• Possible applications of shock wave therapy in complex correction of sexual dysfunction in women
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Possible applications of shock wave therapy in complex correction of sexual dysfunction in women

HEALTH OF WOMAN. 2018.9(135):112–117; doi 10.15574/HW.2018.135.112

Lukyantseva G. V., Frank S. Y.
National University of Physical Education and Sport of Ukraine, Kiev
MC «Ukrainian trauma center», Kiev

In recent decades, interest in the quality of sexual life has significantly increased all over the world, not only among men but also among women, especially in low-birth-rate European countries. Improving this quality will not only resolve health issues in men and women, but will also improve the demographic situation in these countries. Scientific research in the field of both male and female sexual dysfunction is developing at a rapid pace.

Both men and women go through the same phases of sexual reactions cycle: sexual desire, sexual arousal, and, as a result, orgasm and resolution phase. During the phase of sexual arousal, in both men and women, the blood flow to pelvic organs increases, but in the event of erectile dysfunction in men and frigidity in women, this process weakens or does not occur at all. Furthermore, the innervation of genital organs in male and female organisms is identical. Activation, which enables genital innervation, launches the activation of blood circulation in the target organs.

Therefore, in case of ED in men, and in case of female sexual arousal disorder in women, along with other specific treatment methods, it is useful to perform non-invasive stimulation of insufficiently active physiological mechanisms of sexual arousal. However, for the treatment of ED in men, such stimulation has already been successfully used for a long time – that is the low-intensity extracorporeal shock wave therapy, which allows to restore the erection mechanism itself.

Studies from throughout the world, including those conducted by Ukrainian scientists, have established that low-intensity extracorporeal shock wave therapy induces neovascularization and therefore improves blood circulation. The intensity of the basal and sexually stimulated genital blood flow is a necessary physiological tool of sexual arousal and orgasmic discharge, which makes the subject of artificial stimulation of this indicator by means of shock wave therapy in both men and women particularly important. The use of shock wave therapy can have a number of advantages not only due to the increased blood and lymph flow in the genitals, but also due to the powerful stimulation of the release of neurotransmitters and hormones which provide emotional coloring to the sexual feeling and increase libido (serotonin, dopamine, endorphins etc.).

Therefore, along with combined therapy, the method of low-intensity extracorporeal shock wave therapy can be successfully used in the treatment of female sexual dysfunction.

Key words: shock wave therapy, sexual dysfunction, female sexual arousal disorder, erectile dysfunction, DSM-5.


1. Akimova LN. (2005). Psihologiya seksualnosti. Uchebnoe posobie. Odessa, SMIL:198.

2. Aksonov PV. (2015). EndotelIalniy faktor rostu (VEGF) u hvorih z sudinnoyu erektilnoyu disfunktsIEyu pri zastosuvannI nizkoenergetichnoYi udarno-hvilovoYi terapIYi. Zdorove muzhchinyi 53(2):75–77.

3. Aksenov PV. (2014). Nizkoenergeticheskaya udarno-volnovaya terapiya v korrektsii erektilnoy disfunktsii (obzor literaturyi). Zdorove muzhchinyi 48(1):58–61.

4. Aksonov PV. (2015). Suchasni pidkhody v likuvanni vaskulohennoi erektylnoi dysfunktsii metodom nyzkoenerhetychnoi udarno-khvylovoi terapii. Zdorove muzhchynы 52(1):57–63.

5. Aksonov PV, Romaniuk MH, Myronenko VI. (2017). Udarno-khvylova terapiia u likuvanni erektylnoi dysfunktsii. Zdorove muzhchynы 63(4):64–70.

6. Scheplev PA, Apolihin OI. (2007). Zhenskie seksualnyie disfunktsii. V kn. Andrologiya (klinicheskie rekomendatsii). Pod red. PA Schepleva, OI Apolihina. M, Medpraktika-M:128–46.

7. Vasilev AYu, Egorova EA. (2005). Ekstrakorporalnaya udarno-volnovaya terapiya v lechenii travm i zabolevaniy oporno-dvigatelnogo apparata. M, Meditsina:96.

8. Vasilchenko GS, Agarkova TE, Agarkov ST i dr. (1990). Seksopatologiya. M, Meditsina:576.

9. Gorpinchenko II, Aksonov PV, Romanyuk MG, KornIEnko OM. (2015). Otsіnyuvannya efektivnostі lіkuvannya metodom nizkoenergetichnoуi udarno-hvilovoуi terapіуі hvorуh іz sudуnnoyu erektilnoyu disfunktsіеyu. Zdorove muzhchiny 54(3):48–54.

