- Cytokine profile characteristics in infants with food hypersensitivity
Cytokine profile characteristics in infants with food hypersensitivity
SOVREMENNAYA PEDIATRIYA.2017.5(85):117-120; doi 10.15574/SP.2017.85.117
Shadrin O. G., Gayduchik G. A., Misnik V. P., Dyukareva S. V., Kovalchuk A. A., Basaraba N. M., Radushinskaya T. Yu.
SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kyiv
Food hypersensitivity has different pathogenetic mechanisms that characterized by the composition changes of proinflammatory and anti-inflammatory cytokines.
Objective: to determine the features of the cytokine profile (IL-5, TNF-α) in infants with food hypersensitivity.
Material and methods. The study involved 60 children aged 1.5 months to 3 years with gastrointestinal manifestations of food hypersensitivity. The levels of total IgE and allergen-specific IgE to food allergens, eosinophilic cationic protein, IL-5 and TNF-α in serum by using enzyme immunoassay were determined in all patients.
Results. In infants with food allergies there was identified sensitization to food allergens (in 70.0% of cases to the cow's milk proteins) and change of serum proinflammatory cytokines a significant increase in the cytokines serum concentration – IL-5 (5.4±0.82 ng/ml) and TNF-α (25.8±4.2 ng/ml), indicating allergic inflammation activity and correlates with high eosinophilic cationic protein along with normal findings of total IgE. Lactase deficiency is characterized by increased levels of TNF-α (4.03±0.8 ng/ml) at normal rates of IL-5 (1.56±0.5 ng/ml), total IgE and eosinophilic cationic protein.
Conclusions. Composition changes of proinflammatory cytokines in the blood serum of infants with food allergy reflect the activity of allergic inflammation, and in infants with lactase deficiency indicate a possible involvement in the pathogenesis of cell-mediated inflammatory processes.
Key words: infants, food hypersensitivity, cytokines.
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