• Pathogenetic features of the bronchial asthma control in school-aged children, depending upon the nuclear transcription factor NF-kB and interleukins 4, 6 serum levels (a literature review)

Pathogenetic features of the bronchial asthma control in school-aged children, depending upon the nuclear transcription factor NF-kB and interleukins 4, 6 serum levels (a literature review)

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):104-107; doi 10.15574/PP.2018.75.104

Dudnyk V. М., Bulavenko O. V., Kutsak О. V.
National Pirogov Memorial Medical University, Vinnytsia, Ukraine

In a literature review describes the works that deal with the pathogenetic mechanisms of proinflammatory (IL-6), anti-inflammatory (IL-4) interleukins and nuclear transcription factor (NF-kB) in children, which give evidences of the leading role of their interaction in the activity regulation of low-intensity chronic inflammatory process that is bronchial asthma. In our opinion, the study and analysis of current literature sources will clarify the pathogenetic features of the bronchial asthma development and control, clinical course formation, development of a variety of measures to prevent this pathology and contribute toward the adequate therapy that, in turn, will lead to a drug load reduction on the children's body.

Key words: bronchial asthma, children, nuclear transcription factor (NF-kB), interleukins 4, 6.

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Article received: Jun 13, 2018. Accepted for publication: Sep 10, 2018.