• Preventive salpingectomy – necessity or variant of the norm? 

Preventive salpingectomy – necessity or variant of the norm? 

HEALTH OF WOMAN.2016.7(113):34–39 
 

Preventive salpingectomy – necessity or variant of the norm? 
 

Veropotvelyan Р. N., Tsehmistrenko I. S., Veropotvelyan N. P., Volenko N. V.

The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog

Perinatal center, Kiev 
 

The necessity of carrying out of simultaneous salpingectomy in patients with hysterectomy. According to many publications show scientific justification operation with varying degrees of risk of serous ovarian cancer. It discusses the role of the method to increase the effectiveness of the treatment of infertility. Analysis of published data it is clear that the formation of secondary ovarian failure – may recur after salpingectomy. This naturally explains the consequence of estrogen deficiency, which may exceed the benefit of reducing the incidence of ovarian cancer, prevention of inflammatory diseases of the pelvic organs.


Key words: hysterectomy, salpingectomy, ovarian cancer, ovarian reserve.


REFERENCES

1. Matorras R, Rabanal A, Prieto B, Diez S, Brouard I, Mendoza R et al. 2013. Hysteroscopic hydrosalpinx occlusion with Essure device in IVF patients when salpingectomy or laparoscopy is contraindicated. Eur. J. Obstet. Gynecol. Reprod. Biol. 169(1):54–9. http://dx.doi.org/10.1016/j.ejogrb.2013.02.008; PMid:23561020

2. Findley AD, Siedhoff MT, Hobbs KA, Steege JF, Carey ET, McCall CA et al. 2013. Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial. Fertil. Steril. 100(6):1704–8. http://dx.doi.org/10.1016/j.fertnstert.2013.07.1997

3. Hill MJ, Cooper JC, Levy G, Alford C, Richter KS, DeCherney AH et al. 2014. Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location. Fertil. Steril. 101(2):413–9. http://dx.doi.org/10.1016/j.fertnstert.2013.10.027; PMid:24269042 PMCid:PMC3946660

4. Uyar I, Yucel OU, Gezer C, Gulhan I, Karis B, Hanhan HM et al. 2013. Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy. Fertil. Steril. 100(5):1310-3. http://dx.doi.org/10.1016/j.fertnstert.2013.06.040; PMid:23891021

5. Wiser A, Gilbert A, Nahum R, Orvieto R, Haas J, Hourvitz A et al. 2013. Effects of treatment of ectopic pregnancy with methotrexate or salpingectomy in the subsequent IVF cycle. Reprod. Biomed. Online. 26(5):449–53. http://dx.doi.org/10.1016/j.rbmo.2013.01.018; PMid:23518030

6. Xi W, Gong F, Tang Y, Zhang H, Lu G. 2012. Ovarian response to gonadotropins after laparoscopic salpingectomy for ectopic pregnancy. Int. J. Gynaecol. Obstet. 116(2):93–6. http://dx.doi.org/10.1016/j.ijgo.2011.10.009; PMid:22103980

7. Yi QH, Ling SR, Chen KM, He WR, Li L, Yi CJ. 2012. Evaluation of the clinical value of simultaneous hysterectomy and bilateral salpingectomy in perimenopausal women. Zhonghua Fu Chan Ke Za Zhi. 47(2):110–4. PMid:22455742

8. Meng XH, Zhu YM. 2006. Effect of salpingectomy on ovarian function. Zhejiang Da Xue Xue Bao Yi Xue Ban. 35(5):555–9. PMid:17063552

9. Ni L, Sadiq S, Mao Y, Cui Y, Wang W, Liu J. 2013. Influence of various tubal surgeries to serum antimullerian hormone level and outcome of the subsequent IVF-ET treatment. Gynecol. Endocrinol. 29(4):345–9. http://dx.doi.org/10.3109/09513590.2012.743004; PMid:23339657

10. Sezik M, Ozkaya O, Demir F, Sezik HT, Kaya HJ. 2007. Total salpingectomy during abdominal hysterectomy: effects on ovarian reserve and ovarian stromal blood flow. J. Obstet. Gynaecol. Res. 33(6):863–9. http://dx.doi.org/10.1111/j.1447-0756.2007.00669.x

