• Premenstrual syndrome: pathogenesis, prevention and treatment 

Premenstrual syndrome: pathogenesis, prevention and treatment 

HEALTH OF WOMAN. 2016.4(110):52–55; doi 10.15574/HW.2016.110.52 
 

Premenstrual syndrome: pathogenesis, prevention and treatment 
 

Pakharenko L. V.

Ivano-Frankivsk National medical University 
 

The objective: to improve the efficiency of diagnosis and treatment of premenstrual syndrome (PMS) based on the establishment of new aspects of pathogenesis (forming the concept of genetic predisposition) and development of differentiated approach to treatment and prevention of various forms of pathology by studying hormonal, psychological markers.


Patients and methods. Research included 200 women of reproductive age with PMS. We studied the importance of social factors, levels of female sex hormones, as well as the role of polymorphisms of estrogen receptor gene ESR1, progesterone receptor gene PROGINS, angiotensin converting enzyme gene ACE and glutathione-S-transferasegenes (GSTT1 and GSTM1), cytogenetic markers, and psychological aspects, quality of life in these patients. The scheme of correction of clinical manifestations and above data, taking into account the clinical form and severity of the syndrome was developed.


Results. It was determined that social factors, as well as level of progesterone, prolactin, folliclestimulatingand luteinizing hormones, A-351G polymorphism of ESR1estrogen receptor gene, T1T1 genotype of gene PROGINS, DD genotype of geneACE and deletion of GSTT1 gene, specific cytogenetic indiceshave meaning in development of syndrome. In addition, individuals with PMS have certain psychological characteristics and reduced quality of life. Use of differentiated treatment which takes into account the various forms and severity of syndrome has led to decrease of clinical symptoms of the disease, normalization of hormonal, psychological markers and increase quality of life of patients.


Conclusion. Differentiated treatment of PMS, which takes into account the form of pathology has allowed to achieve greater frequency of disappearance of clinical symptoms and improve the quality of life of patients.


Key words: premenstrual syndrome, hormones, gene polymorphism, psychological dysadaptation, quality of life, differentiated treatment.


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