- Pathology of hemostasis and miscarriage
Pathology of hemostasis and miscarriage
HEALTH OF WOMAN. 2018.10(136):65–67; doi 10.15574/HW.2018.136.65
Vozniuk V. P. , Burnaeva S. V. , Vdovina E. P. , Yanyuta A. S.
SI «Institute of Hematology and Transfusiology of the National Academy of Medical Sciences of Ukraine», Kiev
SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician Ye.M. Lukyanova NAMS of Ukraine», Kiev
The objective: to determine of the nature of disorders in a hemostasis system in women with miscarriage in during I trimester of pregnancy.
Materials and methods. 270 women were examined. Habitual miscarriage in during I trimester was noted in the anamnesis of all examined women. During the study screening and basic hemostatic tests were conducted.
Results. Combined coagulation disorders account for about 65.0% of all hypercoagulation states in women with miscarriage. In women with unexplained recurrent miscarriage a decrease in platelets aggregation with ADF and collagen, also tendency to decrease epinephrine-induce platelets aggregation were determined. Isolated and combined changes of platelets function on the background of hyper- or hypocoagulation were detected in more than half of women with miscarriage.
Conclusion. Miscarriage in women in during I trimester in half of the cases noted in the conditions of hemostasis pathology. Pathology of platelet hemostasis were detected in 74.0% women with miscarriage in early stages of pregnancy.
Key words: hemostasis, miscarriage, hypercoagulation, hypocoagulation, platelets.
1. Tkachenko LV, Kostenko TI, Uglova ND, Shklyar AL. (2015). Nevyinashivanie beremennosti. Vestnik VolgGMU Vyip. 1(53):3–9.
2. Brenner B. (2004). Haemostatic changes in pregnancy. Thromb.Res. 114;5–6:409–414.
3. Chen LB, Meng LL, Chen H et al. (2013). Coagulation and prothrombotic state parameters: clinical analysis in early pregnancy. Zhonghua Yi Xue Zhi. 93;27:2146–2148. PMid:24284247
4. Valera MK, Parant O, Vayssiere C et al. (2010). Physiologic and pathologic changes of platelets in pregnancy. Platelets. 21;8:587–595. https://doi.org/10.3109/09537104.2010.509828; PMid:20873962
5. Umazume T, Yamada T, Morikawa M et al. (2015). Platelet aggregation in citrated whole blood of the first trimester of pregnancy. Clin. Chim. Acta. 448:60–64. https://doi.org/10.1016/j.cca.2015.06.011; PMid:26102281
6. Dempsay MA, Flood K, Burke N et al. (2015). Platelet function in patients with a history of unexplained recurrent miscarriage who subsequently miscarry again. Eur. J. Obstet. Gynecol. Reprod. Biol. 188:61–65. https://doi.org/10.1016/j.ejogrb.2015.02.003; PMid:25790916
7. Flood K, Peace A, Kent E at al. (2010). Platelet reactivity and pregnancy loss. Am. J. Obstet. Gynecol. 203;3:281.
8. Rac MW, Minns Crawford N, Worley KC. (2011). Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelets syndrome. Obstet. Gynecol. 117(2 Pt2):501–503. https://doi.org/10.1097/AOG.0b013e318206bde4; PMid:21252804