11. Petrov IA, Tihonovskaya OA, Okorokov AO, Kupriyanova II, Fateeva AS, Petrova MS, Logvinov SV. 2016. Prophylactic salpingectomy. Obstetrics and gynecology 2:36–42. http://dx.doi.org/10.18565/aig.2016.2.36-42

12. Ulug P, Oner G. 2014. Evaluation of the effects of single or multiple dose methotrexate administration, salpingectomy on ovarian reserve of rat with the measurement of anti-Mьllerian hormone (AMH) levels and histological analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 181:205–9. http://dx.doi.org/10.1016/j.ejogrb.2014.07.011; PMid:25171264

13. Dobrokhotova JE, Boyar AE, Haidar LA et al. 2009. Clinical lectures on obstetrics and gynecology. Moscow, GEOTAR-Media:312.

14. Strizhakov AN, Davydov AI, Musayev RD. 2011. Ovarian reserve in patients with endometrioid ovarian cysts after laparoscopic surgery using a surgical high energies. In the book: GT Sukhikh, LV Adamyan. New technologies in the diagnosis and treatment of gynecological diseases. M:101–2.

15. Iwase A, Nakamura T, Nakahara T, Goto M, Kikkawa F. 2014. Assessment of ovarian reserve using anti-Mьllerian hormone levels in benign gynecologic conditions and surgical interventions: a systematic narrative review. Reprod. Biol. Endocrinol. 12:125. http://dx.doi.org/10.1186/1477-7827-12-125; PMid:25510324 PMCid:PMC4274680

16. Mukhopadhaya N, Manyonda IT. 2013. The hysterectomy story in the United Kingdom. Midlife Health 4(1):40–1. http://dx.doi.org/10.4103/0976-7800.109635

17. Schenberg T, Mitchell G. 2014. Prophylactic bilateral salpingectomy as a prevention strategy in women at high-risk of ovarian cancer: a mini-review. Front. Oncol. 4:21. http://dx.doi.org/10.3389/fonc.2014.00021; PMid:24575389 PMCid:PMC3918654

18. Vorwergk J, Radosa MP, Nicolaus K, Baus N, Jimenez Cruz J, Rengsberger M et al. 2014. Prophylactic bilateral salpingectomy (PBS) to reduce ovarian cancer risk incorporated in standard premenopausal hysterectomy: complications and re-operation rate. J. Cancer Res. Clin. Oncol. 140(5):859–65. http://dx.doi.org/10.1007/s00432-014-1622-6; PMid:24573653

19. Chan CC, Ng EH, Ho PC. 2005. Ovarian changes after abdominal hysterectomy for benign conditions. J. Soc. Gynecol. Investig. 12(1):54–7. http://dx.doi.org/10.1016/j.jsgi.2004.07.004; PMid:15629673

20. Nahбs EA, Pontes A, Traiman P, Nahбs-Neto J, Dalben I, De Luca L. 2003. Inhibin B and ovarian function after total abdominal hysterectomy in women of reproductive age. Gynecol. Endocrinol. 17(2):125–31. http://dx.doi.org/10.1080/713603218http://dx.doi.org/10.1080/gye.17.2.125.131; PMid:12737673

21. Vuorento T, Mдenpдд J, Huhtaniemi I. 1992. Follow-up of ovarian endocrine function in premenopausal women after hysterectomy by daily measurements of salivary progesterone. Clin. Endocrinol. (Oxf). 36(5):505–10. http://dx.doi.org/10.1111/j.1365-2265.1992.tb02253.x

22. Chalmers C, Lindsay M, Usher D, Warner P, Evans D, Ferguson M. 2002. Hysterectomy and ovarian function: levels of follicle stimulating hormone and incidence of menopausal symptoms are not affected by hysterectomy in women under age 45 years. Climacteric. 5(4):366–73. http://dx.doi.org/10.1080/cmt.5.4.366.373http://dx.doi.org/10.1080/713605316; PMid:12626216

23. Ciarmela P, Islam MS, Reis FM, Gray PC, Bloise E, Petraglia F et al. 2011. Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications. Hum. Reprod. Update. 17(6):772–90. http://dx.doi.org/10.1093/humupd/dmr031

24. Nahбs EA, Pontes A, Nahбs-Neto J, Borges VT, Dias R, Traiman P. 2005. Effect of total abdominal hysterectomy on ovarian blood supply in women of reproductive age. J. Ultrasound Med. 24(2):169–74.

