• Predictors of rapid HIV-infection progression of in perinatally infected children. 
To content

Predictors of rapid HIV-infection progression of in perinatally infected children. 

SOVREMENNAYA PEDIATRIYA.2014.2(58):40-43; doi 10.15574/SP.2014.58.40 
 

Predictors of rapid HIV-infection progression of in perinatally infected children. 
 

Chernyshova L. I., Stepanovskyy Y. S., Chernyshov V. P., Donskoy B. V., Raus I. V., Yurchenko O. V.

National medical academy of postgraduated education after P.L. Shoupyk

Institute «Pediatrics, obstetrix and ginecology» (National medical academy)

Kiev city AIDS center 
 

Summary. Levels of the cytokines such as IL-10, IFN-γ, TNF-R1 and antiphospholipid antibodies were evaluated in the sera of perinatally HIV infected children. We analyzed different factors from the mother's and child's sides which were associated with either fast or low speed of HIV-infection progression. Children born to HIV-infected mother were under our surveillance during first year of life.Revealed, that elevation of TNF-R1 levels precedes the depletion of CD4+ counts and HIV-symptoms. It turned out the positive correlation of increased viral load and levels of antiphospholipid antibodies. Weight in birth <2500g and height less than 47 cm, prematurely birth < 35 weeks of gestation – these were factors which significantly increased chances for the fast progression of the infection. The psycomotor retardation and oropharyngeal candidiasis are markers of rapid disease progression in HIV'infected children on 2 and 6 month of life. Such mentionned marks can be used as additional criteria for choosing the best time of HAART start. 
 

Key words: children, HIV-infection, rapid progression, HAART, cytokines, antiphospholipid antibodies. 
 

REFERENCES

1. ВІЛ-інфекція в Україні. Інформ бюл. МОЗ України. К. 2012.

2. Самарін ДВ. 2008. Визначення сироваткових рівнів МІР-1-альфа та IL-7 у перинатально інфікованих ВІЛ дітей для оцінки ефективності антиретровірусної терапії. Сімейна медицина. 2(24): 14—18.

3. Alfonzo MA, Diaz A, Sicilliano L, Lopez MG et al. 2012. Functional state of CD4+ and CD8+ T-lymphocytes and their role in the slow progression of HIV infecton in pediatric patients. Jornal de Pediatria. 88;2: 162—168. http://dx.doi.org/10.2223/JPED.2183

4. Harrington M, Carpenter CCJ. 2000. Hit HIV-1 hard, but only when necessary. Lancet. 355: 2147—2152. http://dx.doi.org/10.1016/S0140-6736(00)02388-6

5. Welch SB, Di Gibb. 2008. When Should Children with HIV Infection Be Started on Antiretroviral Therapy? The PLoS MedicineDebate. 5;Issue 3: 73.

6. UNAIDS. UNAIDS world AIDS day report 2011.