• Probiotic therapy of chronic oral candidiasis in children. 
To content

Probiotic therapy of chronic oral candidiasis in children. 

SOVREMENNAYA PEDIATRIYA.2014.2(58):32-34; doi 10.15574/SP.2014.58.32 
 

Probiotic therapy of chronic oral candidiasis in children. 
 

Savichuk N. O. 

 

P.L. Shupik National Medical Academy of Postgraduate Education, Institute of Dentistry Kiev, Ukraine

 

 

Objective: The development of a highly efficient anti-relapsing method of treatment in patients with chronic oral candidiasis (COC). 
 

Patients and methods. A total of 41 children with COC in the age 13–15 years (19 boys, 22 girls) were under clinical observation. The diagnosis was verified on the base of history card, clinical and laboratory examination in dynamics. To the complex treatment was included probiotic containing B. subtilis and B. licheniformis (Biosporin) by the course of 7–10 days, depending on the severity of the disease. BAccording to the data of mycological researches, after 14 days of treatment the elimination of Candida from the surface of the oral mucosa was marked in 95.1 % of cases. The positive effect from the six months therapy was maintained in 87.7 % of children; recurrence rate was 9.75%. In the setting of preparation application was found restoration of the microecology of the oral cavity by reducing the frequency of occurrence of opportunistic bacteria — of traditional Candida assiociants and restoration of Str. salivarius. 
 

Conclusions. Application of Biosporin in the complex treatment of children with COC is highly effective and contributes not only to the elimination of pathogens, but also to restoration of normobiocenosis of oral cavity. 
 

Key words: chronic oral candidiasis, probiotics, microecology, oral cavity. 
 

REFERENCES

1. Савичук НО. 2011. Колонізаційна резистентність слизової оболонки порожнини рота. Ч.1. Совр стоматол. 2: 66—72.

2. Савичук НО. 2011. Колонізаційна резистентність слизової оболонки порожнини рота — сучасні підходи до корекції. Ч.2. Совр стоматол. 3: 87—91.

3. Томников АЮ, Корженевич ВИ. 1996. Микрофлора полости рта: 19.

4. Lim CS-Y, Rosli R, Seow HF, Chong PP. 2012. Candida and invasive candidiasis: back to basics. European Journal of Clinical Microbiology & Infectious Diseases. 31;Issue 1: 21—31. http://dx.doi.org/10.1007/s10096-011-1273-3; PMid:21544694

5. Cannon RD, La Jean W. 2001. Chaffin Colonization is a Crucial Factor in Oral Candidiasis. Journal of Dental Education. 65;8: 785—787. PMid:11518251

6. Cannon RD, Chaffin WL. 1999. Oral colonization by Candida albicans. Crit Rev Oral Biol Med. 10: 359—83.

7. Fiedler T, Catur Riani, Dirk Koczan et al. 2012. Effect of Streptococcus salivarius K12 on the In Vitro Growth of Candida albicans and Its Protective Effect in an Oral Candidiasis Model. Appl Environ Microbiol. 78;7: 2190—2199. http://dx.doi.org/10.1128/AEM.07055-11; PMid:22267663 PMCid:PMC3302625

8. Podbielski A. 2013. Protective Mechanisms of Respiratory Tract Streptococci against Streptococcus pyogenes Biofilm Formation and Epithelial Cell Infection. Appl Environ Microbiol February. 79;4: 1265—1276.