25. Bhattacharya S, Mollison J, Pinion S, Parkin DE, Abramovich DR, Terry P et al. 1996. A comparison of bladder and ovarian function two years following hysterectomy or endometrial ablation. Br. J. Obstet. Gynaecol. 103(9):898–903. http://dx.doi.org/10.1111/j.1471-0528.1996.tb09909.x; PMid:8813310

26. Aylamazyan E. 2004. Gynecology from puberty to menopause. M:409.

27. Morelli M, Venturella R, Mocciaro R, Di Cello A, Rania E, Lico D et al. 2013. Prophylactic salpingectomy in premenopausal low-risk women for ovarian cancer: primum non nocere. Gynecol. Oncol. 129(3):448–51. http://dx.doi.org/10.1016/j.ygyno.2013.03.023

28. Colgan TJ, Murphy J, Cole DE, Narod S, Rosen B. 2001. Occult carcinoma in prophylactic oophorectomy specimens: prevalence and association with BRCA germline mutation status. Am. J. Surg. Pathol. 25(10):1283–9. http://dx.doi.org/10.1097/00000478-200110000-00009

29. Piek JM, van Diest PJ, Zweemer RP, Jansen JW, Poort-Keesom RJ, Menko FH et al. 2001. Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J. Pathol. 195(4):451–6. http://dx.doi.org/10.1002/path.1000; PMid:11745677

30. Crum CP, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y. 2007. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin. Med. Res. 5(1):35–44. http://dx.doi.org/10.3121/cmr.2007.702

31. Salvador S, Gilks B, Kцbel M, Huntsman D, Rosen B, Miller D. 2009. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int. J. Gynecol. Cancer. 19(1):58–64. http://dx.doi.org/10.1111/igc.0b013e318199009c

32. Leblanc E, Narducci F, Farre I, Peyrat JP, Taieb S, Adenis C et al. 2011. Radical fimbriectomy: a reasonable temporary risk-reducing surgery for selected women with a germ line mutation of BRCA 1 or 2 genes? Rationale and preliminary development. Gynecol. Oncol. 121(3):472–6. http://dx.doi.org/10.1016/j.ygyno.2011.02.012

33. Greene MH, Mai PL, Schwartz PE. 2011. Does bilateral salpingectomy with ovarian retention warrant consideration as a temporary bridge to risk-reducing bilateral oophorectomy in BRCA1/2 mutation carriers? Am. J. Obstet. Gynecol. 204(1):19.e1-6. http://dx.doi.org/10.1016/j.ajog.2010.05.038; PMid:20619389 PMCid:PMC3138129

34. Repasy I, Lendvai V, Koppan A, Bodis J, Koppan M. 2009. Effect of the removal of the Fallopian tube during hysterectomy on ovarian survival: the orphan ovary syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 144(1):64–7. http://dx.doi.org/10.1016/j.ejogrb.2008.12.019; PMid:19261370

35. Morse AN, Schroeder CB, Magrina JF, Webb MJ, Wollan PC, Yawn BP. 2006. The risk of hydrosalpinx formation and adnexectomy following tubal ligation and subsequent hysterectomy: a historical cohort study. Am. J. Obstet. Gynecol. 194(5):1273–6. http://dx.doi.org/10.1016/j.ajog.2005.11.014; PMid:16579950

36. Ghezzi F, Cromi A, Siesto G, Bergamini V, Zefiro F, Bolis P. 2009. Infectious morbidity after total laparoscopic hysterectomy: does concomitant salpingectomy make a difference? BJOG. 116(4):589–93. http://dx.doi.org/10.1111/j.1471-0528.2008.02085.x

