• Provision of vitamin D childrens with various forms allergic diseases 
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Provision of vitamin D childrens with various forms allergic diseases 

SOVREMENNAYA PEDIATRIYA.2015.7(71):89-91; doi 10.15574/SP.2015.71.89 
 

Provision of vitamin D childrens with various forms allergic diseases 
 

Tyazhka A. V., Selska Z. V.

A.A. Bogomolets national medical university, Kyiv, Ukraine 
 

Purpose. Determining the level of 25(OH)D in the serum of children with various forms of allergic diseases. 
 

Materials and methods. Under our supervision there were 143 children 3–16 years old with allergic diseases. With asthma — 67 children, 16 children had atopic dermatitis, 10 — allergic rhinitis with asthma and atopic dermatitis were 26 children, 24 patients had both asthma and allergic rhinitis. Determination of 25(OH)D was performed using elektrochemiluminestsencysi method. Assessment of vitamin D status was performed-according to the classification MF Holick (2011). 
 

Results. The evaluation of the transport form of vitamin D in the blood serum in children with allergic diseases depending on the nosology, found that children with asthma average 25(OH)D in the serum was 29.32 ng/ml in children atopic dermatitis — 19.63 ng/ml, in children with allergic rhinitis — 26.91 ng/ml, in children who had both asthma and allergic rhinitis average 25(OH)D levels equal to 17.25 ng/ml in children with asthma and atopic dermatitis — 19.71 ng/ml. When comparing groups of children with allergic diseases among themselves regarding the level of 25(OH)D in the serum, it is found that there is a significant difference between the scores (λ2=21.914; p <0.05). 
 

Conclusions. Thus, in children with allergic diseases decrease levels of vitamin D in the blood serum. This is especially characteristic of children with atopic dermatitis and those who suffer in combined allergic diseases (asthma and atopic dermatitis, asthma and allergic rhinitis). 
 

Key words: childrens, vitamin D, asthma, atopic dermatitis, allergic rhinitis. 
 

REFERENCES

1. Квашніна ЛВ, Родіонов ВП, Ониськова ОВ. 2011. Застосування вітаміну D та його препаратів у сучасній педіатрії. Совр педиатрия. 40;6: 68—71.

2. Охотникова ЕН. 2008. Аллергический «марш»: связь поколений и эскалация аллергии у детей (лекция). Совр педиатрия. 21;4: 190—197.

3. Поворознюк ВВ, Балацька НІ, Янховська ЛВ та ін. 2011. Стан фактичного харчування, мінеральної щільності кісткової тканини та вітамін Д-дефіциту в жителів Львівської області. Журнал проблеми остеології. 14;2: 9—11.

4. Тяжка ОВ, Поворознюк ВВ, Сельська ЗВ. 2013. Вітамін D — статус дітей з алергічними захворюваннями. Проблеми остеології. 2(16): 53—54.

5. Тяжка ОВ, Сельська ЗВ. 2013. Значення вітаміну Д для здоров'я дітей та профілактики різних захворювань у них. ПАГ. 1(76): 37—45.

6. Holick MF, Binkley NC, Bischoff Ferrari HA. 2011. Evalution, treatment and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 96(7): 1911—19. http://dx.doi.org/10.1210/jc.2011-0385; PMid:21646368

7. Brehm JM, Celedon JC, Soto-Quiros ME et al. 2009. The level of vitamin D and markers of severity of asthma in children in Costa Rica. J Respir Critical Care Med. 179: 765—771. http://dx.doi.org/10.1164/rccm.200808-1361OC; PMid:19179486 PMCid:PMC2675563

8. Chinellato I, Piazza M, Sandri M et al. 2011. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 158(3): 437—441. http://dx.doi.org/10.1016/j.jpeds.2010.08.043; PMid:20870246