• Predictors of nephrosclerosis formation in children with chronic pyelonephritis and vesicoureteral reflux

Predictors of nephrosclerosis formation in children with chronic pyelonephritis and vesicoureteral reflux

SOVREMENNAYA PEDIATRIYA.2018.4(92):40-43; doi 10.15574/SP.2018.92.40

Makieieva N., Morozova O.
Kharkiv Medical University, Ukraine

The key place among nephropathies in children is occupied by inflammatory kidney diseases. Vesicoureteral reflux (VUR) is the most common underlying pathology responsible for the development of urinary tract infections or pyelonephritis in children. VUR is diagnosed in 30-40% of children with urinary tract infections. According to the International Reflux Study Committee, the incidence of nephrosclerosis on the background of VUR is formed in 48% of Caucasian children.
Objective: to determine the clinical significance of the level of urinary excretion of biological markers of inflammation (IL-8), fibrogenesis (TGF-β1) and indices of collagen metabolism in children with chronic pyelonephritis and VUR for predicting the development of nephrosclerosis.
Material and methods. In total 79 patients aged from 6 months to 16 years old with VUR grade II-V after treatment in a period of clinical!laboratory remission (more than 3 months) of pyelonephritis were examined.
Results. Urine excretion of IL-8, TGF-β, and free oxyproline in children with VUR was significantly higher than in children of control group. The median excretion of the protein-bound fraction of oxyproline in the urine of all patients with VU was significantly lower than in the control group.
Conclusions. Thus, levels of urinary excretion of biomarkers of inflammation, fibrogenesis and indices of collagen metabolism can be used as markers of the inflammatory process and the development of scarring of the renal parenchyma in children with VUR.
Key words: vesicoureteral reflux, renal scarring, IL-8, TGF-β1, oxyproline.


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