37. Ouldamer L, Caille A, Body G. 2013. Fallopian tube prolapse after hysterectomy: a systematic review. PLoS One. 8(10):e76543. http://dx.doi.org/10.1371/journal.pone.0076543; PMid:24116117 PMCid:PMC3792027

38. Parihar M, Mirge A, Hasabe R. 2009. Hydrosalpinx functional surgery or salpingectomy? The importance of hydrosalpinx fluid in assisted reproductive technologies. J. Gynecol. Endosc. Surg. 1(1):12–6. http://dx.doi.org/10.4103/0974-1216.51903; PMid:22442504 PMCid:PMC3304258

39. Dechaud H, Hedon B. 2000. What effect does hydrosalpinx have on assisted reproduction? The role of salpingectomy remains controversial. Hum. Reprod. 15(2):234–5. http://dx.doi.org/10.1093/humrep/15.2.234; PMid:10655289

40. Strandell A, Lindhard A, Waldenstrцm U, Thorburn J, Janson PO, Hamberger L. 1999. Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF. Hum. Reprod. 14(11):2762–9. http://dx.doi.org/10.1093/humrep/14.11.2762

41. Johnson NP, van Voorst S, Sowter MC, Strandell A, Mol BW. 2010. Surgical treatment for tubal disease in women due to undergo in vitro fertilization. Cochrane Database Syst. Rev. (1):CD002125. PMid:20091531

42. Bontis JN, Theodoridis TD. 2006. Laparoscopic management of hydrosalpinx. Ann. N.Y. Acad. Sci. 1092:199–210. http://dx.doi.org/10.1196/annals.1365.017; PMid:17308145

43. Strandell A, Lindhard A. 2002. Why does hydrosalpinx reduce fertility? The importance of hydrosalpinx fluid. Hum. Reprod. 17(5):1141–5. http://dx.doi.org/10.1093/humrep/17.5.1141; PMid:11980729

44. Atilgan R, Kuloрlu T, Boztosun A, Orak U, Baspinar M, Can B et al. 2015. Investigation of the effects of unilateral total salpingectomy on ovarian proliferating cell nuclear antigen and follicular reserve: experimental study. Eur. J. Obstet. Gynecol. Reprod. Biol. 188(1):56–60. http://dx.doi.org/10.1016/j.ejogrb.2015.02.028; PMid:25790915

45. Gelbaya TA, Nardo LG, Fitzgerald CT, Horne G, Brison DR, Lieberman BA. 2006. Ovarian response to gonadotropins after laparoscopic salpingectomy or the division of fallopian tubes for hydrosalpinges. Fertil. Steril. 85(5):1464–8. http://dx.doi.org/10.1016/j.fertnstert.2005.10.036; PMid:16580673

46. Grynnerup AG, Lindhard A, Sшrensen S. 2013. Anti-Mьllerian hormone levels in salpingectomized compared with nonsalpingectomized women with tubal factor infertility and women with unexplained infertility. Acta Obstet. Gynecol. Scand. 92(11):1297–303. http://dx.doi.org/10.1111/aogs.12234; PMid:24032634

47. Nakagawa K, Ohgi S, Nakashima A, Horikawa T, Irahara M, Saito HJ. 2008. Laparoscopic proximal tubal division can preserve ovarian reserve for infertility patients with hydrosalpinges. J. Obstet. Gynaecol. Res. 34(6):1037–42. http://dx.doi.org/10.1111/j.1447-0756.2008.00801.x

48. Ye XP, Yang YZ, Sun XX. 2015. A retrospective analysis of the effect of salpingectomy on serum anti-Mьllerian hormone level and ovarian reserve. Am. J. Obstet. Gynecol. 212(1);53:1-10.

49. Ashrafyan LA. 2014. Systematic errors in the therapeutic approaches for ovarian cancer. Practical oncology. Practical Oncology 15:4.

50. Kochetkova EO, Degemerzanova NK. 2013, iyul-avgust. Risk razvitiya raka molochnoy zhelezyi i yaichnikov, obuslovlennyiy mutatsiyami genov BRCA1, BRCA2, CHEK2. Kazahstanskiy Meditsinskiy Zhurnal:4(34).