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Modern possibilities of pre-eclampsia prediction and prevention

HEALTH OF WOMAN.2016.7(113):44–48; doi 10.15574/HW.2016.113.44 

Modern possibilities of pre-eclampsia prediction and prevention

Lakhno I. V.

Kharkiv medical Academy of postgraduate education

Prediction of pre-eclampsia (PE) remains a very important problem of modern obstetrics.

The objective: study forecasting capabilities and PE drug prevention.

Patients and methods. Totally 292 pregnant women and 154 pre-eclamptic patients were enrolled in the study. The traditional combination of biochemical and biophysical tests for the selection of high risk for PE patients were used (PI in the uterine arteries> 2.25; PAPP-A <0.69 MoM; b-hCG>3.0 MoM; AFP>2.5 MoM). Patients of group II were divided into subgroup II A and II subgroup B. This was done to evaluate the complex medical prophylaxis (CMP) of PE, which was administered in the II B subgroup.

Results. The prospective study showed the following diagnostic value of a positive result in the screening for PE in subgroup II A. OR was 16.5. The sensitivity of this method was 87,1%, specificity – 71.0%, PPV – 75.0%, NPV – 84.6%, IA – 79.0%. The additional usage of the sympathovagal balance in the position on the right side and active orthostasis increased the predictive value of screening for PE in 4.5 times. The sensitivity of the method was 90.3% and specificity – 84.3%. PPV was 84.8%. NPV had a maximal value – 100.0%. IA – 92.3%. The proposed method of CMP decreased the odds of PE in 8.3 times.

Conclusion. This study led to the development of pathogenetically reasonable screening protocol included biochemical and biophysical tests, as well as an effective method of PE prevention.

Key words: preeclampsia, screening, drug prevention.


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