• Placental disfunction at pregnant women with concomitant pathology of cardiovascular system
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Placental disfunction at pregnant women with concomitant pathology of cardiovascular system

HEALTH OF WOMAN. 2017.7(123):88–92; doi 10.15574/HW.2017.123.88

Gopchuk E. N.
National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev

The objective: study of the effect of Tivomax on the parameters of utero-placental-fetal blood circulation in patients with placental dysfunction and concomitant extragenital pathology of the vascular system.
Patients and methods. The study included 60 pregnant women diagnosed with the diagnosis «placental dysfunction», after 22 weeks of gestation and concomitant extragenital pathology of the vascular system, including varicose veins, thrombophlebitis and endarteritis.
All patients were randomly divided into the main (30 patients) and control (30 patients) epidemically equivalent groups.
During the survey, clinical, laboratory and instrumental (ultrasound) methods of examination were used. Observation of patients was carried out both during pregnancy and in the postpartum period.
Results. The study of the efficacy of Tivomax, 4.2% solution for infusions, against the background of the generally accepted regimen for the treatment of placental dysfunction showed that under the influence of the proposed therapy, dopplerogram normalization occurs by decreasing peripheral resistance in the microvascular bed of the placenta, increasing placental perfusion, and optimizing blood flow in the vessels.
The conclusion. The purpose of the drug Tivomax contributes to the normalization of the dopplerogram by reducing the peripheral resistance in the microvascular bed. The drug Tivomax has no adverse reactions, negative changes in laboratory blood counts. Timely correction of management of pregnancy and childbirth, drug therapy, conducted in accordance with dopplerometric indicators, can reduce perinatal morbidity and mortality.
Key words: Tivomax, L-arginine, endothelium, obstetrics and gynecology, placental disfunction, cardiovascular pathology, extragenital pathology.

REFERENCES

1. Davyidova YuV, Limanskaya AYu, Dvulit MP. 2015. Platsentarnyie sindromyi v klinike ekstragenitalnoy patologii s tochki zreniya endotelialnoy disfunktsii: sovremennyie predstavleniya i puti korrektsii. Zdorove zhenschinyi 5:83–86.

2. Abramchenko VV. 2005. Profilaktika i lechenie gipotrofii ploda i platsentarnoy nedostatochnosti. Farmakoterapiya gestoza. SPb:378–400.

3. Klimov VA. 2007. Endoteliy fetoplatsentarnogo kompleksa pri fiziologicheskom i patologicheskom techenii beremennosti. Akusherstvo i ginekologiya 2:7–10.

4. Slyusar TI, Pilipenko ON, Dzhelomanova OA, Levchenko II. 2015. Izmenenie pokazateley fetoplatsentarnogo kompleksa u patsientok s zaderzhkoy vnutriutrobnogo razvitiya ploda i antenatalnyimi poteryami v anamneze. Zdorove zhenschinyi 3:156–158.

5. Fedorova MV. 1997. Platsentarnaya nedostatochnost. Akush. i ginek. 5:40–43.

6. Zhirova HB. 2005. Osobennosti techeniya beremennosti u zhenschin v zavisimosti ot funktsionalnogo sostoyaniya sosudistogo endoteliya i ego rol v formirovanii platsentarnoy nedostatochnosti. Avtoref. dis. kand. med. nauk. Barnaul:24.

7. Gorpinchenko II, Miroshnikov YaO. 2009. Erektilnaya disfunktsiya. Meditsina svItu: 85.

8. Savelev VS, Kirienko AI, Gavrilov SG. 2007. Klinicheskie aspektyi flebologii. Problemyi klinicheskoy meditsinyi 2:10–14.

9. Sheppard SJ, Khalil RA. 2015. Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy. Cardiovasc Hematol Disord Drug Targets. 10:33–52. https://doi.org/10.2174/187152910790780096

10. Morris RK, Selman TJ, Verma M. 2015. Systematic reviw and meta-analysis of the test accuracy of ductus venosus Doppler to predict compromise of fetal/neonatal wellbeing in high risk pregnancies with placental insufficiency. Eur.J.Obstet.Gynecol. Reprod. Biol. 152:3–12. https://doi.org/10.1016/j.ejogrb.2010.04.017; PMid:20493624

11. Benirchke K, Kaufmann P. 2010. Patology of the Human Placenta. New York: Springer. 947.

12. Greer IA. 2013. Prevention and management of venous thromboembolism in pregnancy. Clin Chest Med. 24:123–137. https://doi.org/10.1016/S0272-5231(02)00055-2