• Modern view on treatment of patients with fibrocystic mastopathy
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Modern view on treatment of patients with fibrocystic mastopathy

HEALTH OF WOMAN. 2016.6(112):149–152; doi 10.15574/HW.2016.112.149 

Modern view on treatment of patients with fibrocystic mastopathy 

Smolanka I. I., Loboda A. D.

The National Cancer Institute, Kyiv

The aim of the study: to determine the effectiveness of the drug Epigalin® Brest in the treatment of fibrocystic breast disease in women.

Materials and methods. The study included 50 women with an established diagnosis of fibrocystic breast disease (diffuse cystic mastopathy). All women complained of pain and swelling of both breast 3-20 days before the start of menstruation. By blind randomization, all women were divided into 2 groups. Patients of the first group used the drug Epigalin® Brest 1 tablet 2 times a day for three months. Patients of the second group used the drug prostrate summer cypress on the approved user scheme. Patients of both groups did not differ in age (from 22 to 48 years, mean age 35 years). All patients during General examination were performed ultrasound of the breast, and patients older than 40 years also performed the mammogram. Patients of both groups were found multiple cysts in both breasts, the size of which ranged from 3 mm to 22 mm. the average size of the cysts groups were comparable. To assess the effectiveness of treatment in both groups was determined by three parameters:

1. Pain in the Breasts, which were evaluated on a scale from 0 (no pain) to 10 (unbearable pain).

2. Tissue density breast, to determine which was performed by transient elastography (kPa).

3. The average diameter of the cyst.

Results. According to the study in the first group identified the implementation of a positive effect of the drug Apigalin Brest. Patients in this group there was a decrease in the average degree of pain, i.e. the patient almost did not feel pain before menstruation, and the complete absence of cystic elements in the Breasts was detected in 90% of patients. No patient noted the deterioration of the breast during the observation. Patients of the second group the average degree of pain, but 10% of the patients noted aggravation of pain syndrome after discontinuation of the drug prostrate summer cypress. In 15% of patients in this group appeared again cysts, and their average diameter began to increase. Tissue density of the breast tended to increase.

Conclusion. 1. Complex herbal preparation Epigalin® Brest is effective in the treatment of mastitis. In the case of regular use Apigalin Brest reduce by 68% the presence of cystic component in women with mastopathy.

2. Epigalin® Brest with regular use reduces the density of the tissue of the breast, realizing the function of oncoprotektor.

3. Epigalin® Brest significantly reduces pain before menstruation, which considerably improves the quality of life.

Key words: mastopathy, pain, breast gland, treatment, Epigalin® Brest.


1. Dace Baltita Dr.hab.med. Riga East University Hospital «Bol v molochnoy zheleze».

2. Dr. Mary Ellen Wewers, Nancy K. Lowe, “Critical review of visual analogue scales in the measurement of clinical phenomena” Article first published online: 19 JAN 2007,http://onlinelibrary.wiley.com/doi/10.1002/nur.4770130405/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+24+March+from+10-14+GMT+%2806-10+EDT%29+for+ essential+maintenance

3. Dinah Gould BSc, MPhil, PhD, RGN, RNT, Cert Ed, DipN, Daniel Kelly BSc, MSc, RGN, NDN, Cert Onc, Cert PGCE, RNT, Len Goldstone BA, MSc, FSS, John Gammon BSc, MA(Ed), MPhil, PhD, RGN “Examining the validity of pressure ulcer risk assessment scales: developing and using illustrated patient simulations to collect the data INFORMATION POINT: Visual Analogue Scale” Article first published online: 21 DEC 2001 http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2702.2001.00525.x/abstract.

4. Stan Grant, PhD, Tom Aitchison, BSc, Esther Henderson, BSc, Jim Christie, BSc, Sharam Zare, PhD, John McMurray, MD and Henry Dargie, MD, “A Comparison of the Reproducibility and the Sensitivity to Change of Visual Analogue Scales, Borg Scales, and Likert Scales in Normal Subjects During Submaximal Exercise”, http://chestjournal.chestpubs.org/content/116/5/1208.abstract

5. Lipkevich Oleg. Grud – bez problem! http://www.likar.info/health/article-42641-grud-bez-problem

6. Radzihovskaya A.A. Vse o boli v molochnoy zheleze. http://www.tiensmed.ru/news/o-boli-v-mol-jelez1.html

7. Krasnozhon D.A. Boli v molochnyih zhe lezah. http://www.lood.ru/ print_mamma-diseases/breast-pain.html

8. Struchkov V., Struchkov Yu. Bol v molochnoy zheleze, povyishenie temperaturyi – simptomyi seroznoy fazyi mastita», http://www.rostmaster.ru /lib/surg/surg-0029.shtml

9. Abdullaev RYa, Golovko TS, Grabar VV, Belevtsov YuP, Lyisenko TL, Dolenko OV. 2009. Luchevaya diagnostika neopuholevyih zabolevaniy grudnoy zhelezyi. Ucheb. posob. Harkov, Novoe slovo:96.

10. Golovko TS, Abdullaev RYa, Sklyar SYu, Krahmaleva LP, Krahmaleva AS, Sorokin IN. 2009. Luchevaya diagnostika opuholevyih zabolevaniy grudnoy zhelezyi. Ucheb. posob. Harkov, Novoe slovo:112.

11. Manihas AG, Martyinyuk VV, Sobolev AA, Kryuchkov SB, Frolkova IM. 2007, Sentyabr. Semiotika i problemyi diagnostiki fibroadenomatoza molochnyih zhelez. Ambulatornaya hirurgiya. Statsionarozameschayuschie tehnologii 3(27):39–41.

12. Vyisotskaya IV, Letyagin VP, Kim EA. 2006. Disgormonalnyie displazii molochnyih zhelez. Aktualnaya tema «Mammologiya» 2:9–12.