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Morphofunctional endometrium state in infertile reproductive age patients

HEALTH OF WOMAN.2015.5(101):141–144; doi 10.15574/HW.2015.101.141
 

Morphofunctional endometrium state in infertile reproductive age patients
 

Kornienko S. M.

SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kiev
 

The purpose of this study was to examine the morphofunctional state of endometrium in women of late reproductive age with infertility before IVF. The study involved 197 patients with infertility. Were performed ultrasound, fluid hysteroscopy and endometrial biopsy to examine the state of its receptor system. Were found that the US is not sufficiently informative for diagnostics of endometrial pathology in this category of patients: diagnostic findings during hysteroscopy included: endometrial polyp – 6.1%, endometrial hyperplasia – 4.0%, saddle uterus – 2.5%, uterine adhesions – 0.5% of cases. In general, primary false negative diagnoses recorded in 18.7% of patients. Immunohistochemical study of the expression of receptors for estrogen and progesterone in the endometrium revealed a dissonance between the indices in the stroma and glands: if the level of estrogen receptors in the glands and stroma in the majority of patients was higher than the population norm (in 84 and 66% cases, respectively), the number of progesterone receptors in stroma was reduced in 46% of women, and in the glands – increased in 59%.
 

Key words: infertility, hysteroscopy, endometrial pathology, assisted reproductive technologies.
 

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