (n = 26) received conventional basic therapy.

Results. In the setting of the application of Trimetabol in children with irritable bowel syndrome is occurred significantly more rapid relief of pain, dyspeptic and asthenovegetative syndromes, normalization of bowel movements; marked positive effect of the preparation on the neuroendocrine regulation of intestinal motility.

Conclusions. Results of the examination are proved the desirability of addition of the «Trimetabol» preparation to the treatment of irritable bowel syndrome in children.

Key words: children, irritable bowel syndrome, serotonin Trimetabol.

 

 

Klimenko V. A., Kandyba V. P., Beekeeper E. V., Karpushenko Y. V., Ascheulov A. M.

Examination of clinical efficacy of ursodeoxycholic acid domestic preparation in the treatment of patients with cystic fibrosis.

114

Purpose: To examine the state of the hepatobiliary system in patients with cystic fibrosis (CF) and to evaluate the clinical efficacy of ursodeoxycholic acid «Ukrliv.»

Patients and methods. The total of 11 children (1 girl and 10 boys) aged from 2 years and 8 months to 16 years were under observation. Mixed form of cystic fibrosis was diagnosed in all children. Examination was conducted twice — before using the «Ukrliv» preparation and after 8 weeks of therapy. All children had received basic therapy of cystic fibrosis in accordance with modern protocols and also preparation «Ukrliv» suspension in the evening, before bed, in individual doses for 8 weeks.

Results. In all patients with cystic fibrosis were found development of the hepatobiliary system affect. A positive clinical dynamics of changes of the hepatobiliary system is observed in the setting of application of the preparation «Ukrliv». «Ukrliv» in the form of a suspension was characterized by high efficacy and tolerability in children with cystic fibrosis.

Conclusions. Choleretic, litholytic, anti-inflammatory, immunomodulatory, anti-fibrotic effects of the preparation «Ukrliv» allow to stabilize and improve the condition of the hepatobiliary system in children with cystic fibrosis which makes its application pathogenetically substantiated.

Key words: children, cystic fibrosis, hepatobiliary system, Ukrliv.

 

 

Solodova I. V., Ivan'ko O. G., Pashchenko I. V.

Application of lactase «Mamalak» during the breastfeeding in children with intestinal infections.

118

Purpose: To study the ability of the use of lactase («Mamalak») during the breastfeeding in the complex treatment of infants with an acute intestinal infection.

Patients and methods. To the observation group were included 46 children aged from 4 weeks to 18 months, hospitalized with an acute infectious diarrhea. In order to reduce the lactose content in food in the complex therapy was introduced lactase («Mamalak» preparation). For children was administrated 1/2 of the capsule on the feeding in 30 ml of expressed breast milk before eating. The comparison group consisted of 15 children aged from 5 weeks to 16 months with similar clinical characteristics.

Results. Observations had shown sufficient clinical efficacy and safety of lactase application with the aim of treatment of the secondary lactase deficiency. The use of enzyme replacement therapy by lactase («Mamalak») allows quickly improve the health of the child, to accelerate his recovery and maintain breastfeeding.

Conclusions. Clinical efficacy and safety of lactase in children for the treatment of secondary lactase deficiency which is complicating the course of acute infectious diarrhea in infants is proved.

Key words: acute intestinal infection, lactase deficiency, infants, breastfeeding, lactase.

 

 

Aryaev N. L., Shevchenko I. M., Titkova E. V.

Hypoallergenic milk formulas in the prevention of atopic dermatitis in children.

124

Objective. to examine the effectiveness of milk formula «NAN Hypoallergenic» in the primary prevention of atopic dermatitis (AD) in children.

Patients and methods. The 66 children up to 6 months of age with a poor history of allergy were under observation in dynamics. By the nature of nursing all patients were divided into 3 groups: the 23 children from the first group had received standard adapted milk formulas, 18 children received «NAN Hypoallergenic»; control group consisted from 25 children who were exclusively under breastfeeding.

