• Prospects for using magnesium and vitamin B6 in pregnant women with undifferentiated connective tissue dysplasia
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Prospects for using magnesium and vitamin B6 in pregnant women with undifferentiated connective tissue dysplasia

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.1(73):30-35; doi 10.15574/PP.2018.73.30

Tovstanovska V. A., Alatorskykh A. Ye.
Bogomolets National Medical University, Kyiv, Ukraine

Objective — to study the prospects and substantiate the use of magnesium and vitamin B6 in pregnant women with undifferentiated connective tissue dysplasia.
Material and methods. In total 45 pregnant women with signs of undifferentiated connective tissue dysplasia were under study. The control group consisted of 38 pregnant women with no signs of undifferentiated dysplasia.
Results. Clinical manifestations of undifferentiated connective tissue dysplasia during pregnancy include vascular disorders and haemorrhagic syndrome that may be associated with a symptom complex of neurocirculatory dystonia. Undifferentiated connective tissue dysplasia is accompanied by high incidence of placental insufficiency, threatening miscarriage in the I–III trimesters, isthmiko-cervical insufficiency, early toxicosis, pregnancy-induced hypertension. Therapy with the drug «Doppelherz® aktive Magnesium B6» contributes to the subjective improvement of the well-being of pregnant women, reducing the frequency of various complaints and risk of potential complications of pregnancy. As a result of the therapy, the laboratory confirmed normalization of the magnesium blood level in pregnant women at 12–20–32 weeks of gestation was observed.
Conclusions. According to the study results, the use of combination drugs, comprising magnesium and vitamin B6, positively affects the gestation course in women with undifferentiated connective tissue dysplasia. Statistically significant normalization of laboratory parameters and clinical course in the groups of patients who were administered the preparations of magnesium and vitamin B6 is established, which indicates the effectiveness of this therapy.
Key words: pregnancy, undifferentiated connective tissue dysplasia, magnesium and vitamin B6 preparations.

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