• Pathology of hemostasis and miscarriage

Pathology of hemostasis and miscarriage

HEALTH OF WOMAN. 2018.10(136):65–67; doi 10.15574/HW.2018.136.65

Vozniuk V. P. , Burnaeva S. V. , Vdovina E. P. , Yanyuta A. S.
SI «Institute of Hematology and Transfusiology of the National Academy of Medical Sciences of Ukraine», Kiev
SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician Ye.M. Lukyanova NAMS of Ukraine», Kiev

The objective: to determine of the nature of disorders in a hemostasis system in women with miscarriage in during I trimester of pregnancy.

Materials and methods. 270 women were examined. Habitual miscarriage in during I trimester was noted in the anamnesis of all examined women. During the study screening and basic hemostatic tests were conducted.

Results. Combined coagulation disorders account for about 65.0% of all hypercoagulation states in women with miscarriage. In women with unexplained recurrent miscarriage a decrease in platelets aggregation with ADF and collagen, also tendency to decrease epinephrine-induce platelets aggregation were determined. Isolated and combined changes of platelets function on the background of hyper- or hypocoagulation were detected in more than half of women with miscarriage.

Conclusion. Miscarriage in women in during I trimester in half of the cases noted in the conditions of hemostasis pathology. Pathology of platelet hemostasis were detected in 74.0% women with miscarriage in early stages of pregnancy.

Key words: hemostasis, miscarriage, hypercoagulation, hypocoagulation, platelets.


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