• Protection against measles and mumps in hiv-infected children
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Protection against measles and mumps in hiv-infected children

SOVREMENNAYA PEDIATRIYA. 2014.8(64):126–131; doi 10.15574/SP.2014.64.126

Protection against measles and mumps in hiv-infected children

Volokha A., Chernyshova L., Raus I., Demchyshina I.

Shupyk National Medical Academy of Postgraduate Education

Kiev City AIDS Center

Virology/AIDS Department of Central Epidemiology Service, Kiev, Ukraine


HIV-infected children are a vulnerable group for the development of vaccine-preventable infections, their frequency and severity. The study found lower levels of vaccination coverage of HIV*infected children against measles and mumps (46,5%) than in general population. Among 66 vaccinated children with HIV-infection revealed a large number of children not protected against measles (42.4%) and mumps (60.6%).The mean level of antibodies to measles and mumps was significantly lower in HIV*infected children compared with children not infected with HIV. Only 10 children (40%) with lacked antibody to measles were optimally immunized, up-to-date immunization has 23 children (56,1%) with detectable antibody. Established predictors of immune protection against measles and mumps: early start of antiretroviral therapy (in the first 24 month of age), the beginning of immunization in children on treatment of HIV-infec-tion and higher level CD4 + T cells at the time of the study. The vaccine against measles and mumps is safe for children with HIV-infection if they do not have severe immunosuppression. Additional vaccinations against measles, mumps and rubella HIV-infected children on ART who have no evidence of immune protection against these viruses may be effective in forming a protective post-vaccination immune response. Vaccination policies should be developed for HIV-infected children on HAART who lack the protective immunity against measles and mumps after up-to-date immunization.

Keywords: HIV-infected children, post-vaccination immunity, measles, mumps.



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