• Pediatric antiphospholipid syndrome
To content Full text of article

Pediatric antiphospholipid syndrome

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.4(76):93-98; doi 10.15574/PP.2018.76.93

Dudnуk V. M., Furman V. G., Demianyshyna V. V.
Vinnytsya National Pirogov Memorial Medical University, Ukraine

The article presents modern data on the prevalence of antiphospholipid syndrome in children. The analysis of the clinical course of syndrome in children was provided and the laboratory criteria for the diagnosis of the disease are specified. Problems that arise in the management of children with antiphospholipid syndrome and possible ways of their solution are determined and discussed.

Key words: antiphospholipid syndrome, children.


1. Aguiar CL, Soybilgic A, Avcin T, Myones BL. (2015). Pediatric antiphospholipid syndrome. Current rheumatology reports. 17(4): 27. https://doi.org/10.1007/s11926-015-0504-5; PMid:25854492

2. Avcin T, Cimaz R, Silverman ED et al. (2007). Register for pediatric patients withantiphospholipid syndrome: clinical and immunological features of 107 children. Arthritis Rheum. 56: S830.

3. Avcin T. (2008). Antiphospholipid syndrome in children. Current opinion in rheumatology. 20(5): 595—600. https://doi.org/10.1097/BOR.0b013e3283060a8c; PMid:18698184

4. Avcin T, Silverman ED. (2007). Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. Lupus. 16: 627—633. https://doi.org/10.1177/0961203307079036; PMid:17711899

5. Berkun Y, Simchen MJ, Strauss T, Menashcu S, Padeh S, Kenet G. (2014). Antiphospholipid antibodies in neonates with stroke — a unique entity or variant of antiphospholipid syndrome? Lupus. 23(10): 986—993. https://doi.org/10.1177/0961203314531842; PMid:24729280

6. Cimaz R, Descloux E. (2006). Pediatric antiphospholipid syndrome. Rheumatic Disease Clinics. 32(3): 553—573. https://doi.org/10.1016/j.rdc.2006.05.005; PMid:16880084

7. Erkan D, Harrison MJ, Levy R. (2007). Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum. 56(7): 2382—2391. https://doi.org/10.1002/art.22663; PMid:17599766

8. Go EL, O'Neil KM. (2017). The catastrophic antiphospholipid syndrome in children. Curr Opin Rheumatol. 29(00). https://doi.org/10.1097/BOR.0000000000000426

9. Groot N, De Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman B, McCann L. (2017). European evidence-based recommendations for diagnosis and treatment of paediatric antiphospholipid syndrome: the SHARE initiative. Annals of the rheumatic diseases, annrheumdis-2016. https://doi.org/10.1136/annrheumdis-2016-211001

10. Meroni PL, Argolini LM, Pontikaki I. (2016). What is known about pediatric antiphospholipid syndrome? Expert review of hematology. 9(10): 977—985. https://doi.org/10.1080/17474086.2016.1235969; PMid:27615277

11. Mukherjee SS, Dhar S, Gaikwad RP, Saha A. (2015). Antiphospholipid antibody syndrome in pediatric population: An overview. Indian Journal of Paediatric Dermatology. 16(1): 5. https://doi.org/10.4103/2319-7250.149401

12. Rao AAN, Elwood K, Kaur D, Warad DM, Rodriguez V. (2017). A retrospective review of pediatric antiphospholipid syndrome and thrombosis outcomes. Blood Coagulation & Fibrinolysis. 28(3): 205—210. https://doi.org/10.1097/MBC.0000000000000576; PMid:27428014

13. Ruiz-Irastorza G, Cuadrado MJ, Ruiz-Arruza I. (2011). Еvidence based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients:report of a task force at the 13th International Congress onantiphospholipid antibodies. Lupus. 20(2): 206—218. https://doi.org/10.1177/0961203310395803; PMid:21303837

14. Rumsey DG, Myones B, Massicotte P. (2017). Diagnosis and treatment of antiphospholipid syndrome in childhood: A review. Blood Cells, Molecules, and Diseases. 67: 34—40. https://doi.org/10.1016/j.bcmd.2017.02.009; PMid:28283251

Article received: Aug 20, 2018. Accepted for publication: Nov 26, 2018.