• Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age
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Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

HEALTH OF WOMAN. 2016.10(116):28–32

Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

Veropotvelyan N. P.

The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog

The article presents data and analysis of their studies on the prevalence of chromosomal aberrations as a whole and separately for different aneuploidy types of missed abortions with first trimester (n = 1808), depending on maternal age and number of previous reproductive losses. According to the results we can mention that: risk to have missed abortion of meiotic aneuploidy and mitotic origin as a whole increased 5.6 times for women over 40 compared to women of 40 years (OR = 5.644) .; regardless of age and women have the following risk of aneuploid pregnancy in the first episode SA / MA two times higher than the subsequent (OR = 2.023 -2.232); after 35 years following risks to have missed abortion with aneuploidy halved if there is a history of three or more pregnancy losses.

Key words: missed abortion, chromosomal abnormalities, maternal age, number of SA episodes.


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