- Preterm membrane rupture – new genetic factors and possible way of their realization
Preterm membrane rupture – new genetic factors and possible way of their realization
HEALTH OF WOMAN. 2017.2(118):26–29; doi 10.15574/HW.2017.118.26
Venckivs‘ka I. B., Strashko I. V., Venckivs‘kiy K. O., Zagorodnya O. S.
A.A. Bogomolets National Medical University, Kiev
Perinatal center, Kiev
The results of the study of gene polymorphism of glutathione-S-transferase in pregnant women with premature rupture of membranes are considered in the article.
The objective: to find the pathogenetic factors of premature rupture of membranes and improve the algorithm of reference of patients with this complication in preterm pregnancy.
Patients and methods. The study involved 68 pregnant women with premature rupture of membranes at term pregnancy and 37 women in the active phase of the first period of preterm birth with intact membranes. Gene polymorphism of glutathione-S-transferase, and the activity of key indicators of lipid peroxidation and antioxidant enzyme system were identified in all patients.
Results. The dominance among pregnant women with premature rupture of membranes carriers homozygous form of one or more of this group of genes is demonstrated. The observed intensity of lipid peroxidation identified as a pathogenic factor in prenatal rupture of amniotic membranes. The dependence of the high content of lipid peroxidation products of phase II detoxification gene polymorphism is demonstrated by high values of the Spirman coefficient – from 0.71 to 0.74.
Conclusion. The phase II detoxification genetic polymorphism is clearly associated with the accumulation of secondary products of oxidation, which may indicate metabolic disorders on the edge of the cell membrane, which actually is a factor in premature rupture of membranes. These features contribute to the pathogenesis of inflammation and generalization.
Кey words: рreterm membrane rupture, glutation-S-transferase, lipid peroxidation.
1. Ahmad Haled Nimer Abu Halil. 2009. Rol’ spoluchnotkanynnych elementiv plidnych obolonok u viniknenni yich peredchasnogo rozryvu pry nedonoshennij vagitnosti, thesis for dPh science degree, Kharkiv: 20.
2. Ventskivskiy BM, Zagorodnya OS, Tsapenko TV, Strashko IV. 2015. Polimirfism genov glutation-S-transerazy – nezavisimyj factor riska pregdevremennogo razryva plodnych obolochek. Reproductivnoje zdorovje. Vostochnaja Evropa 6(42):8-15.
3. Zagorodnya OS, Leush SSt, Tkalich VO, Strashko IV. 2015. Polimorfism geniv drugoji fazy detoksykatsiyi v genesi peredchasnogo rozryvu plodovych obolonok. Zdorovje zhenshchiny 5(101):99-101.
4. Kvashnina LB, Ignatova TB. 2016. Prophylaxis of disturbances of endothelial function within the children during transition from health to a syndrome of vegetative dysfunction. Sovremennaya pediatriya. 5(77): 16-24. doi 10.15574/SP.2016.77.16
5. Morozova NI, Kvashenko VP, Babenko OM. 2014. Vozmozhnosti profilaktiki u zhenshchin s narushenijami involutsii matki. Medico-sitsial’nyje problemy semji 19;1:14-15.
6. ACOG Commitee of Practice Bulletens-Obstetrics, authors. Clinical management guidelines for obstetrician-gynecologist. (ACOG practice Bulletin No80: premature rupture of membranes). Obstet Gynecol. 2007. 109:1007-1019.
7. Allan J, Wild C, Rollinson S, Willett E, Moorman A. 2001. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc. Nat. Acad. Sci. 98:11592-11597. https://doi.org/10.1073/pnas.191211198; PMid:11553769 PMCid:PMC58774
8. Bulmakhanov TS, Khanseitova AK, Nigmatova VG, Ashirbekov EE, Talaeva ShZh, Aitkhozhina NA. 2013. Polymorphisms at GSTM1, GSTP1, GSTT1 Detoxification Genes Loci and Risk of Breast Cancer in Kazakhstan Population. Breast Cancer Research. 2:114-118 https://doi.org/10.4236/abcr.2013.24019
9. Garite TJ. 2001. Management of premature rupture of membranes. J.Clinical Perinatology. 28:837-847. https://doi.org/10.1016/S0095-5108(03)00081-2
10. Wolfensberger A, Zimmermann R, Mandach U. 2006. Neonatal mortality and morbidity after aggressive long-term tocolysis for preterm premature rupture of membranes: a methodologic review. Fetal Diagn.Ther. 21:366-373. https://doi.org/10.1159/000092467; PMid:16757913