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Pregravid preparation of fertile aged women with infertility

PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):53-57; doi 10.15574/PP.2016.67.53 
 

Pregravid preparation of fertile aged women with infertility


Podolskyi Vl. V., Podolsky V. V.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv


Objective — to develop and assess the effectiveness of the pregravid training methods for the fertile aged women with infertility.


Patients and methods. The study involved 50 fertile aged women with infertility, who were divided into groups: Group I — with primary infertility and group II — with secondary infertility. Bacteriological studies were conducted with the aim of evaluation of the species and quantitative composition of the microflora of the women's vagina after the treatment course of autonomic disorders of the nervous system. According to the obtained results about a state of microbiocenosis urogenital organs at the first stage of treatment women with inflammation of genital organs had received basic treatment which was developed especially for women with such diseases and the effectiveness of which has been proven; the second stage of included application of Api-Norm preparation in the form of vaginal suppositories and for sexual partners of these women — Api-Norm in the form of rectal suppositories. Statistical analysis of the obtained results of research was carried out by the use of standard computer packages «Data Analysis» Microsoft Excel for Windows 2007. The values of the arithmetic mean are — the value (M), the average error of the mean value (m), the level of reliability of differences (p). Evaluation of the reliability of the obtained data is carried out by the conventional manner by means of t&test. Reliability was considered established if its reliability was equal to at least 95% (0.05).


Results. The obtained data are pointed on the excess of diagnostic levels of conditionally pathogenic microflora in the vast majority of women. It is noted that qualitative and quantitative indicators of pathogenic microflora in women with secondary infertility are higher than diagnostic levels and more common than in women with primary infertility, which may certifies about the presence of chronic inflammatory diseases of the genital organs. Insufficient number of lactobacilli is one of the reasons for the impossibility of stabilizing of microbiocenosis genitals at studied women. The use of modern methods of microbiocenosis correction allows reducing the level of microbial contamination in the genital tract of women.


Conclusions. The use of vaginal suppositories Api-Norm in the complex pregravid preparation for women with infertility, their preparation for safe motherhood and also the use of rectal suppositories Api&norms in the treatment and prevention of inflammatory diseases in the sexual partners of these women lead to high efficiency, which allows us to recommend this preparation for complex therapy.


Key words: microbiocenosis, fertile aged women, infertility, chronic inflammatory diseases of the genital organs.


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