10. Gorpinchenko II, Aksenov PV, Romanyuk MG, Kornienko AM. (2013). Nizkoenergeticheskaya udarno-volnovaya terapiya – novyiy metod lecheniya erektilnoy disfunktsii. Zdorove muzhchiny 3:39–43.

11. Ekimov MV. (2006). Masturbatsiya i seksualnyie disfunktsii. SPb, ZAO «HOKA»:128.

12. Kogan MI, Perehov AYa. (2011). Zhenskie seksualnyie disfunktsii. M, Prakticheskaya meditsina:206.

13. Kon IS. (1988). Vvedenie v seksologiyu. M, Meditsina:320.

14. Mazurkevich MV, Firsova TA. (2015). Neyrogormonalnyie aspektyi polovogo vlecheniya u zhenschin. Andrologiya i genitalnaya hirurgiya 1:41–44.

15. Svyadosch AM. (1998). Zhenskaya seksopatologiya. 6-e izd. SPb, Piter:288.

16. Sumerova NM, Krizhanovskaya AN, Pushkar DYu, Toktar LR. (2011). Seksualnyie disfunktsii u zhenschin. Vestnik RUDN, ser. Meditsina. Akusherstvo i ginekologiya 6:380–385.

17. Chuprikov AP, Tsupryik BM. (2002). Obschaya i kriminalnaya seksologiya. Ucheb. posobie. K, MAUP:248.

18. Fedorova AI. (2013). Endokrinologicheskie aspekty seksualnogo zdorovya zhenschin. Zhurnal akusherstva i zhenskih bolezney LXII;5:75–84.

19. Aicher A, Heeschen C, Sasaki K, Urbich C, Zeiher AM, Dimmeler S. (2006, Dec 19). Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia. Circulation. 114(25):2823-30. https://doi.org/10.1161/CIRCULATIONAHA.106.628623; PMid:17145991

20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). (2013). Arlington, VA: American Psychiatric Publishing.

21. Bancroft J. (2005). The endocrinology of sexual arousal. J. Endocrinol. 186:411–422. https://doi.org/10.1677/joe.1.06233; PMid:16135662

22. Bitzer J, Alder J. (2010). Female sexual dysfunction. Basel: Frauenklinik, Universitätsspital Basel.

23. Clayton AH, Hamilton DV. (2010). Female sexual dysfunction. Psychiatr. Clin. North Am. https://doi.org/10.1016/j.psc.2010.01.011

24. Mariotto S, Cavalieri Е, Ciampa Е et al. (2003). Effect of shock wave on the catalytic activity of end othelial nitric oxide synthase in umbilical vein endothelial cells. The Ital. J. Biochem. 52:13–19.

25. Fukumoto Y, Ito А, Uwatoku Т et al. (2006). Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease. Coron. Artery Dis. 17:63–70. https://doi.org/10.1097/00019501-200602000-00011; PMid:16374144

26. Ito К, Fukumoto Y, Shimokawa Н, Tohoku Y. (2009). Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy. J. Exp. Med. 219:1–9. https://doi.org/10.1620/tjem.219.1

27. Kuo YR, Wang СТ, Wang FS et al. (2009). Extracorporeal shock-wave therapy enhanced wound healing via increasing topical blood perfusion and tissue regeneration in a rat model of STZ-induced diabetes. Wound Repair Regen. 17:522–530. https://doi.org/10.1111/j.1524-475X.2009.00504.x; PMid:19614917

28. Mariotto S, Cavalieri Е, Amelio Е et al. (2005). Extracorporeal shock waves: from lithotripsy to anti-inflammatory action by NO production. 12:89–96. https://doi.org/10.1016/j.niox.2004.12.005

29. Nishida Т, Shimokawa Н, Oi K et al. (2004). Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pig in vivo. Circulation. 110:2055–2061. https://doi.org/10.1161/01.CIR.0000148849.51177.97; PMid:15520304

30. Serizawa F, Ito К, Matsubara М et al. (2011). Extracorporeal shock wave therapy induces therapeutic lymphangiogenesis in a rat model of secondary lymphedema. Eur. J. Vasc. Endovasc. Surg. 42;2:254–260. https://doi.org/10.1016/j.ejvs.2011.02.029; PMid:21454105

31. Gruenwald I, Appel B and Vardi Y. (2012). Low-intensity extracorporeal shock wave therapy – a novel effective treatment for erectile dysfunction in severe ED patients who respond poorly to PDE5 inhibitor therapy. J Sexual Med. 9:259–264. https://doi.org/10.1111/j.1743-6109.2011.02498.x; PMid:22008059

32. Gutersohn А, Caspari G, Erbel R. (2005). Autoangiogenesis induced by cardiac shock wave therapy (CSWT) increases perfusion and exercise tolerance in endstage CAD patients with refractory angina. Circ. J. 69;1:371–379.

33. ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS), 2018 version. (2018). https://icd.who.int/browse11/l-m/en.

34. Ishikawa Т, Miyagi М, Yamashita М et al. (2013). In-vivo transfection of the proopiomelanocortin gene, precursor of endogenous endorphin, by use of radial shockwaves alleviates pain. J. Orthop Sci. 18;4:636-645. https://doi.org/10.1007/s00776-013-0397-y; PMid:23624847

35. Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi GJ, Takeda M, Fukumoto Y, Yasuda S, Shimokawa H. (2010). Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo. Coron Artery Dis. 21(5):304–11. https://doi.org/10.1097/MCA.0b013e32833aec62; PMid:20617568

36. Kinsey AC, Pomeroy WB, Martin CE. (1953). Sexual Behavior in the Human Female. Philadelphia: WB Saunders.

37. Aicher A, Heeschen A, Sasaki K et al. (2006). Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells. A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia. Circulation. 114:2823–2830. https://doi.org/10.1161/CIRCULATIONAHA.106.628623

38. Ma HZ. (2007). Upregulation of VEGF in subchondral bone of necrotic femoral heads in rabbits with use of extracorporeal shock waves. Calcif: Tissue Int. 81;2:124–131. https://doi.org/10.1007/s00223-007-9046-9; PMid:17629736

39. Masterplus MP50. (2007). Extracorporeal shock wave therapy. Treatment guide. Kiev: Medimeks-Ukraine.

40. Motofei IG, Rowland DI. (2005). The physiological basis of human sexual arousal: neuroendocrine sexual asymmetry. Int. J. Androl. 28:78–87. https://doi.org/10.1111/j.1365-2605.2004.00514.x; PMid:15811068

41. Pauls RN, Segal JL, Silva WA. (2006). Sexual function in patients presenting to a urogynecology practice. Int. Urogynecol. J. Pelvic Floor Dysfunct. 17:576–580. https://doi.org/10.1007/s00192-006-0070-5; PMid:16767528

42. Vardi Y, Appel B, Jacob G, Massarwi O and Gruenwald I. (2010). Can low-intensity extracorporeal shock-wave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunсtion. Eur Urol. 58:243–248. https://doi.org/10.1016/j.eururo.2010.04.004; PMid:20451317

43. Vardi Y, Appel B, Kilchevsky A and Gruenwald I. (2012). Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study. J Urol. 187:1769–1775. https://doi.org/10.1016/j.juro.2012.02.2019; https://doi.org/10.1016/j.juro.2011.12.117; PMid:22425129

44. Bhasin S et al. (2007). Sexual dysfunction in men and women with endocrine disorders. Lancet. 369:597–611. https://doi.org/10.1016/S0140-6736(07)60280-3

45. Lue TF, Basson R, Rosen R et al. (2004). Sexual Medicine. Sexual Dysfunctions in Men and Women. Eds. Paris:991.

46. Wang CJ, Wang FS, Yang КD et al. (2003). Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits. J. Orthop. Res. 21;6:984–989. https://doi.org/10.1016/S0736-0266(03)00104-9

47. Gotte G, Amelio Е, Russo S et al. (2002). Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment. FEBS. Lett. 520:153–155. https://doi.org/10.1016/S0014-5793(02)02807-7

48. Vasyuk YA, Hadzegova AB, Shkolnik EL, Kopeleva MV, Krikunova OV, Iouchtchouk EN, Aronova EM, Ivanova SV. (2002, Sep-Oct). Initial clinical experience with extracorporeal shock wave therapy in treatment of ischemic heart failure. Congest Heart Fail. 16(5):226–30. https://doi.org/10.1111/j.1751-7133.2010.00182.x; PMid:20887620

49. Wang CJ. (2003). An overview of shock wave therapy in musculoskeletal disorders. Med. J. 26:222–232.

50. Wess O. (2004). Physikalische Grundlagen der extrakorporalen Stosswellentherapie. J. Mineralstoff. 11;7:7–18.