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Mycoses in structure of infectious syndrome in primary immunodeficiencies 

SOVREMENNAYA PEDIATRIYA.2015.4(68):96-102; doi 10.15574/SP.2015.68.96 
 

Mycoses in structure of infectious syndrome in primary immunodeficiencies 
 

Bondarenko A. V., Chernyshova L. I., Kostyuchenko L. V., Gilfanova A. M., Rabosh O. V.

P.L. Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine

Western-Ukrainian specialized Children's Medical Center, Lviv, Ukraine

Kiev Municipal Children's Hospital of Intensive Care №1, Ukraine 
 

Fungi as infectious agents generally have low pathogenicity, however, they can cause disease in patients with immune disorders. Antifungal resistance is provided by a chain of cell'cell interactions. The aim was to assess the incidence of fungal infections in congenital defects of the immune system and to determine their characteristics. For this reason the infectious syndrome of 308 patients with different primary immunodeficiency was analyzed. In our study fungal infections were observed in 66 patients (21.4%), most often in combined immunodeficiency (83.3%), chronic granulomatous disease (77.7%), and defects of innate immunity and immune regulation associated with functional defect of Th17 cells. Fungi in primary immunodeficiencies cause life'threatening infections. The most common pathogens are Candida and Aspergillus. In treatment of resistant infections in immunodeficient patient the high awareness regarding fungi as possible pathogens is very important. Therefore, the use of special microbiological methods for clarifying agent is necessary. 
 

Key words: antifungal immunity, mycosis, primary immunodeficiency. 
 

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