• Protein and energy intake of premature babies during parenteral feeding

Protein and energy intake of premature babies during parenteral feeding

SOVREMENNAYA PEDIATRIYA.2017.6(86):56-60; doi 10.15574/SP.2017.86.56

Sydorenko I., Shunko Ye., Baranovska O., Tyshkevich V.
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
Perinatal center of Kyiv, Ukraine

The purpose is to study the protein and energy supplement during total and partial parenteral nutrition in premature infants with very low birth weight.
Materials and methods. Retrospective analysis of nutrients supply, biochemistry of blood and growth of 145 premature infants with birth weight less than 1500 g during parenteral nutrition was made.
Results. Improved energy supply led to a more rapid recovery of body weight and the better weight gain in the first month of life. Gestational age showed a significant negative correlation with blood urea concentrations during parenteral nutrition, especially after 6 days of life (r=-0.76). The relationship between the level of blood urea and protein was observed only on the 2nd day of life (r=0.6), but it was not statistically significant. A statistically significant relationship χ2=24.8 (φ=0.37, p=0.001) between blood urea more than 9 mmol/l and non-protein energy less than 20 kcal of per 1 g of protein was found.
Conclusions. The supply enough of protein without insufficient energy does not improve postnatal growth of very low birth weight premature infants.
Key words: parenteral nutrition, very low birth weight infant, protein, energy.


1. Bielova OO, Shunko YeYe, Krasnova YuYu. (2016). Value the risk of significant developmental delays in infants with very low and extremely low birth weight. Perinatologiya i pediatriya. 2(66): 97-100.

2. Shunko YeYe. (2015). Neonatology: national textbook. Kiev. 2: 640.

3. Adamkin DH. (2013). Early total parenteral nutrition in very low birthweight infants: is it safe? Is it worth it? J Pediatr. 163(3): 622–4. https://doi.org/10.1016/j.jpeds.2013.04.041; PMid:23726543

4. Hay Jr, Hay WW. (2013). Aggressive nutrition of the preterm infant. Current Pediatrics Reports. 1(4): 229–239. https://doi.org/10.1007/s40124-013-0026-4; PMid:24386613 PMCid:PMC3875345

5. Van Goudoever J, Vlaardingerbroek H, van den Akker C, de Groof F, van der Schoor S. (2014). Amino acids and proteins. In Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. World Rev Nutr Diet: 49–63. https://doi.org/10.1159/000358458; PMid:24751621

6. Roggero P, Giannì ML, Morlacchi L, Piemontese P, Liotto N, Taroni F, Mosca F. (2010). Blood urea nitrogen concentrations in low-birth-weight preterm infants during parenteral and enteral nutrition. J Pediatr Gastroenterol Nutr. 51: 213–5. https://doi.org/10.1097/MPG.0b013e3181cd270f; PMid:20479690

7. Moyses HE, Johnson MJ, Leaf AA, Cornelius VR. (2013). Early parenteral nutrition and growth outcomes in preterm infants: a systematic review and meta-analysis. Am J Clin Nutr. 97: 816–826. https://doi.org/10.3945/ajcn.112.042028; PMid:23446896

8. Lee BS. (2015). Nutritional strategy of early amino acid administration in very low birth weight infants. Korean J Pediatr. 58: 77–83. https://doi.org/10.3345/kjp.2015.58.3.77; PMid:25861329 PMCid:PMC4388974

9. Pekka J. (2008). Nutrition Support for Infants and Children at Risk. Acta Paediatrica. 189-191.

10. Tonkin EL, Collins CT, Miller JM. (2014). Protein intake and growth in preterm infants: a systematic review. Global Pediatric Health: 1–20.

11. Velaphi S. (2011). Nutritional requirements and parenteral nutrition in preterm infants. S Afr J Clin Nutr. 24(3): 27-31. https://doi.org/10.1080/16070658.2011.11734377

12. Vlaardingerbroek H, Vermeulen MJ, Rook D, van der Akker CHP, Dorst K, Wattimena JL et al. (2013). Safety and efficacy of early parenteral lipid and high-dose amino acid administration to very low birth weight infants. J Pediatr. 163: 638–644. https://doi.org/10.1016/j.jpeds.2013.03.059; PMid:23660378