Results. To the six months age the various manifestations of atopic dermatitis were marked n the 1st group in 39.13% of children in the 2nd group («NAN Hypoallergenic») — in 22.22% in the control group — 20% of children. The most serious course of atopic dermatitis noted in the group which is receiving standard adapted formulas in comparison with children who were under breastfeeding and infants who had received «NAN Hypoallergenic.»

Conclusions. It should be prescribed milk formulas on the base of partial protein hydrolyzate («NAN Hypoallergenic») with the aim of primary prevention of atopic dermatitis in infants during the insufficiency of breast milk. Feeding by milk formula «NAN Hypoallergenic» allow reducing the chances of atopic dermatitis development in infants by more than in 2 times in comparison with the usual milk formula.

Key words: atopic dermatitis, children, prevention, artificial feeding, NAN Hypoallergenic.

 

 

Kogan B. G.

Clinical experience: of the treatment of atopic dermatitis in children.

128

Purpose: a comparative evaluation of clinical effectiveness and tolerance of 0.1% methylprednisolone aceponate (MPA), and 0.1% hydrocortisone 17-butyrate in the external treatment of children with atopic dermatitis (AD).

Patients and methods. The study included children with erythematous-squamous and erythematous-squamous with lichenification forms of medium severity of atopic dermatitis at the age from 3 to 12 years. In the 1st group of patients were 60 children who had received external therapy of 0.1% methylprednisolone aceponate (Sterokort), which was applied once daily on the areas of atopic dermatitis by a thin layer. The 2nd group included 60 patients who had received external therapy of 0.1% hydrocortisone 17-butyrate, which was applied twice daily on the areas of atopic dermatitis by a thin layer. The study lasted three weeks and included primary clinical examination with the control examination after 1, 2 and 3rd weeks of treatment.

Results. Children from the 1st group (Sterokort) had a pronounced positive dynamics, which was expressed by the reduction of the average value of the SCORAD index and decrease of objective symptoms of atopic dermatitis just in the first days of treatment. In majority of patients from the 2nd group (0.1% hydrocortisone 17-butyrate) positive dynamics was less expressed and recorded in the later periods of observation.

Conclusions. Diagnosed better clinical efficacy and better tolerability of 0.1% methylprednisolone aceponate (Sterokort) in comparison with 0.1% hydrocortisone 17-butyrate allow recommending it for the treatment of medium severity of atopic dermatitis in children aged from 3 to 12 years.

Key words: atopic dermatitis, children, external therapy, methylprednisolone aceponate.

 

 

Lavrenchuk O. V., Korol' L. V., Driyanskaya V. E., Bagdasarova I. V.

Phytoprophylactic treatment of the pyelonephritis recurrence in children.

136

Purpose: To study the influence of the «Canephron N» preparation on oxidative and immunological status of children with pyelonephritis (PN).

Patients and methods. A total of 90 children aged from 1 to 17 years with various forms of pyelonephritis were under observation. The data of lipid peroxidation and antioxidant enzymemia and enzymuria were studied. All patients were divided into 5 clinical groups: 1st group — patients in the active stage of pyelonephritis, who had received antibacterial therapy during the 14 days and 3 months of Canephron; 2nd group 2 — 4 weeks of antibacterial therapy and uroseptic by step scheme and 1 month of Canephron, 3rd group — 4 weeks of antibacterial therapy and uroseptic by step scheme, without Canephron application, 4th group — patients in remission who had received Canephron for 1 month twice a year, and 5th group — patients in remission who had not received Canephron.

Results. Prolonged applications of «Canephron N» preparation (during 3 months) has led to the normalization of the highest antioxidant status and improve the levels of serum cytokines. Observation of patients at 12 months proved decrease recurrence of chronic and cases of acute pyelonephritis.

Conclusions. Canephron N is effective and safe preparation, recommended for restoring of immunological and antioxidant status after antibacterial therapy of pyelonephritis in the active stage and in remission in order to prevent a recurrence of the disease in all patients with pyelonephritis.

Key words: pyelonephritis, oxidative and immunological status, recurrence, Canephron N.

 

 

Memories Danyla Anatolievycha Seimivskogo.

142

 

 

For the good of younger generation.

143