• Peculariries of local cell immunity in children with undifferentiated connective tissue dysplasia

Peculariries of local cell immunity in children with undifferentiated connective tissue dysplasia

SOVREMENNAYA PEDIATRIYA.2017.5(85):26-31; doi 10.15574/SP.2017.85.26

Oshlyanska O. A., Zadorozhna T. D., Pustovalova O. I., Vovk V. M.
SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv, Ukraine
LLC «Children's Medical Center «Dobrobut», Kyiv, Ukraine

Purpose — to examine some specific parameters of the local cell immunity in children with and without undifferentiated connective tissue dysplasia in comparison with clinical peculiarities.
Materials and methods. The analysis of the immunohistochemical and morphological tests of palatal tonsils scrapes, which were made in 20 children during their follow-up care in LLC «Children's Medical Center «Dobrobut», was conducted.
Results. The conducted immunohistochemical and morphological tests revealed lower expression of receptors to immunoglobulin A, CD68, CD16 in children with clinical manifestations of undifferentiated connective tissue dysplasia. Expression of antigens to immunoglobulin E was higher in children with clinical manifestations of undifferentiated connective tissue dysplasia as well.
Conclusions. The conducted research showed that children with clinical manifestations of undifferentiated connective tissue dysplasia have latent local cell immunodeficiency, which requires additional correction.
Key words: children, undifferentiated connective tissue dysplasia, local immunity, palatal tonsils.

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